JPH09299458A - Infection preventing method and sheet for preventing infection - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable safe prevention of infection by using a sheet containing clathrate compound particles obtained by inclusion of a volatile organic antibacterial agent into cyclodextrin. SOLUTION: Clathrate compound particles 1 obtained by inclusion of a volatile organic antibacterial agent into cyclodextrin are mixed with a low density polythylene and the mixture is kneaded and extruded by an extruder to form a sheet 2 for preventing infection containing the clathrate compound particles 1. In the production of the clathrate compound particles 1, firstly, β-cyclodextrin is added stirring up water and then, allyl isothiocyanate is added to stir up the mixture for a specified period of time. The slurry obtained is supplied and dried to be formed as particle with an average size of about 25μm. A sheet 2 thus obtained is laid beneath a bed and is volatilized on use by moisture evaporated from a user.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for protecting pathogens such as pathogenic bacteria, pathogenic fungi, and pathogenic small animals from infecting patients in the internal environment of bedding used in hospitals, geriatric facilities, and the like. It relates to an infection protection sheet that can be used.

[0002]

2. Description of the Related Art Recent advances in medical technology have prolonged the life of human beings and are approaching an aging society. In addition, the number of bedridden elderly people in nursing homes and the like is enormous and tends to increase in the future.

[0003] In such bedridden geriatric facilities, nosocomial infection by pathogenic organisms such as pathogenic bacteria, pathogenic fungi, and pathogenic small animals has become an important problem. In particular, the skin of elderly people is dry and easily causes various problems. For these infected patients, antiseptics such as creams containing antibiotics or antigenic agents or highly irritating croton oil have been applied to the patient's skin. They are often infected and are struggling with repulsion laws. Also,
Since these drugs are applied directly to the skin, problems such as allergies to them are also occurring.

[0004] Even if they are not elderly people, patients who are in an immunodeficient state such as AIDS patients, organ transplant patients, leukemia patients, congenital immunodeficiency patients, etc., are susceptible to the above-mentioned skin diseases, and the conventional methods require expensive sterile materials. The use of rooms and the prophylactic administration of various antibacterial substances orally or intravenously, these medical expenses are enormous.

[0005] On the other hand, although antibacterial materials for food are known, the types of bacteria that cause problems in foods and the pathogens that cause problems in human infection are completely different, so that the antibacterial materials for food can be used as they are to protect against infection. Whether it is applicable is not always clear. For example, antimicrobial targets for food include Aspergil
lus niger, Fsarium, Geotrichum candidum, Altern
aria, etc., but these fungi are rarely found clinically (Manual of clinical micro
biology, −5th ed.,: editor in chief, AlbertBalows, A
American Society for Microbiology, P7-8).

[0006]

An object of the present invention is to provide a method for safely preventing infection without orally or intravenously administering an antibacterial substance or applying an antiseptic or an antibacterial substance to the skin. And to provide an infection-preventing sheet that can be used for it at low cost.

[0007]

As a result of earnest research in view of the above problems, the present inventors have found that inclusion compound particles in which an organic antibacterial agent having volatility as an antibacterial substance is included in cyclodextrin, particularly isothiocyanate. Candid, which is known to infect Candida, especially the human body, by using a sheet containing inclusion compound particles in which Hiba extract oil is included and filling the bed with the above antibacterial agent
The present invention has been completed based on the finding that it can effectively protect against infections of pathogenic organisms such as a albicans and a mite that infect the human body.

That is, the present invention is an infection protection method using a sheet containing inclusion compound particles in which a volatile organic antibacterial agent is included in cyclodextrin. Also,
The present invention is the method for preventing infection, which is characterized in that the sheet is laid under bedding or used as bedding sheets or a cover, and the organic antibacterial agent is volatilized by water evaporated from a person.

Further, the present invention is an infection protection sheet containing inclusion compound particles in which a volatile organic antibacterial agent is included in cyclodextrin. Furthermore, the present invention is a sheet obtained by mixing clathrate compound particles obtained by clathrating a volatile organic antibacterial agent in cyclodextrin with a thermoplastic resin, and processing the clathrate compound particles. An infection-preventing sheet having a particle size larger than the average thickness of the thermoplastic resin sheet.

Further, according to the present invention, a coating film containing inclusion compound particles in which a volatile organic antibacterial agent is included in cyclodextrin is formed on all or part of at least one surface of the thermoplastic resin sheet. It is an infection protection sheet characterized by being provided. Furthermore, the present invention provides a coating film containing clathrate compound particles in which a volatile organic antibacterial agent is clathrated in cyclodextrin, provided on all or part of at least one surface of a breathable sheet. It is a sheet for protection against infection characterized by:

Further, according to the present invention, inclusion compound particles obtained by encapsulating a volatile organic antibacterial agent in cyclodextrin are held between two sheet base materials, and at least one of the sheet base materials. Is an air-permeable sheet base material, which is an infection-preventing sheet.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION The organic antibacterial agent used in the present invention is volatile at room temperature and sterilizes and kills pathogens such as pathogenic bacteria, fungi and small animals that infect humans. Compounds having a fungal action can be used, and among them, isothiocyanate (general formula: RN = C = S) and Hiba extracted oil are particularly preferable from the viewpoint of antibacterial effect.

Examples of isothiocyanates include allyl isothiocyanate (chemical formula: CH ₂ = CHCH ₂ NCS), isoamyl isothiocyanate, isobutyl isothiocyanate, isopropyl isothiocyanate, ethyl isothiocyanate, nitrophenyl isothiocyanate, phenyl isothiocyanate, butyl isothiocyanate. , Propyl isothiocyanate, benzyl isothiocyanate, methyl isothiocyanate and the like can be preferably used. In addition, as the Hiba extracted oil, a commercially available oil can be used.

In the present invention, hinokitiol and terpenes are not suitable as organic antibacterial agents. The use of these substances does not protect against transmission of pathogenic organisms to humans.

Inclusion of the above-mentioned organic antibacterial agent in cyclodextrin may be carried out by a conventional method. For example, the organic antibacterial agent is dissolved in an alcohol which is freely miscible with water to prepare a cyclodextrin-added slurry. After mixing and stirring, spray drying may be performed using a spray dryer or the like. The mixing of the organic antibacterial agent and the cyclodextrin-added slurry is desirably performed at room temperature by convection stirring using a homomixer. The cyclodextrin may be any of α-type, β-type, and γ-type, or may be a mixture of two or more thereof.

The average particle size of the clathrate compound particles thus obtained is not particularly limited, but is preferably about 5 to 200 μm. In addition, as described below, when the inclusion compound particles are mixed with a thermoplastic resin to be processed into a sheet, the average particle diameter of the inclusion compound particles is effectively increased by increasing the average particle diameter to be greater than the average thickness of the sheet. Since the organic antibacterial component can be volatilized, in the case of such an infection protection sheet, the average particle diameter of the clathrate compound particles is 10 to
It is preferably about 200 μm.

The sheet containing the inclusion compound particles in which the volatile organic antibacterial agent is included in cyclodextrin can be used as an infection protection sheet.
The infection-preventing sheet may be in any form as long as it can exert its effect, but firstly, an example is one in which inclusion compound particles are mixed with a thermoplastic resin and the mixture is processed into a sheet shape. be able to. In order to process the sheet into such a sheet shape, generally used blow molding, inflation, an extrusion method such as a T-die method, or the like may be used.

In order to efficiently volatilize the organic antibacterial component from the inclusion compound particles, the average particle size of the inclusion compound particles 1 is made larger than the average thickness of the sheet 2 as shown in FIG. Is preferred. In such infection control sheets, most of the inclusion compound particles are held exposed from the surface of the resin sheet, so that even a small amount of organic antibacterial agent can be efficiently volatilized by the water evaporated from a person. It is possible to effectively fill the bed with the organic antibacterial agent to a concentration at which the antibacterial effect is exerted.

Such an infection-preventing sheet is obtained by extruding a resin in which the inclusion compound particles are kneaded from a slit having a gap larger than the average particle size of the inclusion compound particles, and then molding the resin by an appropriate method. It can be manufactured by stretching. The amount of the inclusion compound particles mixed with the resin is preferably 0.1 to 20% by weight, and if it is in this range, stable antibacterial properties can be exhibited.

The thermoplastic resin is not particularly limited, but for example, a polyolefin resin (for example, polyethylene resin, polypropylene resin), a styrene resin, an EVA (ethylene / vinyl acetate copolymer) resin, a vinyl chloride resin. Polyamide resin (eg, aliphatic polyamide), polyester resin (eg, aliphatic polyester), polyesteramide and the like are preferable. Particularly, in the infection-preventing sheet obtained by mixing the inclusion compound particles with the thermoplastic resin as in this embodiment, a polyolefin resin, an EVA resin, a vinyl chloride resin or the like that can be kneaded at a relatively low temperature is used. Preferably.

The second aspect of the infection-preventing sheet of the present invention is, for example, one in which a coating film containing the inclusion compound particles is provided on a thermoplastic resin sheet. The coating film may be provided on any surface of the thermoplastic resin sheet,
It may be provided on both sides. Further, it may be provided on the entire surface or partially. FIG. 2 shows an example in which the coating film 10 is provided on one surface of the sheet 2.

For such a coating film, the inclusion compound particles are dispersed in an organic solvent such as toluene to which a stabilizer, a dispersant and the like are appropriately added, and the dispersant is applied by a general method such as a roll coater or a spray sprayer. Can be formed. Further, as other application methods, printing means such as gravure printing, offset printing, and silk screen can be used. Such a printing means can be particularly suitably used when partially applying the thermoplastic resin sheet. The coating film has a content of inclusion compound particles of 1 to ²⁰ g / m ² , particularly 1 to
It is preferably provided so as to be 10 g / m ^2, and within this range, antibacterial properties can be stably exhibited.

In the infection-preventing sheet according to this embodiment, since the inclusion compound particles are retained on the surface of the sheet, even a small amount of the organic antibacterial agent can be efficiently volatilized by the water evaporated from the person. Therefore, it is possible to easily fill the bed with the organic antibacterial agent to a concentration at which the antibacterial effect is exerted. Providing a plurality of cuts or holes in such an infection-preventing sheet can improve breathability, especially in the summer when it is easy to sweat. In FIG.
An example of an infection protection sheet having a plurality of cuts 20 is shown.

A third aspect of the infection-preventing sheet of the present invention is, for example, one in which a coating film containing the inclusion compound particles is provided on a breathable sheet. Also in this embodiment, the coating film may be provided on any surface of the breathable sheet, or may be provided on both surfaces. Further, it may be provided on the entire surface or partially. FIG. 4 shows an example in which the coating film 10 is provided on one surface of the breathable sheet 2 '.

Examples of the air-permeable sheet include paper such as Japanese paper and Watting paper, non-woven fabric such as synthetic fiber and cellulosic fiber, and woven fabric made of fibrous material. They may be composed of one layer, or may be a laminate of a plurality of types in consideration of strength and the like.
The formation of the coating film on the breathable sheet can be performed by a method similar to the method described in the second embodiment. The coating film has a content of the inclusion compound particles of 1 to ²⁰ g / m ² , particularly 1 to 10 g / m ² .
It is preferably provided so as to be g / m ^2, and within this range, antibacterial properties can be stably exhibited.

The infection-preventing sheet according to the present embodiment, particularly the infection-preventing sheet partially provided with a coating film containing inclusion compound particles, has excellent breathability and therefore can be directly used as a bed, a bed sheet for a futon, or a pillow cover. Can be used. In this infection protection sheet, the coating film acts as an adhesive layer,
The inclusion compound particles do not easily fall off. With such an infection-preventing sheet, even a small amount of organic antibacterial agent can be efficiently volatilized by the water evaporated from a person, and the organic antibacterial agent exerts its antibacterial effect in a hospital bed. It can be easily filled up to the required concentration.

As the fourth aspect of the infection-preventing sheet of the present invention, there can be exemplified one in which the inclusion compound particles are held between two sheet base materials. At least one of the sheet substrates needs to have air permeability. As the sheet substrate having air permeability, the same paper, nonwoven fabric, woven fabric, and the like as described above can be used.
The other sheet substrate may be a similar breathable sheet or a thermoplastic resin sheet as described above. The amount of clathrate compound particles is 1 when grasping clathrate compound particles.
It is preferable to carry out the treatment in an amount of ˜20 g / m ² , particularly 1 to 10 g / m ^2, and in this range, the antibacterial property can be stably exhibited.

To hold the inclusion compound particles, for example,
The clathrate compound particles may be wholly or partially adhered to one surface of one sheet, and the other sheet may be laminated (adhered or non-adhered) to the adhered surface, or on one side of one sheet. Clathrate compound particles in whole or in part,
The other sheet may be laminated on the spray surface and two sheet base materials may be circumferentially attached, that is, shaped like a bag. FIG. 5 shows an example of the former, and FIG. 6 shows an example of the latter.

However, when the whole sheet is made into one bag like the latter, the clathrate compound particles may move and be biased. Therefore, as shown in FIG. 7, if two sheet base materials are shaped so as to form a large number of bag portions 21, the deviation can be prevented. Thus, the infection-preventing sheet shaped so as to form a large number of bags efficiently volatilizes the organic antibacterial agent by the water evaporated from a person, even if the amount of the organic antibacterial agent is small. It is possible to effectively fill the bed with the organic antibacterial agent to a concentration at which the antibacterial effect is exerted.

The infection-preventing sheet of the present invention is not limited to those exemplified above, and is, for example, a sheet obtained by weaving or knitting the fibers containing the inclusion compound particles. May be. Further, the fibers may be used to form a nonwoven fabric. The infection-protecting sheet of the present invention can be used by laying it under bedding or as a bedding sheet or cover. Further, this infection protection sheet can be cut and sewn and used as a sleeping cloth.

Examples of pathogenic bacteria capable of controlling infection to humans by the infection-preventing sheet of the present invention include, for example, Esch
erichia coli, Staphylococcus aureus, Psedomonas a
eruginosa, Cytrobacter freundii, Proteus mirabili
s, Klebsiella pneumomiae, Serratia marcescens, S
almonella enteritidis, Vibrio cholerae, Vibriopar
ahaemolyticus, and the pathogenic fungi include Cand
ida albicans and the like, and the pathogenic small animals include hizen mites, larvae of the phytoseiid moss, Dermatophagoides pteronyssinus, and the like.

Further, according to the infection-preventing sheet of the present invention, floor rub can be prevented. According to the infection prevention method of the present invention using the sheet as described above, there is no need to administer an antibacterial substance orally or intravenously, or to apply a disinfectant or an antibacterial substance to the skin, which may cause allergy. Nor.

[0033]

The present invention will be described in more detail with reference to the following examples and test examples, but the scope of the present invention is not limited to these examples and test examples. [Example 1] An inclusion compound in which allyl isothiocyanate was included in cyclodextrin was produced as follows. This manufacturing process is schematically shown in FIG. FIG.
In Fig. 9, 9 is an air filter, 10 'is an electric heater, and hot air heated by the electric heater 10' through the air filter 9 enters the spray dryer 5 from the hot gas chamber 11 and is an atomizer of the spray dryer 5. The clathrate slurry 3 sprayed by 6 is dried and granulated while flowing out from the discharge hole 12 toward the cyclone 8.

200 g of water was 24000 rpm with a homomixer.
100 g of β-cyclodextrin with convective stirring
After that, 10 g of allyl isothiocyanate was added, and the mixture was stirred for 1 hour. Slurry 3 obtained here
Was supplied to a spray drier (L-8 manufactured by Okawara Kako Kikai Co., Ltd.) 5 at a supply rate of 1 to 3 kg / h by a metering pump 4. Spray dryer 5 with atomizer 6 from 10,000
Set to 30000 rpm, set the inlet temperature of the hot gas chamber 11 to 150 to 200 ° C, and set the outlet temperature at the outlet to 60 to 100 ° C.
The inclusion compound particles (inclusion compound particles A) 1 in which allyl isothiocyanate was included in cyclodextrin were obtained by adjusting the above. The average particle size of the clathrate particles A was about 25 μm.

3 parts by weight of the obtained inclusion compound particles A and 97 parts by weight of low-density polyethylene were mixed and then kneaded and extruded using an extruder to produce a sheet having an average thickness of about 30 μm. . This sheet was stretched so as to have an average thickness of about 20 μm to obtain an infection protection sheet A. The infection protection sheet A has a structure as shown in FIG.

Example 2 5 parts by weight of the clathrate compound particles A obtained in Example 1 and 95 parts by weight of EVA resin were mixed and then kneaded and extruded using an extruder to obtain an average thickness. Is about
A 30 μm infection-preventing sheet B was produced.

[Example 3] An inclusion compound in which Hiba extract oil was included in cyclodextrin was produced as follows. 100 g of β-cyclodextrin was added while convection stirring 200 g of water at 24000 rpm with a homomixer, and then Hiba extracted oil (trade name: Aomori Hiba essential oil (using Hiba from Aomori Prefecture), Osaka Organic Chemical Industry ( Co., Ltd.) was added and stirred for 1 hour. The slurry obtained here was supplied by a metering pump 4 to a spray drier (L-8, manufactured by Okawara Kakoki Kikai Co., Ltd.) 5 at a supply rate of 1 to 3 kg / h. Spray dryer 5 with atomizer 6 from 10,000
Set to 30000 rpm, set the inlet temperature of the hot gas chamber 11 to 150 to 200 ° C, and set the outlet temperature at the outlet to 60 to 100 ° C.
The inclusion compound particles (inclusion compound particles C) in which Hiba extracted oil is included in cyclodextrin
was gotten. The average particle size of the clathrate particles C is about 20
μm.

An ink composition was prepared by adding 20 parts by weight of clathrate compound particles C thus obtained to 20 parts by weight of vinyl acetate, 60 parts by weight of toluene, 12 parts by weight of chlorinated polypropylene, 0.5 parts by weight of polyethylene wax and 16 parts by weight of methyl ethyl ketone. It was a thing. This ink composition was applied by gravure printing to one entire surface of a polypropylene resin sheet having a thickness of about 1.0 mm. Then, an incision having a length of 1 cm was formed with a width of 1 cm on the entire sheet to form an infection protection sheet C. The infection protection sheet C has an appearance as shown in FIG.

Example 4 20 parts by weight of the clathrate compound particles A obtained were added to 20 parts by weight of vinyl acetate, 60 parts by weight of toluene, 12 parts by weight of chlorinated polypropylene, 0.5 part by weight of polyethylene wax and 16 parts by weight of methyl ethyl ketone. The ink composition was prepared by adding parts. This ink composition is partially applied to one surface of a woven cloth (made of vinyl chloride) having a thickness of about 2 mm by gravure printing to form an infection protection sheet D.
And The infection protection sheet D has an appearance as shown in FIG. In FIG. 9, 2 ″ indicates a woven cloth, and 22 indicates a printing section.

Example 5 The clathrate compound particles A obtained in Example 1 were sprinkled onto a non-woven fabric (made of polypropylene, 50 g / m ² ) so as to have a weight of about 5 g / m ^2, and A non-woven fabric similar to the above non-woven fabric was laminated on. 10 of these two non-woven fabrics
A large number of cm × 10 cm bags are formed, and the inclusion compound particles A are sprinkled on the above-mentioned non-woven fabric so that the inclusion compound particles A are held in the bags, and then a heat-sealing part is formed in a stitch pattern. Heat sealing was performed using the provided heat seal. The infection protection sheet E thus obtained has an appearance as shown in FIG.

[Example 6] 10 parts by weight of shellac resin (manufactured by Giff-Selac Co., Ltd.) was dissolved in 90 parts by weight of ethanol, and this was sprayed with a nonwoven fabric (made of polypropylene, 50 g / m 2) so that the average film thickness was about 30 μm. ² ) Sprayed on. Then, the clathrate compound particles A obtained in Example 1 were sprayed onto the shellac resin layer in the form of powder so as to be about 5 g / m ² . The shellac resin used in this example is a natural resin, which is used as a food additive.

[Test Example 1] Candida albicans was grown on a potato dextrose agar medium (manufactured by Eiken Chemical Co., Ltd.) at 30 ° C. under 18 to 18 ° C.
After culturing for 24 hours, the number of bacteria is about 10 ³ cells /
It was prepared so as to obtain a test bacterial solution. GPLP agar medium (Nihon Pharmaceutical Co., Ltd.)
Co., Ltd.) was dispensed in 5 ml portions, solidified, air-dried in a clean bench, and 0.1 ml each of the test bacterial solution was smeared to form a test plate. The number of bacteria in the test bacterial solution used was determined by GPL.
It was measured by a pour plate method (25 ° C., 7 days) using a P agar medium, and the number of inoculated bacteria was calculated.

Inclusion compound particles A 0.2 obtained in Example 1
g and the above test plate together with a beaker containing 50 ml of water in a plastic square container (1.6 liter),
Capped and cultured at 30 ° C. Two days after the culture, the presence or absence of bacterial growth on the test plate was visually observed. As a control, the same test was carried out when no inclusion compound particles A were added.
The results are shown in Table 1.

[0044] Salmonella enter
Itidis, Staphylococcus aureus, Vibrio cholerae and Vibrio parahaemolyticus were also tested. However, Salmonella enteritidis and Staphylococc
For Us aureus, 1 g of clathrate compound particles A was used. The results are shown in Table 1.

[0045]

[Table 1]

As is clear from Table 1, the inclusion compound particles used in the present invention are Candida albicans and Salmonella e.
nteritidis, Staphylococcus aureus, Vibrio cholera
e) Excellent antibacterial activity against Vibrio parahaemolyticus.

Test Example 2 Escherichia coli
Was cultured until the number of bacteria reached 2.9 × 10 ⁹ cells / ml. 1-fold dilution of this bacterial solution (not diluted), 100-fold dilution, 10,000
Prepare a 1-fold dilution and a 1,000,000-fold dilution, and
Each 10 μl was dropped on the L plate. 0.1 g of the clathrate compound particles A obtained in Example 1 were placed inside the upper lid of the L plate, and the upper lid was placed upside down on the plate on which the bacteria were dropped. In this condition, culture at 37 ° C,
The number of bacteria after the passage of time was examined. Table 2 shows the results.

The same test was conducted on the inclusion compound particles C obtained in Example 3. The results are also shown in Table 2. On the other hand, each inclusion compound particle was produced in the same manner as in Example 3 using cypress extraction oil (Osaka Organic Chemical Industry Co., Ltd .: Kiso cypress oil) and limonene oil (Yasuhara Chemical Co., Ltd.). 1 ml of the above hinoki oil and 1 ml of limonene oil, 2.5 g of the obtained inclusion compound particles of hinoki oil (inclusion compound particles H) and inclusion compound particles of limonene oil (inclusion compound particles L) 2.
The same test as above was performed on 5 g. Table 2 shows the results
Shown in

[0049]

[Table 2]

As is clear from Table 2, the inclusion compound particles used in the present invention are excellent in antibacterial activity against Escherichia coli, but hinoki oil and limonene oil and their inclusion compound particles are effective against Escherichia coli. There is almost no.

[Test Example 3] Cytrob known for opportunistic infection
acter freundii, Proteus mirabilis, Klebsiella pne
umomiae and Serratia marcescens, each with 5.
2 × 10 ⁹ cells /ml,1.3 × 10 ⁹ pieces /ml,9.4 × 10 ⁹ pieces / m
l, The culture was continued until 3.3 × 10 ⁹ cells / ml. A 1-fold diluted solution (not diluted), a 100-fold diluted solution, a 10,000-fold diluted solution, and a 1,000,000-fold diluted solution of these bacterial solutions were prepared, and the antibacterial activity of the inclusion compound particles A was tested in the same manner as in Test Example 2. did. Table 3 shows the results.

[0052]

[Table 3]

As is clear from Table 3, the inclusion compound particles used in the present invention were Cytrobacter freundii and Proteus m.
irabilis, Klebsiella pneumomiae, Serratia marces
Excellent antibacterial activity against bacteria such as cens.

[Test Example 4] Infection protection sheets A, B, D
When E and E were placed under a humidity of 80%, the transpiration of allyl isothiocyanate (AIT) was measured. The measurement of the amount of transpiration was performed as follows.

Each infection-preventing sheet (10 cm × 10 cm) was wrapped with a non-woven fabric, housed in a 1100 ml glass container (holding humidity 80%), and sealed. The amount of allyl isothiocyanate in the air in the glass container was measured over time by gas chromatography. The results are shown in the graph of FIG. In addition, the measurement conditions of the gas chromatography method were as follows.

(Measurement conditions) Detector: FID Column: PEG20M (column length 25 cm, column diameter 0.25 m
m, film thickness 0.25μm) Inlet temperature: 200 ° C Detector temperature: 230 ° C Carrier gas: He 11.3psi (70 ° C) Column oven heating pattern: 70 ° C (1min) → 100
Temperature rise to ℃ (5 ℃ / min) → temperature rise to 220 ℃ (40 ℃ / mi)
n) → 220 ° C. Hold for 1.75 min As is clear from the graph of FIG. 10, the infection protection sheets A, B, D and E can exert an antibacterial effect for 7 days under a humidity of 80%.

Test Example 5 Diameter 3.8 cm, Depth 0.5 cm
In the styrene petri dish of No. 3, the infection protection sheet D (diameter: about 3.8 cm) obtained in Example 4 was placed, and the center of the sheet D was set to 0.
1 g of powdered feed (oriental yeast Co., Ltd., powder feed for small animals MF) was placed. This is placed in the center of a styrene petri dish with a diameter of approximately 8.5 cm and a depth of approximately 1.4 cm, and 25 Noshimedarameiga (larvae about 14 days after hatching) are released between the central petri dish and the outer petri dish. A hole having a diameter of 5 cm was pierced, and a lid with a 120-mesh wire net was attached.

After the petri dish was allowed to stand at room temperature for 2 days, the number of larvae transferred to the central petri dish was counted. This test was performed for four sections. As a control, a test was conducted in the same manner as described above except that no infection protection sheet was inserted. The results are shown in Table 4.

[0059]

[Table 4]

From the values in Table 4, the repellent rate of the infection protection sheet D is calculated by the following formula, and it is 32.6%. Repellent rate (%) = (Average transfer rate of untreated section−Average transfer rate of treated section) / Average transfer rate of untreated section × 100 As is clear from the results, the infection prevention sheet of the present invention is It has an excellent repellent effect on the larvae of Madara moth.

[Test Example 6] The infection-protecting sheet C obtained in Example 3 was cut into 2 cm squares, and 41 adult subjects (in their 20s to
(Men and women in their 50s) closely adhered to the upper arm side and observed 24 hours later. All subjects showed itching, swelling,
There were no akami or other discomfort, and no change in physical condition occurred.

[0062]

According to the present invention, an antibacterial agent can be filled especially in a bed, and the bed is in an immunodeficiency state such as the elderly, AIDS patients, organ transplant patients, leukemia patients and congenital immunodeficiency patients. Candida susceptible to patients
It is possible to effectively prevent skin diseases caused by pathogenic organisms such as albicans and mite. In addition, it is possible to prevent floor rubbing.

[Brief description of drawings]

FIG. 1 is a schematic sectional view of an infection protection sheet according to an example of the present invention.

FIG. 2 is a schematic sectional view of an infection protection sheet according to another example of the present invention.

FIG. 3 is a perspective view of an infection protection sheet according to another example of the present invention.

FIG. 4 is a schematic sectional view of an infection protection sheet according to another example of the present invention.

FIG. 5 is a perspective view of an infection protection sheet according to another example of the present invention.

FIG. 6 is a perspective view of an infection protection sheet according to another example of the present invention.

FIG. 7 is a perspective view of an infection protection sheet according to another example of the present invention.

FIG. 8 is a diagram illustrating a production process of clathrate compound particles used in the infection-preventing sheet of the present invention.

FIG. 9 is a perspective view of an infection protection sheet D manufactured in Example 4.

FIG. 10 is a graph showing the change over time in the amount of transpiration of allyl isothiocyanate from the infection protection sheets A, B, D and E.

[Explanation of symbols]

 1 ... Inclusion compound particles 10 ... Coating film 2 ... Sheet 2 '... Non-woven fabric 2' '... Woven fabric 20 ... Notch 21 ... Bag part 22 ... Printing part 3 ... Slurry 4 ... Metering pump 5 ... Spray dryer 6 ... Atomizer 8 ... Cyclone 9 ... Air filter 10 '... Electric heater 11 ... Hot gas chamber 12 ... Exhaust hole

Claims (13)

[Claims] 1. A method for protecting against infection using a sheet containing inclusion compound particles in which a volatile organic antibacterial agent is included in cyclodextrin. 2. The organic antibacterial agent according to claim 1, wherein the sheet is laid under bedding or used as a bedding sheet or cover, and the organic antibacterial agent is volatilized by moisture evaporated from a person. How to prevent infection. 3. The method according to claim 1, wherein the volatile organic antibacterial agent is isothiocyanate and / or hiba extracted oil. 4. Candida albicans, Escherichia coli,
Staphylococcus aureus, Psedomonas aeruginosa, Cy
trobacter freundii, Proteus mirabilis, Klebsiella
pneumomiae, Serratia marcescens, Salmonella ent
eritidis, Vibrio cholerae or Vibrio parahaemoly
The method according to any one of claims 1 to 3, wherein the infection is protected against at least one kind of ticus. 5. An infection protection sheet comprising inclusion compound particles in which a volatile organic antibacterial agent is included in cyclodextrin. 6. A sheet obtained by mixing clathrate compound particles obtained by clathrating a volatile organic antibacterial agent with cyclodextrin into a thermoplastic resin, and processing the clathrate compound particles, wherein the mean particle size of the clathrate compound particles. An infection protection sheet having a diameter larger than the average thickness of the thermoplastic resin sheet. 7. A coating film containing clathrate compound particles in which a volatile organic antibacterial agent is clathrated in cyclodextrin is provided on all or part of at least one surface of a thermoplastic resin sheet. Infection protection sheet characterized by the following. 8. The infection protection sheet according to claim 6, wherein the infection protection sheet is provided with a plurality of cuts or holes. 9. A coating film containing clathrate compound particles in which a volatile organic antibacterial agent is clathrated in cyclodextrin is provided on all or part of at least one surface of a breathable sheet. Infection-prevention sheet characterized by 10. The infection-preventing sheet according to claim 9, wherein the breathable sheet is a sheet made of one type of paper, non-woven fabric or woven fabric or a laminate of a plurality of types. 11. Inclusion compound particles obtained by encapsulating a volatile organic antibacterial agent in cyclodextrin are held between two sheet base materials, and at least one of the sheet base materials is breathable. An infection-preventing sheet, which is a sheet base material having the same. 12. The infection protective sheet according to claim 5, wherein the volatile organic antibacterial agent is isothiocyanate and / or hiba extract oil. 13. Candida albicans, Escherichia col
i, Staphylococcus aureus, Psedomonas aeruginosa
, Cytrobacter freundii, Proteus mirabilis, Klebsi
ella pneumomiae, Serratia marcescens, Salmonella
enteritidis, Vibrio cholerae or Vibrio parahae
The infection protection sheet according to any one of claims 5 to 12, which protects against infection with at least one type of molyticus.