JPH10114666A - Organism recovering agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject recovering agent having pharmacological and physiological actions such as biologically active action and ionization suppressing action and capable of activating he organism and recovering and healing organisms by combinedly using a specific organism-activating agent and royal jelly, etc. SOLUTION: This organism recovering agent jointly uses (A) an organism- activating agent comprising a substance containing (ii) a component of divalent and trivalent ion salts in (i) water and (iii) an organogermanium compound and (B) royal jelly or/and (C) propolis. Furthermore, the organism recovering agent comprises further (iv) seawater concentrate, and the component (ii) comprises a compound represented by the formula [(m) and (n) are each variable] and especially the component (ii) has magnetism. A material obtained by dissolving, e.g. iron (III) chloride in an aqueous solution of a strong alkali, neutralizing iron (III) chloride and concentrating the solution is preferably used as the component (ii).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention comprises a ferric (III) salt or a ferrous (III) salt having a magnetic property and has pharmacological and physiological actions such as a biological activity action and an ionization suppression action. And
The present invention relates to a living body recovery agent that activates a living body to recover and heal. The biological recovery agent of the present invention is mainly used as an oral preparation.

[0002]

In recent years, research in the life sciences is promoted, novel active substances Fe of divalent and trivalent iron salts _{^{+2 m Fe +3 n Cl 2 m}} + 3 n
(Where m and n indicate variables). This active substance is an inorganic salt such as iron hydrochloride, sulfate, nitrate and the like, and an organic salt such as formate, acetate, propionate, etc., which exhibit properties intermediate between ferrous and ferric irons. , Is obtained as a transition form when valence conversion is caused by adding ferric chloride to an aqueous solution of a strong alkali such as sodium hydroxide, calcium hydroxide, potassium hydroxide, and lithium hydroxide. It can be industrially produced.
-63593 and JP-B-4-27171).

[0003] It has been found that the substance of the above-mentioned divalent and trivalent iron salt has the following effects upon contact with water. That is, the substance is added to ordinary water in an extremely small amount (concentration 2 ×
By mixing 10 ^-12 ml = 1/20 trillion), it was found that a 1/20 trillion wt% aqueous solution of this substance (hereinafter, this aqueous solution is referred to as “pie water” for convenience) has the following properties. I have.

(Structural Change of Water Molecule) Normally, the water molecule of water has positive and negative polarities because the centers of gravity of hydrogen and oxygen do not change. Therefore, since water molecules are combined in a cage shape by hydrogen bonding, hydrocarbons, methane, gas, and the like are dissolved in the cage. In contrast, piwater changes the bonding structure of water molecules and water molecules from polar molecules to nonpolar molecules by electron spin, that is,
The center of gravity of H (hydrogen) and O (oxygen) is raised, and bipolarity is eliminated. That is, it is considered that the water molecule itself does not have the plus and minus, and as a result, the structure of the water molecule changes from a cage shape to a string shape. Therefore, the dissolution of hydrocarbons and the like as in normal water does not occur.

[0005] (Deionization reaction) ... Usually, in water, metals and metal salts are ion-dissociated, and a substance change occurs mainly by ionic reaction. However, in pi water, since there is no plus or minus, deionization of metal ions is caused. Dissociation occurs to form a non-ionic reaction system.

(Variation of gas expansion coefficient) When the pi water and the gas (air) coexist in the same system, the apparent expansion coefficient of the gas with respect to the temperature varies with the temperature. In other words, the volume of air in distilled water expanded linearly in proportion to the rise in temperature, whereas in the case of pie water, the temperature increased to 22 ° C.
It changed along a curve with an inflection point near it.

(Change in potential difference) Normally, in water, the potential difference increases with an increase in metal ions, but in pi water, the potential difference decreases due to deionization and dissociation, leading to removal of contained heavy metal ions.

(PH stabilizing effect) Normally, the pH is determined by the degree (amount) of an acidic substance and an alkaline substance contained in water. Controls substances, deionizes and dissociates and stabilizes to neutrality.

(Inhibition of pathogenic bacteria): Bacteria such as bacteria are unicellular microorganisms having a negative charge and usually inhabit in the ion reaction system of water, but suppress the ionic reaction in pie water to change the equilibrium state of the bacteria. In an environment where it can not inhabit, of course, proliferate.

As described above, it has been experimentally proved that the substance is activated by changing the structure of water molecules.
Currently, it is widely used as a water-modifying activator, and in recent years, further experiments have been conducted on pharmacological and physiological uses of the piwater, and remarkable results are being obtained. .

The present inventor has also developed a new magnetically active divalent and trivalent iron salt active substance (see JP-A-7-61822). This active substance is an active substance that reforms and activates water, which has both the properties of the electromagnetic treatment and the properties of the chemical treatment at the same time, and is obtained, for example, by chemically treating magnetite. Will be described later.

The above-mentioned magnetically active substance of divalent and trivalent iron salt has the following properties upon contact with water. That is, by mixing a very small amount (concentration: 2 × 10 ⁻¹² ml = 1/20 trillion) of the active substance into ordinary water, a 1/20 trillion weight% aqueous solution of the substance (hereinafter, referred to as “water”)
This aqueous solution is called "magnetic pie water" for convenience.)
Has the same characteristics as pie water in addition to the above-mentioned characteristics of activated water, and in particular, this active substance dissolves in water and coexists with water. Acts strongly and effectively. This active substance can be used as a water-modifying activator similarly to the active substance of the pie water, and the magnetic pi water also has potential for pharmacological and physiological uses like the pi water.

As described above, pie water and magnetic pie water are active waters that can be used in a wide range of fields.
Although it has the potential to be used as a medicinal product, the above-mentioned pie water and magnetic pi water remain unsatisfactory for use as a medicinal product, leaving room for improvement.

Therefore, the present inventor has developed active water which is useful as a medicament as a result of research and experiment. This activated water is one in which an organic germanium compound or / and a seawater concentrate are contained in the pie water, and one in which an organic germanium compound or / and / or a seawater concentrate is contained in the magnetic pie water (Japanese Patent Application (See Japanese Patent Application Laid-Open Nos. 8-161174 and 9-130373). It has been found that the above-mentioned activated water can obtain the effects originally expected by the present inventors for medicinal purposes.

[0015]

SUMMARY OF THE INVENTION The inventor of the present invention makes use of the properties of the active substance of the above-mentioned iron (III) salt or the iron (III) salt having magnetism to make the pharmacological / physiological effect the above-mentioned activity. It is an object of the present invention to provide a novel biological restorative agent that can further improve water.

[0016]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventor has continued his research and experiment, and has achieved the object. Therefore, the present invention is provided here.

A biorecovery agent according to one of the present invention is a bioactive agent comprising a substance containing a component of a ferrous iron salt in water and an organic germanium compound or / and a seawater concentrate. It is characterized in that it is configured to be used in combination with royal jelly and / or propolis.

Here, as the bioactive agent, a substance containing a component of a ferric (III) salt is used as an essential component, and either one or both of an organic germanium compound and a seawater concentrate are selected. It includes all of the materials contained. That is, specifically, as the bioactive agent,
Either a substance containing the above-mentioned substance and an organic germanium compound in water, a substance containing a seawater concentrate instead of the above-mentioned organic germanium compound, or a substance containing both an organic germanium compound and a seawater concentrate is included.

Either royal jelly or propolis used in combination with the bioactive agent can be selected and employed, or both may be employed. In this case, royal jelly and propolis may be manufactured separately from the bioactive agent and taken together with the bioactive agent, or may be used by mixing with the bioactive agent. When royal jelly and / or propolis is mixed with a bioactive agent and used, it may be mixed immediately before taking, or may be previously prepared and mixed with the bioactive agent.

Examples of the substance containing the component of the divalent and trivalent iron salt include the following formula: Fe ⁺² m Fe ⁺³ n Cl ₂ m + ₃ n (where m and n indicate variables) (1) The compound shown can be illustrated. As described above, the substance represented by the formula (1) has an intermediate property between iron (II) and iron (III), inorganic salts such as hydrochloride, sulfate, and nitrate of iron, and formate, acetate, Organic salts such as propionate,
For example, it is obtained as a transition form when valence conversion is caused by adding ferric chloride to an aqueous solution of a strong alkali such as sodium hydroxide, calcium hydroxide, potassium hydroxide, and lithium hydroxide. As a specific method for producing a substance, for example, a method obtained by the following steps is exemplified.
That is, it is produced by dissolving ferric chloride in an aqueous solution of strong alkali, neutralizing the solution with hydrochloric acid, and concentrating the neutralized solution to obtain crystals. In addition, the said manufacturing method showed an example, and it is not limited to this.

In the present invention, the active substance (Fe ⁺² m Fe ⁺³ nCl ₂ m + ₃ n) produced by the above-mentioned steps can be used alone. For example, sodium chloride, sodium sulfate, ammonium chloride, diatomaceous earth, It may be used by being carried on a carrier material composed of inorganic compounds such as bentonite, silica, aluminum and the like, and organic compounds such as vitamins, hormones, proteins and amino acids. In this case, the effect of the active substance is maintained and works effectively. .

As the organic germanium compound, for example, a compound represented by the following formula can be exemplified.

[0023]

Embedded image

Any of these organic germanium compounds can be used in accordance with the object of the present invention. However, these germanium compounds are merely examples of specific names, and are not limited to those described above. is not. Reported examples have demonstrated that organogermanium compounds have a wide variety of pharmacological actions not found in other compound systems due to subtle differences in chemical structure. These organic germanium compounds can be selected from commercially available ones (powder or the like).

The above-mentioned seawater concentrate is obtained by concentrating seawater. Seawater, which is the source of life, has a good balance of various minerals, and is very good at taking minerals in a balanced manner. However, seawater has a high salt content, so it is not preferable to take a large amount as it is. Therefore, the present invention concentrates seawater, removes salt (NaCl) contained in seawater during this step, and reduces the salt content as much as possible, and a very small amount of water (concentrated solution) remaining until the end. Is collected, and the mineral in this concentrated liquid is used as an active ingredient.

The concentrated solution can be produced, for example, by the following method. An appropriate amount of seawater is placed in a pot or other heating vessel and heated, and the seawater is heated and concentrated to about 30% of the initial amount.
Next, when this is cooled by natural cooling or the like, NaCl precipitates. Therefore, the precipitated NaCl is removed by filtration. Further, the remaining water is concentrated by heating to about 5% to 3% of the initial water and cooled. The cooled seawater is filtered to remove precipitated NaCl. At this time, when filtering so that water does not remain in the precipitated salt, suction filtration is performed as desired. This filtrate contains calcium necessary for physiological action as nutrients, etc.
It becomes a seawater concentrate containing minerals such as iron, zinc, cobalt, and manganese in a well-balanced manner.

There is no particular limitation on the equipment used for seawater concentration, and there is no limitation on the heating method, treatment temperature / time, seawater treatment amount, etc., as long as the equipment can perform the concentration operation. The cooling step of the seawater before the filtration is performed in order to increase the precipitation amount of NaCl by lowering the water temperature. In order to increase the efficiency of collecting the concentrated liquid, the amount of seawater to be treated at a time is preferably 5 l or more. The above seawater concentrating method is an example, and is not limited to this treatment method. Further, the concentration method is preferably a heating method under reduced pressure rather than heating under normal pressure.

As the water, ordinary drinking water such as tap water and groundwater can be used, and distilled water obtained by distilling such water, pure water permeated through a hollow fiber membrane and sterilized, and the like can also be used. it can.

The bioactive agent of the biorecovery agent according to one aspect of the present invention is obtained by mixing an active substance containing the above-mentioned divalent iron (III) salt and an organic germanium compound or / and seawater concentrate in water. (Each of the above substances is dissolved in water). The mixing ratio of each substance to water is not particularly limited and can be arbitrarily set according to the purpose of use and the like. As a ratio, a substance containing a component of a ferrous ferric salt with respect to water is 2 × 10 ⁻⁴ to 2 × 10 ^4
-20 % by weight, 0.01 to 1% by weight of the organic germanium compound, and 0.01 to 3% by weight of the seawater concentrate. In addition, in this specification, the said unit (weight%) shows the ratio with respect to the total weight of the bioactive agent including water.

The bioactive agent of the present invention may be produced by mixing each of the above substances in water in the range of the above mixing ratio from the beginning, or the mixing ratio of the above substances to the total amount is, for example, 100%. It is also possible to mix it with water at a high ratio such as twice as high and use it as a stock solution of the bioactive agent, and dilute this stock solution with water at a set magnification to use. Further, as another method, a mixture of water and a substance containing the component of the divalent ferric iron salt in the above-described mixing ratio range is produced, and an organic germanium compound or / and a seawater concentrate are optionally added thereto. A bioactive agent can also be obtained by mixing at a predetermined mixing ratio at a point in time.

The aqueous solution produced as described above may be a substance containing a component of a ferric (III) salt, an organic germanium compound or /
It has been found that this is a bioactive agent exhibiting excellent pharmacological and physiological actions due to the synergistic effects of the respective actions of the concentrated water and seawater.

Royal jelly used in combination with the above-mentioned bioactive agent has been attracting attention as a potent enzyme, a carotenoid and a carcinogen, which are attracting attention as factors such as anti-aging, mental stability and rejuvenation, in addition to various vitamins and minerals. 1
0 Hydroxy-2-decenoic acid and the like are contained as components. The royal jelly processed into a paste or the like is generally commercially available. In the present invention, these commercially available royal jellies can be arbitrarily selected and employed.

The propolis used in combination with the bioactive agent is
A bee-like substance in which bees mix sap collected from trees such as eucalyptus, pine, birch, and oak with secretions such as their saliva components. This propolis contains as components parotin and other enzymes, various flavonoids, various vitamins and minerals, and the like. It is said that this propolis exerts effects on antibacterial action, activation of immune function, antiallergic action, activation of bioenergy, prevention of aging, prevention of adult diseases and cancer, among which flavonoids and enzymes are particularly effective. It is considered to be a healing power of propolis. When these bioactive substances regulate the whole body's immune function and hormonal system, they will eventually cure a wide range of diseases such as digestive, respiratory, circulatory and nervous system diseases. It is said.

Propolis is commercially available in the form of a liquid (concentrated extract) or a solid (tablet) obtained by mixing a propolis extract component with a base acceptable in foods or pharmaceuticals and the like. These commercially available products can be arbitrarily selected and employed. As the liquid propolis, for example, an original propolis stock solution prepared by appropriately pulverizing a raw propolis lump (a piece of lump), immersing it in a solvent such as alcohol, extracting it, and purifying and filtering it to prepare a concentrated extract is also commercially available. In the present invention, this propolis stock solution (propolis extract) can also be used.

The biorecovery agent according to one of the present inventions is a combination of the above-mentioned bioactive agent and royal jelly or / and propolis. Is set in accordance with the type, medical condition, usage, or the like of. The biological restoration agent according to the present invention has an effect of activating and recovering a living body by the action of the bioactive agent and the action of royal jelly and / or propolis, and the synergistic effect of these actions. Since it has an effect, it is extremely useful for treating various diseases such as cancer immunotherapy.

A biological restorative agent according to another aspect of the present invention comprises a substance containing a component of a ferrous iron salt which is magnetic to water and an organic germanium compound or / and a seawater concentrate. The present invention is characterized in that the bioactive agent is used in combination with royal jelly and / or propolis.

Here, as the bioactive agent, a substance containing a component of a magnetic ferrous iron (III) salt is an essential component, and either one of an organic germanium compound and a seawater concentrated solution, or It includes all of those containing both selected. That is, specifically, as the bioactive agent, a substance containing the substance and an organic germanium compound in water, or a substance containing seawater concentrate instead of the organic germanium compound, or an organic germanium compound and seawater concentrate It includes all containing both of the liquids.

Examples of the substance containing the component of the magnetic ferrous divalent iron (III) salt include a substance obtained by chemically treating magnetite, and a specific method for producing this substance is, for example, a substance obtained by the following steps. Show. That is, a step of dissolving magnetite in concentrated hydrochloric acid, a step of neutralizing this solution with a strong alkali such as sodium hydroxide, calcium hydroxide, potassium hydroxide, lithium hydroxide, and the like. And obtaining the crystals in a solution of magnetite in a semi-dissolved solution of concentrated hydrochloric acid. In addition, the said manufacturing method showed an example, and it is not limited to this.

The active substances prepared according to the above exhibit in particular the following two remarkable properties: One of them is a characteristic by electromagnetic processing. In other words, water is activated by applying a magnetic field to water using the magnetism of magnetite itself. Magnetite has a saturation magnetization of 471 G (G: Gauss) at room temperature, which is considerably larger than that of other materials, and is a ferromagnetic material that generates spontaneous magnetization. For this reason, when magnetite is made to act on water, it has the same characteristics as activated water subjected to electromagnetic treatment. Particularly, since the above-mentioned active substances are dissolved in water and coexist, they act stronger and more effectively on water than active water to which a magnetic field is applied from the outside.

Another one is a characteristic by a chemical treatment. That is, magnetite has the property of dissolving in acid to generate Fe ²⁺ and Fe ³⁺ ions, and the chemical composition of magnetite Fe ³⁺ (Fe ²⁺ F
Using the iron (Fe) ion shown in e ³⁺ ) O ₄ , the hydrogen bond of water is broken to increase the polarization and activate the water.
Since water is a collective molecule (cluster), it has less polarization and is more stable than a single molecule. The iron ions of the magnetite act on the clusters to reduce the molecular size, increase the polarization, and activate water. Since iron ions have various catalytic actions, they are also involved in the growth of animals and plants.

In the present invention, the active substance produced by the above-mentioned process can be used alone, but other compounds such as inorganic substances such as sodium chloride, magnesium chloride and aluminum, fertilizers such as ammonium sulfate and calcium phosphate, clay, and oxidized substances Minerals such as aluminum and silica oxide,
An organic compound such as glucose or an amino acid may be used as a carrier, and in this case, the effect of the active substance is maintained and works effectively.

A bioactive agent of a biorecovery agent according to another invention of the present invention utilizes a substance containing a component of the above-mentioned ferrous iron (III) salt having magnetic properties as an active ingredient. The bioactive agent is obtained by mixing a substance containing a component of ferrous iron (III) salt that is magnetic with water and the above-mentioned organic germanium compound or / and the above-mentioned seawater concentrate (each of the above-mentioned substances is mixed with water). Dissolves). The compounding ratio of each of the above substances to water can be arbitrarily set according to the purpose of use and the like as in the above-described invention, but as an exemplary mixing ratio of each of the above substances when used for internal use. , A substance containing a component of a magnetic ferrous ferric salt with water
× 10 ^-4 ~2 × 10 ^-20 wt%, the organic germanium compound 0.01 to 1 wt%, and the sea water concentrate can be exemplified range of about 0.01 to 3 wt%. In addition, the bioactive agent of the present invention is also manufactured by mixing each of the above substances from the beginning with water in the range of the above mixing ratio, or increasing the mixing ratio of each of the above substances to water in the same manner as described above. It is also possible to mix and use this as a stock solution of the bioactive agent, and dilute this stock solution with water at a predetermined magnification for use. Moreover, it can also be manufactured by the other preparation methods described above.

The aqueous solution produced as described above has excellent pharmacological properties due to the action and synergistic effect of each of the substance containing the component of the ferrous iron salt having magnetism, the organic germanium compound and / or the concentrated seawater. It turned out to be a bioactive agent that exerts a physiological action.

The biological restoring agent according to another aspect of the present invention comprises the bioactive agent and royal jelly and / or royal jelly.
Combined use with propolis and its use (taking)
The dosage is set according to the age of the target human, the type of disease, the medical condition, the usage, and the like, similarly to the above-described invention. The biorecovery agent according to the present invention also has the effect of activating and recovering a living body by the action of a bioactive agent and the action of royal jelly and / or propolis, and the synergistic effect of these actions, similarly to the above-mentioned invention. Since it has various pharmacological and physiological actions, it is extremely effective as a therapeutic agent for various diseases such as cancer immunotherapeutic agents.In addition, it has excellent properties such as promoting plant and animal growth, keeping plant and animal freshness, and preventing corrosion and rust. Having.

[0045]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, the present invention will be described specifically with reference to examples. It should be noted that the following embodiments are merely examples, and are not intended to limit the present invention.

[0046]

Example 1 (Production of a substance containing a component of ferric ferric salt) 1.0 mg of ferric chloride was placed in 100 ml of a 0.5N aqueous solution of sodium hydroxide, stirred and dissolved, and allowed to stand for 24 hours. After removing the insoluble substance generated in the above solution, the solution is neutralized with hydrochloric acid, concentrated under reduced pressure, and dried and crystallized in a desiccator. The obtained crystals were re-dissolved by adding 50 ml of an 80% by weight aqueous solution of isopropyl alcohol, concentrated under reduced pressure to remove the solvent, dried, and the re-dissolution, concentration, and drying were repeated several times to obtain 0.25 mg of crystal A. (An active substance containing a component of divalent and trivalent iron salts) was obtained.

(Treatment of Water) Tap water is permeated through a hollow fiber membrane to obtain pure water which has been subjected to a sterilization treatment.

(Preparation of Bioactive Agent) The pure water is mixed with 2 × 10 ⁻¹² wt% of the crystal A and 0.05 wt% of the organogermanium compound (formula 2) and stirred. (1) was obtained.

(Selection of Propolis) As a propolis,
An original propolis mass was appropriately pulverized, immersed in alcohol, extracted, and purified and filtered to obtain a concentrated propolis concentrate, and a commercially available propolis stock solution (propolis extract) was employed.

(Usage as a biological recovery agent) A predetermined amount (for example, 20 to 6) of the active agent (1) is placed in a glass or other container.
0 cc), and several drops of the propolis (for example, 1
５5 drops) to give a single dose of the biological recovery agent and take it.

[0051]

Example 2 (Production of Seawater Concentrate) 5 l of seawater was placed in a pot and heated,
When the amount of seawater is about half, it is filtered to remove dirt and foreign matter. This seawater is heated again, heated and concentrated until the amount of the seawater reaches about 30% of the initial amount, and then naturally cooled, NaCl precipitates. Therefore, filtration is performed to remove the precipitated NaCl. Further, the remaining seawater is heated and concentrated to about 5% of the initial water, and cooled. The cooled seawater is filtered to deposit N
The aCl is removed to obtain a seawater concentrate. The obtained concentrated liquid contains many minerals in a well-balanced manner.

(Production of Bioactive Agent) The pure water of Example 1 was mixed with 2 × 10 ^-12 % by weight of the crystal A obtained in Example 1 and 0.08% by weight of the above-mentioned water concentrate and stirred. Thus, a bioactive agent (2) was obtained.

(Usage as a biorecovery agent) The active agent (2) was put in a predetermined amount (for example, 20 to 60 cc) in an arbitrary container in the same manner as in Example 1, and several drops of the propolis extract of Example 1 were added thereto. For example, 1 to 5 drops) is added to give a single dose of the biological recovery agent, and this is taken.

[0054]

Example 3 In the pure water of Example 1, 2 × 10 ⁻¹² wt% of the crystal A obtained in Example 1, 0.05 wt% of the organogermanium compound (formula 2) and 0.05 wt% of Example 2 Seawater concentrate
The mixture was stirred at 0.05% by weight to obtain a bioactive agent (3).

(Usage as a biorecovery agent) A predetermined amount (for example, 20 to 60 c) of the bioactive agent (3) is placed in an arbitrary container.
c) Add, and add a few drops (for example, 1 to 5 drops) of the propolis extract of Example 1 to a single biorecovery agent,
Take this.

[0056]

Example 4 (Selection of Combination Agent) As the combination agent, a commercially available paste-like royal jelly is employed.

(Usage as a biological recovery agent) A predetermined amount of the active agent (1) of Example 1 is put in a container in the same manner as described above, and a predetermined amount of the royal jelly is added thereto (for example, half to 1 teaspoon).
Mix and stir to obtain a single biorecovery agent and take it. In addition, the active agent (1) and the royal jelly in the one dose may be taken without mixing.

[0058]

Example 5 A predetermined amount of the activator (2) of Example 2 was placed in a container in the same manner as described above, and the royal jelly was mixed with, for example, half to 1 teaspoon, and stirred. I do. And take this.

[0059]

Example 6 A predetermined amount of the activator (3) of Example 3 was placed in a container in the same manner as described above, and the royal jelly was mixed with, for example, half to 1 teaspoon and stirred to form a single dose of the biorecovery agent. I do. And take this. In Examples 5 and 6, the same effect can be obtained even if the active agent (2) or (3) and royal jelly are not mixed and taken as they are.

The biorecovery agents of Examples 1 to 6 are used, for example, once to three times per day for a predetermined period (for example, 1 to 6 months).
According to Examples 1 to 6, which were taken continuously, a biological recovery agent exhibiting excellent pharmacological and physiological effects was obtained. In addition, when a compound other than the above (Formula 2) [the above (Formula 3)... (Formula 11)] was used as the organic germanium compound, almost the same effect was obtained. Further, by changing the mixing ratio of the crystal A, the organogermanium compound (formula 2), and the seawater concentrate to the pure water within the above-mentioned ranges, bioactive agents having respective properties were obtained.

Next, an example of a test example will be described. The following test was performed using the bioactive agent (3) prepared in Example 3. 1. Human subjects and in vivo test methods Five human volunteers were tested. Their ages ranged from 31 to 46 years. To these subjects, 50 cc of the active agent (3) prepared in Example 3 was orally administered daily for 5 months (long term). Twenty cc of blood was collected from each subject before and two weeks after the start of the administration of the active agent, at three months and six months. In addition, the other group received the active agent (3) for 2 weeks (short term). 2. Separation of peripheral blood lymphocytes (PBL) Ficoll-Hypaque density gradient centrifugation (Litton B
Ionetics, Rockville, MD) was used to isolate mononuclear cells from fresh whole blood. After collecting the lymphocyte band at the interface, sedimenting the cells by centrifugation and washing twice with RPMI-1640, RPMI-1640, 10% (V / V) fetal calf serum, 2 mM glutamine, 25 mM HEPES (pH
7.2), complete medium (CM) consisting of 50 units of penicillin and 50 μg / ml of streptomycin (Grand
Island Biologicals, Santa Clara, CA). 3. In vitro test Mononuclear cells were prepared as described above under aseptic conditions and 2
It was suspended at a concentration of × 10 ⁶ . PBL is 16
After incubation for an hour, NK activity was measured by a Cr release test. 4. NK Cell Activity To estimate NK anti-cancer activity, a commonly used method is to use a CR release test, in which a fixed number of target tumor cancer cells labeled with chromium ₅₁ (CR) are varied. With NK effector cells. Cellular lymphocyte lysis is calculated using the following equation:

[0062]

(Equation 1)

However, the experimental release is the count in the supernatant obtained from the well containing the effector cells, the spontaneous release is the spontaneous release only in the medium, and the total release is the maximum count obtained by dissolution using a detergent. The NK effector cells are serially diluted four times and applied to a microtiter plate together with the tumor cells as a set of four groups. Briefly, 5 × 10 ⁶ were suspended per 1 ml of CM and 1 m
1 into 4 wells and each effector:
Target cell ratios of 100: 1, 50: 1, 25: 1, 12:
It was set to 1. Then, place the microtiter plate in 500r
After centrifugation at pm for 3 minutes and culturing at 37 ° C. for 4 hours, the radiation of the supernatant was measured with an r counter. The isotope release rate was calculated by the above equation.

Results from the above test: Activator (3) significantly increased NK activity 2 weeks after administration. The NK activity was 21, 31.6, 40.7 and 54.1 after the start of administration, compared to the baseline values of 6.6, 11.9, 21.5 and 27.5.
318% increase. After that, when the administration was continued, 2
〜5 months later, NK activity further increased. On the other hand, in an in vitro test, peripheral blood lymphocytes were combined with activator (3) for 16 hours.
Incubation for hours only increased NK activity by 15%.
From the above results, the active agent (3) is a potent biological response modifier (BRM) and is useful as a drug used for cancer immunotherapy.

The effect of the biorecovery agent of Example 3 was further improved by using the active agent (3) in combination with propolis extract.

[0066]

Example 7 (Production of a substance containing a component of a ferrous iron salt having a magnetic property)
0.1 g of magnetite is placed in 10 ml of concentrated hydrochloric acid, dissolved by stirring and allowed to stand for 24 hours. To this solution, 25 ml of a 2N aqueous sodium hydroxide solution is added and left standing for 24 hours to neutralize. The solution is concentrated under reduced pressure to precipitate crystals, and the crystals are dried in an air dryer. The crystals are washed in 10 ml of ethyl alcohol. This washing operation is repeated several times to purify the crystal to obtain an active substance (crystal). The yield at this time was 0.88 g. Then 5 g of magnetite in 10 ml
And concentrated to a half concentration by stirring. Then, 0.1 g of the active substance crystal obtained in the above step is added, and the mixture is stirred well and allowed to stand for 24 hours. The supernatant is separated from the insoluble magnetite by a decantation method to obtain an active substance solution (a solution of an active substance containing a component of a ferrous iron (III) salt having magnetism).

(Preparation of Bioactive Agent) The pure water of Example 1 was mixed with 2 × 10 ^-12 % by weight of the active substance solution and 0.05% by weight of the organic germanium compound (formula 2) and stirred. Thus, a bioactive agent (4) was obtained.

(Preparation and Usage of Biorecovery Agent) A predetermined amount (for example, 20 to 60 cc) of the active agent (4) is placed in an arbitrary container.
And several drops of the propolis of Example 1 (e.g.
5 drops) to make a single dose of the biorecovery agent and take it.

[0069]

Example 8 (Production of bioactive agent) The pure substance of Example 1 was mixed with the active substance solution of Example 7 at 2 × 10 ⁻¹² wt% and the concentrated seawater of Example 2 at 0.08 wt%. And stir, bioactive agent (5)
I got

(Preparation and Usage of Biorecovery Agent) A predetermined amount (for example, 20 to 60 cc) of the active agent (5) is placed in an arbitrary container.
Then, several drops (for example, 1 to 5 drops) of the propolis extract of Example 1 are added thereto to prepare a single biorecovery agent, which is then taken.

[0071]

Example 9 (Production of Bioactive Agent) The active substance solution of Example 7 was added to the pure water of Example 1 at 2 × 10 ⁻¹² wt%, and the organogermanium compound (formula 2) was 0.05 wt%. And 0.05% by weight of the seawater concentrate of Example 2 was mixed and stirred to obtain a bioactive agent (6).
I got

(Preparation and Usage of Biorecovery Agent) A predetermined amount (for example, 20 to 60 cc) of the active agent (6) is placed in an arbitrary container.
Then, several drops (for example, 1 to 5 drops) of the propolis extract of Example 1 are added thereto to prepare a single biorecovery agent, which is then taken.

[0073]

Example 10 (Preparation and Usage of Biorecovery Agent) A predetermined amount (for example, 20 to 60 cc) of the activator (4) of Example 7 was placed in an arbitrary container, and the royal jelly of Example 4 was added thereto in a predetermined amount (for example, (Half teaspoon to 1 teaspoon), mix and stir to obtain a single dose of the biorecovery agent and take it. In addition, the same effect is obtained even if the dose of the active agent (4) and the royal jelly in the one dose are taken without mixing.

[0074]

Example 11 (Preparation and Usage of Biorecovery Agent) A predetermined amount of the activator (5) of Example 8 was placed in a container in the same manner as described above, and the royal jelly was mixed with, for example, half to 1 teaspoon and stirred. Then, take one dose of the biological recovery agent and take it.

[0075]

Example 12 (Preparation and Usage of Biorecovery Agent) A predetermined amount of the active agent (6) of Example 9 was placed in a container in the same manner as described above, and the royal jelly was mixed with, for example, half to 1 teaspoon and stirred. Then, use it as a single biorecovery agent and take it. Example 1
Regarding 1 and 12, the same effect can be obtained even if the active agent (5) or (6) and the royal jelly are used without being mixed.

In the same manner as described above, the biological restoratives of Examples 7 to 12 are to be taken continuously, for example, about 1 to 3 times / day for a predetermined period (for example, 1 to 6 months). According to Nos. To 12, a biological restorative agent exhibiting excellent pharmacological and physiological effects was obtained. In addition, almost the same effect was obtained when an organic germanium compound other than the above (Formula 2) was adopted as the organic germanium compound as described above. Further, by changing the mixing ratio of the active substance solution, the organic germanium compound (formula 2) and the seawater concentrate to the pure water within the above-mentioned ranges, bioactive agents having respective properties were obtained.

In the above-mentioned embodiment, the case where propolis extract is used as the propolis is exemplified. However, a commercially available solid (tablet) may be used. Is obtained.

[0078]

According to the present invention, it is possible to provide a living body restoring agent which exhibits excellent pharmacological and physiological effects and activates and recovers a living body.

Claims (9)

[Claims] 1. A bioactive agent comprising a substance containing a component of divalent iron (III) salt in water and an organic germanium compound,
A biological recovery agent characterized in that it is used in combination with royal jelly and / or propolis. 2. A bioactive agent comprising a substance containing a component of a ferrous iron salt in water and a concentrated solution of seawater, and royal jelly and / or propolis are used in combination. Biological recovery agent. 3. A method in which a substance containing a component of divalent iron (III) salt in water, a bioactive agent containing an organic germanium compound and a seawater concentrated solution, and royal jelly and / or propolis are used in combination. A biological recovery agent characterized by the following. 4. The substance containing a component of the ferrous (III) salt,
The ^biorecovery agent according to claim 1, 2 or 3, comprising a compound represented by the formula: Fe ⁺² m Fe ⁺³ n Cl ₂ m + ₃ n (wherein m and n represent variables). . 5. A method in which a substance containing a component of a ferric salt of ferric water and a bioactive agent containing an organic germanium compound is used in combination with royal jelly and / or propolis. A biological recovery agent characterized by the following. 6. A bioactive agent comprising a substance containing a component of a ferrous iron (III) salt magnetically attached to water and a concentrated seawater solution;
A biological recovery agent characterized in that it is used in combination with royal jelly and / or propolis. 7. A method of using a substance containing a component of ferrous iron (III) salt that is magnetic to water, a bioactive agent containing an organic germanium compound and a concentrated solution of seawater, and royal jelly or / and propolis. A biological restoration agent characterized by comprising: 8. The substance containing a component of the magnetic ferrous divalent iron (III) salt may be obtained by dissolving magnetite in concentrated hydrochloric acid, neutralizing the solution, and concentrating the neutralized solution to crystallize. 8. The agent according to claim 5, 6 or 7, comprising a compound obtained by a step of adding the crystals to a solution in which magnetite is semi-dissolved in concentrated hydrochloric acid. 9. The agent according to claim 2, wherein the seawater concentrate is a concentrate obtained by concentrating seawater to remove precipitated salt (NaCl).