JPH0987686A - Cleaning agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cleaning agent capable of giving a smooth and moist moisture-retaining effect to skin after used, and little in unpleasant smell such as fish smell. SOLUTION: This cleaning agent such as soap or shampoo contains arachidonic acid and/or its derivative saponification product, or further docosahexaenoic acid and/or its derivative saponification product as components. When the arachidonic acid and/or its derivative saponification product, and the docosahexaenoic acid and/or its derivative saponification product are simultaneously used, the components are preferably used in a weight ratio of 2:8 to 8:2.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a detergent for toilet soap, shampoo and the like.

[0002]

2. Description of the Related Art Cleaning agents such as toilet soaps and shampoos are produced by a method in which fats or fatty acids obtained by preliminarily hydrolyzing fats or oils are saponified with an alkaline agent and then various additives are added. There is.

Generally, it is said that the quality of the cleaning agent largely depends on the type and blending composition of the raw material fats and oils. As the raw material fats and oils, beef tallow, coconut oil, palm oil, soybean oil, and the like are used in a very wide range of fats and oils, but it is rare to use these alone, and usually several kinds of raw fats and oils or fatty acids are used in advance. Use by mixing. Normally used solid toilet soap contains beef tallow and coconut oil in a weight ratio of 8
Oil and fat mixed at a ratio of 5:15 to 80:20 is saponified with an alkaline agent such as sodium hydroxide, and there are also toilet soaps made by mixing palm oil and olive oil with the oil and fat. .

The additives include, for example, superfatting agents such as lanolin, higher alcohols and fatty acids, clarifying agents such as sugar and glycerin, chelating agents such as EDTA salts, antioxidants such as tocopherols, BHA and BHT. Agents, fragrances, pigments, vitamins, etc. are used depending on the application.

By the way, in recent years, a soap containing a saponified product of docosahexaenoic acid (hereinafter abbreviated as DHA) and / or a derivative thereof has been marketed, which gives a smooth and moist feeling to the skin after use and psoriasis. And atopic dermatitis have been reported to be effective (JP-A-6-
40887, and JP-A-6-136394).

[0006]

DISCLOSURE OF THE INVENTION Problems to be Solved by the Invention
The soap containing a has a problem that DHA, which is a highly unsaturated fatty acid, is oxidized during the manufacturing process or during use to generate an unpleasant odor such as a strong fish odor. Therefore, the unpleasant odor is reduced by adding a fragrance to the soap and masking it, but it is unavoidable that the unpleasant odor remains, and it is sometimes avoided by some people.

[0007] Therefore, an object of the present invention is to provide a cleaning agent which is excellent in moisturizing property, has an effect of giving a feeling of smoothness and moistness to the skin after use, and has a significantly reduced unpleasant odor.

[0008]

Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned object, the present inventors have found that a soap containing a saponified product of arachidonic acid which is an n-6 type unsaturated fatty acid is
Similar to a soap containing a saponified product of DHA, which is an n-3 unsaturated fatty acid, it has a smooth and moisturizing effect on the skin, and has a more unpleasant odor than a soap containing a saponified product of DHA. It was found that the number would be significantly reduced, and the present invention was completed.

That is, one of the detergents of the present invention is characterized by containing a saponified product of arachidonic acid and / or its derivative.

Another cleaning agent of the present invention is characterized by containing a saponified product of arachidonic acid and / or its derivative and a saponified product of docosahexaenoic acid and / or its derivative.

In the above case, the mixing ratio of the saponified product of arachidonic acid and / or its derivative and the saponified product of docosahexaenoic acid and / or its derivative is from 2: 8 by weight.
It is preferably 8: 2.

The cleansing agent of the present invention contains a saponified product of arachidonic acid and / or its derivative, so that the skin after use has a smooth and moisturizing effect (see Example 1). Moisturizing effect) is brought about.
When the saponified product of arachidonic acid and / or its derivative and the saponified product of DHA and / or its derivative are used together, the above moisturizing effect is further improved.

On the other hand, as compared with a detergent containing only a saponified product of DHA and / or its derivative as an active ingredient for providing a moisturizing effect, unpleasant odor such as fishy odor is remarkably reduced, and a large amount of fragrance is not added. However, it is possible to manufacture a product in which an unpleasant odor is hardly felt.

[0014]

BEST MODE FOR CARRYING OUT THE INVENTION The detergent targeted by the present invention includes various types of detergents such as solid soap such as toilet soap, cream soap contained in a tube, liquid soap such as shampoo, and the like. Further, the type of soap may be any of various types such as overfat soap, transparent soap, mustache soap, baby soap, medicated soap, body shampoo and hair shampoo. However, those used particularly in contact with the skin, that is, cosmetic soap, shampoo, etc., are particularly preferable.

Arachidonic acid, which is a raw material for the detergent of the present invention, is one of the polyunsaturated fatty acids having four double bonds represented by the following chemical formula 1, and is contained in the animals, namely, liver, kidney and lung. It is present in lipids obtained from the pancreas, brain and others.

[0016]

[Chemical 1] CH ₃ (CH ₂ ) ₄ (CH = CHCH ₂ ) ₄ (CH ₂ ) ₂ COOH

It has been reported that when arachidonic acid is ingested, leukotriene, which is a causative substance of pain and inflammation, is easily produced in the body. However, as shown in the test examples described below, when it is applied to the skin as soap. Had no inflammatory effect.

As the raw material of the detergent of the present invention, arachidonic acid as a free acid or a derivative of arachidonic acid can be used. As the derivative of arachidonic acid, its ester, glyceride, phospholipid, choline derivative, amino acid derivative, ascorbic acid derivative and the like can be used.

As the arachidonic acid or its derivative, not only highly purified arachidonic acid or a mixture of oils and fats containing arachidonic acid or its derivative can be used. Examples of such an oil and fat mixture include "SUN
-TG25 "(trade name, manufactured by Suntory Ltd., arachidonic acid content 22% or more)," SUN-TG40 "(trade name, manufactured by Suntory Ltd., arachidonic acid content 37% or more) are known. The above products are Mortierella (Mor
Filamentous fungus belonging to the genus tierella) is liquid-cultured using a medium consisting of glucose, yeast extract, soybean oil, etc., and the obtained bacterial cells are granulated and dried, and then produced according to a normal edible oil / fat purification step. Is.

In addition to the above-mentioned arachidonic acid or its derivative, DHA or its derivative can be used in combination as a raw material of the detergent of the present invention. DHA is one of the polyunsaturated fatty acids having 6 double bonds represented by the chemical formula of C ₂₂ H ₃₂ O ₂ , and is present in various fish oils such as tuna, sardines, herring, cod and the like.

As the derivative of DHA, its ester,
Glycerides, phospholipids, choline derivatives, amino acid derivatives, ascorbic acid derivatives and the like can be used. Further, as DHA or a derivative thereof, not only a highly purified one containing only DHA or a derivative thereof, but also a mixed oil in a state in which other fats and oils components such as eicosapentaenoic acid (EPA) are contained. You may use. The mixed oil containing DHA is commercially available from each company and can be easily obtained.

In the present invention, a saponified product of arachidonic acid and / or a derivative thereof may be used alone as an active ingredient having a moisturizing effect. However, a saponified product of arachidonic acid and / or a derivative thereof, DHA and / or Alternatively, a saponified product of its derivative may be used in combination. When using both together,
The mixing ratio is such that the saponified product of arachidonic acid and / or its derivative: DHA and / or its saponified product is
The weight ratio is preferably 2: 8 to 8: 2, and more preferably 4: 6 to 6: 4. By setting the blending ratio in the range of 2: 8 to 8: 2 by weight, an excellent moisturizing effect can be obtained, and unpleasant odor can be significantly reduced as compared with the case where DHA is used alone.

The detergent of the present invention comprises a saponified product of arachidonic acid and / or a derivative thereof, or a saponified product of arachidonic acid and / or a derivative thereof and a saponified product of DHA and / or a derivative thereof, as an active ingredient giving a moisturizing effect. However, other components usually used in detergents can be freely added as required.

That is, the above-mentioned arachidonic acid and / or its derivative,
In addition to DHA and / or its derivatives, it is possible to use a mixture of oils and fats ordinarily used as raw materials for detergents, such as palm oil, coconut oil, olive oil, castor oil, sesame oil, cottonseed oil, soybean oil. , Vegetable oils such as tung oil, peanut oil, rapeseed oil, or animal oils such as beef tallow, lard, whale oil, etc., and fatty acids derived from these animal and vegetable oils, and mixtures of these oils and / or fatty acids You can

When a saponified product of arachidonic acid and / or its derivative is used alone as an active ingredient for imparting a moisturizing effect, the saponified product of arachidonic acid and / or its derivative is mixed in the fat and / or fatty acid component of the product. It is preferable that the amount is 1 to 5% by weight. When a saponified product of arachidonic acid and / or a derivative thereof and a saponified product of DHA and / or a derivative thereof are used together as an active ingredient that gives a moisturizing effect, the total amount of the both is the oil or fat in the product. And / or in the fatty acid component, 1 to
It is preferably set to 5% by weight.

If the amount of the saponified product of arachidonic acid and / or its derivative and the saponified product of DHA and / or its derivative is less than the above, a sufficient moisturizing effect cannot be obtained, and the above-mentioned components cannot be obtained. If the blending amount is larger than the above amount, the raw material cost becomes high and, for example, in the case of soap or the like, problems such as difficulty in solidifying occur, which are not preferable. In addition, in the above, the oil / fat and / or fatty acid component means the oil / fat and / or fatty acid contained in the final product, saponified with an alkaline agent, or left unsaponified.

As the alkaline agent used for saponification in the present invention, those conventionally used such as sodium hydroxide, potassium hydroxide and triethanolamine are used depending on the application. Generally, sodium hydroxide is suitable for obtaining a solid detergent, and potassium hydroxide or triethanolamine is suitable for obtaining a liquid detergent.

In the detergent of the present invention, in addition to the above-mentioned components, if necessary, fats, lanolin, higher alcohols, superfatting agents such as fatty acids, clarifiers such as sugar and glycerin, and chelating agents such as EDTA salts. Agents, tocopherols, antioxidants such as BHA and BHT, fragrances, pigments, vitamins and the like can be appropriately added.

The cleaning agent of the present invention is a conventional cleaning agent using an oil and / or fatty acid containing arachidonic acid and / or its derivative or a mixture of arachidonic acid and / or its derivative and DHA and / or its derivative as a raw material. It can be produced by adding an alkali agent for saponification in the same manner as in the production of the agent, and optionally adding the other components as described above.

In this case, it is preferable to carry out the saponification in an atmosphere of an inert gas such as nitrogen, because the oxidation of arachidonic acid and / or its derivative or DHA and / or its derivative is prevented. As a method for making the atmosphere of an inert gas, for example, a method of replacing the air existing in the space surrounding the reaction vessel and the reaction tank with an inert gas is preferably adopted.

The temperature of the saponification reaction is preferably 60 to 85 ° C, more preferably 70 to 85 ° C. If the reaction temperature exceeds 85 ° C, arachidonic acid and / or its derivative, or DH
Oxidation of A and / or its derivative is likely to proceed, while if the reaction temperature is lower than 60 ° C, it becomes difficult to produce a detergent, although it depends on the melting point of the oil or fat or fatty acid used as the raw material.

Further, the time required to add the alkaline agent (the time from the start of the addition of the alkaline agent to the end)
Is preferably 1 hour or more, and is preferably added gradually over the entire saponification time.

After arachidonic acid and / or its derivative, DHA and / or its derivative, and other fats and / or fatty acids are separately saponified,
It can also be mixed.

[0034]

【Example】

Examples 1 to 6 and Comparative Example 1 (soap) Arachidonic acid-containing fats and oils (arachidonic acid content 22%) 4.5
To 15 parts by weight of ethanol, 15 parts by weight of ethanol was added and mixed by heating at 80 ° C. Separately, an aqueous solution prepared by dissolving 2 parts by weight of sodium hydroxide in 6 parts by weight of water was added dropwise little by little over 60 to 120 minutes, and the saponification reaction was carried out at a temperature of 70 ° C to give a saponified product of arachidonic acid. Obtained.

Separately, 50 parts by weight of a soap base consisting of beef tallow and coconut oil, 10 parts by weight of glycerin, and an appropriate amount of sucrose, vitamin E and purified water were added and dissolved by heating, and then the saponified product of arachidonic acid. Was added and kneaded to obtain a soap dough A containing a saponified arachidonic acid.

On the other hand, fats and oils containing DHA (DHA content of 20
%) 5 parts by weight was added with 15 parts by weight of ethanol, and the mixture was heated and mixed at 80 ° C. Add 2 parts by weight of sodium hydroxide to 6 parts of water.
The aqueous solution dissolved in 1 part by weight was added dropwise little by little over 60 to 120 minutes, and the saponification reaction was carried out at a temperature of 70 ° C. to obtain a saponified product of DHA.

Then, in the same manner as in the production of the above soap material A,
50 parts by weight of soap base composed of beef tallow and coconut oil, and glycerin
After adding 10 parts by weight and appropriate amounts of sucrose, vitamin E, and purified water, and heating and dissolving, a DHA saponification product was added and kneaded to obtain a soap material B containing the DHA saponification product.

The above soap material A and the above soap material B are in a weight ratio of 100: 0, 80:20, 60:40, 50:50, 40:60, 2
The mixture was mixed at a ratio of 0:80 and 0: 100, poured into a mold, cooled and solidified, cut, and dried to obtain soaps having various compositions.

A soap produced only from the soap cloth A was used in Example 1, and the soap cloth A and the soap cloth B were mixed in a weight ratio of 80: 20,6.
Soaps produced by mixing 0:40, 50:50, 40:60, and 20:80 are Examples 2 to 6, respectively, and soap produced only with the soap fabric B is Comparative Example 1. The arachidonic acid content in the fat and / or fatty acid component of the soap of Example 1 was 2
%, And the DHA content in the fat and / or fatty acid component of the soap of Comparative Example 1 is also 2% by weight.

On the other hand, 15 parts by weight of ethanol was added to 5 parts by weight of coconut oil, and the mixture was heated and mixed at 80 ° C. Add 60 parts of an aqueous solution of 2 parts by weight of sodium hydroxide to 6 parts by weight of water.
It was added dropwise little by little over 120 minutes, and the saponification reaction was carried out at a temperature of 70 ° C. to obtain a saponified coconut oil.

Next, a soap base 50 composed of beef tallow and coconut oil
Parts by weight, 10 parts by weight of glycerin, and appropriate amounts of sucrose, vitamin E, and purified water, respectively, and dissolved by heating, and then kneaded by adding the saponified product of the above coconut oil, and kneading the soap dough C containing only beef tallow and coconut oil Got The soap produced using this soap material C is referred to as Comparative Example 2.

Test Example 1 With respect to the soaps of Examples 1 to 6 and Comparative Examples 1 and 2, five experienced panelists applied the degree of fishy odor and the moisturizing property (smoothness, moistness) on the skin after use. ) Was evaluated according to the criteria in Table 1, and the average was obtained. The results are shown in Table 2.

[0043]

[Table 1]

[0044]

[Table 2]

From the results of Table 2, arachidonic acid and DHA
It can be seen that the soap of Comparative Example 2, which does not contain any of the above, has no fishy odor but does not have moisturizing properties. On the other hand, all the soaps containing arachidonic acid and / or DHA have an effect of imparting moisturizing property. Further, among the soaps containing arachidonic acid and / or DHA, it is found that the soap having the smallest fishy odor is the soap containing arachidonic acid of Example 1 and containing no DHA. Furthermore, the saponified product of arachidonic acid and the saponified product of DHA are 8: 2 to 2:
It can be seen that by mixing at 8, preferably 6: 4 to 4: 6, it is possible to obtain a soap which has little fishy odor and also has a considerable moisturizing property.

Test Example 2 Example 1 (soap containing saponified arachidonic acid) and Example 4 (saponified arachidonic acid and saponified DHA 5)
0:50 soap), Comparative Example 1 (soap containing saponified DHA), and Comparative Example 2 (soap containing neither arachidonic acid nor DHA), a 1% by weight aqueous solution of each soap was prepared. A patch test was conducted by 5 panelists of E. Tap water was used as a control. The criteria are shown in Table 3, and the patch test results are shown in Table 4.
Shown in In this judgment, the smaller the score, the safer it is.

[0047]

[Table 3]

[0048]

[Table 4]

From the results in Table 4, it can be seen that the soaps of Examples 1 and 4 and Comparative Examples 1 and 2 have almost no skin irritation. That is, it can be seen that even if the saponified arachidonic acid and / or the saponified DHA is contained, the safety to the skin is the same as that of ordinary soap and there is no problem.

[0050]

As described above, according to the present invention,
By containing a saponified product of arachidonic acid and / or a derivative thereof, or a saponified product of DHA and / or a derivative thereof, a moisturizing effect for smoothing and moisturizing the skin after use can be obtained. It is possible to provide a detergent having significantly less unpleasant odor such as a fish odor, as compared with a detergent containing only a saponified product of DHA and / or its derivative as an active ingredient that gives

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yoichi Kobayashi 6-18-18 Kamimizumoto-cho, Kodaira-shi, Tokyo (72) Inventor Kayo Goda 925-48 Shimohideya, Okegawa-shi, Saitama (72) Inventor Kazu Takekawa Koto, Saitama Prefecture, Kawagoe City, Sand 332-20 (72) Inventor, Kazuyoshi Yazawa 1-28-10, Unomori, Sagamihara City, Kanagawa Prefecture

Claims (3)

[Claims] 1. A detergent comprising a saponified product of arachidonic acid and / or its derivative. 2. A detergent comprising a saponified product of arachidonic acid and / or a derivative thereof and a saponified product of docosahexaenoic acid and / or a derivative thereof. 3. The saponification product of the arachidonic acid and / or its derivative and the saponification product of the docosahexaenoic acid and / or its derivative are mixed in a weight ratio of 2: 8 to.
The cleaning agent according to claim 2, which is 8: 2.