JPH0853368A - Ointment preparation - Google Patents

Abstract

PURPOSE:To prepare an ointment preparation which contains a vasoconstrictor and an antimicrobial agent, is in a stick form and simply applicable to wound surfaces in an adequate amount without waste, thus is useful in treatment for incised wounds and in sterilization and disinfection of wound surfaces with no sticking to fingers. CONSTITUTION:This preparation comprises (A) a vasoconstrictor such as naphazoline hydrochloride or nitrate, tetrahydrozoline hydrochloride or nitrate, oxymetazoline hydrochloride, tramazoline hydrochloride or the like and (B) an antimicrobial agent of a variety of antibiotics such as penicillins, cephems, carbapenems, monobactams, aminoglycosides, macrolides, tetracyclines, chloramphenicol, peptides or the like and is charged in an extrudable tube as a stick form.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ointment preparation for treating wound surfaces such as cuts.

[0002]

2. Description of the Related Art Ointments for the purpose of hemostasis and sterilization are usually used for small wound surfaces such as cuts when shaving. The ointment is usually filled in a container or a tube, and at the time of use, the ointment in the container is scraped off with a finger, or the ointment filled in the tube is extruded and taken on the finger, and the wound surface Applied to.

However, in order to stop bleeding, it is necessary to apply a thick ointment to the wound surface, and to prevent the ointment from adhering to clothing or the like, further apply a bandage to the wound surface. There is.

If the finger is not washed before applying the ointment, the wound surface may become purulent due to various bacteria such as Staphylococcus adhered to the finger. In such a case, the wound surface may be completely healed. It takes a long time.

Furthermore, since the ointment is taken on the finger in a proper amount,
If the amount taken is too large, it is necessary to spread the excess ointment on the skin surface other than the wound surface, or wipe it off with paper.On the contrary, if the amount taken is too small, contact the wound surface to contaminate it. It is necessary to scrape off the ointment in the container again with the finger. Also, since the ointment is applied with a finger, it is necessary to wash the finger after application, for example, by washing away excess ointment adhered to the finger with water, which is uneconomical and lacks in convenience. It was

[0006]

In view of the above-mentioned circumstances, the present invention can apply an appropriate amount of ointment to the wound surface, so that the ointment can be used without waste and is easy to use. An object is to provide an ointment preparation which is excellent and does not adhere to fingers.

[0007]

The ointment preparation of the present invention is characterized in that it contains a vasoconstrictor, an antibacterial agent, and optionally a disinfectant, and is in the form of a stick.

Particularly preferably, it is characterized by being filled in an extrudable container.

Examples of the vasoconstrictor which can be incorporated in the ointment preparation of the present invention include hydrochloric acid or naphazoline nitrate, hydrochloric acid or tetrahydrozoline nitrate, oxymetazoline hydrochloride, tramazoline hydrochloride and the like.

Examples of antibacterial agents include various penicillin-based, cephem-based, carbapenem-based, monobactam-based, aminoglycoside-based, macrolide-based, tetracycline-based, chloramphenicol-based, and peptide-based antibiotics.

As the penicillin system, benzylpenicillin potassium, benzylpenicillin benzathine, phenoxymethylpenicillin potassium, phenoxymethylpenicillin benzathine, oxacillin, pheneticillin potassium, propicillin potassium, methicillin sodium, cloxacillin sodium, dicloxacillin. Sodium, flucloxacillin sodium, ampicillin, sultamicillin tosylate, bacampicillin hydrochloride, tarampicillin hydrochloride, lenampicillin, hetacillin potassium, cyclacillin, amoxicillin, potassium clavulanate,
Examples include pibumecillinum hydrochloride, aspoxicillin, carbenicillin sodium, calfecillin sodium, calindacillin sodium, sulbenicillin sodium, ticarcillin sodium, piperacillin sodium.

The cephems include cephaloridine, cephalothin sodium, cefazolin sodium, cephapirine sodium, cefradine, ceftezol sodium, cephalexin, cephaloglysin, cefatrizine propylene glycol, cefloxazin, cefachlor, cefadroxil hydrochloride, cefotianum hydrochloride, cefotiam hydrochloride. Hexetil, cefmetazole sodium, cefoxitin sodium, cefuroxime sodium, cefuroxime axetil, cefamandole sodium, cefotetan sodium, cefpyramide sodium, cefminox sodium, cefsulodin sodium, cefotaxime sodium, Cefoperazone sodium, ceftizoxime sodium, cefmenoxime hydrochloride, ceftriaxone sodium , Ceftazidime, cefbuperazone sodium, Joseph Pi Mi tetrazole sodium, cefixime,
Examples include cefteram pivoxil, cefzonam sodium, cefpodoxime proxetil, cefodizime, latamoxef sodium, flomoxef sodium, and the like.

Examples of monobactams include imipenem and cilastatin sodium, and examples of monobactams include aztreonam and carmonam sodium.

The aminoglycoside-based compounds include streptomycin sulfate, kanamycin sulfate, fradiomycin sulfate, amikacin sulfate, gentamicin sulfate, paromomycin sulfate, bekanamycin sulfate, ribostamycin sulfate, dibekacin sulfate, tobramycin, sisomycin, micronomycin sulfate, and sulfate. Astromycin, netilmicin sulfate, isepamicin sulfate, arbekacin sulfate and the like are exemplified.

Examples of the macrolide system include erythromycin, kitasamycin, acetylquitasamycin, oleandomycin phosphate, triacetyloleandomycin, josamycin, acetylspiramycin, midecamycin, midecamycin acetate, rokitamycin and roxithromycin. It

Examples of the tetracycline system include tetracycline hydrochloride, oxytetracycline hydrochloride, tetracycline metaphosphate, demethylchlortetracycline hydrochloride, lolitetracycline, lolitetracycline nitrate, doxycycline hydrochloride, and minocycline hydrochloride.

Examples of the chloramphenicol system include chloramphenicol, chloramphenicol sodium succinate, chloramphenicol palmitate, thianphenicol, and thianphenicol hydrochloride aminoacetate.
Examples of the peptide system include colistin sulfate, colistin sodium methanesulfonate, polymyxin B sulfate, bacitracin, vancomycin hydrochloride and the like.

Other antibiotics include lincomycin hydrochloride, clindamycin, spectinomycin hydrochloride,
Examples include fosfomycin calcium and fosfomycin sodium.

Further, as antibacterial agents, sulfadiazine, sulfisomidine, sulfamethizole, sulfamethoxazole, sulfamonomethoxine, sulfamethopyrazine, sulfadimethoxine, salazosulfapyridine, and other sulfa drugs, nalidixic acid, pyromidic acid. ，
Quinolone-based chemotherapeutic agents such as pipemidic acid, sinoxacin, norfloxacin, enoxacin, ofloxacin, ciprofloxacin hydrochloride, lomefloxacin hydrochloride, tosufloxacin tosylate, and the bactericidal / disinfectant described below can be used.

Further, dibucaine hydrochloride, procaine hydrochloride,
Local anesthetics such as oxybuprocaine hydrochloride, ethyl aminobenzoate, epilocaine hydrochloride, lidocaine hydrochloride, benzalkonium chloride, chlorhexidine gluconate, benzethonium chloride, methylrosaniline chloride, tesitdecitin, cetylpyridinium chloride, chlorhexidine hydrochloride,
Disinfectants such as allantoin, acrinol, resorcin, and sulfur, cortisone acetate, hydrocortisone acetate, corticosteroids such as prednisolone valerate acetate, chlorpheniramine, chlorpheniramine maleate, diphenhydramine, diphenhydramine hydrochloride, and other antihistamines It may be incorporated in the ointment preparation.

As the ointment base, white petrolatum, paraffin, liquid paraffin, lanolin, purified lanolin, adsorption purified lanolin, stearic acid, stearyl alcohol,
Examples include ceresin, ceresin wax, microcrystalline wax, jojoba oil, white beeswax, isopropyl myristate, and the like. Furthermore, if necessary, triethanolamine, gum arabic, tragacanth, gelatin, polysorbate 80 (Tweens), sodium lauryl sulfate, sorbitan monofatty acid ester (Sp
an)), polyoxyl 40 stearate, other surfactants and other emulsifiers, stabilizing / adhesives such as sodium carboxymethyl cellulose, humectants such as propylene glycol and purified water, preservatives such as parabens, benzoic acids and salicylic acids. Agents and the like may be blended.

The ointment preparation of the present invention is formed in a stick form by appropriately combining the above-mentioned ointment base, emulsifier, stabilizing / adhesive, and moisturizing agent according to the physicochemical properties of the above-mentioned active ingredient. It Specifically, one or more ointment bases are heated and melted, the above-mentioned agents are mixed and sufficiently stirred, and then the melted ointment preparation is poured into a mold to be solidified into a stick shape. . The stick-shaped ointment preparation is required to have shape-retaining property, appropriate softness and spreadability, and it is desirable that the sticky ointment has such softness that it does not adversely affect the wound surface, especially when contacting the wound surface.

The ointment preparation of the present invention is preferably filled in an extrudable container. The container is not particularly limited in terms of material, shape, size, etc. as long as it can be filled with the ointment preparation and extruded with the ointment preparation, but it is usually large enough to be carried in a bag. A resin container made of resin is used. For example, in the case of a cylindrical container, the one end of the container in the longitudinal direction is axially pressed with a finger or the like to push out the ointment preparation in the container, and the rotational drive formed on the one end of the container in the longitudinal direction. It is possible to use a device having a mechanism for converting the rotational drive into an axial drive by rotating the rotatable part capable of moving. When preparing an ointment preparation filled in an extrudable container, a molten ointment preparation is usually filled in the container and solidified.

The ointment preparation of the present invention is effective for the treatment of cuts, abrasions, punctures, scratches, shoe abrasions, acne, rash, eczema, ringworm and the like, and sterilization and disinfection of wound surfaces.

[0025]

EXAMPLES In order to explain the present invention in more detail, examples will be given below, but the present invention is not limited thereto.

Example 1 0.1 g of naphazoline hydrochloride and 0.1 gentamicin sulfate
g, dibucaine hydrochloride 0.1 g, benzethonium chloride 0.
1 g, 0.2 g of chlorpheniramine maleate, 50 g of purified water were added and dissolved, and further triethanolamine 5 was added.
g and propylene glycol 2 g are added, and the mixture is sufficiently stirred to obtain a solution A.

On the other hand, white petrolatum 10 g, stearic acid 10 g, paraffin 10 g, stearyl alcohol 8
g and 4.4 g of purified lanolin are heated and melted to obtain a solution B.

Solution A was added to the obtained solution B, and the mixture was heated and sufficiently stirred for homogenization, and then filled in an extrudable stick-shaped container to obtain a stick-shaped ointment preparation. .

Example 2 White petrolatum 10 g, paraffin 25 g, ceresin 10
g, microcrystalline wax 10 g, squalane 15 g, adsorption-purified lanolin 20 g, jojoba oil 7 g, and heated to melt with sufficient stirring. When warm, nafazoline hydrochloride 0.1 g and oxytetracycline hydrochloride 0.
1 g, lidocaine 2 g, allantoin 0.5 g, and diphenhydramine 0.3 g were added and sufficiently stirred for homogenization, and then filled in an extrudable stick-shaped container to obtain a stick-shaped ointment preparation. .

Example 3 Nafazoline nitrate 0.1 g, sulfadiazine 5 g, hydrocortisone acetate 0.5 g, diphenhydramine 1 g
To 30 g of white petrolatum, 30 g of paraffin, 20 g of purified lanolin, and 13.4 g of liquid paraffin are added and heated to melt, and after sufficient stirring, they are filled in an extrudable stick-shaped container to prepare a stick-shaped ointment preparation. Got

Example 4 Chlorhexidine hydrochloride 0.2 g, naphazoline hydrochloride 0.
To 1 g, 0.1 g of dibucaine hydrochloride, and 0.2 g of chlorpheniramine maleate, 42 g of purified water was added and dissolved, 5 g of triethanolamine and 2.9 g of propylene glycol were added, and the mixture was sufficiently stirred to obtain a solution A.

On the other hand, white petrolatum 15 g, stearic acid 10 g, paraffin 10 g, stearyl alcohol 10
g and purified lanolin 4.5 g are heated and melted to obtain a solution B.

Solution A was added to the obtained solution B, and the mixture was heated and sufficiently stirred for homogenization, and then filled in an extrudable stick-shaped container to obtain a stick-shaped ointment preparation. .

Example 5 Benzalkonium chloride 0.1 g, naphazoline hydrochloride 0.1.
To 1 g, dibucaine hydrochloride 0.1 g, and chlorpheniramine maleate 0.2 g, 42 g of purified water was added and dissolved, and further triethanolamine 5 g and propylene glycol 3 were added.
g and sufficiently stirred to obtain a solution A.

On the other hand, white petrolatum 15 g, stearic acid 10 g, paraffin 10 g, stearyl alcohol 10
g and purified lanolin 4.5 g are heated and melted to obtain a solution B.

Solution A was added to the obtained solution B, and the mixture was heated and sufficiently stirred for homogenization, and then filled in an extrudable stick-shaped container to obtain a stick-shaped ointment preparation. .

[0037]

EFFECTS OF THE INVENTION Since the ointment preparation of the present invention contains a vasoconstrictor, it is possible to stop bleeding by applying a very small amount to a small wound surface such as a cut when shaving. As a result, an excess ointment formulation does not adhere to clothing and the like, and it is not necessary to apply a bandage on the wound surface.
In addition, since the ointment preparation contains an antibacterial agent, it is possible to prevent purulence on the wound surface due to various bacteria, and even if the bacteria adhere to the ointment preparation when the ointment preparation is brought into contact with the wound surface, the ointment can be used. It is possible to suppress the growth of various bacteria in the preparation.

Since the ointment preparation has a stick shape, it is possible to directly apply an appropriate amount of the ointment preparation to the wound surface without taking the ointment on the finger like a conventional ointment, so that the ointment preparation is not wasted. Can be used. Since the ointment formulation can be applied without directly touching the wound surface with the finger, it is possible to reduce pain caused by the finger touching the wound surface,
It is possible to prevent suppuration on the wound surface due to various bacteria adhering to the finger.

In particular, in an ointment preparation filled in an extrudable container, a necessary amount of the ointment preparation can be extruded and the protruding portion can be directly applied to the wound surface. After applying the preparation, it is not necessary to wash the fingers with water or the like, and the ointment preparation can be easily administered. Furthermore, it is easy to carry and highly convenient for carrying.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical indication location A61K 31/415 ABT 31/635 31/65 31/71 ADZ (A61K 45/06 31: 415 31: 71) (A61K 45/06 31: 415 31:65) (A61K 45/06 31: 415 31: 635) (A61K 45/06 31: 415 31:14) (A61K 45/06 31: 415 31: 155)

Claims (2)

[Claims] 1. A stick-shaped ointment preparation containing a vasoconstrictor and an antibacterial agent. 2. The ointment preparation according to claim 1, which is filled in an extrudable container.