JPH08266618A - Indwelling catheter - Google Patents

Abstract

PURPOSE: To follow a movement of the body, and ideally prevent an intrusion of bacteria or the like into the body by covering the outer periphery of a conduit to form a gate to a living body with a member made of a tissue adhesive material having an early tissue adhesive property and follow-up performance by which tissue bonding does not separate by a movement of a living body. CONSTITUTION: An intra-aperitoneal indwelling catheter 1 is composed of a catheter main body 10 composed of a indwelling part 2, an extending part 4 being the base end side to be extended outside of the abdominal cavity and a subcutaneous tunnel part 3 between both. A lumen is arranged in the shaft direction of the catheter main body 10, and a dializing fluid passage is formed. A cuff member 5 whose outside surface is composed of a tissue adhesive material is arranged so as to cover a part of the outer periphery of the subcutaneous tunnel part 3. The cuff member 5 is arranged at least on the extending part 4 side. This cuff member 5 is formed of a tissue adhesive material having an early tissue adhesive property and follow-up performance by which tissue bonding does not separate by a movement of a living body. A first cuff 6 is arranged in the indwelling part 2 of the subcutaneous tunnel part 3, and a second cuff 7 is arranged near the apex of a loop.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an indwelling catheter such as an intraperitoneal indwelling catheter and a shunt for hemodialysis.
More specifically, a conduit for connecting the outside and the inside of the body through the skin, and an early contact with the living body arranged on the outer periphery of the conduit to preferably prevent the invasion of bacteria from the outside, and the movement of the living body. The present invention relates to an indwelling catheter having excellent biocompatibility, which is provided with a member capable of following the above.

[0002]

2. Description of the Related Art Indwelling catheters that connect the inside and outside of the body via the skin are used for peritoneal dialysis, hemodialysis and the like, and various devices have been devised.

Conventionally, such an indwelling catheter, as disclosed in Japanese Unexamined Patent Publication No. 63-46171, has a biocompatible material such as ceramic for the percutaneous portion in order to prevent invasion of bacteria and the like from the outside of the body. By arranging a member made of a highly flexible material, the adhesion with living tissue is improved. However, ceramics have high biocompatibility,
Because it is rigid, it cannot follow the flexible movements of the body,
There is a problem that the bond with the tissue is easily peeled off due to the movement of the body.

Particularly, in the case of a peritoneal dialysis catheter, the percutaneous portion of the catheter is not in the vertical direction (longitudinal direction of the catheter) due to the movement of the body during the liquid exchange operation 3 to 4 times a day and the operation of the catheter. Is often stressed. Since the hard ceramic member cannot follow this movement and has a problem of being separated from the tissue, the above-mentioned technique has not been widely used. Therefore, at present, the percutaneous portion of the indwelling catheter remains the body of the connecting tube made of silicone rubber, metal, or the like, and it has no bondability to the tissue, and the invasion of bacteria is a problem.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problems of the prior art by providing a member made of a tissue adhesive material having flexibility and early tissue adhesiveness in the body. By arranging it in the percutaneous part of the conduit that connects the outside of the body and the outside of the body, even if the body or the catheter moves, it can follow the flexible movement of the body without breaking the bond with the tissue and enter the body such as bacteria It is an object of the present invention to provide an indwelling catheter capable of suitably preventing the invasion of the blood.

[0006]

In order to achieve the above object, the present invention provides an early tissue adhesive, which is arranged so as to cover a conduit forming an entrance / exit to a living body and at least a part of the circumference of the conduit. And a member made of a tissue adhesive material having followability in which the bond of the tissue is not separated by the movement of the living body.

The tissue-adhesive material is preferably cellulose or a cellulose derivative, and further, heparin or a cell-adhesive protein is preferably adhered to the cellulose or cellulose derivative, or
It is preferably alkali-activated, the cellulose derivative preferably has an electric charge, the tissue-adhesive material is preferably heparin or a cell-adhesive protein, and a member made of the tissue-adhesive material. Are preferably selected from non-woven fabrics, films and porous bodies, or the member is preferably formed by coating the conduit with a tissue adhesive material.

The indwelling catheter of the present invention will be described in detail below. FIG. 1 is an overall side view of an intraperitoneal indwelling catheter that is an embodiment of the indwelling catheter of the present invention.
2 is a cross-sectional view taken along the line AA in FIG.

The intraperitoneal indwelling catheter 1 of the present invention is used in the peritoneal dialysis method when performing a procedure of injecting dialysate into the abdominal cavity and discharging the dialysate drainage to the outside of the abdominal cavity after a certain period of time. It is used as an exchange channel for dialysate.
That is, the tip of the indwelling catheter 1 (see FIG.
The indwelling part 2 side of the catheter is inserted into the abdominal wall of the patient by penetrating the abdominal wall, and the distal end portion of the indwelling catheter 1 is indwelled in the abdominal cavity, and the proximal end part of the indwelling catheter 1 (see FIG.
The patient has a daily life while maintaining the state in which the extension portion 4 side of the) is extended to the outside of the abdominal wall, and the dialysate is exchanged through the intraperitoneal indwelling catheter 1 at regular intervals.

This intra-abdominal indwelling catheter 1 includes an indwelling part 2 which is inserted and left in the abdominal cavity, an extending part 4 which is a proximal end side extending out of the abdominal wall, and an indwelling part 2 and an extending part 4. It has a catheter body 10 consisting of a subcutaneous tunnel portion 3 between and a lumen 11 which is a dialysate passage formed by penetrating the catheter body 10 in the axial direction. A cuff member 5 made of a tissue adhesive material is provided on the outer surface of the cuff member 5 so as to cover it. Further, the cuff member 5 is provided at least on the extension 4 side of the subcutaneous tunnel portion 3. The subcutaneous tunnel portion 3 is the lumen 1 of the catheter body 10.
1 creates a subcutaneous tunnel between the abdominal cavity and the outside of the abdominal wall.

At the tip of the indwelling section 2, the catheter body 10
The opening 21 of the inner cavity 11 is formed in the axial direction of the inward direction, and the groove 23 along the axial direction is formed on the outer surface of the indwelling part 2.
And a side hole 22 formed at the bottom of the groove 23. As shown in FIG. 2, four side holes 22 are provided at equal intervals in the circumferential direction in the cross-sectional view, and are arranged at equal intervals on a straight line parallel to the axis of the catheter body 10. . The dialysate is exchanged through the opening 21 and the side holes 22.

Further, by forming the groove 23, the space between the groove 23 and the groove 23 becomes thick and the convex portion 9 is formed. Since the plurality of protrusions 9 formed in this way have a large area of contact with the inner wall of the abdominal cavity, the pressure applied when contacting the inner wall of the abdominal cavity is dispersed, and the influence on the body is small. Further, the tip 92 of the convex portion 9 projects from the tip of the indwelling portion 2,
The tip 92 is formed in an arc shape, and has a shape that does not damage the inner wall of the abdominal cavity or the Douglas stalk. The provision of the tip 92 ensures that the opening 21 of the inner cavity 11 is not blocked when the indwelling portion 2 comes into contact with the Douglas stalk located at the lowest position in the abdominal cavity.

As a method of forming such a thick and wide convex portion 9, for example, a method of forming a thick tube body by extrusion molding and then cutting the outer surface to form the groove 23. Alternatively, there is a method of using a die for forming the convex portion 9 at the time of extrusion molding. In the case of forming the convex portion 9 by a method of using a die for forming the convex portion 9 during extrusion molding, after molding the tube in which the convex portion 9 is formed over the entire length, the convex portion 9 is formed by a predetermined length. There is a method of burying the groove 23 formed by forming the above or scraping off the convex portion 9 by a predetermined length. In addition, the projection 9
Even in the case of forming the above, the strength can be improved by providing the connecting portion 91 formed by filling the groove 23 at a predetermined interval and connecting the adjacent convex portions 9.

On the other hand, a connector (not shown) or the like is provided at the base end of the extending portion 4, and a dialysate bag, a drainage bag or the like is connected by a tube via this connector or the like. A peritoneal dialysis system or the like is connected.

The subcutaneous tunnel portion 3 is curved and formed in a loop shape, and has a U shape (swan neck shape). Then, a first cuff 6 is fixed to the indwelling portion 2 side of the subcutaneous tunnel portion 3, and a second cuff 7 is fixed to the vicinity of the loop apex with a silicone adhesive or the like. In addition, a cuff member 5 made of a tissue adhesive material is provided on the extension 4 side of the subcutaneous tunnel portion 3 so as to be movable along the outer surface of the catheter body.

The catheter body 10 thus constructed
Is, for example, silicone rubber, thermoplastic fluororesin, fluororubber, polytetrafluoroethylene (PTFE),
It is formed of polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate (PET), polystyrene, polyurethane, or the like, and particularly preferably formed of a thermoplastic material. Among them, silicone rubber is particularly preferable from the viewpoint of excellent biocompatibility, and it is preferable to use thermoplastic fluororesin from the viewpoint of processability. Further, in order to improve biocompatibility, for example, polyurethane elastomer, polyamide elastomer, non-plasticized vinyl chloride resin,
Silicone rubber or the like may be attached to the surface.

The catheter body 10 may have the indwelling portion 2 (or the tip of the indwelling portion 2) formed independently and may be connected to the subcutaneous tunnel portion 3 and the extension portion 4. The indwelling portion 2, the subcutaneous tunnel portion 3 And the extension part 4 are integrated into the catheter body 1
It may be formed as 0.

The first cuff 6 and the second cuff 7 are PET non-woven fabrics or the like formed in a tubular shape. By fixing the cuffs 6 and 7 to the living tissue by suture fixing, fibroblast, which is the living tissue. Cells proliferate in the cuffs 6 and 7 and the catheter body 10 is left in place.

The cuff member 5 is made of a tissue adhesive material having an early tissue adhesive property and a followability that does not cause separation of the tissue bond due to the movement of the living body. Therefore, the fibroblasts enter the cuff member 5 and are concentrated around the catheter body 10 to cause granulation, so that the catheter body 10 is fixed. Further, since the cuff member 5 is arranged on the side of the extending portion 4 and is therefore located under the dermis, the down-close of a proper depth is maintained and the down-close is prevented from becoming deep.

As the tissue adhesive material forming the cuff member 5, cellulose and cellulose derivatives such as cellulose acetate, carboxymethyl cellulose, cellulose-N, N-diethylaminoethyl ether (DEAE cellulose) are preferably used.

When cellulose or a cellulose derivative is used as the tissue adhesive material, heparin or a cell adhesive protein or the like is attached to the surface, alkali activation is performed, or a charged cellulose derivative is used. It is preferable to use. In addition, as the cell adhesive protein, the following substances can be used. With such a configuration, preferable results are obtained in terms of early granulation, promotion of cell induction, biocompatibility, improvement of adhesive strength, and the like.

There is no limitation on the method of attaching heparin or cell-adhesive protein to the cellulose or cellulose derivative and activating the alkali, and various known methods may be used. For example, the adhesion of heparin to cellulose is performed by adding 0.5 wt% Na at 25 ° C to a cellulose nonwoven fabric or the like.
Immerse in an aqueous OH solution for about 30 minutes, and then add a heparin solution (188 IU / mg heparin sodium 0.
2 g of distilled water 10 mL and tetrahydrofuran 90 mL
It can be carried out by immersing it in a solution) which has been dissolved for about 6 hours, and then thoroughly washing with water and drying. The adhesion of pronectin (cell adhesive protein) to cellulose can be carried out by immersing the cellulose nonwoven fabric or the like in 1.0 mg / mL of pronectin / PBS (phosphate buffer solution) and then drying. Further, the adhesion of collagen (cell-adhesive protein) to cellulose can be carried out by immersing a cellulose nonwoven fabric or the like in a collagen solution to form a collagen sponge layer as an outer layer.
At this time, in order to fill the inner space of the non-woven fabric with collagen, the non-woven fabric may be depressurized in a state of being immersed in the collagen solution, the collagen solution is poured into a syringe or the like, and the needle is pierced into the inner space. It may be filled with collagen.

The alkali activation of cellulose can be carried out by immersing the cellulose non-woven fabric or the like in a 10 wt% NaOH aqueous solution at 60 ° C., dry-distilling for about 5 hours, and then thoroughly washing with water and drying.

When the cuff member 5 is made of cellulose or a cellulose derivative, a nonwoven fabric, a film, a porous body or the like made of these materials is formed, and this is formed into a tube to form the cuff member 5, and the catheter body 10 is used. Should be loosely inserted. The method for forming the nonwoven fabric, the film, the porous body, etc. may be a known method, or various commercially available products may be used. For loose insertion of the cuff member 5, for example, the catheter body 10 is expanded to reduce the outer diameter, and in this state, the cuff member 5 is inserted.
It may be loosely inserted and installed at a predetermined position. By mounting in this manner, there is no risk of the cuff member 5 falling off the catheter body 10. In addition, the above-mentioned adhesion of heparin or the like and alkali activation may be performed after the cuff member 5 is made of a cellulose nonwoven fabric or a porous body, or the cuff member 5 may be attached after the heparin or the like is adhered to the cellulose nonwoven fabric or the like. You may produce.

As the tissue adhesive material, heparin or cell adhesive protein can be preferably used. When using these, the cuff member 5 may be formed by directly coating them on the catheter body 10. As a cell adhesive protein, an extracellular matrix such as collagen or gelatin (extra celler m
atrix), pronectin, fibronectin, fibrin, buibritogen, laminin, von Willebrand factor, invasin, thromboplastin and the like.

The method for coating the catheter body 10 with these is not particularly limited, and any known method depending on the forming material of the catheter body 10 can be used. Specifically, methods such as anchoring and chemical bonding are exemplified.

At least the indwelling portion 2 of the catheter body 10
It is preferable that the marker 12 made of a radiopaque material is embedded or attached to the inner and outer surfaces. This allows the position of the catheter body 10 to be confirmed under fluoroscopy during catheter implantation. The shape of the marker 12 may be linear as shown in the drawing, extending from the indwelling portion 2 to the subcutaneous tunnel portion 3, or may be provided over the entire length of the catheter body 10. Furthermore, it may be provided so as to be scattered at a predetermined position from the indwelling section 2 to the subcutaneous tunnel section 3. Examples of the X-ray opaque material forming the marker 12 include tungsten, barium sulfate,
Examples thereof include gold, platinum, alloys thereof, and the like.

By providing a plurality of fins in the lumen 11 of the catheter body 10 at least from the indwelling portion 2 to the subcutaneous tunnel portion 3, a catheter is transplanted or a dialysate is exchanged in the abdominal cavity or abdominal wall. Occasionally, it is possible to prevent the lumen 11 from being crushed and blocked in the abdominal wall or abdominal cavity.

Here, the total length of the catheter body 10 varies depending on the case, but is about 250 to 600 mm, preferably about 300 to 550 mm, more preferably 350 to 50 mm.
It is about 0 mm, of which the indwelling part 2 is 150 to 200
mm, and the subcutaneous tunnel portion 3 is 100 to 150 mm
The extent of the extension 4 is preferably about 100 to 150 mm. Furthermore, the convex portion 9 forming portion of the indwelling portion 2 is
It is about 110 to 60 mm, and the first and second cuffs 6,
7 is preferably about 5.0 to 15 mm. Further, the protruding length of the tip 92 of the convex portion is about 1.0 to 20 mm,
It is preferably about 2.0 to 10 mm. The position of the second cuff 7 is near the loop apex of the subcutaneous tunnel portion 3 curved in a loop shape in order to fix the catheter body 10 to the abdominal wall with the dialysate injection / exhaust port of the catheter 1 facing downward. Preferably.

Cuff member 5 located in the subcutaneous tunnel section 3
Is about 3.0 to 50 mm, preferably about 5.0 to 50 mm. If the total length of the cuff member 5 is less than 3.0 mm, it is difficult to densely collect the living tissue around the catheter body 10, and it is difficult to appropriately maintain the downgrowth.
If the total length is 50 mm or more, it is necessary to change the position of the second cuff 7. Further, the cuff member 5 may have any position up to the position of the second cuff 7 on the proximal side as long as the distal side is located near the percutaneous portion of the catheter 1, and the total length is 3.0 to 3.0. Plural pieces having a size of about 25 mm may be arranged adjacently or at intervals. The thickness of the cuff member 5 is 1.0
It is about 4.0 mm, preferably about 1.5 to 2.5 mm. When the wall thickness is less than 1.0 mm, it is difficult to densely collect living tissues around the catheter body, and it is difficult to appropriately maintain downgrowth. The damage to the abdominal wall during transplantation is great, and it may take a long time to form downgrowth.

The inner diameter of the catheter body 10 is
The thickness of the catheter body 10 is about 1.0 to 3.5 mm, preferably about 2.0 to 3.0 mm, and only the indwelling portion 2 or only the protruding portion 9 forming portion of the indwelling portion 2 is formed thick. The thickness may be the same over the entire length, but specifically, it is about 1.0 to 3.0 mm, preferably about 2.0 to 2.5 mm in the thick portion. The height of the convex portion 9 (depth of the groove 23) formed in the indwelling portion 2 is 0.5 to
It is about 1.5 mm, preferably about 1.0 to 1.3 mm.

The number of the convex portions 9 or the grooves 23 is not limited to four and may be one to three or five or more, and is determined according to the outer diameter of the catheter body 10 and the like. It is preferable to set the height of the convex portion 9 in accordance with the number of. Further, the connecting portion 91 may be provided as necessary depending on the material forming the catheter body 10, the thickness, and the like. Also,
Although the number of the side holes 22 depends on the number of the grooves 23, it is about 6 to 20, preferably about 8 to 16 per number of the grooves 23.

It is preferable that at least the outer surface of at least the indwelling portion 2 of the intraperitoneal indwelling catheter 1 extending from the indwelling portion 2 to the subcutaneous tunnel portion 3 is subjected to a hydrophilic treatment. Examples of the hydrophilic treatment include poly (2-hydroxyethyl methacrylate), polyhydroxyethyl acrylate, hydroxypropyl cellulose, methyl vinyl ether maleic anhydride copolymer, polyethylene glycol, polyacrylamide, polyvinylpyrrolidone,
Examples of the method include coating with a hydrophilic polymer such as. By performing such a treatment, the insertion resistance when inserting the catheter into the abdominal cavity can be reduced,
By reducing the time for catheter implantation surgery, the burden on the patient when implanting a catheter in the patient is reduced. In addition, it also has the effect of suppressing damage to the mucous membrane and suppressing tissue adhesion.

Next, the state in which the intraperitoneal indwelling catheter 1 according to the preferred embodiment of the present invention is transplanted to a patient will be specifically described. 3 is a partial cross-sectional view showing a state in which the intraperitoneal indwelling catheter according to the embodiment of the present invention is transplanted to the abdominal wall of a patient.

As shown in FIG. 3, the subcutaneous tunnel portion 3 of the intraperitoneal indwelling catheter 1 is implanted by penetrating the abdominal wall 100, and the inner cavity 11 of the catheter body 10 connects the abdominal cavity 120 and the abdominal wall outside 110. A subcutaneous tunnel is formed between them. The dialysate is exchanged via this subcutaneous tunnel. Further, the distal end side of the subcutaneous tunnel portion 3 formed in a loop shape is penetrated through the peritoneum 101 and left in the abdominal cavity 120, and the proximal end side of the subcutaneous tunnel portion 3 is the epidermis 1
It extends through 05 to the outside 110 of the abdominal wall. The tip of the indwelling part 2 placed in the abdominal cavity 120 is located in the Douglas stilt, and a connector is connected to the base end of the extension part 4 extended to the outside 110 of the abdominal wall.

The first cuff 6 provided on the indwelling section 2 side of the subcutaneous tunnel section 3 is located at the bottom of the muscular tissue 102,
It is fixed to the peritoneum 101 by suture. The catheter body 10 is fixed to the abdominal wall 100 by the first cuff 6, and the indwelling portion 2 is indwelled at a fixed position. In addition, the first cuff 6 prevents the dialysate from leaking out of the abdominal cavity 120 when the dialysate is injected into the abdominal cavity 120.

The second cuff 7 provided near the loop apex of the subcutaneous tunnel portion 3 is located at the bottom of the subcutaneous tissue 104 and fixed to the rectus fasciae 103 by suture. This second
With the cuff 7 of, the dialysate inlet / outlet is turned downwards,
The subcutaneous tunnel portion 3 is fixed to the living tissue.

The cuff member 5 provided on the extending portion 4 side of the subcutaneous tunnel portion 3 is located below the epidermis 105. As described above, the cuff member 5 is formed of a tissue adhesive material having early tissue adhesiveness and followability that does not separate the tissue bond due to the movement of the living body, so that the fibroblasts enter and the surroundings. get together. Therefore, by having such a cuff member 5, the percutaneous portion of the abdominal wall 100 and the catheter body 10 (the cuff member 5) are favorably adhered, and the catheter 1 is extended when the dialysate is injected or discharged. Part 4
Even if the mouse is moved in the vertical direction or the abdominal wall 100 is moved, the movement of the catheter 1 follows the biological tissue in the vicinity of the percutaneous portion without peeling. For this reason, the down-groove 150 having an appropriate depth is maintained and prevented from becoming deep.

The above description is an example in which the indwelling catheter of the present invention is applied to an intraperitoneal indwelling catheter, but the present invention is not limited to this, and is suitable for various indwelling catheters such as a shunt for hemodialysis. It is available. In any case, the member formed of the tissue adhesive material is preferably located under the dermis of the living body wall.

[0040]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples.

[Example] A peritoneal perfusion dialysis catheter as shown in Figs. 1 and 2 was prepared as follows. The total length of the catheter is a tubular body having a total length of 435 mm, an inner diameter of 2.5 mm and an outer diameter of 4.7 mm, and an X-ray opaque line is included in the major axis direction of the wall thickness of the tubular body. One of the base ends is placed in the abdominal cavity, and four grooves are formed along the major axis direction on the side surface of the tip part 85 mm, the groove width is 1.4 mm and the groove depth is 0.4 mm. Pour and drain holes having a diameter of 0.5 mm are formed in the groove at predetermined intervals. PET with a width of 1 cm is placed on the outer circumference of the catheter at the base of the indwelling part.
A first cuff made of non-woven fabric (Dacron manufactured by DuPont) is provided and the catheter is fixed. Further, a subcutaneous tunnel portion is provided from the first cuff toward the middle portion of the catheter, and a PET non-woven fabric with a width of 1 cm is provided around the catheter of the subcutaneous tunnel portion so that the catheter is fixed to the rectus fascia fascia (same as above).
A second cuff consisting of Further, a cuff member was arranged immediately below the dermis of the extending portion. As the cuff member, three types of a tubular body made of cellulose nonwoven fabric (the present invention product), a tubular body made of PET nonwoven fabric (the same as above) (Comparative Example 1), and a tubular body made of PTFE nonwoven fabric (Comparative Example 2) were used, 3 different cuff members
Seed catheters were made.

A scalpel was placed on the back of the rat, the first cuff was fixed to the base of the abdominal cavity, and the second cuff was fixed to the rectus fascia fascia, and the cuff member was positioned so as to be directly below the dermis and placed. The peritoneal perfusion dialysis catheter was fixed by extending the part into the abdominal cavity and the extending part outside the body. The tissue reactivity of the test piece collected immediately below the dermis of the rat 4 weeks after subcutaneous implantation in the back of the rat was examined histopathologically. The results are shown in Table 1 below.

Table 1 ─────────────────── Pathology after 4 weeks ─────────────────── Book Invention ++ Comparative Example 1 ++ Comparative Example 2 + to ++ ────────────────────

The evaluation criteria are as follows. ──────────────────────────────────── Evaluation Fibroblast and capillary invasion Collagenogenesis ── ────────────────────────────────── +++ Even to the center of the cuff member Even to the center of the cuff member ++ Uniformly up to the center of the cuff member There is little center of the cuff member + No intrusion of the center of the cuff member Only around the cuff member ± No outside of the cuff member ──────────────────── ─────────────────

As is clear from the results shown in Table 1,
The product of the present invention using a cuff member made of a cellulose non-woven fabric has excellent hydrophilicity and low inflammatory property,
Granulation accompanied by a poor food reaction is promoted as compared with the comparative example using the TFE nonwoven fabric. Further, the same test was performed on the product of the present invention using a cuff member made of a cellulose acetate nonwoven fabric, and as a result, granulation was further promoted. From the above results, the effect of the present invention is clear.

[0046]

As described above in detail, according to the indwelling catheter of the present invention, the adhesion and connection between the connecting device and the percutaneous tissue are increased, and even when the body or the catheter moves. It can follow the flexible movement of the body without breaking the bond with the tissue, and it can prevent the invasion of bacteria etc. into the body and do not become an infection nest, and the initial purpose can be effectively achieved. .

[Brief description of drawings]

FIG. 1 is an overall side view of an intraperitoneal indwelling catheter according to an embodiment of the present invention.

FIG. 2 is a sectional view taken along line AA in FIG.

FIG. 3 is a partial cross-sectional view showing a state in which the intraperitoneal indwelling catheter according to the embodiment of the present invention is implanted in the abdominal wall of a patient.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Intraperitoneal indwelling catheter 2 Indwelling part 3 Subcutaneous tunnel part 4 Extension part 5 Cuff member 6 1st cuff 7 2nd cuff 9 Convex part 10 Catheter body 11 Lumen 12 Marker 21 Opening 22 Side hole 23 Groove 91 Connection part 92 Tip of convex part 100 Abdominal wall 101 Peritoneum 102 Muscle layer tissue 103 Rectus fascia 104 Subcutaneous tissue 110 Outer abdominal wall 120 Abdominal cavity 150 Downgrowth

Claims (6)

[Claims] 1. A conduit that forms an entrance / exit to a living body, and is arranged so as to cover at least part of the outer circumference of the conduit, and has early tissue adhesiveness and followability that does not cause separation of tissue bonds due to movement of the living body. An indwelling catheter having a member made of a tissue adhesive material. 2. The indwelling catheter according to claim 1, wherein the tissue adhesive material is cellulose or a cellulose derivative. 3. The indwelling catheter according to claim 2, wherein heparin is attached to cellulose or a cellulose derivative. 4. The indwelling catheter according to claim 2, wherein the cell adhesive protein is attached to cellulose or a cellulose derivative. 5. The indwelling catheter according to claim 1, wherein the member made of the tissue adhesive material is formed by coating the conduit with heparin. 6. The indwelling catheter according to claim 1, wherein the member made of the tissue adhesive material is formed by coating the conduit with a cell adhesive protein.