JPH0873323A - Method for modifying cuticle fiber - Google Patents

Abstract

PURPOSE: To enable the continuons and more effective development of a modifying effect on a cuticle fiber by selectively impregnating a chemical into a target part in the cuticle fiber. CONSTITUTION: A chemical is impregnated into a cuticle fiber by impregnating the chemical at a specific fixing temperature and varying the temperature. The fixing temperatur is defined by the temperature to keep >=25% of the shape by fixing cuticle fiber to a definite shape for 1hr and immersing the fiber in a water/ethanol mixture at -15 deg.C to release the fixation of the fiber, the temperature to keep >=15% and <25% of the shape or the temperature to keep <15% of the shape.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a method for modifying keratinous fibers represented by hair, and more specifically, agents for modifying keratinous fibers, such as dyes, elasticity-imparting agents, softening agents, reducing agents,
The present invention relates to a method of promoting the penetration of an oxidant, an anti-damage agent and the like into the inside of keratinous fibers, and sufficiently exerting the effect of the agent.

[0002]

2. Description of the Related Art Dyes, elasticity-imparting agents, softening agents, reducing agents, oxidizing agents, damage-preventing agents, etc. for the purpose of changing the mechanical properties of keratin fibers typified by hair and changing the color thereof. In order to permeate keratinous fibers of various drugs, for example, the simplest method of diffusing the drug into the fibers while swelling the keratinous fibers with water, warm water, etc., or benzyl alcohol, benzyloxyethanol, etc. In order to accelerate the rate of substance penetration, a method has been adopted in which the substance is permeated with the permeation enhancer.

[0003]

However, in these conventional means, no consideration has been given to which part of the keratinous fibers the applied drug permeates, and to what extent. That is, a technique for more effectively penetrating the drug to a target site without damaging the keratinous fibers, and a technique for allowing the penetrated drug to remain in the keratinous fibers for a long period of time and maintaining the effect are It didn't exist at all.

Therefore, an object of the present invention is to enhance the effect of a drug and to maintain the effect by allowing a necessary amount of the drug to penetrate into a region where the keratin fiber is needed in order to exert a modifying effect on the keratin fiber. To provide a method of expressing the effect.

[0005]

In view of the above situation, the present inventor has conducted various researches on the interrelationship of the substance permeability of keratinous fibers, the permeation site, the chemical change inside keratinous fibers, the deformability of the shape of keratinous fibers, and the like. As a result, the keratinous fibers have drastic changes in the drug permeability and the like at the boundaries of the two types of temperature with the shape deformability as an index, and the two types of temperatures can be controlled. Furthermore, they have found that the permeability of a drug into keratinous fibers can be controlled by utilizing changes in the properties of keratinous fibers due to the two types of temperature changes, and have completed the present invention.

That is, according to the present invention, when keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at -15 ° C to release the fixation, the shape is 25%.
Provided is a method for permeating a drug into the inside of keratinous fibers, which is characterized in that the drug is brought into contact with the keratinous fibers at the fixing temperature maintained as above.

Further, according to the present invention, when the keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at -15 ° C. to release the fixation, the shape is maintained at 25% or more. After bringing the drug into contact with the keratinous fibers at a fixed temperature, lowering the temperature to the fixed temperature at which the shape is maintained at 15% or more and less than 25% or the fixed temperature at which the shape is maintained at less than 15%. It is intended to provide a method for penetrating a drug into the inside of the characteristic keratinous fibers.

Furthermore, according to the present invention, when keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at -15 ° C. to release the fixation, the shape is maintained at 15% or more and less than 25%. A method for permeating a drug into keratinous fibers, which comprises: bringing the drug into contact with the keratinous fibers at the fixed temperature, and then lowering the temperature to the fixed temperature where the shape is maintained at less than 15%. It is provided.

After fixing the keratinous fibers in the present invention in a constant shape for 1 hour and then immersing them in a water / ethanol mixed solvent at -15 ° C to release the fixation, the shape is maintained at 25% or more. Lower limit temperature (hereinafter referred to as "Th") and after fixing the keratinous fiber in a constant shape for 1 hour -1
The shape is maintained at less than 15% when the fixation is released by immersing the mixture in a water / ethanol mixed solvent at 5 ° C. After fixing to a certain shape, water at -15 ° C /
The shape is retained by immersing it in an ethanol mixed solvent to release the fixation (hereinafter referred to as "shape retention rate").
Can be determined by measuring. For example, one hair fiber is wound around a column made of Teflon, for example, a column having a diameter (D ₀ ), and is fixed for 1 hour under a certain constant temperature condition (either in liquid or gas). Then -15 ° C
The curling diameter (D) is measured after immersing in a water / ethanol mixed solution (50%) cooled to 1, removing the fixing material, and leaving it in that state for 24 hours. Shape retention rate is D ₀ / D × 100
Can be measured by From the shape retention rate, it may be determined whether the fixed condition temperature is Th or higher, Tl or higher and lower than Th, or lower than Tl.

First, Th or more, that is, the shape retention rate is 2
At a fixed temperature of 5% or more, the keratinous fibers are extremely easily deformed, but the permeability of the drug into the keratinous fibers is extremely high, and by treating the keratinous fibers with a solution containing various drugs, The drug can easily penetrate inside the keratinous fibers. However, above Th, it is also easy to remove the permeated drug by an operation such as washing.
Above Th, the drug penetrates both macrofibrils in the keratinous fibers and between macrofibrils.

Next, at a fixed temperature of Tl or more and less than Th, that is, a shape retention rate of 15% or more and less than 25%, the deformation of the keratinous fibers is slightly good, and the drug permeability is slightly good, and various If the keratinous fiber is treated with a solution containing the drug, the drug can be permeated into the keratinous fiber. Above Tl and below Th, the drug penetrates only between macrofibrils in keratinous fibers. In addition, if the drug is permeated into the keratinous fibers under the condition of Th or more and then this temperature range is set, the drug is retained only in the macrofibril portion. As described above, when Tl or more and less than Th, it is possible to selectively permeate the drug only between the macrofibrils in the keratinous fibers.

Further, it is less than Tl, that is, the shape retention rate is 1
At a fixed temperature of less than 5%, the keratinous fibers hardly plastically deform and the drug hardly penetrates inside the keratinous fibers. That is, when the keratinous fibers infiltrated with the drug under the condition of Th or more are set to the condition of less than Tl, the drug is retained at both the macrofibril portion and the site between the macrofibrils. When the keratinous fibers in which the drug has penetrated in the range of Tl or more and less than Th are set to less than Tl, the drug is retained only between the macrofibrils.

Th in the present invention is about 70 in pure water.
Although it is at 0 ° C, it can be controlled by addition of a reducing agent (decreased by addition), alcohol (decreased by addition), amine (decreased by addition), etc., and change in pH of the solvent (decreased at pH 8 or lower).

Although Tl is about 0 ° C. in pure water,
It can be controlled by addition of alcohol (increased by addition), formamide (decreased by addition) and the like.

Since Th and Tl can be controlled as described above, it is preferable to control the transition points of these agents when the drug penetrates into the keratinous fibers.

In the present invention, hair is used as the keratinous fiber,
Wool and the like can be mentioned, but hair is particularly preferable.

The agents that can be used in the present invention include:
It is not particularly limited as long as it dissolves in a solvent applicable to keratinous fibers, for example, a syrup imparting agent such as naphthalenesulfonic acid and naphthoic acid; a dye; a softening agent such as glycolic acid and lactic acid; ethyl carbitol, UV shielding Anti-damage agents such as agents; reducing agents, oxidizing agents and the like.

Means for contacting the keratin fibers with the drug include a method of immersing the keratin fibers in a liquid in which the drug is dissolved in a solvent, and a method of applying the liquid to the keratin fibers.

In order to retain the drug at a desired site in the keratinous fiber, for example, after contacting the keratinous fiber with the drug at Th or more, the temperature is lowered to Tl or more and less than Th,
When the keratinous fibers are washed, the drug is retained in the macrofibril part. The same applies to the case where it is selectively held at another site.

[0020]

The present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Example 1 (1) Unchemically treated Japanese hair was wrapped around a Teflon rod having a diameter of 3 mm and immersed in water at various temperatures for 1 hour. After that, the Teflon rod was removed in a water / ethanol mixed solution (50%) at −15 ° C. and left for 24 hours. The curl diameter (D) of the hair was measured to obtain the shape retention rate (3 / D × 100). When the obtained shape retention rate was plotted against the fixed temperature, a sharp bending point (inflection point) appeared at 0 ° C and 70 ° C, and Tl and Th were 0 ° C and 70 ° C, respectively.
It turned out to be.

(2) Solvent fixed for 1 hour from water to 30 mM
When changed to an aqueous solution of sodium sulfite, Tl and T
h was 0 ° C. and 25 ° C., respectively. On the other hand, when the solvent fixed for 1 hour was changed to a 95% propanol solution, Tl and Th were 60 ° C and 70 ° C, respectively. From this fact, it was found that Th and Tl can be controlled independently.

Example 2 Unchemically treated Japanese hair (black) was treated with a water-soluble dye, red 1
When dyeing with No. 06 (1 mM aqueous solution), permeation treatment was performed at the following three different temperatures, and the permeation amount and appearance were visually compared. When permeated at −3 ° C., which is lower than Tl (0 ° C.) in water, the hair was not dyed at all in the permeation time of 24 hours (Sample 1).
When the dye is permeated at 50 ° C, which is less than 2
The dye penetrated to a perceptible extent with a penetration time of 0 minutes (Sample 2). In addition, the dyed hair had a slight red coloration without losing the blackness of the hair. Further, when the hair was dyed for 20 minutes at a temperature higher than Th at 90 ° C., the hair color was deeply dyed, and the hair color was greatly changed from black to reddish black (Sample 3). Therefore, it was found that the permeation of Th or Tl or more promotes the permeation.

Example 3 After the treatment of Example 2, the hairs of Sample 2 and Sample 3 were immersed in warm water at 50 ° C. and washed for 30 minutes. As a result, sample 2
The hair color of the product returned to the original black color and the reddish color disappeared almost completely (Sample 4). When the hair of Sample 3 was washed in the same manner (Sample 5), the degree of dyeing was considerably smaller than that of Sample 3, but the shade remained reddish black.
Colors completely different from those of Samples 2 and 3 were obtained. A dye containing a heavy element observable with a transmission electron microscope was permeated into the hair by the same treatment as the five kinds of samples of Examples 2 and 3, and the cross section of the hair was observed with the transmission electron microscope.
The penetration site of the dye was observed. As a result, sample 1 and sample 4
The presence of the dye in the hair cannot be confirmed in the sample, the sample 2 selectively penetrates between the maloc fibrils, the sample 3 penetrates the entire hair, and the sample 5 selectively selects only the macrofibrils. It was found that the difference in the color of these treated hairs was due to the difference in the permeation site. Therefore, as a result of these, it can be seen that different effects can be obtained by selective drug penetration.

Example 4 Samples 2 and 3 prepared in Example 2 were repeatedly washed with warm water of 40 ° C. for 10 minutes, assuming daily hair washing treatment. As a result, as shown in Table 1, Sample 3 showed almost no change in the amount of staining even after the observation after washing 30 times (corresponding to one month later), but for Sample 2, the amount of staining gradually decreased and after 15 times, It was not possible to determine whether or not it was almost colored. From the above results, it was found that the effect of the permeative substance is continuously maintained for a long period of time by the permeation treatment at Th or more.

[0026]

[Table 1]

Example 5 Hair was wrapped around a Teflon rod having a diameter of 10 mm, immersed in a 20% t-butyl alcohol aqueous solution in that state, and heat-treated at various temperatures for 30 minutes. After that, the hair 2
It was dried in an environment of 5 ° C. and 50% RH for 12 hours, removed from the fixing and the curl diameter was measured, and the quality of the set was judged. T
When the dipping treatment was performed at 0 ° C., which is lower than both the h and Tl temperatures, the hair could not be set at all, but when the dipping treatment was performed at 35 ° C. between the both temperatures, setting was possible. Furthermore, when the immersion treatment was performed at 70 ° C., which is higher than both the Th and Tl temperatures, the set was more effective. Furthermore, assuming daily hair washing treatment, the operation of washing these treated hair with warm water at 40 ° C. for 10 minutes was repeated. As a result, as shown in Table 2, the hair treated at 35 ° C returned to its original shape with one washing, but the hair treated at 70 ° C retained its shape after being washed 30 times with water. The set was made.

[0028]

[Table 2]

Example 6 Glycolic acid, which has the effect of softening the hair, was used in Example 2.
In the same manner as above, it was permeated at three different temperatures and its softening effect was evaluated. When the hair was permeabilized at -3 ° C, which is lower than Tl (0 ° C), the hair could not be softened at all. However, when the hair was permeated at 35 ° C between both Th and Tl temperatures, the softening effect was not achieved. Admitted. In addition, Th (70 ℃),
When treated at 80 ° C, which is higher than both Tl (0 ° C), the softening effect was further improved. Furthermore, assuming daily hair washing treatment, the operation of washing these treated hair with warm water at 40 ° C. for 10 minutes was repeated. As a result, as shown in Table 3,
The elasticity of the hair treated at 35 ° C returned to the original value after washing 5 times, but the hair treated at 80 ° C maintained its softening effect even after 30 times of washing with water, and the hair was permanently softened. Made

[0030]

[Table 3]

[0031]

EFFECTS OF THE INVENTION According to the method of the present invention, a drug can be selectively permeated into a target site in keratinous fibers to more effectively and continuously exhibit their respective modifying effects.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Shinya Ueda Shinya Ueda 1-3 Asahioka, Hanamigawa-ku, Chiba, Chiba 205 Kao Kemigawa Dormitory (72) Inventor Kaoru Tsujii 1-11-23 Yohito, Utsunomiya-shi, Tochigi 405 Naoi Heights 405

Claims (4)

[Claims] 1. At the fixing temperature at which the shape is maintained at 25% or more when the keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at -15 ° C. to release the fixation. A method for permeating a drug into the inside of keratinous fibers, which comprises contacting the drug with the keratinous fibers. 2. The fixing temperature at which the shape is maintained at 25% or more when the keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at −15 ° C. to release the fixation, After contacting a drug with the keratinous fibers, the temperature is lowered to the fixing temperature at which the shape is maintained at 15% or more and less than 25% or the fixing temperature at which the shape is maintained at less than 15%. Method of penetrating the drug into the fiber. 3. The immobilization in which the shape is maintained at 15% or more and less than 25% when the keratinous fibers are fixed in a constant shape for 1 hour and then immersed in a water / ethanol mixed solvent at −15 ° C. to release the fixation. A method for permeating a drug into keratinous fibers, which comprises contacting the drug with the keratinous fibers at a temperature and then lowering the temperature to the fixed temperature at which the shape is maintained at less than 15%. 4. The drug is selected from a dye, a tension imparting agent, a softening agent, a reducing agent, an oxidizing agent, a damage preventing agent, a setting agent and a habit straightening agent (shape controlling agent).
4. The method for permeating a drug into the inside of keratinous fibers according to any one of 3 above.