JPH08283137A - Skin lightening cosmetic - Google Patents

Abstract

PURPOSE: To obtain a skin lightening cosmetic containing a gallic acid ester as an active ingredient, excellent in suppressing effect on wrinkles and on the formation of a pigmentation caused by the irradiation of ultraviolet rays and useful for preventing the pigmentation. CONSTITUTION: This skin lightening cosmetic contains a gallic acid ester expressed by the formula (R is a 1-2C or a 10-20C alkyl or alkenyl which may be substituted with a hydroxyl group) as an active ingredient, and is blended in a cosmetic by 0.0001-20wt.%, preferably by 0.01-5wt.%. It is possible to aim at the improvement of suppressing effect on the formation of wrinkles and spots by adding an antiinflammatory agent, etc., such as allantoin, glycyrrhetinic acid, etc. Furthermore, by blending commonly used cosmetic components suitably, the cosmetics such as O/W type and W/O type emulsified cosmetics, a cream, a milky lotion, a pack, a detergent, a foundation, etc., are prepared.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition having an excellent action of suppressing and improving pigmentation of skin.

[0002]

2. Description of the Related Art In recent years,
Maintaining healthy and beautiful skin has become a serious concern for people of all ages. However, the skin is subtly affected by temperature, humidity, ultraviolet rays, aging, illness, stress, eating habits, etc. Therefore, various troubles such as deterioration of various functions of the skin and aging of the skin occur.

[0003] Stain, freckles and pigmentation on the skin after sunburn are caused by an increase in melanin pigment synthesized in the epidermis by melanocytes, and the pathogenic mechanism thereof is ultraviolet rays, female hormones and inheritance. Although it has been pointed out that the social factors are involved, it has not been fully clarified yet. Therefore, drugs for the purpose of suppressing the production of melanin or reducing existing melanin have been studied as whitening agents, and arbutin, kojic acid, vitamin C, licorice extract (JP-A-63-23809,
Japanese Unexamined Patent Publication No. 1-149706), and parentheses (Japanese Unexamined Patent Publication No. Sho 6-6)
4-16709), hydroxystilbene (JP-A-64-38009), 3-hydroxychromone (JP-A-55-111410, JP-A-55-1439).
08), isoflavones (JP-A-58-22500).
No. 4) is proposed. However, under the present circumstances, there are almost no substances that have excellent blending properties in actual cosmetics and have a high pigmentation-inhibiting effect, and conventional whitening agents are not sufficiently effective.

Therefore, an object of the present invention is to provide a whitening cosmetic composition which is effective in preventing and improving pigmentation on the skin.

[0005]

Under such circumstances, the present inventor has conducted diligent studies, and as a result, found that gallic acid ester has an excellent pigmentation-inhibiting action, and completed the present invention. .

That is, the present invention provides the following general formula (1):

[0007]

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A gallic acid ester represented by the formula [wherein R represents a linear or branched alkyl or alkenyl group having 1, 2 or 10 to 20 carbon atoms which may be substituted by a hydroxy group] The present invention provides a whitening cosmetic composition containing an active ingredient.

In the gallic acid ester represented by the general formula (1), R represents a linear or branched alkyl group or alkenyl group having 1, 2 or 10 to 20 carbon atoms which may be substituted with a hydroxy group. The carbon number is 1, 2, 10
-15 are preferable. Specific examples of R include methyl group, ethyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadecyl group,
Isohexyl group, 2-ethylhexyl group, propenyl group, butenyl group, pentenyl group, oleyl group, linoleinyl group, 3,5,5-trimethylhexyl group, 3,7-
Dimethyloctyl group, 3,7,11-trimethyldodecyl group, 3-methyl-2-butenyl group, 3,7-dimethyl-2,6-octadienyl group, cyclohexylmethyl group, cyclohexylethyl group, 2-hydroxypropyl group, Examples thereof include 8-hydroxyoctyl group, 10-hydroxydecyl group, 11-hydroxyundecyl group, 12-hydroxydecyl group, and 12-hydroxyoctadecyl group. In the present invention, the linear alkyl group is preferable among them. That is, as the gallate ester, methyl gallate, ethyl gallate, decyl gallate, undecyl gallate, tridecyl gallate and the like are preferable.

The amount of gallic acid ester of the formula (1) is not particularly limited, but it is 0.0001 to 20% by weight in the whitening cosmetic composition of the present invention from the viewpoint of color and the like at the time of compounding. Is preferable, and it is particularly preferable to set it to 0.01 to 5% by weight.

The whitening cosmetic composition of the present invention contains, in addition to the above essential components,
By adding known anti-inflammatory agents such as allantoin and glycyrrhizic acid, the effect of suppressing the formation of wrinkles and spots can be improved. In addition, oils commonly used as cosmetic ingredients, moisturizers such as hyaluronic acid and ceramide, ultraviolet absorbers, alcohols, chelating agents, pH
A regulator, an antiseptic, a thickener, a pigment, a fragrance and the like can be combined in any combination.

The whitening cosmetic of the present invention is not limited to general whitening cosmetics, but includes quasi drugs, medicated cosmetics and the like. The whitening cosmetic composition of the present invention can be used in various forms and applications, for example, oil / water type, water / oil type emulsified cosmetics, creams, lotions, lotions, oily cosmetics, packs, foundations and the like. .

[0013]

The whitening cosmetic composition of the present invention is excellent in the effect of suppressing the formation of wrinkles and pigmentation caused by the irradiation of ultraviolet rays, and is therefore useful as a cosmetic composition for preventing pigmentation.

[0014]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

Test Example 1 UV-on the back of a brown guinea pig
Effect of B on pigmentation: After brown hair of a guinea pig was shaved carefully with a hair clipper and a shaver, 1.
It was divided into eight 5 cm squares. Evaluation sample (2%
An ethanol solution (20 μl) was applied, and after 2 hours, the applied sample was wiped with ethanol and irradiated with ultraviolet rays in the UV-B region at twice the minimum erythema dose (MED). After UV irradiation, the evaluation sample was applied again. The above operation was repeated for 3 days. After that, samples (2% ethanol solution, 10
μl) was applied continuously for 1 week, and after 2 weeks, the amount of pigmentation was examined. As a control, a sample coated with only ethanol was tested in the same manner as the sample.

A color difference meter (CMS-12, manufactured by Murakami Color Co., Ltd.) was used for evaluation.
00) was used for measurement, and L was calculated from the obtained Munsell value.
^{* The} value was calculated, ΔL ^* was calculated according to the following formula, and the degree of pigmentation was compared. The larger the value of −ΔL ^*, the stronger the degree of pigmentation. The results are shown in Table 1.

[0017]

[Formula 1] ΔL ^* = (L ^* value 2 weeks after UV-B irradiation) −
(L ^* value before UV-B irradiation)

[0018]

[Table 1]

From Table 1, it can be seen that gallic acid ester has an excellent pigmentation suppressing effect.

The cosmetics shown in Examples 1 to 3 were prepared by a conventional method.

Example 1 Cream:

Table 2 (Components) (wt%) Ethyl gallate 0.2 Cholesterol 0.5 Cholesterol isostearate 1 Polyether-modified silicone 1.5 Cyclic silicone 20 Methylphenylpolysiloxane 2 Methylpolysiloxane 2 Magnesium sulfate 0.5 55% Ethanol 5 Carboxymethyl chitin 0.5 Ceramide 1 Perfume, pigment Micro purified water Residual amount meter 100.0

Example 2 Skin lotion:

[Table 3] (Components) (wt%) Ethyl gallate 2 Glycerin monostearate 1 Ethanol 15 Propylene glycol 4 Isopropyl palmitate 3 Lanolin 1 Ceramide 0.5 Methyl paraoxybenzoate 0.1 Vitamin C 0.5 Perfume, pigment Micro Purified Water Fuel Gauge 100.0

Example 3 Packing agent:

[Table 4] (Components) (% by weight) Ethyl gallate 3 Polyvinyl alcohol 20 Glycerin 5 Ethanol 16 Perfume, pigment Micro purified water Residual amount meter 100

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yoshinori Nishizawa 1-17-10 Kiyoharadai, Utsunomiya City, Tochigi Prefecture

Claims (1)

[Claims] 1. The following general formula (1): [Wherein R represents a linear or branched alkyl group or alkenyl group having 1, 2 or 10 to 20 carbon atoms which may be substituted by a hydroxy group] as a gallic acid ester Whitening cosmetics contained.