JPH089530B2 - Toothpaste - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention provides a cloth-like material which is loaded with hydroxyapatite, tricalcium phosphate, quaternary calcium phosphate, or a mixture thereof, and the softness thereof. To facilitate contact with the tooth surface by utilizing the properties of the tooth, and to obtain an effective tooth brushing effect for any person. In addition, by the remineralizing action of hydroxyapatite, tricalcium phosphate, and quaternary calcium phosphate, The present invention relates to a dentifrice which does not require cleaning of the mouth after brushing while protecting and protecting the tooth surface, restoring demineralized wounds.

(Problems to be Solved by Conventional Techniques and Inventions) To prevent caries and alveolar pyorrhea, toothbrushes are generally used in order to remove food residue, dirt, plaque, etc. adhering to teeth and gums and keep teeth clean. Brushing your teeth with
For those who cannot brush their own teeth, another method is to brush their teeth with a toothbrush. However, when someone else brushes their teeth, some infants dislike using a toothbrush, and even when brushing their teeth with a toothbrush, it is difficult to ensure that the tooth surface is completely brushed. As a result, tooth brushing is neglected and tooth decay often occurs. If you use your finger instead of a toothbrush and brush your teeth while directly checking the contact with the tooth surface, you can brush your teeth well and it is easy to evaluate the degree of brushing, so you can brush it to some extent with other people's teeth, but the contact surface between teeth It is difficult to clean fine parts such as with fingers, and it is not preferable to brush teeth with fingers because of custom and hygiene. Therefore, there is a demand for a dentifrice that can efficiently brush the teeth of others. On the other hand, brushing the teeth with hydroxyapatite, tricalcium phosphate and quaternary calcium phosphate cleans the tooth surface, and these substances easily bind to the tooth surface, strengthening the tooth surface, protecting it, and removing the initial symptoms of tooth decay. Repair the ash wound. Further, these substances have strong adsorptive power, are stably adsorbed on various objects, and are used in health foods as calcium enhancers. Therefore, by utilizing these properties of hydroxyapatite, tricalcium phosphate, and quaternary calcium phosphate, the present invention enables efficient and hygienic brushing even for those who cannot brush their teeth. The purpose of the present invention is to provide a dentifrice material that contributes to the prevention and treatment of tooth decay such as strengthening and protecting the tooth surface and repairing ash and ash wounds, and is harmless to the human body so that it is not necessary to wash the mouth after brushing.

(Means for Solving the Problem) The present invention provides a toothpaste that can be brushed around a finger or a cotton swab so that even a person who cannot brush his or her teeth can efficiently brush it. . That is, while cleaning the tooth surface, hydroxyapatite that easily binds to the tooth surface and restores its strengthened protection and demineralized wound,
Utilizing the property that tricalcium phosphate and quaternary calcium phosphate have strong adsorptive power and are easily adsorbed and supported on a material having good wettability such as cotton, nylon and other cloths and non-woven fabrics, and a flexible cloth shape supporting these substances. An object is a toothpaste, which is wound around a finger or a cotton swab to brush the teeth. Since these cloth-like objects have flexibility, they can be inserted even in the minute gaps between teeth, and depending on the method of use, they also have the effect of dental flow, and the substance carried is a calcium reinforcement material. Since it is used as a health food, it is harmless to the human body and it is not necessary to wash the mouth after brushing teeth. Hydroxyapatite, tricalcium phosphate and quaternary calcium phosphate (hereinafter referred to as calcium phosphate materials) used for the production of the dentifrice of the present invention are desired to be as fine particles as possible, and generally 0.
The cloth-like substance which is finely pulverized to have a size of about 02 to 10 μm and which carries a calcium salt is a soft cloth or a non-woven cloth made of cotton, nylon, or other material having an adsorbing power and having good wettability. A cloth-like substance is impregnated with a suspension containing a finely ground product of a calcium phosphate agent or a mixture thereof and dried to obtain a dentifrice. Or, in a soluble calcium salt solution coexisting with a cloth-like object, a phosphate solution is added under the condition of producing each calcium phosphate agent, and the cloth-like object is filtered to obtain a cloth impregnated with each calcium phosphate agent, or The cloth-like object is immersed in an acidic solution of calcium phosphate, and a calcium phosphate agent produced by neutralizing with a calcium salt or the like is carried on the cloth-like object. A cloth is made by using nylon, cotton, and other fibers in which a finely ground calcium phosphate agent is kneaded. The toothpaste can be easily obtained by such as. At this time, it is not necessary to specifically limit the amount of the calcium phosphate agent carried. When the above treatment is carried out using a solution in which glycerin, sorbit and other moisturizers are dissolved, a dentifrice having a good moisturizer is obtained, and the obtained dentifrice is an enzyme that decomposes plaque, such as dextranase. , Mutanase or revanase, etc. are treated with a solution containing the enzyme by a conventional method so that the enzyme is immobilized and stabilized on the dentifrice,
The effect of brushing teeth is further improved. Furthermore, a calcium phosphate agent is added to a solution in which commonly used dentifrice ingredients such as glycerin, sodium lauryl sulfate, butyl paraoxybenzoate, sodium saccharin, and a fragrance are added, and the cloth-like object is passed through the solution to give the same effect as in ordinary toothpaste. You can use it with a feeling of use, and you can get a toothpaste that cleans the mouth and rubs calcium phosphate material on your teeth at the same time.

(Effect) The dentifrice according to the present invention has the same component as that of the tooth, and has hydroxyapatite having a tooth surface protection and demineralization wound repairing action, tricalcium phosphate which changes into hydroxyapatite after binding to the tooth surface, and It is used by supporting calcium tetraphosphate on a soft cloth-like object and winding it around a finger or a cotton swab. Compared with the case of using a toothbrush, not only can the polishing condition be better understood, but the tooth surface is protected and the demineralized wound is restored, so that cleaning of the mouth, strengthening of teeth, and prevention of tooth decay can be achieved at the same time in the following examples of the present invention. Will be specifically described.

Example 1) Add 5% of hydroxyapatite into nylon fiber to make a nylon cloth.

Example 2) A cotton cloth is placed in a 10% solution of hydroxyapatite, impregnated with hydroxyapatite, and then the cotton cloth is taken out and dried.

Example 3) A cotton cloth is placed in a solution of 10% hydroxyapatite and 50% glycerin, the solution is impregnated, and then the cotton cloth is taken out and dried.

Example 4) A cotton cloth is placed in a solution of 20% hydroxyapatite, 20% glycerin, 1.2% sodium lauryl sulphate, 0.01% ethyl paraoxybenzoate, 0.1% saccharin, 1.2% fragrance and after impregnating this solution, Remove the cotton cloth and let it dry.

The same applies to tricalcium phosphate and quaternary calcium phosphate.

Example 5) Using the dentifrice prepared as described above, an experiment for measuring the amount of calcium salt adhered was conducted as follows.

1. Preparation of artificial tooth A hydroxyapatite tablet was prepared by molding a hydroxyapatite sintered body into a disc with a diameter of 1 cm and a thickness of 5 mm. The surface was polished with a No. 600 sandpaper so as to have a uniform surface, and then the powder was carefully removed by brushing while flowing distilled water and used as an artificial tooth.

2. Method This hydroxyapatite tablet was firmly fixed, the dentifrice prepared above was wrapped around a finger, and the tablet was rubbed 2-3 times. The tablet was immediately washed with distilled water to remove the deposit, and hydrochloric acid was added to the solution containing the deposit to dissolve calcium phosphate. Then, distilled water was added to bring the total amount to 100 ml, and the amount of calcium was measured by atomic absorption spectrometry. From these measured values, the amount of each calcium phosphate attached was determined. Also, as a control, wash the tablets not rubbed with toothpaste with distilled water,
The amount of calcium was measured in the same manner.

3. Results Reference Example The following test was conducted to measure the binding force of hydroxyapatite to the tooth surface.

(A) Synthesis of hydroxyapatite and brushite 0.1M CaH ₂ (Ameroham) was added to 100-200 ml of 0.1M NaHPO ₄ solution.
Solution (containing ⁴⁵ CaCl ₂ ) was gradually added dropwise with stirring to synthesize hydroxyapatite by a conventional method. On the other hand, 0.1M ⁴⁵ CaCl ₂ solution was similarly added dropwise to 100-200 ml of 0.1M NaHPO ₄ solution to adjust brushite. The adjusted hydroxyapatite and brushite are each 0.1M Na ₂ HPO ₄
And 0.1 M Na ₂ HPO ₄ solution and resuspended in 0.1 M phosphate buffer of each pH before use.

(B) Preparation of artificial tooth A hydroxyapatite tablet was prepared by shaping hydroxyapatite into a disc having a diameter of 1 cm and a thickness of 3 mm. The surface was polished with a No. 600 sandpaper so as to have a uniform surface, and then the powder was carefully removed by brushing while flowing distilled water, and used as an artificial tooth.

(C) Experimental method 5 blind holes for fixing hydroxyapatite tablets with a diameter of 1 cm and a depth of 2 mm are provided at the bottom of an acrylic tank having a length of 12 cm, a width of 4 cm and a depth of 10 mm, and five hydroxyapatite are provided in the blind holes. The tablet was fixed, 5 ml of a hydroxyapatite or brushite suspension was added, the tablet was dipped, and the upper surface of the tablet was rotationally polished at a rate of once per second through a rubber film. After a certain period of time, the tablet was taken out, washed immediately with a large amount of distilled water added dropwise, 2 ml of PCS cocktail was added, and the radioactivity bound to the tablet was measured with a liquid scintillation counter.

(D) Results Stable p of hydroxyapatite and brushite
H, pH 9.0 and pH 5.0, respectively, shows the specific activity of the used hydroxyapatite 5.4 * 10 ⁵ CPM / mg,
When calculated from 8.9 * 10 ⁵ CPM / mg of brushite, the amount of hydroxyapatite bound to the tablet was 5 μg after 5 minutes, and then gradually increased to 164 μg after 40 minutes. The amount of binding was much higher than that of brushite and was 20 times after 5 minutes and 109 times after 40 minutes.

It should be noted that the same pH during rubbing should be used for pH 5.5, 6.8, 7.4 and
The results obtained under the condition of 8.5 also showed that the binding strength of hydroxyapatite tablets was remarkably large.

These results indicate that hydroxyapatite is selectively bound to the tooth surface.

(Effects of the Invention) Calcium phosphate such as hydroxyapatite, tricalcium phosphate, or quaternary calcium phosphate is a safe substance and may be swallowed. It is also suitable for brushing teeth of animals that do not, and can strengthen the tooth surface, repair demineralized wounds, and prevent tooth decay.

Claims (1)

[Claims] 1. Hydroxyapatite and phosphoric acid obtained by adding a water-soluble phosphate solution to a soluble calcium salt aqueous solution containing glycerin in the presence of a cloth-like object under conditions for producing respective calcium phosphate agents. A cloth-like dentifrice material which does not require cleaning in the mouth and carries tricalcium, tetracalcium phosphate or a mixture thereof.