JPH08245333A - Transparent two phase cosmetics composition - Google Patents

Abstract

PURPOSE: To obtain a cosmetic as a transparent two-phase composition having surfactant action, comprising a phase containing a liquid organic acid and a 2nd phase containing an alkaline agent. CONSTITUTION: This cosmetic composition comprises a 1st phase containing 0.01-50 wt.% of a liquid organic acid (e.g. isostearic acid) and 0.01-99 wt.% of a pharmaceutically acceptable carrier such as an ester, silicone oil, acidifying agent, thickening agent or antiseptic and a 2nd phase containing 0.5-30 wt.% of an alkaline agent (e.g. triethanolamine) for forming a surfactant through neutralizing the liquid organic acid. This cosmetic is in such multicompartment dispenser form as to separately hold both the phases respectively into different compartments of a dispenser. When the acid and the neutralizing agent are released from the separate compartments, they are mutually blended, forming a surfactant following neutralization.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to cosmetics formed as transparent two-phase compositions having surfactant activity.

[0002]

2. Description of the Related Art Two co-pending applications (applicant subject No.
92-0310-EA and 92-0312-EA) describe two-phase compositions for delivering ascorbic acid (vitamin C). In developing this two-phase product, it was discovered that it is necessary to contain a surfactant while maintaining transparency in both phases. Furthermore, since the first phase is an anhydrous species, there was the problem that a relatively low pH was required to maintain the stability of ascorbic acid against degradation. The other phase was a relatively high pH aqueous system. The use of conventional surfactant salts in the aqueous phase caused transparency problems. Incorporation of a relatively basic substance, surfactant, into the anhydrous composition resulted in unacceptable conversion of the surfactant salt to the acid form.

[0003]

Accordingly, it is an object of the present invention to provide a system for delivering a surfactant from a two phase cosmetic.

Another object of the invention is that both phases are transparent.
It is to provide a system capable of delivering a surfactant from a phase system.

[0005]

The above and other objects of the invention are set forth in the Summary, Detailed Description and Examples section below.

The present invention relates to a cosmetic product formed as a multi-compartment dispenser in which the first and second substances are separately housed in separate compartments of the dispenser, respectively, wherein (i) the first substance is a liquid organic acid ．
01 to 50% by weight and 0.01 to 99% by weight of a pharmaceutically acceptable carrier, and (ii) the second substance is effective for neutralizing a liquid organic acid to form a surfactant. Amount of alkaline agent.

It has been found that the surfactant can be preserved in a transparent and stable manner by separating the organic acid surfactant precursor from the alkali neutralizer by a compartment. Only after the acid and the neutralizing agent have been released from each of the two separate compartments are these materials blended together to form a surfactant after neutralization.

Accordingly, the present invention provides a cosmetic product in the form of a multi-compartment dispenser. First and second
Substances are contained in respective separate compartments of the dispenser. The first substance is about 0.
It contains a concentration of liquid organic acid of from 01 to about 50% by weight, preferably from about 0.5 to about 25% by weight, optimally from about 1 to 5% by weight.

According to the invention, the term "liquid" is 50
It means an acid having a melting point of ≤C, preferably ≤40C, optimally ≤20C.

Examples of typical liquid organic acids are C ₁₀ -C ₂₂ fatty acids, hydrocarbyl sulfonic acids, hydrocarbyl sulphates,
Hydrocarbyl phosphate and hydrocarbyl phosphonate. The term “hydrocarbyl” is substituted or unsubstituted and is defined as an organic C ₁ -C ₄₀ moiety selected from the group consisting of alkyl, alkenyl, benzyl and aryl groups, which may be branched or unbranched. . The hydrocarbyl group and the acid group may be alkoxylated. Examples of organic acids are isostearic acid, oleic acid, linolenic acid,
Linoleic acid, palmitol acid, ricinoleic acid, oleyl isethionic acid, isostearyl isethionic acid, isostearyl sulfonic acid, monoisostearyl phosphoric acid, di (oleyl) phosphoric acid and 1-linoleyl sulfonic acid.

The other component of the first substance is a pharmaceutical agent at a concentration of about 0.1 to about 99% by weight of the first substance, preferably about 25 to about 90%, optimally about 70 to 85% by weight. Is an acceptable carrier.

A wide variety of carriers can be used to deliver the liquid organic acid. The carrier may be water, but is preferably anhydrous vehicle. Monohydric and / or polyhydric alcohols are particularly suitable. Molecular weight 200-1,
Optimally, polyethylene glycol of 000, preferably about 400.

Another suitable carrier is esters. The esters that can be used are listed below.

(1) Fatty acid alkyl esters having 10 to 20 carbon atoms. Methyl, isopropyl and butyl esters of fatty acids are useful in the present invention. For example, hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, diisopropyl adipate, diisohexyl adipate. , Dihexyldecyl adipate, diisopropyl sebacate, lauryl lactate, myristyl lactate and cetyl lactate. Particularly preferred are C ₁₂ -C ₁₅ alcohol benzoates.

(2) Fatty acid alkenyl esters having 10 to 20 carbon atoms. Examples include oleyl myristate, oleyl stearate and oleyl oleate.

(3) Ether-esters such as fatty acid esters of ethoxylated fatty alcohols.

(4) Polyhydric alcohol esters. Ethylene glycol mono and di fatty acid esters, diethylene glycol mono and di fatty acid esters, polyethylene glycol (200-6000) mono and di fatty acid esters, propylene glycol mono and di fatty acid esters, polypropylene glycol 2000 monooleate, polypropylene glycol 2000 monostea Rate, ethoxylated propylene glycol monostearate, glyceryl mono- and difatty acid esters, polyglycerol polyfatty esters, ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate Rate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid ester, and polyoxyethylene sorbitan Fatty acid esters are satisfactory polyhydric alcohol esters.

(5) Wax esters such as beeswax, spermaceti, myristyl myristate and stearyl stearate.

(6) Sterol esters, for example cholesterol fatty acid esters.

Silicone oils can also be used as carriers. The silicone oil may be volatile or non-volatile. The term "volatile" as used herein refers to a material that has a measurable vapor pressure at ambient temperature. Volatile silicone oils preferably have from about 3 to 9 silicon atoms, preferably about 4 silicon atoms.
To about 5 cyclic or linear polydimethylsiloxanes.

Linear volatile silicone materials are generally at 25 ° C.
Has a viscosity of less than about 5 centistokes, and the annular material generally has a viscosity of less than about 10 centistokes.

Suitable volatile silicone oils useful in the present invention are, for example, Dow Corning 344, Dow C.
orning 345 and Dow Corning 2
00 (manufactured by Dow Corning Corp.); Si
silicone 7207 and Silicone 715
8 (manufactured by Union Carbide Corp.); S
F 1202 (General Electric
Manufactured); and SWS-03314 (SWS Silic
ones, Inc. Made).

Nonvolatile silicone oils useful in the compositions of the present invention are, for example, polyalkyl siloxanes, polyalkylaryl siloxanes and polyether siloxane copolymers. The substantially non-volatile polyalkyl siloxanes useful in the present invention have a viscosity at 25 ° C. of from about 5 to about 100,0.
It is a polydimethylsiloxane having a viscosity of 00 centistokes. Suitable non-volatile silicones useful in the compositions of the present invention include polydimethylsiloxanes having viscosities of from about 10 to about 400 centistokes at 25 ° C. Examples of such polyalkyl siloxanes include the Viscasil series (General El
(available from the Electric Company) and Dow
Corning 200 Series (Dow Corni
(commercially available from ng Corporation). As polyalkylaryl siloxane, 25 ℃
And poly (methylphenyl) siloxane having a viscosity of about 15 to about 65 centistokes. These materials are, for example, SF1075 methylphenyl fluid (G
general Electric Company) and 556 Cosmetic Grade Fl
uid (Dow Corning Corporation
on sale). Useful polyether siloxane copolymers include, for example, about 1 at 25 ° C.
Mention may be made of polyoxyalkylene ether copolymers having a viscosity of 200 to 1500 centistokes. Such fluids are SF-1066 organosilicone surfactants (General Electric Comp).
(sold as any)). Cetyl dimethicone copolyol and cetyl dimethicone are particularly suitable because they also function as emulsifiers and emollients.

Other skin improvers, especially when the first substance is dissolved or suspended in an anhydrous composition.
Ascorbic acid may be incorporated as it agents). The amount of ascorbic acid incorporated can in any case be from about 0.001 to about 50% by weight of the first substance.

An acidifying agent may also be included in the composition of the first substance. The acidifying agent may be an organic material or an inorganic material, and its amount is about 0.1 to about 20% by weight, preferably about 1 to 10%.
%, Optimally about 2-6%. Examples of acids include alginic acid, citric acid, malic acid, succinic acid, lactic acid, glycolic acid, tartaric acid, sorbic acid, phosphoric acid, acid phosphate, acid pyrophosphate, bitartrate and metal acid citrate. Can be mentioned.

Thickeners or thickeners up to about 10% by weight may also be included. As known to those skilled in the art, the exact amount of thickener will depend on the desired consistency and consistency of the composition. Examples of thickeners include xanthan gum, sodium carboxymethyl cellulose, hydroxyalkyl cellulose, alkyl cellulose, and crosslinked acrylic acid polymers (eg, trade name C from BF Goodrich).
such as those commercially available from arbopol). 0.1-5% by weight of the aqueous composition, preferably about 0.2-1
Optimally, a weight percent, optimally about 0.5 weight percent of methylcellulose and hydroxypropylmethylcellulose is included.

It is desirable to incorporate a preservative into the cosmetic composition of the present invention to prevent the growth of potentially harmful microorganisms. Microorganisms tend to grow in the aqueous phase but can also be present in the anhydrous or oil phase. Therefore, it is preferable to use a preservative that is soluble in both water and oil in the composition of the present invention. Conventional preservatives suitable for the compositions of the present invention are the alkyl esters of parahydroxybenzoic acid. Other preservatives that have recently come into use include hydantoin derivatives, propionates and various quaternary ammonium compounds. Suitable preservatives are well known by cosmetic chemists and are routinely selected to satisfy the preservative attack test and to provide product stability. Methylparaben, imidazolidinyl urea, sodium dehydroacetate, propylparaben, ethylenediaminetetraacetic acid (EDTA) trisodium and benzyl alcohol are particularly preferred. The preservative should be selected with regard to the incompatibility of the preservative with other ingredients. The amount of preservative used is preferably about 0.01 to about 2% by weight of the composition.

Minor additives such as fragrances, defoamers, opacifiers (eg titanium dioxide) and colorants may also be present in amounts effective to achieve their respective functions. Particularly useful trace ingredients are vitamin E linoleate, sodium hyaluronate, aloe vera gel and other botanicals.

Another desirable ingredient of the composition of the present invention is a sunscreen. This component is preferably incorporated into the anhydrous substance or oil phase. The term "sunscreen agent" as used herein means an ultraviolet blocking compound that absorbs in the wavelength range of 290 to 400 nm. Sunscreens can be divided into five groups based on their chemical structure: para-aminobenzoates, salicylates, cinnamates, benzophenones and other chemicals (including menthyl anthranilate and digaroyl trioleate). Inorganic sunscreens including titanium dioxide, zinc oxide, iron oxide and polymer particles (eg polyethylene and polyamides) can also be used. Suitable materials include p-aminobenzoic acid and its derivatives; anthranitrate; salicylate; cinnamate; coumarin derivatives; azoles; and tannic acid and its derivatives.

According to the present invention, there is also a need for a separate second material containing an effective amount of alkaline agent to neutralize the liquid organic acid to form the surfactant. The amount of the alkaline agent may be about 0.5 to about 30% by weight of the aqueous composition, preferably about 1.5 to about 10% by weight, and optimally about 2 to 5% by weight.

The alkaline agent can be an organic or inorganic material with a pH <7. Typical examples of inorganic materials are sodium hydroxide and potassium hydroxide. However, organic alkaline agents are preferable because they are less irritating to the skin. Examples of organic materials include ammonia, alkylamines, hydroxyalkylamines and alkanolamines. Examples are triethylamine, triethanolamine, diethanolamine, tetra (hydroxypropyl) diamine, 2-amino-2-methylpropane-1-.
All, 2-amino-2-ethyl-1,3-propanediol and 2-amino-2-hydroxymethyl-1,3-
Propanediol.

There is also a pharmaceutically acceptable carrier for the second substance. The carrier may be anhydrous, but aqueous is preferred. For example, the aqueous composition may contain a major amount of water corresponding to about 40 to about 99% by weight of the second material, preferably about 60 to 95%, optimally 80 to 85%. Additional or alternative carriers, as well as thickeners, preservatives and minor additives mentioned as formulations of the first substance, can also be used in the second substance.

According to the present invention, a multi-compartment dispenser is needed. Examples of such dispensers are described in US Pat.
39,699 and 1,699,532, which patents describe double collapsible tubes. Further, US Pat. No. 4,211,341 (Weyn) describes the separation of reactive components.
Another example is U.S. Pat. No. 4,487,757 (Kiosp
1 of Eoplou), and Schaeffer, respectively
US Pat. Nos. 4,528,180 and 4,687, in the name of
663 and 4,849,213.

For the purposes of the present invention, the weight ratio of the first composition to the second composition is about 10: 1 to 1:10, preferably 2: 1 to 1: 2, optimally about 1: 1. Can be.

[0035]

EXAMPLES The present invention will be further described below with reference to examples.
All parts, percentages and proportions used herein and in the claims are by weight unless otherwise specified.

Example 1 Deionized water 83.0% by weight, ethyl alcohol 7.5% by weight, butylene glycol 5.0% by weight, sodium bicarbonate 3.0% by weight, triethanolamine 1.0% by weight, Methocel 40-101 (hydroxypropyl methylcellulose) 0.5% by weight aqueous composition (composition A), Carbowax 400 (polyethylene glycol) 84.0% by weight, ascorbic acid (vitamin C) 5.0% by weight, ethyl Alcohol 5.0
An anhydrous composition (composition B) was prepared that was composed of 3.0% by weight of anhydrous citric acid and 3.0% by weight of isostearic acid. Each composition was then filled into each separate compartment of the dual compartment dispenser.

Example 2 Deionized water 77.0% by weight, ethyl alcohol 8.0% by weight, butylene glycol 6.0% by weight, triethanolamine 4.0% by weight, dimethicone copolyol 4.
0% by weight, Eusolex 232 (sunscreen)
An aqueous composition (composition A) consisting of 0.5% by weight of methylcellulose and 0.5% by weight of methylcellulose, and Carbowax 200
82.0% by weight, ascorbic acid (vitamin C) 5.
0 wt%, ethyl alcohol 5.0 wt%, glycolic anhydride 3.0 wt%, isostearic acid 3.0 wt%,
An anhydrous composition (composition B) consisting of 2.0% by weight dimethicone was prepared. Each composition was filled into each separate compartment of the dual compartment dispenser.

Example 3 83.7% by weight of deionized water, propylene glycol 8.
Aqueous solution consisting of 0% by weight, 3.0% by weight of isopropanol, 3.0% by weight of 2-amino-2-methylpropan-1-ol, 2.0% by weight of dimethicone copolyol and 0.3% by weight of hydroxypropylmethylcellulose. Composition (Composition A) and Carbowax 400 83.0
% By weight, ascorbic acid (vitamin C) 5.0% by weight,
Glycerin 5.0% by weight, lactic acid anhydride 3.0% by weight, linolenic acid 2.0% by weight, dimethicone copolyol 2.0
An anhydrous composition (Composition B) consisting of wt% was prepared. Each composition was filled into each separate compartment of the dual compartment dispenser.

Example 4 Deionized water 80.7% by weight, propylene glycol 8.
Aqueous composition consisting of 0% by weight, 6.5% by weight of ethyl alcohol, 4.0% by weight of triethanolamine, 0.5% by weight of Eusolex 232 (sunscreen agent), and 0.3% by weight of sodium carboxymethyl cellulose (composition A) and Carbowax 200 76.0% by weight,
Ascorbic acid (vitamin C) 10.0% by weight, ethyl alcohol 5.0% by weight, malic anhydride 3.0% by weight,
An anhydrous composition (composition B) consisting of 3.0% by weight of oleic acid and 3.0% by weight of polyoxyethylene 15 trimethylolpropane isostearate was prepared. Each composition was filled into each separate compartment of the dual compartment dispenser.

Example 5 Deionized water 83.0% by weight, ethyl alcohol 5.0% by weight, butylene glycol 5.0% by weight, ammonium hydroxide 4.0% by weight, dimethicone copolyol 2.5
An aqueous composition (composition A) consisting of 100% by weight and 0.5% by weight of methylcellulose, and Carbowax 400 8
0.9% by weight, isostearic acid 7.0% by weight, ascorbic acid (vitamin C) 5.0% by weight, ethyl alcohol 5.0% by weight, polyoxyethylene 15 trimethylolpropane isostearate 2.0% by weight, An anhydrous composition (composition B) consisting of 0.1% by weight of anhydrous citric acid was prepared. Each composition was filled into each separate compartment of the dual compartment dispenser.

Example 6 A set of experiments was conducted to evaluate the effect of stearic acid and isostearic acid on the clarity of solutions when an aqueous composition and an anhydrous composition were mixed. These tests and results are summarized in Table 1 below. Product A was a white milky solution when components I and II were combined. On the other hand, using isostearic acid instead of stearic acid gave a clear solution. Product C based on isostearic acid also formed an opaque solution when components I and II were combined in the absence of triethanolamine. As is apparent from these experiments, anhydrous compositions require a liquid organic acid such as isostearic acid and aqueous compositions require an alkaline agent to obtain a clear solution.

[0042]

[Table 1]

The above description and examples specifically explain selected modes of the present invention, and a person skilled in the art will come to various modifications within the spirit and scope of the present invention based on this description.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Alan Jyoel Mayers United States, Connecticutt 06611, Trumbull, Frederick Street 68

Claims (9)

[Claims] 1. A cosmetic product, formed as a multi-compartment dispenser, in which separate first and second substances are contained in separate compartments of the dispenser, wherein (i) the first substance is a liquid organic acid. 01-
50% by weight and 0.01 pharmaceutically acceptable carrier
To 99% by weight, and (ii) a cosmetic containing a second substance in an amount effective to neutralize a liquid organic acid to form a surfactant. 2. The cosmetic product according to claim 1, wherein the melting point of the organic acid is 50 ° C. or lower. 3. The cosmetic product of claim 1, wherein the organic acid is selected from the group consisting of C ₁₀ -C ₂₂ fatty acids, hydrocarbyl sulfonic acid, hydrocarbyl sulfuric acid, hydrocarbyl phosphoric acid and hydrocarbyl phosphonic acid. 4. The cosmetic product of claim 1, wherein the organic acid is selected from the group consisting of isostearic acid, oleic acid, linolenic acid, linoleic acid and combinations thereof. 5. The cosmetic product according to claim 1, wherein the amount of the organic acid compounded is about 0.5 to about 25% by weight. 6. The cosmetic product according to claim 1, wherein the alkaline agent is selected from the group consisting of ammonia, alkylamines, hydroxyalkylamines and alkanolamines. 7. The cosmetic product according to claim 1, wherein the alkaline agent is triethanolamine. 8. The cosmetic product according to claim 1, wherein the amount of the alkaline agent is about 0.5 to about 30% by weight of the second substance. 9. The cosmetic product according to claim 1, wherein the first substance and the second substance are each transparent.