JPH09175970A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity, containing a high-molecular electrolyte gel in which pigment is embedded. SOLUTION: This composition contains 1-10wt.% high-molecular electrolyte gel obtained by embedding a pigment with an electrolytic high-molecular substance, e.g. a copolymer of an anionic compound with a nonionic compound such as sodium acrylate-vinyl alcohol copolymer. Gel, preferably having 10-500μm average particle diameter is stimulated even by 10-20μA feeble electric current at 3V electric voltage to cause contraction of gel and the pigment is released out of gel and a composition for oral cavity is colored thereby. Therefore, the gel is combinedly used with a tool for cleaning oral cavity capable of generating electric current, e.g. an ion toothbrush. It that case, since release time of the pigment in electric current is controlled by controlling ion concentration of the gel to 0-10<-1> M, the composition can carry out indicator function after finishing tooth brushing.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a polyelectrolyte gel containing a dye contracted during brushing when used in combination with an oral cleaning tool, such as an ionic toothbrush, which generates an electric current. The present invention relates to an oral composition capable of performing an indicator function of time.

[0002]

2. Description of the Related Art Heretofore, various proposals have been made for oral compositions in which granules and capsules are added to oral compositions to impart various functions. For example, there is one that is intended to be an indicator at the end of tooth brushing by blending a pigment into granules or the like so that the pigment is exposed during brushing. Examples of such blended pigments include water-insoluble fatty acid ester and xanthene-based pigment. (JP-B-58-20929), opaque microcapsules and oil-based dyes (JP-A-55-102436), zeolites and color-forming organic compounds (49-1737).
Gazette), polymer compounds, inorganic powders, and pigments (ibid.
6912), magnesium aluminometasilicate and dyes (63-250314), and the like. In all of these proposals, the dyes are externalized by physical force by brushing with a toothbrush or the like. To color the oral composition during brushing.

[0003] Further, capsules of fragrances, foaming agents and the like as active ingredients are blended to form capsules of fragrances (JP-A-48-29566 and JP-A-62-116506), foaming agents and defoaming agents. And coated (same as 5
No. 8-20928), a combination of a water-soluble polymer, an inorganic powder and a pigment (No. 60-16913), and an active ingredient coated with sodium chloride (No. 55-1).
No. 53709) has been proposed.

By the way, in recent years, an oral cleaning tool such as an ion toothbrush that generates an electric current has been used.
In addition to the physical force of a normal toothbrush, the effect of removing plaque is also obtained by an electric current. However, none of the proposals using the above-mentioned dyes as an indicator of the completion of tooth brushing release the contents (dyes, etc.) to the outside by an extremely small current due to the ion toothbrush etc. Even when used in combination with the above, regardless of the presence or absence of an electric current, only the coloring was observed by the physical force as in the case of a normal toothbrush, and there was no such thing as coloring by energization.

Therefore, when an ion toothbrush or the like is used, the dye is exposed by energization during brushing and functions as an indicator at the end of tooth brushing. The development of compositions has been desired.

The present invention has been made in view of the above circumstances. For the oral cavity, the pigment liquid is released to the outside by the stimulation of a slight electric current and colored with an appropriate brushing time when used in combination with an ion toothbrush or the like. It is intended to provide a composition.

[0007]

Means for Solving the Problems and Modes for Carrying Out the Invention As a result of intensive studies to achieve the above-mentioned object, the present inventor has found that a dye is an anionic compound and a nonionic compound,
A polymer electrolyte gel embedded with an electrolyte polymer material such as sodium acrylate-vinyl alcohol copolymer, preferably having an average particle size of 10 to 500 μm.
It was found that the gel of (1) contracts by being stimulated by a weak current of 10 to 20 μA at a voltage of about 3 V, and the contraction time at this time can be adjusted by the ion concentration of the gel. When the polyelectrolyte gel is blended in the oral composition, by brushing with an oral cleaning tool that generates a weak current such as an ionic toothbrush, the gel shrinks at an appropriate time and is encapsulated. It has been found that an oral composition having a function of an indicator for notifying the brushing time necessary for removing plaque, for example, can be obtained by coloring the oral composition during the brushing by releasing the pigment, and thus forming the present invention. I arrived.

That is, the present invention provides an oral composition comprising a polymer electrolyte gel in which a dye is embedded.

The present invention will be described in more detail below. Examples of the oral composition of the present invention include toothpaste, paste for treating periodontal disease and the like. Particularly, a weak current such as an ion toothbrush, for example, 10 It is preferably used as a dentifrice for an oral cleaning tool that generates a current of about 20 μA, and contains a polymer electrolyte gel in which a dye is embedded.

In the above-mentioned oral composition, the dye prepared as the polyelectrolyte gel is not particularly limited, and any so-called legal dye which is usually added to the oral composition as a dye or a coloring component may be used. Good, for example red 2
No. 3, Red 3, Red 225, Red 226, Yellow 4
No. 5, Yellow No. 5, Yellow No. 205, Blue No. 1, Green No. 3, and the like. These may be used alone or in combination of two or more. .

The proportion of the above-mentioned dyes is preferably 0.001 to 0.5% (weight%, the same applies below) with respect to the total amount of the polyelectrolyte gel. If it is less than 0.001%, the oral composition is used. May not be clearly observed, and if it exceeds 0.5%, the stability of the gel in the composition may deteriorate. If the coloring property of the oral composition during brushing is taken into consideration, it is 0.0 with respect to the total amount of gel.
It is desirable to be 1 to 0.1%.

The polymer starting material for the above-mentioned polymer electrolyte gel may be any polymer that is an electrolyte polymer that swells and gels with water, and such polymer starting material may be an anionic compound. And a nonionic compound can be mentioned, and specifically, for example, sodium acrylate-vinyl alcohol copolymer, sodium acrylate-vinylpyrrolidone copolymer, and the like, but particularly sodium acrylate -Vinyl alcohol copolymer is preferably used and has a pure water absorption capacity of 500 to 700.
It is preferably doubled.

In the present invention, as a method for preparing the polymer electrolyte gel in which the dye is embedded, for example, a method in which a dye aqueous solution and an electrolyte aqueous solution are added to a gel swollen with pure water can be selected. The polymer electrolyte gel is not limited to this as long as it can produce a similar polymer electrolyte gel.
In the case of the present invention, in producing a gel, it is preferable to use the above dye after preparing it in an aqueous solution.
Usually, it is preferably 0.1 to 0.5% aqueous solution.

The polyelectrolyte gel of the present invention has an average particle size of 10 to 500 μm, particularly 100 to 3
It is preferably 00 μm. When it is less than 10 μm, it does not take the shape of particles when it is embedded in the aqueous dye solution as described above, and it remains powdery and may be inconvenient to handle. When it exceeds 500 μm, it may be destroyed by physical force. It often happens, and the color of the indicator in the formulation is too clearly visible, and the change as an indicator may be poor. In the case of the present invention, the polyelectrolyte gel has an absorption capacity of 40 to 80 for 0.9% sodium chloride.
40 to 60 times, and 500 to pure water.
It is preferably 700 times. Outside the above range, the dye may not be embedded sufficiently. Furthermore,
The polyelectrolyte gel preferably releases a dye by an electric current generated by an oral cleaning tool such as an ordinary ionic toothbrush, and for example, at a voltage of 1.5 to 6 V, particularly 3 V, at least 10 to 20 μA, preferably 10-80 μA,
In particular, it is preferable to contract with a current of 40 to 50 μA.

The contraction time of the above polyelectrolyte gel due to the electric current, that is, the coloring time of the oral composition can be adjusted by various factors. In the case of the present invention, it is adjusted by the ion concentration when the gel is prepared. It is preferable that the range is appropriately selected, but it is usually 0 to 10 ^-1.
It is preferable to adjust in the ion concentration range of M. 10 ^-1 M
If it exceeds, the stability of the gel in the oral composition may be deteriorated or the coloring property may be deteriorated. The component for adjusting the ion concentration is not particularly limited as long as it can be incorporated into the composition for oral cavity and can be stably incorporated into the gel in an appropriate amount, and examples thereof include NaHC.
Examples thereof include inorganic salts such as O ₃ , Na ₂ CO ₃ , KHCO ₃ , and K ₂ CO ₃ .

The blending ratio of the polymer electrolyte gel in the oral composition of the present invention is 1 to 1 with respect to the total amount of the oral composition.
0%, especially 5 to 8% is preferable because the degree of coloring and the stability in the preparation are good.

In the oral composition of the present invention, components used in ordinary oral compositions can be used as components other than those described above, and the added amount of these components impairs the effects of the present invention. Normal amounts can be used within the range not present.

In the case of dentifrices, for example, abrasives, binders,
Various active ingredients such as a thickener, a surfactant, a sweetener, an antiseptic and the like can be blended, and these ingredients can be mixed with water for production.

Here, as the abrasive, precipitated silica,
Silica-based abrasives such as silica gel, aluminosilicate, zirconosilicate, dibasic calcium phosphate dihydrate and anhydrate, calcium pyrophosphate, calcium carbonate,
Aluminum hydroxide, alumina, magnesium carbonate, tertiary magnesium phosphate, zeolite, zirconium silicate, synthetic resin-based abrasives and the like are preferably used.

Examples of the thickener include glycerin, sorbitol, propylene glycol, polyethylene glycol,
Xylit, maltit, lactit, and the like are preferably used.

As the binder, carboxymethyl cellulose sodium, hydroxyethyl cellulose, carrageenan, sodium alginate, xanthan gum, carbopol, guar gum, montmorillonite, gelatin and the like are preferably used.

As the surface active agent, an anionic surface active agent, a cationic surface active agent, a nonionic surface active agent or the like may be blended, and specifically, sodium lauryl sulfate, α-
Sodium olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, 2-alkyl-N-
Carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, pluronic, polyoxyethylene sorbitan monostearate, etc. It is preferably used.

As sweeteners, sodium saccharin,
Examples thereof include stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartine and the like.

Examples of preservatives include paraoxybenzoic acid ester and sodium benzoate.

Other various active ingredients include fluorides such as sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride, sodium monofluorophosphate, potassium salts of orthophosphoric acid, sodium salts and the like. Water-soluble phosphate compounds, allantoin chlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride,
Tranexamic acid, epsilon aminocaproic acid, acetic acid d
Copper compounds such as 1-tocopherol, azulene, glycyrrhetinic acid, sodium copper chlorophyllin, and copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, dextranase, mutanase, amylase , Methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, dihydrocholesterol, zinc citrate, touki, oat, extract of clove, rosemary, augon, safflower and the like, but the present invention In the case of the oral composition, it is preferably used for ionic toothbrushes and the like, and the ionic toothbrush etc. has a function of increasing the uptake amount of fluorine, and at the same time, it releases the dye due to gel disintegration to the oral cavity. Since it is also possible to serve the indicator function of the incorporation of fluorine into the tooth that is contained in the formed product, it is particularly effective to blend a fluoride as an active ingredient.

As the fragrance, terpenes such as 1-menthol, carvone, anethole and limonene or derivatives thereof are suitable.

[0027]

EFFECT OF THE INVENTION The oral composition of the present invention contains a polyelectrolyte gel in which a dye is embedded, so that the gel contracts by the stimulation of an electric current and the dye is released to the outside of the gel during brushing. Since the composition for oral cavity is colored, when used in combination with an oral cavity cleaning tool such as an ionic toothbrush that generates an electric current,
The indicator function at the end of tooth brushing can be fulfilled by controlling the release time of the dye at a predetermined current by the ion concentration of the gel and the like.

[0028]

EXAMPLES The present invention will be specifically described below by showing experimental examples and examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%. [Experimental Example] Sumikagel S-50 (average particle size 250 μm,
Product name: acrylic acid-vinyl alcohol copolymer, manufactured by Sumitomo Chemical Co., Ltd.
A 1% aqueous solution was added so as to have a ratio shown in Table 1, and the ion concentration shown in Table 1 was further adjusted using a 0.1 M aqueous solution of NaHCO ₃ , followed by mixing and stirring with Sumikagel S-50, and thereafter. A fine particle gel containing a dye is prepared by allowing it to stand for an appropriate time, and added to the dentifrice A described below so that the blending ratio of the gel is 5% (dentifrice A: gel = 95: 5 (weight)), A dentifrice containing a polymer electrolyte gel in which a dye was embedded was obtained by mixing so as to be entirely uniform.
A current of 30 μA was applied at a voltage of 6 V to a dentifrice dispersion in which each dentifrice was dispersed in water so that the ratio of dentifrice / water was 1/2, and coloring of the dentifrice dispersion was caused by contraction of the polymer electrolyte gel. It was visually observed and evaluated according to the following evaluation criteria. The results are also shown in Table 1. The time in parentheses in the table indicates the time when coloring was confirmed.

Evaluation Criteria ◯: The dentifrice dispersion is colored. Δ: The toothpaste dispersion is slightly colored. X: The toothpaste dispersion is not colored at all.

[0030]

[Table 1]

According to the results shown in Table 1, when the content of the dye was 0.01%, the coloring of the dentifrice dispersion was observed after 4 minutes when NaHCO ₃ was 0M, and the ion concentration was 10 ^-3 M and 10%.
As the color density increases to ^-1 M, coloring is not observed in 4 minutes, and some coloring is observed after 10 minutes, while the dye has a color density of 0.
In the case of 1%, coloring of the dentifrice dispersion was observed after 1 minute when NaHCO ₃ was 0M, and the ion concentration was 10%.
^It was confirmed that the coloring time was changed by adjusting the dye concentration and the ion concentration, such that coloring was observed after 10 minutes at ⁻³ M and 10 ⁻¹ M. For example, in the case of the above experimental example, when the polyelectrolyte gel contains a dye, the coloring time of the dentifrice dispersion can be controlled by adjusting the ion concentration in the range of 0 to 10 ^-1 M. confirmed.

Next, the polyelectrolyte gels were made to have the compositions shown in Tables 2 and 3 so that the swelling degree was 100 times, and the respective dyes and electrolytes had the concentrations shown in the table in the swollen gel. Was prepared by mixing the aqueous solution blended in with the polymer copolymer in the table and then leaving it for 5 hours, and blending the resulting polymer electrolyte gel into a dentifrice as shown in Tables 2 and 3, Examples 1 to 17 were mixed by uniformly mixing the whole.
Dentifrice (oral composition containing polyelectrolyte gel in which pigment is embedded) was obtained, and these dentifrice dispersions (dispersed dentifrice in water so that dentifrice / water = 1/2) The coloring property of the 33% aqueous solution) and the stability in the preparation (oral composition) were evaluated according to the following evaluation criteria. The results are shown in Tables 2 and 3. The values in parentheses in the table are the same as above.

Dentifrice A Aluminum hydroxide 40.0% Carboxymethylcellulose 1.0 Sodium lauryl sulfate 1.0 Sodium saccharin 0.2 Sorbit solution (60%) 20 Perfume 1.0 Sodium monofluorophosphate 0.5 Water balance meter 100% Dentifrice B Silicic Acid 16% Propylene Glycol 3 Sorbit Solution (60%) 25 Carboxymethyl Cellulose 1 Saccharin Sodium 0.1 Sodium Lauryl Sulfate 1.5 Perfume 1.1 Sodium Fluoride 0.2 Tranexamic Acid 0.05 Water Balance total 100% dentifrice C dicalcium phosphate dihydrate 40 glycerin 18 xanthan gum 0.5 sodium polyacrylate 0.8 sodium saccharin 0.2 dipotassium glycyrrhizinate 0.05 laurylsulfate Na Potassium 1.0 Perfume 1.0 Sodium monofluorophosphate 0.7 Water Balance Total 100%

Evaluation criteria Coloring properties of dentifrice dispersion ⊚: The dentifrice dispersion is colored in a short time. ◯: The toothpaste dispersion is colored after about 10 minutes. Δ: The toothpaste dispersion is slightly colored. ×: The dentifrice was colored before brushing,
Toothpaste dispersion does not stain forever. Stability of the dye gel in the formulation ○: The color of the dentifrice does not change during storage at room temperature. X: The dentifrice is colored during storage at room temperature.

[0035]

[Table 2]

[0036]

[Table 3]

According to the results shown in Tables 2 and 3, in the case of the dentifrice containing the dye-containing polyelectrolyte gel comprising the acrylic acid-vinyl alcohol copolymer, the dentifrice is dispersed depending on the average particle size of the gel and its absorbability. It is observed that the colorability of the liquid and the stability of the polyelectrolyte gel in the formulation are different. For example, in the case of the above experimental example, when the blending ratio of the pigment is 0.01 to 0.1% with respect to the total amount of the gel, the coloring property of the dentifrice dispersion liquid is good, whereas the blending ratio thereof is When it is 1%, not only the stability of the polyelectrolyte gel in the preparation is deteriorated, but also the coloring property of the toothpaste dispersion is deteriorated. On the other hand, when the ion concentration of the inorganic salt such as sodium hydrogencarbonate is 1M or more, Although the stability of the polyelectrolyte gel in the preparation is good, it is observed that the coloring property of the dentifrice dispersion becomes poor.

Next, examples will be shown.

Example 1 To 1 g of Sumika Gel S-50, 10 g of 0.1% aqueous solution of Blue No. 1 and 90 g of water were added, stirred and left for 5 hours to obtain a fine particle gel containing a dye. The gel was added to the above dentifrice A containing fluorine so that the mixture ratio was 5%, and mixed to obtain a dentifrice containing the polymer electrolyte gel in which the dye was embedded. Using an ionic toothbrush (current 50 μA) with a built-in 3 V dry cell, brushing with the above toothpaste gave approximately 4
After -5 minutes, the entire dentifrice (dentifrice dispersion) during brushing turned blue.

Example 2 To 1 g of Sumika Gel S-50, 100 g of a 0.1% aqueous solution of Blue No. 1 and 1 g of a 0.1 M aqueous solution of NaHCO ₃ were added, and the mixture was allowed to stand for 5 hours to give a pigment-containing fine particle gel. This gel was added to the above-mentioned fluorine-containing dentifrice B so that the blending ratio was 5%, and the mixture was mixed to obtain a dentifrice containing a dye-embedded polymer electrolyte gel. When brushing was performed in the same manner as in Example 1, the entire dentifrice (dentifrice dispersion liquid) during brushing was colored blue after about 8 to 10 minutes.

[0041] 0 [Example 3] 1 g Sumikagel S-50 Blue 1 0.2% No. aqueous 50g and NaHCO ₃ to a.
50 g of a 2M aqueous solution was added, and the mixture was allowed to stand for 5 hours to obtain a fine particle gel containing a dye, and this gel was added to the above-mentioned fluorine-containing dentifrice C so that the mixture ratio was 5%,
A dentifrice mixed with a polyelectrolyte gel in which a dye was embedded was obtained by mixing. When brushing was performed in the same manner as in Example 1, the entire dentifrice (dentifrice dispersion liquid) during brushing was colored blue after about 8 to 10 minutes.

Claims (2)

[Claims] 1. A composition for oral cavity comprising a polyelectrolyte gel in which a dye is embedded. 2. The oral composition according to claim 1, which is used for an ionic toothbrush.