JPH0959165A - Production of stabilized polyiodide preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To economically produce the subject preparation by mixing a polyiodine ion with solid urea, maintaining a proper effective iodine concentration for a long period of time, suppressing sublimability of iodine, useful as an iodoform antimicrobial agent. SOLUTION: This stabilized polyiodide preparation is obtained by blending (A) a polyiodine ion (diiodated ion, pentaiodated ion or heptaiodated ion) with (B) solid urea to form a stable complex. The component A is preferably mixed with solid glycine to form diglycine/polyiodide. The component A is obtained by blending an iodide (hydroiodic acid, an alkali metal salt of iodine, an alkaline earth metal salt of iodine, ammonium salt of iodine, amine salt of iodine, etc.) with iodine and dissolving the blend in a small amount of water. The concentration of the component B is preferably 10-90wt.% and that of the component A is preferably 1-60wt.%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an iodine hole bactericide, which is used as a bactericidal disinfectant in various fields such as medical care, dairy farming, food processing and environmental hygiene.

[0002]

2. Description of the Related Art Conventional iodine-hole bactericides often use a surfactant as a carrier and have iodine dissolved therein. However, since the surfactant is used, foaming during use is severe and the use of washing water after sterilization It had the drawback of being large in quantity. On the other hand, a conventional solid iodine hole is produced by reacting polyvinylpyrrolidone and iodine under certain conditions, but the production process is complicated. Also, there are products in which iodide, a surfactant and an oxidant are mixed, but there is a problem in long-term stability.

Conventionally, there has been known a method of mixing one molecule of diglycine hydroiodide and one molecule of iodine to produce a diiodinated acid salt of glycine and a molecular compound of iodine. However, diglycine hydroiodide is known. When one molecule and one molecule of iodine were mixed, it was difficult to uniformly obtain diglycine hydroiodic acid di-salt iodide even if iodine was mixed for a long time.

[0004]

SUMMARY OF THE INVENTION The present invention solves the above drawbacks. It is an object of the present invention to provide a method for producing an iodine preparation which is easy to produce and stable over a long period of time.

[0005]

Means for Solving the Problems One of the features of the present invention that achieves the above-mentioned object is that urea or a solid amino acid is prepared by previously mixing iodide and iodine to form polyiodine ion. Alternatively, a stable complex is formed by mixing a mixture of urea and a solid amino acid. Also, polyiodine ion is dissolved in a small amount of water, urea,
Alternatively, a stable complex can be formed by adding a solid amino acid or a mixture of urea and a solid amino acid and thoroughly mixing them. In this case, it is desirable to remove the small amount of water used for dissolution by heating.

Another feature of the present invention is to dissolve the produced polyiodide complex of urea in water to generate available iodine suitable for the purpose of use. In this case, in order to maintain the effective iodine concentration of the aqueous solution, it is desirable to add an acidic salt or a mineral acid in advance so that the aqueous solution has a pH of 5 or less.

[0007]

According to the constitution of the complex of the present invention, urea and solid amino acid act as a monoacidic base to form a stable complex with polyiodine ion. Since iodine is not sublimated in the produced complex, the concentration as effective iodine is maintained for a long period of time without decreasing, and thus the bactericidal effect is maintained.

[0008]

EXAMPLES Hereinafter, examples of the present invention will be described, but the present invention is not limited to the examples. (1) Unit weight% Urea 85.0% Iodine 5.0% Potassium iodide 5.0% Sodium monophosphate 5.0% After dissolving potassium iodide with a small amount of water, iodine is added to Mix until uniform. Next, urea and sodium monophosphate are added and mixed well. Then, it was dried with a drier to remove water to obtain a solid iodine hole containing 5% of available iodine. The following Examples (2), (3),
For (4), (5), (6) and (7), the same operations as in Example (1) were performed.

(2) Glycine 65.0% Iodine 10.0% 57% Hydroiodic acid 15.0% Sodium monophosphate 10.0% Solid iodine containing 10% effective iodine was used.

(3) Glycine 8.0% Urea 62.0% Iodine 10.0% Potassium iodide 10.0% Sodium monophosphate 10.0% Solid iodine containing 10% effective iodine was used.

(4) Glycine 45.0% Iodine 20.0% Potassium iodide 20.0% Sodium monophosphate 15.0% Solid iodine having 20% available iodine was used.

(5) Urea 94.0% Iodine 2.0% Potassium iodide 2.0% Sodium monophosphate 2.0% Solid iodine containing 2% of available iodine was used.

(6) Glycine 16.0% Urea 29.0% Iodine 20.0% Potassium iodide 20.0% Sodium monophosphate 15.0% Solid iodine containing 20% effective iodine was used.

(7) Urea 85.0% Iodine 5.0% Sodium iodide 5.0% Sodium monophosphate 5.0% Solid iodine 5% effective iodine was used.

(8) Urea 15.0% Iodine 20.0% Potassium iodide 20.0% 75% Phosphoric acid 10.0% Water 35.0% After dissolving potassium iodide and iodine with a small amount of water, Add urea and mix well. Then, add the prescribed water and 75% phosphoric acid to make the weight percentage 100%, and add the available iodine 2
It was set to 0% iodine hole.

(9) Urea 8.0% Iodine 10.0% Potassium iodide 10.0% 35% Hydrochloric acid 15.0% Water 57.0% After dissolving potassium iodide and iodine with a small amount of water, urea is added. Add and mix well. After that, the specified water and 35% hydrochloric acid were added to make 100% by weight, and the available iodine 10
% Iodine hole.

(10) Embodiments (1), (2), (3),
A stability test was conducted for 6 months at room temperature for each of the iodine holes (4), (5), (6), (7), (8), and (9). The effective iodine concentration did not decrease after 6 months for each composition.

[0018]

[Table 1] Stability test

[0019]

INDUSTRIAL APPLICABILITY The solid iodine hole according to the present invention maintains a suitable effective iodine concentration for a long period of time. Further, since the sublimation property of iodine is suppressed, it can be held as a tablet, and a simple plastic bag is sufficient for packaging. The present invention is characterized in that the manufacturing method is simplified, the economic effect is great, and the storage is easy.

Claims (8)

[Claims] 1. A polyiodine ion (triiodide ion, pentaiodide ion, heptaiodide ion) is mixed with solid urea,
A method for producing a stabilized polyiodide preparation, which comprises forming a stable complex. 2. A method for producing a diglycine / polyiodide preparation, which comprises mixing polyiodide ion (triiodide ion, pentaiodide ion, heptaiodide ion) with solid glycine to produce diglycine / polyiodide. Method. 3. The iodide constituting the polyiodine ion comprises iodide such as hydriodic acid, an alkali metal salt of iodine, an alkaline earth metal salt of iodine, an ammonium salt of iodine, an amine salt of iodine and the like. A method for producing a stabilized stabilized polyiodide preparation. 4. A method for producing a polyiodide preparation, which comprises mixing iodide and iodine and dissolving them with a small amount of water to form polyiodide ions. 5. The urea or the solid amino acid as described above is used alone or in a mixture thereof.
The method for producing the stabilized polyiodide preparation according to 1. 6. The urea concentration is 10% to 9% by weight.
The concentration of polyiodine ion added is in the range of 1% to 60% in weight percentage. When using solid amino acids, the concentration is 16% to 99% by weight. Further, in the case of a mixture of urea and a solid amino acid, the method for producing a stabilized polyiodide preparation is characterized in that the mixing ratio of urea: solid amino acid is selected in the range of 50:50 to 90:10. 7. A stabilized polyiodide preparation as an acidic salt,
For example, sodium phosphate monobasic, potassium phosphate monobasic, sodium bisulfate, citric acid, etc., in a weight percentage of 5% to 20%
%, And a method for producing a stabilized polyiodide preparation, which is characterized in that it is added in the range of%. 8. A method for producing an aqueous solution of a stabilized polyiodide preparation using the urea according to claim 1. 1% by weight of urea
-40% range, 1% to 4% by weight of polyiodide
A method for producing an aqueous solution of stabilized polyiodide, which comprises adding a mineral acid in the range of 0% by weight and in the range of 1% to 20% by weight to make the total amount 100% by weight of water.