JPH0910296A - Body fluid absorbent article - Google Patents

Abstract

PURPOSE: To obviate the occurrence of infection in spite of coating the surface of a body having a wound over a long period of time by incorporating an antimicrobial agent into the absorbent of body fluid absorbent articles having the absorber for absorbing the body fluid. CONSTITUTION: The antimicrobial agent is incorporated into the absorbent of the body fluid absorbent articles having the absorbent for absorbing the body fluid. A liquid permeable sheet may be stuck to one surface of the absorbent and further, a liquid impermeable sheet ma be stuck to the other surface. The antimicrobial agent may be incorporated into one or both of the liquid permeable sheet and the liquid impermeable sheet. The exuding liquid and excretion liquid from the inside of the body are absorbed on the surface of the body and the propagation of microorganism with the exudate and excretion as nutrients and the infiltration thereof into the body are prevented according to such body fluid absorbent articles. The possibility of the occurrence of the infection is eliminated even if the surface of the body having the wound is coated with these articles over a long period of time.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a body fluid absorbent article,
More specifically, it covers the skin where the body fluid is exuded or discharged, absorbs the exudate or discharged fluid, and can prevent entry of microorganisms such as pathogens from the exuded portion of the body fluid, and the absorbed body fluid. The present invention relates to a body fluid absorbent article capable of preventing the propagation of microorganisms such as pathogenic bacteria and preventing infection therein.

[0002]

2. Description of the Related Art Conventionally, a body fluid absorbent article has been used for absorbing body fluid exuded or discharged from a living body such as a wound dressing (dressing), a plaster, a sanitary article, a paper diaper and the like. These body fluid absorbent articles are composed of an absorbent body that absorbs water interposed between a liquid-permeable sheet and a liquid-impermeable sheet, and as the absorbent body that absorbs water, for example, polyvinyl alcohol, A water-soluble polymer compound such as polyacrylic acid or a cross-linked product thereof is used. Since these absorbent bodies can hold moisture of several hundred times the weight of their own weight, and the surface is covered with a liquid-impermeable sheet, body fluid does not easily leak out of the body fluid absorbent article. One body fluid absorbent article is used for a relatively long time.

[0003]

These absorbents for body fluids have a high water absorbency and can hold water several hundred times their own weight, but such a humid environment is very suitable for the growth of microorganisms. In addition, since the absorbed body fluid contains a large amount of substances that serve as nutrients for microorganisms, when such a body fluid absorbent article is used in a wounded area, the microorganisms propagate inside the absorbent body, May invade the body and cause serious infection. In particular, patients who have indwelled catheters or tracheostomy tubes or patients with pressure ulcers have a low resistance, and thus have a high risk of infection.

Even if there is no scratch on the surface of the body, if an article containing water is kept in contact for a long time, symptoms such as discoloration, itchiness, and sometimes redness may appear, and the skin may be scratched. There is a possibility that it will be more likely to occur, or that the microorganisms that have propagated inside the absorber will migrate and enter the body from other parts to cause infection. The present invention solves such problems,
It is intended to provide a body fluid absorbent article which does not cause infection even if it covers the surface of a body having a wound for a long period of time.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that the above problems can be solved by incorporating an antibacterial agent into the absorbent body of the body fluid absorbent article. The inventors have found that they can be solved and reached the present invention. That is, the gist of the present invention is a bodily fluid absorbent article having an absorbent body for absorbing bodily fluids, characterized in that the absorbent body contains an antibacterial agent.

Hereinafter, the present invention will be described in detail. First, the body fluid absorber of the present invention contains an antibacterial agent in the absorber. A liquid-permeable sheet may be attached to one surface of the absorber, and a liquid-impermeable sheet may be attached to the other surface. Further, one or both of the liquid-permeable sheet and the liquid-impermeable sheet may contain an antibacterial agent.

In the present invention, the absorbent material is a hydrophilic polymer material, for example, cellulose, carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, rayon, carboxymethyl rayon, or other cellulosic polymer, chitin, chitosan, alginic acid. , Gum arabic, guar gum, tragacanth gum, mannan and other polysaccharide polymers,
Proteins such as collagen, gelatin, casein and glue, natural polymers such as starch-based polymers such as starch, carboxymethyl starch and dialdehyde starch,
Polyacrylonitrile, polyamide, polyurethane, polyester, polyacrylic acid, sodium polyacrylate,
Polyhydroxyethyl phthalate ester, methyl isopropyl ketone formaldehyde, polyamine, polyacrylamide, polystyrene sulfonate, polyvinyl alcohol, polyamino acid, polylactic acid, polyethylene glycol, polyethylene oxide, polyvinylpyrrolidone, methyl vinyl ether-maleic anhydride copolymer,
Synthetic or semi-synthetic polymer compounds such as activated carbon and their derivatives, salt compounds, copolymers, and mixtures are preferably used. These absorbers are used alone or in combination of several kinds. In addition, even hydrophobic materials such as polyethylene, polypropylene, polysulfone, polystyrene, polyvinyl chloride, polyvinylidene chloride, silicone, and polytetrafluoroethylene can have a porous shape with a large porosity or have a hydrophilic surface. It can also be used as an absorber by introducing a functional group.

[0008] The shape of the absorbent body is any shape such as cotton, sponge, gel, non-woven fabric, porous hydrophilic film, woven fabric, knitted fabric, etc., which can absorb liquid. Although it may have a shape, a shape having a large porosity such as a cotton shape, a non-woven fabric, and a sponge shape is preferable in order to absorb a large amount of body fluid with a small amount.

The antibacterial agent contained in the absorbent may be any antibacterial agent, but an antibacterial agent which is effective at a low concentration for various kinds of bacteria and has a low solubility is preferable from the viewpoint of safety. Examples of such antibacterial agents include erythromycin, oxytetracycline, tetracycline, chloramphenicol, fusidic acid, micamycin, kanamycin, gentamicin, fradiomycin, gramicidin, streptomycin, polymyxin, colistin, bacitracin, and the like, chlorhexidine, and the like. Biguanide compounds, benzethonium, benzalkonium, lauryl sulfate, alkyl polyaminoethylglycine, domiphen bromide, compounds having surface activity such as fatty acids, thymol,
Phenol, hexachlorophene, phenol derivatives such as resorcin, boric acid, boric acid compounds such as borax, iodine compounds such as iodine, iodoform and povidone iodine,
Examples thereof include metals such as gold, silver, copper and mercury, metal compounds such as thimerosal and methylobromine, antibacterial dye compounds such as acrinol and methylrosarinine, and sulfa drugs such as mafenide acetate, sulfadiazine, sulfisomidine and sulfamethoxazole. These antibacterial agents may be salt compounds such as sodium salts, potassium salts, magnesium salts, calcium salts, hydrochlorides, acetates, sulfates and gluconates of the above compounds, and two or more kinds of antibacterial agents may be used. You may use together.

As a method of incorporating an antibacterial agent into the absorbent body, a method of absorbing a solution of the antibacterial agent into a preformed absorbent body, and then removing the solvent by evaporating the solvent or replacing the solvent with a nonsolvent of the antibacterial agent, etc. Alternatively, a method may be employed in which an antibacterial agent is mixed with a material forming the absorber before forming a sponge or a non-woven fabric to form the absorber into a desired shape.

The content of the antibacterial agent is preferably 0.0001 to 50% by weight, more preferably 0.001 to 20% by weight, and further preferably 0.1 to 10% by weight. If it is less than 0.0001% by weight, the antibacterial property may be insufficient. On the other hand, if it exceeds 50% by weight, the ratio of the absorber itself is small and the strength tends to be insufficient. As the liquid-permeable sheet, any sheet may be used as long as the sheet has holes for allowing the liquid to pass therethrough, and for example, non-woven fabric, porous hydrophilic film, woven fabric, knitted fabric, mesh or the like is used. Since the liquid-permeable sheet is used in direct contact with the skin as described below, it is preferable that the sheet has low irritation to the skin.

As the liquid-impermeable sheet, for example, a film or a porous hydrophobic film is used. This sheet is used to prevent the bodily fluid absorbed by the absorbent from leaking out from the bodily fluid absorbent article as described below, but it is gas permeable to prevent the area covered with the bodily fluid absorbent article from becoming loose. Those having are preferred. The liquid-permeable sheet and the liquid-impermeable sheet preferably contain an antibacterial agent, and the content of the antibacterial agent is preferably 0.0001 to 50% by weight, like the absorber. To contain an antibacterial agent in these sheets, for example, the sheet may be formed by mixing the antibacterial agent with the material forming the sheet before forming the sheet.

In the case of forming a body fluid absorbent article in which an absorbent body is interposed between a liquid-permeable sheet and a liquid-impermeable sheet, the liquid-permeable sheet and the liquid-impermeable sheet are respectively heated. A method of attaching by fusion or adhesive,
Examples include a method in which a liquid-permeable sheet and a liquid-impermeable sheet are overlapped and the three sides are attached to each other to form a bag, and the inside of the bag is filled with an absorber. The former method is preferably used particularly when the absorbent body is a sheet-shaped sponge,
The latter method is preferably used particularly when the absorbent body is cotton-like.

The body fluid absorbent article of the present invention is for absorbing the body fluid in the absorbent body by covering the surface of the body from which the body fluid is exuded or discharged. When a liquid permeable sheet is attached to one surface of the absorber and a liquid impermeable sheet is attached to the other surface, the liquid permeable sheet is used by contacting with the body. .

The body fluid absorbent article of the present invention is specifically used, for example, as a wound dressing material or as a coating for a puncture part of a medical device such as a catheter or a tracheostomy tube, which is placed in the body. It is used to absorb the exudate from the wound and prevent infection from the wound. In particular, tracheostomy tubes, endotracheal catheters,
When a medical device placed in the trachea is used, a large amount of exudate and a short distance from the skin to the trachea allow microorganisms to easily enter the body. Therefore, an antibacterial body fluid absorbent article is preferably used.

When a catheter or the like left in a blood vessel is used for high calorie infusion or dialysis, the catheter penetrates from the skin to the blood vessel, so that when the microorganism enters the body, the blood vessel can be easily reached. The bodily fluid absorbent article of the present invention is suitable because it may reach and cause serious infections such as sepsis. Alternatively, also in the peritoneal dialysis catheter, the invasion of microorganisms from the insertion portion of the catheter is a main infection route, and it is important to remove exudate and keep the vicinity of the insertion portion sterile. Since the drain tube contains a large amount of exudate, the puncture part becomes wet and microorganisms easily propagate.Therefore, covering the puncture part of the drain tube with an antibacterial body fluid absorbent product prevents infection. Highly effective. The body fluid absorbent article of the present invention can be used to directly contact the skin to absorb discharged body fluid, such as a disposable diaper and a sanitary article.

[0017]

The body fluid absorbent article of the present invention absorbs body fluid exuded or discharged from the living body, prevents the propagation of pathogens and the like by using the absorbed body fluid as nutrients, and from the wound when there is a wound on the skin. Prevent pathogens from entering.

[0018]

The present invention will be specifically described below with reference to examples. Example 1 A polyurethane dressing in which a thin polyurethane film was attached to one surface of a polyurethane sponge having a thickness of 5 mm and a length and width of 9 cm × 9 cm, and a polyurethane mesh was attached to the other surface [Smith and Neph
Allevyn manufactured by ew) was cut into 2 cm × 2 cm, dried in a heating vacuum dryer at 60 ° C. for 16 hours, and then weighed. Next, it was immersed in an aqueous solution of chlorhexidine hydrochloride (manufactured by Maruishi Pharmaceutical Co., Ltd.) (concentration: 500 ppm) to sufficiently allow this aqueous solution to drip, and then taken out and dried in a dryer at 50 ° C. for 48 hours. After further drying it in a vacuum dryer at 60 ° C. for 16 hours, the weight was measured. When the content of chlorhexidine hydrochloride per sample was determined from the difference in dry weight before and after immersion, the average was 0.59% by weight.

Three samples of the above-mentioned polyurethane dressing containing chlorhexidine hydrochloride were sterilized in an autoclave at 121 ° C. for 20 minutes, and then Brain Heart Infusion medium (Becton Dickinson and Company ( Be
cton Dickinson and Company)], and 5 × 10
Immerse it in the bacterial solution of Staphylococcus aureus (ATCC 6538P) adjusted to ⁵ cells / ml, absorb the solution sufficiently, take it out, put it in a sterilized vial bottle, and incubate at 37 ° C for 4 hours. After culturing, 10 ml of physiological saline containing 0.1% nonionic surfactant Tween 80 (polyoxyethylene sorbitan alkyl ester manufactured by Becton Dickinson & Co.) was added to the vial and shaken vigorously. Then, the bacterial solution was washed out. After that, when the bacterial concentration in these liquids was measured by the colony counting method, no bacteria were detected in the liquid from which the bacterial liquid was washed out from the above three samples.

On the other hand, the above bacteria were cultured in the same manner as above on three samples of polyurethane dressing containing no chlorhexidine hydrochloride, and the bacteria concentration was measured in the same manner as above. 10
⁶ cells / ml, 8.5 × 10 ⁵ cells / ml, 4.4 × 10 ⁵ c
It was ells / ml. As is clear from the above results, the chlorhexidine hydrochloride-containing polyurethane dressing was clearly antibacterial.

Example 2 A cotton non-woven fabric (Cott Ace manufactured by Unitika Ltd.) 8 cm × 10
The sample was cut into cm, the dry weight was measured by the method described in Example 1, the sample was immersed in a 500 ppm chlorhexidine hydrochloride aqueous solution, and the sample was dried again to measure the weight. When the content of chlorhexidine hydrochloride was calculated from the difference in weight of the sample before and after the immersion, the average was 0.48% by weight. Using three samples of the above chlorhexidine hydrochloride-containing nonwoven fabric, the same test as in Example 1 was performed except that the initial bacterial concentration was 1 × 10 ⁵ cells / ml and the culture time in the vial was 6 hours. No bacteria were detected in the three samples.

On the other hand, when the same test was conducted on three samples of cotton non-woven fabric containing no chlorhexidine hydrochloride, the bacterial concentration was 3.1 × 10 ⁵ cells / ml,
It was 6.3 × 10 ⁵ cells / ml and 5.4 × 10 ⁵ cells / ml.

Example 3 A non-woven cotton fabric (Cott Ace manufactured by Unitika Ltd.) was applied to a polyethylene mesh (Applied Extrusion Technologies, Inc.).
Technologies Inc.)] was heat-fused with a hot press machine (manufactured by Hayashi Kikai Seisakusho) at 200 ° C to obtain 8 cm x 10 cm.
The sample was cut into slices, the dry weight was measured by the method described in Example 1, the sample was immersed in a 500 ppm chlorhexidine hydrochloride aqueous solution, and then dried again to measure the weight. When the content of chlorhexidine hydrochloride per sample was determined from the difference in weight of the sample before and after the immersion, the average was 0.27% by weight.

3 of the above non-woven fabric containing chlorhexidine hydrochloride
Candida albicans (Ca
ndida albicans; ATCC 1002) and the initial bacterial concentration is 5
× 10 ⁴ cells / ml, except for using the culture time in the vial 6 hours, was subjected to the same tests as in Example 1, 3
No fungus was detected in any of the samples. on the other hand,
When the same test was conducted on three pieces of cotton non-woven fabric containing no chlorhexidine hydrochloride, the bacterial concentrations were 8.5 × 10 ⁴ cells / ml and 6.5 × 10 ⁴ cells / ml, respectively.
It was 6.9 × 10 ⁴ cells / ml.

Example 4 Ethylene-vinyl acetate copolymer resin [EVAFLEX manufactured by Mitsui DuPont Polychemical Co., Ltd.] 25
Kg and 375 g of chlorhexidine hydrochloride (manufactured by Maruishi Pharmaceutical Co., Ltd.) were mixed, and 120 with a twin-screw melt-kneading extruder (manufactured by Ikegai Tekko KK).
Kneaded at ℃. The obtained resin composition was extruded at 120 ° C. into a thread shape having a thickness of about 50 μm by an extrusion molding machine (Kasamatsu Kako Laboratories), and then formed into a sheet at 110 ° C. by a hot press machine (Hayashi Kikai Seisakusho). . This sheet was heat-fused to a cotton non-woven fabric (Cott Ace manufactured by Unitika Ltd.) with a hot press machine at 120 ° C. to form a sheet-bonded non-woven fabric, which was cut into 8 cm × 10 cm and dried by the method described in Example 1. After being measured, it was immersed in a 500 ppm chlorhexidine hydrochloride aqueous solution, and then dried again to measure the weight. When the content of chlorhexidine hydrochloride per piece of cotton nonwoven fabric was determined from the difference in weight of the sample before and after the immersion, the average was 0.3.
It was 4% by weight.

Staphylococcus aureus (ATCC 6538P) was cultivated on a glass plate in Brain Heart Infusion Medium 0.3 ml (bacterial concentration 2.4 × 10
⁽³ cells / ml) was placed on the sheet-bonded non-woven fabric, and the liquid was immediately absorbed by the non-woven fabric. The non-woven fabric that has absorbed the bacterial solution is dipped in 5 ml of new Brain Heart Infusion Medium and allowed to stand in an incubator at 37 ° C for 24 hours, then 0.5 ml of the solution is exchanged with Brain Heart Infusion Medium.
Infusion agar medium [Brain Heart Infusion Aga
r, Becton Dickson and Company (Bect
on Dickinson and Company)] at 37 ° C for 2
After culturing for 4 hours, no fungus was detected.

Example 5 Ethylene-vinyl acetate copolymer resin [EVAFLEX manufactured by Mitsui DuPont Polychemical Co., Ltd.] 30
g, polyvinyl alcohol (Poval manufactured by Unitika Chemical Co., Ltd.) 15 g, domiphen bromide (Aldrich Chemical Co.
2 g) was melt-kneaded with a biaxial melt-kneader at 120 ° C., and the obtained resin composition was pressed into a sheet. The obtained sheet was immersed in warm water at 80 ° C. to dissolve and remove the polyvinyl alcohol to obtain a sponge.

The above sponge was cultured in Brain Heart Infusion Medium and immersed in Staphylococcus aureus (ATCC 6538P) bacterial solution adjusted to 5 × 10 ⁵ cells / ml to sufficiently absorb the solution. Then, it was taken out and put into a sterilized vial, and cultured at 37 ° C. for 1 hour. After culturing, 10 ml of physiological saline containing 0.1% Tween 80 was added to the vial and shaken vigorously to wash out the bacterial solution. 0.5 ml of this solution was added to Brain Heart Infusion Agar [Becton Dickinson and C
Ompany)) and cultured at 37 ° C for 24 hours.
No fungus was detected.

[0029]

According to the body fluid absorbent article of the present invention, the exudate or the exudate from the body is absorbed on the surface of the body, and the exudate or the exudate is used as a nutrient for the propagation of microorganisms,
It is possible to prevent the invasion into the body, and even if the surface of the body having a wound is covered for a long period of time, there is no risk of infection.

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Claims (3)

[Claims] 1. A body fluid absorbent article having an absorbent body for absorbing body fluid, wherein the absorbent body contains an antibacterial agent. 2. The body fluid absorbent article according to claim 1, wherein a liquid-permeable sheet is attached to one surface of the absorbent body, and the liquid-permeable sheet contains an antibacterial agent. 3. A liquid-permeable sheet is attached to one surface of an absorber, and a liquid-impermeable sheet is attached to the other surface, and the liquid-permeable sheet and the liquid-impermeable sheet are antibacterial. The body fluid absorbent article according to claim 1, which further comprises an agent.