JPH10118480A - Agitation type granulator with temperature regulating jacket apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable a process in which high quality granules are produced automatically, and granules are also produced by various granulation-drying methods. SOLUTION: In the granulator in which a temperature regulating jacket apparatus 15 for regulating the temperature of an agitation tank 1 is attached to the agitation tank 1 equipped with a means 2 for agitating supplied raw materials, the jacket apparatus 15 is composed of jacket parts 15A-15C to which hot water and cold water are supplied from a temperature regulator 16, the temperature of each jacket part 15A-15C is controlled independently by an automatic controller 19.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an agitation type granulator equipped with a temperature control jacket device for manufacturing granules, and a method for producing granules by the agitation type granulator, and relates to pharmaceuticals, foods and the like. It can be used in the field.

[0002]

2. Description of the Related Art As one of the tumbling stirring granulation methods for producing granules by a wet method, there is a high-speed stirring granulation method using a stirring-type granulator. In this granulation method, a stirring blade as stirring means is disposed at the bottom of a stirring tank into which a raw material (granulated material) is charged, and the granulated material is tumbled and stirred by rotation of the stirring blade.
This creates a circulating flow that has become a spiral motion of the granulated material, adds the binding liquid to this, granulates, and locally imparts a strong shear force to the crushing blades provided on the inner wall of the stirring tank. By crushing, a heavy spherical granular material is produced.

[0003] Some conventional agitation-type granulators are equipped with a temperature control jacket device outside the stirring tank, and this jacket device is generally used for heating, drying and cooling after the granulation step. Used in According to this jacket device, the operations from the granulation to the drying step can be performed continuously in a closed system, so that contamination in the production line can be prevented and the productivity can be improved. When an organic solvent is used as the binding solution, the solvent can be recovered by drying under reduced pressure, which is advantageous in terms of environmental hygiene and explosion-proof safety.

[0004] The conventional jacket device is disposed around the side of the stirring tank or integrally provided outside the stirring tank including the bottom. The temperature becomes the same depending on the heating and cooling fluid supplied, and the temperature changes at the same temperature.

[0005]

According to such a conventional jacket device, there are the following problems.

[0006] The first problem is that when the jacket device is used as a drying means, the dried matter adheres to the heated surface of the stirring tank, and it is difficult to automate and unmanned production of the granular material. It is.

That is, when the jacket device is used as a drying means after the granulation step, the stirring blades are rotated at a low speed and the inside of the stirring tank is swirled slowly in order to suppress the destruction of the granules during drying. As the solvent evaporates, the dried matter adheres to the inner wall of the stirring tank, and gradually accumulates and adheres in a layered manner. Such a phenomenon is more remarkable in a granular material having a large particle bonding force, and the attached material causes deterioration of the portion and a decrease in the drying ability of the device. , Causing product failure. In particular, if the product is a pharmaceutical product, the heterogeneity of the product due to the contamination of the altered deposits is due to GMP (Good Manufa
cturing Practice (a standard for pharmaceutical manufacturing and quality control).

[0008] For this reason, conventionally, an operator must perform a removal operation such as scraping off the adhered matter during drying.
It has been difficult to automate and unmann the process from granulation to drying.

As a cleaning device for removing adhering substances, a rotating shaft is provided vertically at the center of the lid of the stirring tank, a scraper is attached to the rotating shaft via a support arm, and the rotating shaft is rotated manually or automatically. There is known a configuration in which the scraper is moved in the horizontal circumferential direction along the inner wall portion of the stirring tank to remove the attached matter, but this is also provided on the inner wall on the side of the stirring tank. In addition, since the scraper cannot act on the vicinity of the rotation axis of the crushing blade, it is impossible to remove the deposits on this portion.

A conventional device for preventing the generation of such deposits is to improve the shapes of the stirring blades and the stirring tank, and no device focusing on the jacket device has been made.

The second problem is that it cannot cope with various granulation and drying methods, and is poor in versatility.

That is, in the conventional jacket device, as described above, the temperature of each section becomes the same temperature and changes at the same temperature, and the adjustment of the drying capacity is performed from the low temperature range to the high temperature range of the jacket device. Depends only on the control up to
As a result, it was difficult to set an accurate desired drying rate, and the controllable range of the drying rate was narrow.

[0013] For this reason, it is not possible to cope with various granulation drying methods in which the drying temperature and the drying speed in each part inside the stirring tank must be different, and the type of granular material that can be produced using a conventional jacket device is not available. Was limited.

SUMMARY OF THE INVENTION An object of the present invention is to provide a stirring type equipped with a temperature control jacket device which enables the manufacturing operation of high-quality granular materials to be automated and unmanned, and to manufacture granular materials by various granulation drying methods. It is an object of the present invention to provide a granulator and a method for producing granules using the granulator.

[0015]

In order to achieve this object, a stirrer-type granulator with a jacket for temperature control according to the present invention is provided with a stirrer inside, and the rotation of the stirrer causes the raw material to be removed. In a stirring type granulator equipped with a temperature control jacket device configured to include a stirring tank in which the granular material is manufactured, and a temperature control jacket device mounted on the stirring tank and adjusting the temperature of the stirring tank, the jacket device includes: It is characterized by comprising a plurality of jacket portions that can be individually adjusted in temperature.

Here, the jacket device may be provided on the whole of the stirring tank or on a part thereof. The stirring tank to which the jacket device is attached is cylindrical, conical,
Any shape such as a sphere may be used. Further, the heating and cooling source of each jacket portion of the jacket device may be a fluid such as steam, water, oil or the like supplied or held in each jacket portion, or may be an electric means such as a heater or a cooler.

A plurality of jacket portions constituting the jacket device may be arranged or buried in each portion of the jacket device as a whole to constitute the jacket device. May be formed separately from each other, and a jacket device may be constituted by the entire divided jacket portions. As described above, when the respective jacket portions are formed separately from each other, the operation of attaching the jacket device to the stirring tank can be performed for each of the jacket portions, so that there is an advantage that the operation can be simplified.

In the case where the jacket device is composed of jacket portions formed separately from each other, a heat insulating material such as rock wool or a foam material, an air layer, and a vacuum layer are provided between the jacket portions. It is desirable to be thermally independent of each other.

The agitation type granulator according to the present invention has an automatic control device for the jacket device, and each jacket portion is heated and cooled by the control action of the automatic control device, and its temperature is controlled. The automatic control device may be based on a relay system with contact control or may be based on sequence control using a programmable controller with non-contact control. When a computer is used, various control programs are recorded in advance on recording means such as a hard disk, and the temperature of each jacket portion is controlled by a predetermined control program read according to the granular material to be manufactured. Alternatively, various control programs may be recorded on one or more portable recording media such as a magnetic disk and an optical disk, and the control program for the recording media may be input to a computer when manufacturing the granular material. You may.

The stirring tank generally has a bottom, sides and a lid. The bottom portion is a horizontal surface portion or a curved surface portion at the lower portion of the stirring tank in which the rotating stirring blade serving as the stirring means is disposed,
The side part is a connection part between the bottom part and the lid part, and is a place where the crushing blade is usually arranged. Further, the lid portion is an upper sealed portion of the stirring tank, and is provided when air is sent into the stirring tank by a blowing device such as a compressor or the like and air is discharged by a pressure reducing device such as a vacuum pump. It also includes a bag filter holding container.

The jacket portion of the jacket device may be provided at two of the bottom, the side and the lid, for example, at the bottom and the side, but provided at least at the bottom, the side and the lid. It is desirable. When the jacket portion is provided at least for each of the bottom portion, the side portions, and the lid portion in this manner, a wide variety of temperature controls can be performed. The quality and the type of granular materials can be improved.

In the method for producing a granular material by the agitation type granulator equipped with a temperature control jacket device according to the present invention, the temperature required at a plurality of locations inside the agitation tank is required in the granulation and drying step of the granular material. The temperature of each jacket portion of the jacket device is adjusted so as to obtain a suitable temperature to produce a granular material.

One specific example of this production method is that, after a binder is added to a granulated product and granulated, the bottom portion of a jacket portion of a jacket device provided at a bottom portion and a side portion of a stirring tank as drying means. Only the jacket portion is heated, and the stirring blade is rotated at a low speed to prevent the granules from sticking to the bottom. Thereby, it is possible to prevent the generation of dry deposits on the bottom, which is the heating surface. When the bottom jacket is heated, cold water or the like is circulated or held in the side jacket according to the drying speed of the granulated material, thereby reducing the temperature of the jacket to the temperature of the granulated material. Lower temperature. Thereby, like the bottom portion, no deposits are generated on the side portions.

In this production method, when the moisture evaporating from the granulated material is reduced and the process reaches a reduced-rate drying stage in which no deposits are formed, the side jacket portion is also heated to transfer the entire jacket device to the stirring tank. By increasing the amount of heat transfer, the drying speed can be increased.

When the scraper is provided in a stirring tank as a device for cleaning dry deposits,
The rotating side of the scraper is divided into a working part and a non-working part, and the cooling liquid is circulated without heating the jacket of the non-working part. Instead, it is also possible to heat and use the jacket portion of the working portion and the jacket portion of the bottom portion.

Another specific example of the production method according to the present invention is disclosed in a published patent “High-speed stirring granulation method and high-speed stirring granulator”.
This is a case of a special granulation method in which a granulation operation by a spray means and a drying operation by a jacket device described in (Application No. PCT / JP94 / 01919) are simultaneously performed. In the case of this granulation method, since the granulation proceeds in a state where the moisture content of the granulated particles is small, no deposits are generated on the inner wall of the stirring tank, so that the entire surface of the bottom jacket portion and the side jacket portion is not formed. By heating, the amount of heat transferred from the jacket device to the stirring tank is increased to increase the drying capacity, thereby shortening the time required to complete the desired granular material.

Further, since this granulation method is a condensation granulation method of the raw material powder, powder adhesion due to vapor condensation at the lid portion occurs remarkably in the initial stage of granulation, but the powder is attached to the bottom and side jackets. In addition, this problem can be solved by heating the jacket of the lid.

Further, in a melt granulation method using a powdery low-melting substance as a binder, a rotating disk is used instead of the stirring blade, and air is blown from a circumferential slit between the inner wall surface of the stirring tank and the rotating disk. When heating and granulating the granulated material while rolling, only the jacket portion on the side above the rotating disk, which is a required heating portion, can be heated and used. As a result, the temperature of the air blown from the circumferential slit is not affected by the temperature of the bottom jacket portion, and the temperature of the granulated material can be accurately controlled by the side jacket portion during heating and cooling. Yes, in addition to this, because the bottom of the jacket is not used for heating,
Energy saving can be achieved.

In a stirring-type granulator, when a jacket device for temperature control is attached to a stirring tank, a manufacturing method in which drying is performed after granulation, a manufacturing method in which granulation and drying are performed simultaneously, and a manufacturing method by melt granulation. Although the method can be performed, as can be seen from the above description, according to the present invention in which the jacket device is composed of a plurality of jacket portions that can individually adjust the temperature, each point inside the stirring tank is Each jacket portion can be selectively used so as to reach a desired temperature. As a result, it is possible to eliminate the generation of dry deposits which cause production trouble, thereby improving the quality of the granular material produced, and improving production efficiency. Can be improved,
The automatic operation of the agitation type granulator for continuously performing the manufacturing process becomes possible, and unmanned operation can be realized.

In the conventional jacket device, since each part of the jacket device is at the same temperature and changes at the same temperature, it is not possible to perform various granulation drying methods for producing various granular materials. However, the agitation type granulator equipped with the jacket device was poor in versatility.However, according to the agitation type granulator with a jacket device according to the present invention, various types of granulation drying methods can be performed. The mold granulator can be used as a multifunctional granulator.

In the conventional jacket device, the temperature control for adjusting the drying rate is performed by adjusting the amount of heat to be supplied. However, in the present invention, in addition to the adjustment of the amount of heat to be supplied, the jacket unit to be heated is also controlled. Can be selected, the total heating area of the jacket portion can be adjusted, and as a result, fine temperature control can be performed. For this reason, for example, the granules to be produced are pharmaceuticals,
If the crystallized or hydrated state of the drug has a significant effect on the effectiveness of the product, the jacket to be heated should be used for both the bottom and side jackets, one jacket, or a partial jacket. By selecting such a portion, an optimum drying speed state can be created by adjusting the amount of heat to be supplied and adjusting the total heating area of the jacket portion. For this reason, when rapid drying is unsuitable for the quality of the product such as fluidized-bed drying, in the present invention, the drying can proceed slowly, so that a high-quality product can be manufactured.

The agitation type granulator according to the present invention is a high-speed agitation type granulator, that is, the agitation means provided inside the agitation tank has an axis perpendicular to the inside of the bottom of the agitation tank as a rotation center axis. A stirring type granulator provided with a stirring blade provided with a crushing blade having a horizontal axis as a rotation center axis may be provided inside the side portion of the stirring tank. A stirring granulator other than the granulator may be used.

In addition, the granular material that can be produced by the stirring granulator and the production method according to the present invention is not limited to pharmaceuticals, and foods can also be produced.

[0034]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is a schematic diagram including a drive system and a control system of an agitation type granulator having a jacket for temperature control according to the present embodiment. Stirring tank 1 into which raw materials are charged
Has a bottom 1A, a side 1B tapered upward,
A stirring blade 2 which is a conical shape having a lid portion 1C and is a stirring means having a vertical axis serving as a rotation center axis is disposed inside the bottom portion 1A, and a horizontal portion is provided inside the side portion 1B. A crushing blade 3 as crushing means having a shaft serving as a rotation center axis is provided. The stirring blade 2 is, for example, a three-blade type, and the crushing blade 3 is, for example, a multi-stage type in which five cross blades are arranged coaxially. The stirring blade 2 rotates with the driving force of the stirring blade motor 4, and the crushing blade 3 rotates with the driving force of the crushing blade motor 5.

The lid 1C is provided with a spray gun 6 whose tip faces the inside of the stirring tank 1. This spray gun 6
This is an addition means for adding the binding liquid to the granulated material in the stirring tank 1. The coupling liquid stored in the liquid storage tank 7 is supplied to the spray gun 6 through the liquid feed pipe 9 by driving of the roller pump 8. An air supply pipe 11 extending from a compressor 10 which is a blower is connected to the stirring tank 1, and an exhaust pipe 13 is connected from the stirring tank 1 to a vacuum pump 12 which is a pressure reducing apparatus.
When the air is supplied to or exhausted from the stirring tank 1 during the granulation step or the drying step, the compressor 1
0, vacuum pump 12 is used. The exhaust pipe 13 extends from the bag filter 14 arranged on the lid 1C of the stirring tank 1, and therefore, the lid 1C also serves as a holding container for the bag filter 14.

A jacket device 15 for temperature control is mounted on the outer surface of the stirring tank 1, and the jacket device 15 has a bottom 1A.
15A, a jacket 15B attached to the side 1B, and a jacket 15C attached to the lid 1C, which are separately formed and thermally insulated. I have. The heat source fluid from the temperature control device 16 is circulated and supplied to the three jacket portions 15A to 15C via the fluid forward circuit 17 and the fluid return circuit 18, and the jacket portions 15A and 15B are formed by the heat source fluid as described later. Heated and cooled, jacket part 15C
Is heated.

The above-described stirring blade motor 4, crushing motor 5,
Roller pump 8, compressor 10, vacuum pump 12,
The operation timing, the operation amount, and the like of each of the temperature control devices 16 are controlled by an automatic control device 19, and the automatic control device 19 is based on a non-contact control sequencer.

FIG. 2 is a specific circuit diagram of the temperature control device 16, the fluid forward circuit 17, and the fluid return circuit 18 in FIG. The temperature control device 16 includes a water heater 20 and a water cooler 21. The fluid outflow circuit 17 includes jacket portions 15A to 15A.
It consists of outgoing pipelines 22 to 24, each of which is connected to 5C,
The fluid return circuit 18 includes return conduits 25 to 27 extending from the jacket portions 15A to 15C. Outgoing pipelines 22 and 23 have branch pipelines 22A, 22B, 23A and 23B, and branch pipelines 22A and 23A are connected to branch pipelines 22B and 22B from hot water heater 20.
Reference numerals 23B extend from the chilled water supply unit 21A of the chiller 21. The return pipes 25 and 26 are connected to the branch pipes 25A,
25B, 26A, 26B, and branch pipes 25A, 26A.
A is to the water heater 20 and branch pipes 25B and 26B are to the water heater 2
One cold water return part 21B is connected to each. In the branch circuits 22A, 22B, 23A, and 23B, the control valve 3 controlled by the automatic control device 19 via the driving units 28 to 31 is provided.
Switching valves 38 and 39 which are switched by the automatic control device 19 via the driving units 36 and 37 are provided at the connection between the branch circuits 25A and 25B and the connection between the branch circuits 26A and 26B. Is provided.

The automatic control device 19 controls the opening and closing of the control valves 32 to 35 and the degree of opening thereof, so that the hot water supplied from the hot water device 20 to the jacket portions 15A and 15B and the cold water supply portion of the cold water device 21. The switching from the cold water from 21A is performed, and the supply amount is adjusted, whereby the heating and cooling of the jacket portions 15A and 15B are selected, and the heating temperature and the cooling temperature are set. The hot water and cold water supplied to the jacket portions 15A and 15B are selectively returned to the hot water heater 20 and the cold water return portion 21B of the cold water heater 21 by the switching control of the switching valves 38 and 39 by the automatic control device 19. It is. The switching valve 3
When the jackets 8 and 39 are fully closed, the jacket sections 15A and 15B
Can hold hot or cold water.

The outgoing line 24 extends from the water heater 20, and the return line 27 extends to the water heater 20. Outgoing line 24
Is provided with a control valve 41 that is controlled by the automatic control device 19 via a drive unit 40, and by controlling the opening and closing of the control valve 41 and its opening degree, the jacket unit is heated by hot water from the water heater 20. Heating and non-heating of 15C are selected, and a heating temperature is set at the time of heating.

As described above, the temperatures of the jackets 15A to 15C of the jacket device 15 attached to the bottom 1A, the side 1B, and the lid 1C of the stirring tank 1 can be individually adjusted. The adjustment is performed as set in advance by the automatic controller 19, whereby a predetermined amount of heat is transmitted from the jacket portions 15A to 15C to the bottom portion 1A, the side portion 1B, and the lid portion 1C of the stirring tank 1, and The inside of each part is heated or the like.

A temperature sensor is arranged inside each of the bottom 1A, the side 1B, and the lid 1C of the stirring tank 1, and a temperature signal from these sensors is input to the automatic control device 19 to input the jackets 15A to 15C. The temperature inside each part of the stirring tank 1 may be feedback-controlled by controlling the supply of the hot water and the cold water and the supply amounts thereof.

[0043]

EXAMPLES Next, examples performed using the above-described stirring type granulator will be described.

EXAMPLE 1 5 kg of a granulated product comprising 57 parts by weight of lactose, 20 parts by weight of partially pregelatinized starch, 20 parts by weight of low-substituted hydroxypropylcellulose and 3 parts by weight of hydroxypropylcellulose
Was mixed in the stirring tank 1, purified water corresponding to a solid content of 38 parts by weight was added by the spray gun 6, and granulated for 5 minutes. After granulation, the jacket 15 of the bottom 1A and the lid 1C is formed.
A and 15C are circulated with hot water of 60 ° C., and the jacket part 15B of the side part 1B is kept cold water. The inside of the stirring tank 1 is set at a vacuum of 40 cmHg. The resultant was subjected to conduction heat transfer drying under reduced pressure.

Separately from this, the jacket portion to be used for heating is divided according to the drying time, and the jacket portions 15A, 15A of the bottom portion 1A and the lid portion 1C in the constant-rate drying period up to 2.5 hours.
5C is heated (the jacket portion 15B of the side portion 1B holds cold water), and in the subsequent reduced-rate drying period, the entire bottom portion 1A, the side portion 1B, and the lid portion 1C are heated by all the jacket portions 15A to 15C. As in the case of the conventional temperature control jacket device, the other conditions were the same as above for the case where the entire bottom portion 1A, side portion 1B, and lid portion 1C were heated by all the jacket portions 15A to 15C during drying. .

FIG. 3 shows the change in the temperature and moisture value of the granulated product at each drying time obtained in this example, and Table 1 shows the presence or absence of the adhered substance in the stirring tank 1. In addition,
The moisture value was measured by an infrared moisture meter (manufactured by Kett Chemical Laboratory).

[0047]

[Table 1]

According to FIG. 3 and Table 1, the reduced-rate drying period is observed after 2.0 to 2.5 hours from the change in the product temperature. At this time, the jacket used for heating is changed to the jacket 1 of the bottom 1A and the lid 1C.
When switching from 5A and 15C to all the jacket portions 15A to 15C and heating the entire bottom portion 1A, side portion 1B, and lid portion 1C, no dry deposits are observed inside the stirring tank 1, and Automation was possible throughout the manufacturing process.
Further, the drying time until the dried material (granulated material) reaches a moisture value of 2.5% is shorter than the case where only the bottom portion 1A and the lid portion 1C are heated using the jacket portions 15A and 15C, and the manufacturing time is reduced. It became clear that it could be shortened.

Example 2 After 5 kg of a granulated product comprising 95 parts by weight of lactose and 5 parts by weight of carmellose were mixed in a stirring vessel 1, an aqueous solution of 5 parts by weight of hydroxypropylcellulose corresponding to 3 parts by weight in solids ratio was used. Was heated and sprayed with a spray gun 6 at a constant spraying speed to granulate. During this granulation, the bottom 1A,
All jacket portions 15A to 15 of side portion 1B and lid portion 1C
C. circulate hot water of 80 ° C.
cmHg. vac. FIG. 4 shows the product temperature and moisture value of the granulated product at each drying time obtained in this example. The moisture value was measured while monitoring with an infrared moisture meter (manufactured by Fuji Paudal Co., Ltd.).

In this embodiment, in addition to the progress of granulation in the low moisture region, the lid 1C was also heated by the jacket 15C against the powder adhesion in the initial stage of granulation, so that the inside of the stirring tank 1 was formed. No kimono was generated. In addition, the bottom 1A and the side 1 are used in all the jackets 15A to 15C.
B, by heating the entire surface of the lid 1C to increase the drying rate, the granulation changes at a constant spraying speed from the spray gun 6 and is performed in a stable granulation state with almost no change in the product temperature. As in Example 1, automatic operation of the agitation type granulator was possible.

[0051]

According to the present invention, since the temperature control jacket device mounted on the stirring tank is composed of a plurality of jacket portions which can individually adjust the temperature, the jacket portion to be used for heating can be appropriately selected. As a result, it is possible to eliminate the generation of dry deposits inside the stirring tank, thereby achieving high quality of the product, improvement of the production efficiency, and realization of continuous automation of the production process. As a result, it is also possible to produce granules by various granulation drying methods.

Further, since the drying capacity can be adjusted by the amount of heat transferred to the entire jacket device and the total heating area of the jacket portion which is selectively heated and used, the optimum drying speed for the granular material to be produced is obtained. In this regard, it is possible to manufacture high-quality products.

[Brief description of the drawings]

FIG. 1 is a schematic view showing an agitation type granulator according to one embodiment of the present invention including a drive system and a control system.

FIG. 2 is a diagram showing specific circuits of a temperature control device, a fluid forward circuit, and a fluid return circuit shown in FIG. 1;

FIG. 3 is a graph showing the results of Examples.

FIG. 4 is a graph showing the results of another example.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Stirrer 1A Bottom part 1B Side part 1C Lid 2 Stirring blade which is a stirring means 3 Crushing blade which is a crushing means 10 Compressor which is a blowing device 12 Vacuum pump which is a decompression device 15 Jacket device for temperature control 15A-15C Jacket portion 16 Temperature control device 19 Automatic control device 20 Water heater 21 Cooler

──────────────────────────────────────────────────続 き Continued on front page (51) Int.Cl. ⁶ Identification symbol FI // A61K 9/16 A61K 9/16 E

Claims (6)

[Claims] An agitation means is provided therein, and a stirring tank in which a granular material is produced from an input material by rotation of the agitation means;
In the agitation type granulator equipped with a temperature control jacket device, which is mounted on the stirring tank and configured to include a temperature control jacket device for adjusting the temperature of the stirring tank, the jacket devices can be individually temperature-controlled. An agitation type granulator with a jacket device for temperature control, comprising a plurality of jacket portions. 2. The agitation type granulator with a temperature control jacket device according to claim 1, wherein each jacket portion of the jacket device is divided and formed. Machine. 3. The stirring type granulator with a jacket device for temperature control according to claim 1 or 2, wherein the stirring tank has a bottom portion, a side portion, and a lid portion, and each jacket portion of the jacket device has at least these components. A stirring type granulator with a jacket device for temperature control, which is provided for each of a bottom portion, a side portion, and a lid portion. 4. The agitation type granulator with a jacket device for temperature control according to claim 1, further comprising an automatic control device for said jacket device, wherein said automatic control device controls said jacket device. A stirring type granulator with a jacket device for temperature control, wherein the temperature of each jacket portion is controlled. 5. The agitation type granulator with a jacket device for temperature control according to claim 1, wherein said agitating means is provided with an axis perpendicular to the inside of a bottom portion of said agitation tank as a rotation center axis. A stirring blade is provided, and a crushing blade having a horizontal axis as a rotation center axis is provided inside the side portion of the stirring tank, thereby being a high-speed stirring type granulator. Agitation type granulator with jacket for temperature control. 6. A method for producing a granular material using the agitation type granulator with a jacket device for temperature control according to claim 1, wherein a temperature of a plurality of points inside the agitation tank is controlled. A temperature control jacket, wherein the temperature of each jacket portion of the jacket device is adjusted to produce the granular material so that the temperature becomes an appropriate temperature required in the granulation and drying step of the granular material to be manufactured. A method for producing a granular material using a stirring-type granulator equipped with a device.