JPH08295626A - Alkaline analgesic cream for joint - Google Patents

Abstract

PURPOSE: To obtain an alkaline analgesic cream for joint having remarkable effect and free from side effect. CONSTITUTION: A cream base is compounded with indomethacin and >=0.1 pts. of a compound selected from calcium hydroxide, magnesium carbonate, sodium acetate, calcium oxide and sodium carbonate. The agent is remarkably effective for the treatment of the pain of the joint of knee, ankle, elbow, wrist, arm and leg and the amelioration of knee edema and is absolutely free from side effect.

Description

Detailed Description of the Invention

FIELD OF THE INVENTION The present invention relates to an analgesic cream. In particular, in order to enhance the effect of relieving pain in the knees, water on the knees, joints such as ankles, elbows, wrists, limbs, etc., an alkaline analgesic cream containing conventional indomethacin ingredients mixed with calcium, magnesium, sodium, calcium, etc. Is.

[01]

2. Description of the Related Art The conventional analgesics, indomethacin, have a low external analgesic effect and cannot be said to have a sufficient improving effect.
This is because the conventional external preparation for joint is characterized by acidity. In order to show the effect of improving pain relief in joints and the like, the first condition is to make alkaline the main constituent. In addition, the only treatments available at surgical hospitals are preventive treatments such as painkillers injections, draining water from the knees with a syringe, ship agents (acidic), and external creams (acidic). The rate is low, and the treatment methods for knees and ankles, in particular, have remained unrecoverable with current medical practice.

On the other hand, there are actual cases in which the hot spring treatment methods known from old days have recovered various diseases and recovered to rheumatoid arthritis, neuralgia, diabetes, arthralgia, and intractable diseases such as cancer. It is not well known that hot spring treatment has different effects and effects depending on acidity and alkalinity. I have often heard that the hot spring treatment exacerbated the illness, which is due to the difference in efficacy and effect between acidity and alkalinity depending on the illness.
In this way, humoral has the property of greatly changing the recovery of the disease, and acidity and alkalinity are deeply involved in nerves, muscles, cells, etc.,
It is important to properly use acidity and alkalinity depending on the disease. In addition, the hot spring fluid contains sulfur, germanium, potassium, calcium, magnesium, sodium, etc., and these components play important roles in the human body, and are deeply involved in joint cell metabolism, fluid regulation, and normal skeletal muscle activity. Are involved.

DISCLOSURE OF INVENTION Problems to be Solved by the Invention The present invention has been studied to obtain an analgesic cream which requires an analgesic effect without the above-mentioned problems and drawbacks. As a result, indomethacin component contains calcium hydroxide, magnesium carbonate, sodium acetate, It was found that the composition has an extremely excellent analgesic effect by changing the acidic external cream which has conventionally used the indomethacin component into alkalinity by adding calcium oxide, sodium carbonate and the like, and succeeded in the analgesic cream of the present invention.

The joint alkaline analgesic cream of the present invention comprises an ointment base containing 0.5 or more indomethacin components and 0.1 or more potassium, calcium, magnesium, sodium, etc., and a pH of 7.1. The above-mentioned alkaline-based analgesic cream. In addition, when each reagent (calcium hydroxide, magnesium carbonate, sodium acetate, calcium oxide, sodium carbonate) is added alone to the ointment base containing the indomethacin component, and the alkalinity is the main ingredient, the improvement effect is far superior to the conventional indomethacin external cream. However, in the present invention, immediate effect, stable recovery, excellent improvement effect is required, such as calcium hydroxide, magnesium carbonate, sodium carbonate, sodium acetate, calcium oxide and the like reagents, or Japanese Pharmacopoeia compatible products, It is a preferable combination. In addition, depending on the application requiring the effects of the present invention, the dosage form of an external drug such as a water-soluble cream, an oily cream, a poultice, a gel, a film, a tape, a lotion, a jelly, a pasta, and a poultice. Can be

[Action] Joint fluid is caused by local body fluid (acidic and alkaline)
It is because of the imbalance of. It is said that the normal body fluid of pH 7.2 to 7.4 is the body fluid of the human body, but acid easily accumulates in the human body, and 70% of the disease occurs from the acid body fluid. In addition, water that accumulates on the knees and knees and joint pains on the ankles, elbows, and wrists cause acidification of local body fluids, which causes water to accumulate on joint pains and joints. The joint alkaline analgesic cream of the present invention contains potassium, calcium, magnesium, which are required for acidified local affected areas,
The affected area acidified by using alkalinity such as sodium and indomethacin returns to normal body fluid by permeation and absorption of the skin, and the cause of the disease is removed to recover. In addition, each component absorbed by the human body is a major electrolyte in the cell, and is involved in the formation of cell membrane potential, regulation of acid-base balance, maintenance of osmotic pressure, etc. in nerve excitement and intracellular metabolism of each tissue, It plays an important role and maintains the normal activity of skeletal muscle.

The present invention will be described in more detail below with reference to examples of the present invention, but the present invention is not limited thereto. Example 1: Joint Alkaline Analgesic Cream Part 1 Weight Based on 100 g of Total (g) 1 White Vaseline 25.5 2 Stearyl Alcohol 20.0 3 Propylene Glycol 12.3 4 Polyoxyethylene Hydrogenated Castor Oil 60 4.0 5 Monostearin Acid glycerin 1.0 6 Methyl paraoxybenzoate 0.1 7 Propyl paraoxybenzoate 0 18 Purified water 35.3 9 Indomethacin 0.5 10 Calumium hydroxide 0.1 11 Calcium oxide 0.2 12 Magnesium carbonate 0.5 13 Sodium carbonate 0.3 14 Sodium acetate 0.1 Characteristic of ointment base of 1 to 8 of Example 1 It has general characteristics of emulsion base, and in particular, evaporates the water content to cool the skin to prevent inflammation and itch. Provides a stopping effect.
First, add 70 g of cream (Japanese Pharmacopoeia hydrophilic ointment) to a container, add 0.5 g of indomethacin, mix thoroughly using a glass rod, add an appropriate amount of itanol, and mix indomethacin with the cream. Stir evenly while checking each reagent such as potassium, calcium oxide, magnesium carbonate sodium carbonate, sodium acetate etc. as a single product, and when the cream condition becomes soft, add the remaining 30 g of cream base and joint alkaline chain pain cream Got The joint alkaline analgesic cream was applied to 5 males and 15 females having pain in joints such as knees and ankles between the ages of 46 and 86, and the results were examined. The symptoms before application are as follows: The effects of use by symptom are as follows. Knee pain (13 cases in total) Improved 10 out of 13 slightly improved 2 out of 13 unchanged 1 in 13 1 pain in ankle (3 cases in total) 3 out of 3 improved slightly 0 0 out of 3 0 unchanged 0 out of 3 Painful water in my knees (4 cases) Improved 4 out of 4 slightly improved 0 out of 4 0 unchanged 4 out of 0 As described above, as a result of the application of the joint alkaline analgesic cream according to the present invention, the results were observed in many testers.
Next, the following table shows how many times the effect is applied in one day. In addition, the following shows how many days the effects began to appear. Application: 1st to 3rd day 0 person 4th to 6th day 1 person 7 to 14th day 17 person 15th day and later 1 person or more From the above, the joint alkaline analgesic cream of the present invention has an analgesic effect on 95% of testers. Admitted. Further, the appearance of the effect reached 90% within 2 weeks after application. Furthermore, application twice a day was sufficiently effective, and no side effects were observed in any of the cases. Each of the following (1 to 9) compounding creams (A to E) was individually compounded, and pH of 7.1 or more was used as the main component of Example 2 A.
~ E cream. Example 2: Joint alkaline analgesic cream Part 2 Total weight 100 g (g) 1 White petrolatum 25.5 2 Stearyl alcohol 20.0 3 Propylene glycol 12.3 4 Polyoxyethylene hydrogenated castor oil 60 4.3 5 Monostearin Acid glycerin 1.0 6 Methyl paraoxybenzoate 0.1 7 Propyl paraoxybenzoate 0.1 8 Purified water Appropriate amount 9 Indomethacin 0.5 A Potassium hydroxide PH 7.1 or higher cream B Magnesium carbonate PH 7.1 or higher cream C Calcium oxide PH 7.1 or higher cream D Sodium carbonate PH 7.1 or higher cream E Sodium acetate PH 7.1 or higher cream A cream prepared by mixing 1-9 mixed cream with potassium hydroxide, 1-9 mixed cream B with magnesium carbonate Over arm, also C creams containing a combination of calcium oxide, D cream blended with sodium carbonate,
Alkaline-based A to E creams such as E cream containing sodium acetate are used for knees of 50 to 76 years old,
It was applied to 2 males and 8 females who have pains in joints such as ankles, and the A to E creams were used by 2 individuals each, and the results were examined. The symptoms before application are as follows. The effects of using the types are as follows. A cream (2 cases in total) 2 out of 2 improved slightly 0 out of 2 0 unchanged 2 out of 0 B cream (2 cases in total) 1 out of 2 improved 1 out of 2 0 out of 2 unchanged 1 out of 2 C cream (2 cases in total) improved 2 out of 2 slightly improved 0 out of 2 0 unchanged 2 out of 2 D cream (total 2 cases) Improves 1 out of 2 Improves a little 1 out of 2 1 does not change 0 out of 2 E cream (2 cases in total) Improves 2 out of 2 Improves a little 0 out of 2 0 out of 2 In addition, the day that the effect began to appear is as follows. Application: 1st to 3rd day 0 persons 4th to 6th day 0 persons 7 to 14th day 2 persons 20th day 7 persons If so, it was found to have a sufficient analgesic effect. 90 out of 10 testers
The analgesic effect of 10% was shown, and the way of showing the effect reached 90% within 3 weeks after application. No side effects were observed in any of the cases. From the content of the previous example, a folk remedy characterized by acidic indomethacin topical absorption topical drug 50 years old ~
Two 78-year-old men with pain in knee, ankle and other joints
It was applied twice a day to eight women and the treatment results for 20 days were examined. The symptoms before application are as follows. The effects of use by symptom are as follows. Knee pain (all 5 cases) Improved 0 out of 5 slightly improved 1 out of 5 1 unchanged 5 out of 5 Ankle pain (3 cases) Improved 0 out of 3 0 slightly better 0 out of 3 0 unchanged 3 out of 3 water in my knees hurt (all 2 cases) 0 out of 2 improved 0 out of 2 0 out of 2 more than 2 out of 2 As a result, indomethacin topical absorption topical drug, which is characterized by acidity, showed almost no effect on joints such as knees and ankles in many testers, and pH of 7.1 or more on joints such as knees and ankles was alkaline. It was found that the main effect is that the indomethacin analgesic effect is more effective.

As described in detail above, the present invention is mainly effective for arthralgias such as knees and ankles, has no adverse side effects, and has a prompt therapeutic effect.

Claims (3)

[Claims] 1. A cream base containing indomethacin and calcium hydroxide. Magnesium carbonate. Sodium acetate calcium oxide. Alkaline pH 7.1 or higher alkaline sodium pain relief cream. 2. A cream containing an indomethacin component is added with calcium hydroxide. Magnesium carbonate. Sodium acetate. Calcium oxide. Alkaline pH 7.1 or more alkaline alkaline analgesic cream mainly composed of alkaline agents with a pH of 7.1 or higher, containing individual reagents such as sodium carbonate, or more than one item. 3. A joint analgesic cream which is mainly alkaline with a pH of 7.1 or more containing an indomethacin component.