JPH08291036A - New hair-dyeing agent - Google Patents

Abstract

PURPOSE: To obtain a hair-dyeing agent comprising the first agent containing a basic polymer and the second agent containing a hair-dyeing agent combined with an acidic polymer, capable of giving a dyeing effect good in dyeability, capable of remarkably increasing the dyeing degree by the repeated use of the hair-dyeing agent, and not dying skin. CONSTITUTION: This new hair-dyeing agent comprises the first agent and the second agent. The first agent contains a basic polymer in an amount of 0.01-1wt.% and further a buffer solution, an organic solvent, a surfactant, a protein, glycerol, etc. The second agent contains a dyeing agent combined with an acidic polymer such as polyglutamic acid or deoxyribonucleic acid in an amount of 0.01-5wt.%, and further, a buffer solution, a glycerol, etc. On the employment of the hair-dyeing agent in the hair, for example, the first agent is adsorbed on the hair in a weight ratio of 1/1000 to 1/20 based on the weight of the hair directly or after contained in a hair-care product. Subsequently, the second agent is applied to the hair in the same manner as in the first agent. The first and second agents can thus alternately applied to the hair several times to remarkably dye the hair.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel hair dye which is expected to have a hair dyeing effect with good colorability and whose colorability is remarkably increased by repeated use and which is difficult to dye the skin.

[0002]

2. Description of the Related Art It is known that basic substances are easily adsorbed on hair, and various basic peptides are added to treatment agents. However, there is no report that after the basic polymer was adsorbed on the hair, the hair was dyed with a coloring agent to which an acidic polymer was bound. On the other hand, the conventional hair dye tends to be deeply dyed when it is repeatedly used, but since the amount of the dye that permeates the hair is limited, no significant increase in the hair dyeing effect can be obtained no matter how many times it is used. I was not able to admit.

[0003]

SUMMARY OF THE INVENTION Therefore, the object of the present invention is to provide a novel hair dye which can be expected to have a hair dyeing effect with good colorability, and which can be remarkably increased in colorability by repeated use and which is difficult to dye the skin. To provide.

[0004]

That is, the present invention provides a first agent containing a basic polymer such as polylysine and protamine and a second agent containing a colorant to which an acidic polymer such as polyglutamic acid and deoxyribonucleic acid is bound. And a novel hair dye.

The structure of the present invention will be described in detail below.

Examples of the basic polymer used as the first part of the hair dye of the present invention include basic polyamide, basic polyether, basic polyester, and basic polypeptide. Specific examples thereof include polylysine, polyarginine, protamine, histone and the like. Polylysine is recognized as having an antibacterial action and an antidandruff effect, and is preferable for incorporation into hair care products.

Specific examples of polylysine include synthetic products obtained by copolymerizing lysine, and ε-polylysine (molecular weight 2000-4000) obtained by fermentation production.

Protamine is complexed with deoxyribonucleic acid in the sperm nucleus of vertebrates. Molecular weight 2000-1200
It is a basic protein of 0. Specific examples include protamine sulphate obtained from the mature testis of salmonids and other fish (see the 12th Revised Japanese Pharmacopoeia C-2360, Japan Official Book Association, published by Hirokawa Shoten, 1991). .

Examples of the acidic polymer used in the second agent include acidic polyamide, acidic polyether, acidic polyester, acidic polypeptide, polynucleotide and the like. Examples of the acidic polypeptide include polyglutamic acid and polyaspartic acid. Examples of the polynucleotide include deoxyribonucleic acid.

Examples of polyglutamic acid and polyaspartic acid include those obtained by chemical synthesis, and examples of deoxyribonucleic acid include those derived from bacteria and those derived from sperm nuclei of vertebrates.

The second agent is preferably selected from those having a high affinity with the basic polymer used in the first agent. Specifically, when polylysine is used as the first agent, it is desirable to use polyglutamic acid or polyaspartic acid as the second agent. Further, when protamine is used as the first agent, protamine strongly binds to deoxyribonucleic acid. Therefore, by using the second agent as a deoxyribonucleic acid binding colorant, dark hair can be expected.

Examples of the colorant used in the second agent include dyes, pigments, and dyes included in a polymer compound. Examples of the polymer compound include synthetic polymer polymers such as polystyrene and liposomes. To be

The acidic polymer-bonded colorant used in the second part of the hair dye of the present invention is prepared by admixing the acidic polymer with the colorant by stirring and stirring, or by covalently bonding it with various crosslinking agents. Then, it can be prepared by washing and removing excess acidic polymer.

The first agent of the hair dye of the present invention includes water, saline, a general buffer such as sodium carbonate buffer, and ethanol.
In addition to organic solvents such as polyvinyl alcohol, polyoxyethylene sorbitan monolaurate (Tw
It is possible to add a surfactant such as een 20), a protein such as serum albumin, and a base such as glycerin.

Examples of the form of the first agent include hair care products such as treatments, rinses, shampoos, hair creams and hair lotions.

The content of the basic polymer in the first agent is preferably 0.01 to 1% by weight based on the total amount of the first agent.

To the second agent of the hair dye of the present invention, a commonly used base such as glycerin can be added in addition to water and a general buffer solution.

Examples of the form of the second agent include hair care products such as treatments, rinses, shampoos, hair creams and hair lotions.

The content of the acidic polymer-bonded colorant in the second agent of the present invention is preferably 0.01 to 5% by weight based on the total amount of the second agent.

The hair treatment method using the first agent containing a basic polymer is, for example, 1/1000 of the weight of hair.
Examples include a method of directly applying the first agent containing 1 to 20 times the amount of the basic polymer, or a method of using the first agent by including it in a hair care product, whereby it can be easily adsorbed on the hair.
Further, unadsorbed substances can be easily removed by rinsing the hair with an appropriate water-soluble solvent.

The second agent of the hair dye of the present invention may be applied to the hair after the treatment with the first agent. The method is as in the case of the first agent, such that it is directly applied to the hair or a hair care product. Examples thereof include a method of containing and using.

The hair dye of the present invention obtained as described above can be dyed by binding an acidic polymer-bonded colorant to hair to which a basic polymer is adsorbed.
Further, the hair dye of the present invention can be markedly colored by alternately treating the hair with the first agent and the second agent a plurality of times.

[0023]

[Examples] Prior to the examples, the methods of the hair dyeing test and the skin dyeing test used for evaluating the hair dye will be described.

(1) Hair dye test method 0.1% polyoxyethylene sorbitan monolaurate (Tw
The acidic polymer binding colorant (2nd agent) dispersed in physiological phosphate buffer containing een 20) was added to the hair bundle (50mg) treated with the 1st agent containing the basic polymer for 5 minutes and rotated for 5 minutes. Let
It was then washed with water and dried.

(2) Skin dyeing test 0.1% polyoxyethylene sorbitan monolaurate (Tw
een 20) containing acidic polymer-bonded colorant (second agent) (50 μl) dispersed in physiological phosphate buffer containing een 20) and applying the first agent (50 μl) containing basic polymer for 5 minutes. Arm skin (1 cm
All four sides) and left for 5 minutes. It was then washed with water and dried.

After the hair dyeing and skin dyeing operations, the degree of coloration was visually evaluated according to the following criteria. 4 ... It was dyed in a remarkably dark black color. 3 ... It was dyed in a dark black color. 2 ... It was dyed black. 1 ... It was dyed in a light black color. 0 ... It didn't stain at all.

Hereinafter, the present invention will be described in more detail with reference to examples. Example 1 (First agent containing polylysine) 1 mg of ε-polylysine (manufactured by Chisso Corporation) was dissolved in 1 ml of physiological phosphate buffer containing 0.1% polyoxyethylene sorbitan monolaurate (Tween 20) to prepare the first agent. Prepared.

Example 2 (Protamine-containing first agent) 1 mg of protamine (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) was added to 0.1% polyoxyethylene sorbitan monolaurate (Tween 20).
It was dissolved in 1 ml of a physiological phosphate buffer containing the above to prepare a first agent.

Example 3 (Second agent containing polyglutamic acid binding colorant) 20 g of distilled water was added to 1 g of titanium black 10S (manufactured by Mitsubishi Metals Co., Ltd.) and dispersed by ultrasonic waves. To this dispersion was added 15 μl of a zircoaluminate coupling agent having a carboxyl group (Type C, manufactured by Manchem), and the mixture was stirred at room temperature for 2 hours. The dispersion was dried under reduced pressure with an evaporator while heating at 40 ° C, and then dried at 110 ° C for 10 minutes. 10 mg of titanium black treated with a zircoaluminate coupling agent was dispersed in 1 ml of purified water. To this, polyglutamic acid sodium salt (Peptide Institute Co., Ltd.) 1
What dissolved mg in physiological phosphate buffer 1 ml was added, and it stirred at 4 degreeC all day and night. Unreacted polyglutamic acid was removed by centrifugation and dispersed in physiological phosphate buffer. Centrifuge again, redisperse in physiological phosphate buffer, leave at room temperature for 1 hour, and then use 0.1% polyoxyethylene sorbitan monolaurate (Tween 20).
A polyglutamic acid-bonded pigment (second agent) was obtained by dispersing in a physiological phosphate buffer containing The pigment concentration of this second agent is 0.1
% By weight.

Example 4 (Second agent containing deoxyribonucleic acid binding colorant) 10 mg of titanium black treated with the zircoaluminate coupling agent obtained in the same manner as in Example 3 was dispersed in 1 ml of purified water, and deoxyribonucleic acid was added thereto. A solution prepared by dissolving 1 mg of sodium salt (manufactured by Yukifines Co., Ltd.) in 1 ml of physiological phosphate buffer was added, and the mixture was stirred at 4 ° C. overnight. Unreacted deoxyribonucleic acid was removed by centrifugation and dispersed in physiological phosphate buffer.
Centrifuge again, redisperse in physiological phosphate buffer, leave at room temperature for 1 hour, then disperse in physiological phosphate buffer containing 0.1% polyoxyethylene sorbitan monolaurate (Tween 20) and deoxyribonucleic acid binding pigment. (Second agent) was obtained. This second
The pigment concentration of the agent was 0.1% by weight.

Test Example 1 (human hair and skin treated with the first agent obtained in Examples 1 and 2 using the second agent obtained in Examples 3 and 4) A polylysine-containing first agent obtained from the bundle in Example 1;
The polyglutamic acid-bonded pigment (second agent) obtained in Example 3 on the hair and skin treated with the protamine-containing first agent obtained in Example 2 and the additive-free first agent of Comparative Example 1 and Example 4
Table 1 shows the results obtained by the hair dyeing test and the skin dyeing test using the deoxyribonucleic acid-bonded pigment (second agent) obtained in.

[0032]

[Table 1]

Human hair treated with the basic polymer-containing first agent of Examples 1 and 2 was treated in Examples 3 and 4 respectively.
It was colored with the acidic polymer-bonded pigment prepared in. Further, hair was markedly dyed by repeating the treatment of the first agent and the second agent. Moreover, in any case, the skin was less likely to be colored than the hair.

[0034]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, it is possible to provide a novel hair dye which can be expected to have a hair dyeing effect with good colorability and whose remarkably increased coloring degree by repeated use, and which hardly causes skin dyeing.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Umeji Murakami 5-3 28, Kotobuki-cho, Odawara-shi, Kanagawa Kanebo Co., Ltd.

Claims (4)

[Claims] 1. A novel hair dye, which comprises a first agent containing a basic polymer and a second agent containing an acidic polymer-bonding colorant. 2. The basic polymer is a basic polyamide, a basic polyether, a basic polyester or a basic polypeptide, and the acidic polymer is an acidic polyamide, an acidic polyether, an acidic polyester, an acidic polypeptide or a polynucleotide. The novel hair dye according to claim 1. 3. The novel hair dye according to claim 1, wherein the basic polymer is polylysine and the acidic polymer is polyglutamic acid. 4. The novel hair dye according to claim 1, wherein the basic polymer is protamine and the acidic polymer is deoxyribonucleic acid.