JPH08182643A - Moist adsorbent material to clean article and surface - Google Patents

Abstract

PURPOSE: To enhance the polarity and wettability of organic and lipophilic wastes by damping a wet adsorbing material for cleaning a product and a surface, for example, wet towel in a water solution containing liposome having a vehicle with a specified diameter to denaturalize the physical nature of the organic and lipophilic wastes. CONSTITUTION: A wet towel individually packed by alumina sealing is made available to wash and keep hands fresh wherever water is not readily obtained. The towel is damped in a water solution containing liposome having a vehicle with the diameter of up to about 100 nm. The liposome herein used is employed for the towel formed from unwoven cloth, paper or woven cloth made of cotton, viscose, viscose polyester, or viscose polyethylene. This liposome is also used in combination with a disinfectant such as chlorohexidine gluconate, cetramide, benzylchromium chloride or peptide such as polymixyn as required.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION This invention relates to wet adsorbent materials for cleaning articles and surfaces. In particular, the invention relates to wetting materials, especially wet towels, for cleaning articles and surfaces by applying liposomes.

[0002]

Prior art and patents have been directed to increased oil recovery using modified liposomes. Therefore,
For example, in U.S. Pat. No. 4,811,791, when recovering petroleum from an underground petroleum source, a petroleum displacing agent containing a fluid and a modified liposome is injected into the underground source, and the interfacial tension between the fluid and the petroleum is about 50 millidyne. Disclosed below is a method comprising the presence of a sufficient amount of said liposomes to reduce. The patent, however, was limited to recovering oil from underground sources.

As described later in this specification, it has been found in the present invention that liposomes modify the physical properties of oils and other organic lipophilic wastes by increasing their polarity and wettability.

Phospholipids (phospholipids) from which the liposomes of the present invention are prepared are naturally occurring membrane lipids, in which glycerol is bound to long chain fatty acids, phosphate residues and nitrogen-containing bases (eg choline). It is something. Most phospholipids from animals have one saturated and one unsaturated fatty acid, while plants (eg soybean) provide phospholipids with most two polyunsaturated fatty acids. There are two main prerequisites for large scale application of liposomal phospholipids from an environmental point of view, availability and low cost. Plant phospholipids meet both requirements. It produces over 500,000 tons per year and is used as a by-product of the edible oil industry for animal feed.

The liposome used in the adsorbent material of the present invention can be prepared from phospholipids, which are supplied in a dry state or in a phospholipid solution dissolved in an organic solvent, and are incompatible with water (eg, , Ether, alkyl halogen compounds, etc.) or water compatibility (for example, alcohols, dimethyl sulfoxide, etc.).

[0006]

Various methodologies have been developed for the preparation of liposomes. They can be prepared in a large number of membranes with different dimensions. For use in the adsorbent material of the present invention, unilamellar vesicles are preferred.

Small-scale preparation of only single liposomal vesicles can be accomplished by ultrasonic irradiation or extrusion of hydrated phospholipids. For large-scale preparations, dry phospholipids are hydrated by mechanical vibration in water or hydrated salts. The multilamellar liposomes thus formed are then homogenized with a conventional high pressure homogenizer. Using this technique, small unilamellar vesicles of natural or modified soybean phospholipids up to about 100 nm in diameter are produced, stable for storage at room temperature and resistant to aggregation or fusing for at least 2 years. I was able to.

As mentioned above, it has now been found that these multilamellar liposomes modify the physical properties of organic and lipophilic wastes, increasing their polarity and wettability.

The use of liposomes in combination with organic waste consuming microorganisms has been described, the liposomes providing essential nutrients for microbial growth, but used as such in the absence of liposome organic waste consuming microorganisms. It has now been found that when it is applied, it is an excellent cleaning agent and has improved properties as compared with conventional cleaning agents. In accordance with the present invention, it has now been found that liposomes can be included in a variety of articles such as cotton balls, cotton tip sticks, wet towels, and adsorbent materials having a variety of uses for cleaning surfaces.

Wet towels of various compositions and their applications are well known. Originally wet towels were airplanes,
It was available in individually alumina-sealed packs for freshening hands and washing in areas where water was not readily available, such as for hiking walks. A further development was a pack of large wet towels that could be individually removed from the semi-sealed container for use in the toilet as well as for caring for babies. Thus, for example, Scott Paper Company manufactures and markets wet towels under the trade name Baby Fresh (R) and is labeled as having the following ingredients. Pure water, propylene glycol, PEG75, lanolin, cocoamphodiacetate, polysorbate for washing and moistening, and methylparaben, propylparaben, 2-bromo-2-nitropropane-1,3-diol and for freshness and aroma Fragrance. Other products manufactured and sold in Israel show the following as their ingredients. Water, Lanolin, Amphoteric-6, Tween-20 (Tweee
n-20), propylene glycol, fragrance and EDT
A. As can be seen from the above, these and similar products together are based on a combination of water, propylene glycol and a surface-active agent in order to achieve a cleaning action.

[0011]

SUMMARY OF THE INVENTION Unlike the previously known wet towels, the present invention provides a wet towel for cleaning articles and surfaces, the towel containing liposomes having vesicles up to about 100 nm in diameter. Provide a towel that is wet with an aqueous solution.

Cotton swabs, ie those with small cotton balls on one or both ends of the rod, have been available for decades, the most common product being the registered trademark "Q-Chips" manufactured by Johnson & Johnson. (Q-T
ips). However, all swabs on the market are dry swabs, which can cause irritation to the ears or nasal passages during use. The present invention produces pre-moistened swabs with improved properties by pre-soaking the swabs in the liposome solution.

The adsorbent material of the present invention can be prepared to contain different liposome concentrations depending on its intended use. As described below, suspensions, dispersions and even gels of aqueous solutions from liposomes can be prepared, limited only to the saturation point of the solution. Therefore, in a preferred embodiment of the present invention, the adsorbent material is wetted with an aqueous solution containing about 0.01-60 wt% dissolved in water. In a particularly preferred embodiment of the invention, the wetting material is wet with an aqueous solution containing 0.05 to 25% by weight liposomes dissolved in water. Further, the liposome is cotton,
It can be incorporated into a towel made of non-woven fabric such as viscose, viscose polyester or viscose polyethylene, paper or woven fabric.

Due to the special and unique properties of liposomes used in the present invention, wet towels containing liposomes are not only contaminated with organic and / or lipophilic deposits, not only for general use in personal hygiene, caring for red dragonfly. It can also be used to clean articles and surfaces, increasing its polarity, wettability, thereby facilitating removal of the deposits and cleaning of articles and surfaces. Further, the wet towels of the present invention are useful for cleaning household and industrial articles and surface grease and dust deposits.

According to another feature of the invention, the liposomes of the invention are chlorohexidine gluconate, cetramide, benzylkniu chloride.
m)) or a peptide such as polymyxin B (polymixin B) can be combined with a disinfectant to produce a wet towel with disinfectant properties, for example, to wash cow nipples before squeezing, or to clean women. It has been found that various forms of adsorbent material for hygiene can be produced. While the disinfectants presently used in commercial liquid cleaners today must clean the article or surface to be cleaned, the towel of the present invention leaves a desirable protective lamina. Furthermore, it has been found that the protective layer has a water-repellent effect when it is deposited on the glass surface, as shown in the following example.

As mentioned above, preferred liposomes of the present invention have vesicles with a diameter of up to about 100 nm, from about 20 to
80 nm diameter vesicles are particularly preferred.

US Pat. Nos. 4,230,52 and 4,41
No. 4,333 describes methods and compositions for purifying fresh water and salt water from crude oil, petroleum products and their derivatives, especially those that provide lecithin as a phosphorus source. But,
As described above, in order to rapidly and sufficiently convert from a phospholipid source such as lystin into a structural shape of a small unilamellar liposome having a desired property of modifying the polarity and wettability of organic waste for use in the method of the present invention. Must be subjected to ultrasonic irradiation, extrusion or similar process. Therefore, these patents do not teach or suggest the preparative use of the towels of the present invention. US Pat. No. 5,019,174 describes a method of removing oil from a surface using a lipid bicycle skin cleaner by encapsulating a lipid bicycle skin cleaner and liposomes. However, as will be appreciated, the above patent is limited to the use of disrupted, comminuted, modified small membrane lipid vesicles, thereby encapsulating the oil present on the surface. . Unlike the teachings of the above patents, the present invention utilizes liposomes that modify the physical properties of organic and lipophilic deposits and increase their polarity and wettability, removing them from the surface where organic and lipophilic deposits are found. Easy to do. Therefore, in the present invention, a small vehicle, i.
It has been found that the 80 nm one is particularly effective. This is contrary to what would be expected from the teachings of the patent, since encapsulation volume and liposome size are inversely proportional.

The constitutions and embodiments of the present invention will be listed below.

1. A wet adsorbent material for cleaning articles and surfaces, characterized in that the material is wetted with an aqueous solution containing liposomes having vesicles with a diameter of up to about 100 nm. Wet adsorbent material.

2. The wet adsorbent material according to the above 1, wherein the material is a non-woven fabric.

3. 2. The wet adsorbent material according to the above 1, wherein the material is a woven cloth.

4. The wet adsorbent material according to the above 1, wherein the material is a towel.

5. The wet adsorbent material according to the above 1, wherein the material is a cotton swab.

6. The wet adsorbent material according to the above 1, further comprising a bactericide.

7. The liposome has a diameter of about 20-80n.
2. The wet adsorbent material according to the above 1, which has m vesicles.

8. 2. The wet adsorbent material according to the above 1, wherein the liposome is a phospholipid liposome.

9. 2. The wet adsorbent material according to the above 1, wherein the liposome is a unilamellar liposome.

10. A moistening towel for cleaning articles and surfaces, characterized in that the towel is moistened with an aqueous solution containing liposomes having vesicles with a diameter of about 20-80 nm. Wet towel.

11. Approximately 0.01-60 the towel in water
11. The wet towel according to the above 10, which is moistened with an aqueous solution containing wt% of liposomes.

12. 11. A wet towel according to claim 10, wherein the towel is moistened with an aqueous solution containing about 0.1-25% by weight of liposomes in water.

13. A wetted adsorbent material as described in 1 above for cleaning organic and lipophilic deposits on articles and surfaces, wherein said liposomes alter the physical properties of said deposits to increase their polarity and wettability. The wet adsorbent material of claim 1 for cleaning organic and lipophilic deposits on articles and surfaces, which facilitates removal of the deposits and cleans the articles and surfaces.

[0032]

The following examples describe the invention in terms of certain preferred embodiments, and its features are more fully understood and evaluated, but are not intended to limit the invention to these particular embodiments. Absent. On the contrary, all alternatives, modifications and equivalents are intended to be covered and included within the scope of the invention as defined by the appended claims. Therefore, the following examples, including the preferred embodiments, serve to illustrate the practice of the invention and the details shown are examples and are for the purpose of an explanatory description of the preferred embodiments of the invention only. And is considered to be the most useful, and is presented in the process of providing a formal description of the invention, as well as an easy understanding of the principles and conceptual features.

Example 1A 10 g of soybean lecithin was dispersed in 100 ml of distilled water,
Then high pressure homogenize at 10,000 psi for 5 minutes. The liposomes formed are monolayers of approximately <100 nm.

Example 1B The liposomes of Example 1A are added to a small container containing 4.5 m of non-woven viscose (13.5 cm wide). The viscose was predivided into 200 equal pieces, but they are still connected to each other. The container is sealed and stored until all liposome suspension is attached to viscose. These pieces of cloth are used for cleaning as described in the examples below.

Example 2 15 g of egg lecithin containing 0.2 mol% of vitamin E antioxidant is dissolved in 30 ml of chloroform. The solvent is removed by flash evaporation. Antioxidants used in parallel liposome preparation are butylhydroxytoluene (BHT), butylhydroxyanisole (BHA).
And Oxynex 2003. Large multilamellar liposomes are prepared by adding 100 ml of distilled water containing EDTA chelator and shaking the aqueous solution with a thin fat layer. Start with a pore size of 600 nm and have a pore size of 5
The liposomes are miniaturized to less than 100 nm by stepwise extruding multilamellar liposomes through a series of polycarbonate filters ending at 0 nm. Match the pressure to the filter pore size. The final extrusion through a 50 nm pore size filter is repeated three times. All liposomes formed are below 100 nm,
It is a single film. These liposomes are used to moisten a viscose cloth as described in Example 1B.

Example 3 100 g of soy lecithin are dispersed in 1.0 liter of distilled water using a high shear homogenizer. Paraban preservative is added at a bacteriostatic concentration. As described in Example 1 above, high pressure homogenization is used to miniaturize the liposomes to make the liposome size less than 100 nm. The liposome suspension is divided into 100 ml each of 10 dove coats.

Example 4 100 ml of the liposome dispersion prepared in Example 3 is used to moisten a woven fabric as described in Example 1 and used to wash the entire human body.

Example 5 A paper towel is moistened with 100 ml of the liposomal dispersion described in Example 3.

Example 6 To 100 ml of the liposome dispersion prepared in Example 3, rubber such as sodium alginate, gum arabic, and condulus is added and applied to a woven or non-woven fabric as described in Example 1B.

Example 7 To the liposome dispersion prepared in Example 3, carboxymethylcellulose (CMC), polyvinylpyrrolidone (P
A thickener such as VP) or Veegum K is added to obtain the desired viscosity. The liposome dispersion is then applied to a woven or non-woven fabric as described in Example 1B.

Example 8A Preparation of a Liposome-Wetted Tissue for Use on the Face or Body 10 g of soybean lecithin was added with an antioxidant as used in Example 2 and a preservative as used in Example 3. Additionally dissolved in 50 ml ethanol with rose extract for washing and tonic, camphor extract for skin irritation and comfort, and chamomile extract for soothing. A double distilled water solution of an ethanol solution with stirring 1
Pour into the liter at a rate of 0.1 ml per minute.

Example 8B The liposomes formed in Example 8A have a size of less than 100 nm and are used to moisten a woven or non-woven fabric as described in Example 1B. These fabrics are used as described in the examples below.

Example 9A Preparation of a tissue containing liposome-moistened collagen and elastin: 100 ml of 10% soybean lecithin small unilamellar liposomes <50 nm in size are prepared in doubly distilled water. These liposomes are 0.05-2.0%
Coriophyllize with a 100 ml solution containing a mixture of collagen and elastin at the protein concentration of. Disperse the dry powder in a final volume of 100 ml of water or buffer of desired pH. The formed multilamellar liposome was used in Example 1.
Miniaturization by either high pressure homogenization as described in A or stepwise extrusion as described in Example 2.

Example 9B The liposomes formed in Example 9A have a size of less than 100 nm and are used to moisten a woven or non-woven fabric as described in Example 1B. These fabrics are used as described in the examples below.

Example 10 Preparation of Liposome-Wetted Tissue for Washing or Sterilization: Liposomes smaller than 100 nm in size are prepared as described in Examples 1A, 2, 3, 8A, or 9A, but with chlorohexane. A bactericidal agent selected from the group consisting of peptides such as xydyne, gluconic acid, cetramide, benzylcnium chloride, and polymyxin B having a high affinity for liposomes is added to ethanol or an aqueous phase to obtain bactericidal activity. Therefore, the optimum concentration is used.

Example 11 Preparation of Liposome Wetting Tissue for Sedation and Local Sterilization: As described in Example 10 with the addition of a topical bactericide selected from the group consisting of benzocaine and tetracaine to water or ethanol. First, a liposome moistening cloth is prepared.

Example 12 A liposome dispersion was prepared as described in Examples 1A, 2, 3, 8A, and 9A above, and various fabrics made of synthetic or natural fibers were placed in a sealed container. Wet with the liposome dispersion.

Example 13 A liposome dispersion is prepared as described in Examples 1A, 2, 3, 8A and 9A and used to moisten cotton balls contained in a sealable container. .

Example 14 Wetting a cotton swab tip of a "cotton swab" with a liposomal dispersion prepared as described in Examples 1A, 2, 3, 8A, and 9A in a sealable container. . These tips are used to clean the ears of humans or animals.

Example 15 A sterilized liposome dispersion was prepared according to Examples 1A, 2, 3, 8
Prepared as described in A and 9A and used to wet tampons of various types and sizes. Each tampon is sealed in a separate packet to prevent evaporation and keep it sterile.

Example 16 Examples 1A, 2, 3, 8A, in buffer of neutral pH,
And liposome dispersion is prepared as described in 9A. Woven or non-woven fabric with a diameter of 5c
m pad to moisten. These pads are used to remove eye and face makeup.

Example 17 A liposome dispersion is prepared as described in Examples 1A, 2, 3, 8A and 9A and used to moisten a woven or non-woven fabric as described in Example 1B. . Attach the container to the vacuum pump and remove a part of the water that moistens the cloth by vacuum to obtain 0.01-60% in water.
% Of the desired lipid in the range. After that, the container is sealed.

Example 18 A liposome dispersion is prepared as described in Examples 1A, 2, 3, 8A and 9A. 0.05 ~ this dispersion
Dilute to the desired lipid concentration of 25%, apply to woven or non-woven towels, cotton balls or swabs and store in sealed containers.

Example 19 A liposome dispersion is prepared as described in Example 18, diluted and used to wet a tampon as described in Example 15.

Example 20 A non-woven fabric is moistened with an aqueous solution containing 1% liposomes,
Created a damp towel. This towel was used to remove the eye makeup. The make-up was completely removed and the skin became clean, moist and soft.

Example 21 A non-woven fabric was moistened with an aqueous solution containing 0.1% liposomes to prepare a moist towel. This towel was used to clean spectacle lenses. The lens was clean without being scratched.

Example 22 A non-woven fabric was moistened with an aqueous solution containing 17% liposomes to prepare a moist towel. This towel was used to clean the oily hands of a car mechanic and the hands were clean and moist.

Example 23 A paper towel was moistened with an aqueous solution containing 0.2% liposomes. This towel was used to clean the computer and TV screens. Both screens were clean without scratches or static electricity.

Example 24 A non-woven fabric was moistened with an aqueous solution containing 0.05% liposomes to prepare a moist towel. This towel was used to clean the windshield of a motorcycle helmet. When driving in heavy rain, liposomes on the windshield repelled water droplets, giving the driver a clear view.

Example 25 A non-woven fabric was moistened with an aqueous solution containing 0.5% liposomes to prepare a moist towel. This towel was used to clean the baby's back. The skin became clean and soft with no noticeable inflammation.

Example 26 A wet towel was prepared by wetting a nonwoven fabric with an aqueous solution containing 0.5% liposomes. This towel was used to moisten a thick layer (about 2 mm) of soot covering the interior (burner and combustion chamber) of a Delville kerosene heater. Five minutes after application, the soot was wiped off with a cloth lightly moistened with water, the soot was completely removed and the metal was completely clean. Treating soot with a cloth moistened with water (instead of liposomes) in parallel experiments,
When wiped with a damp cloth, only a small amount of soot was removed and most remained attached to the burner and chamber metal.

Example 27 The soot of the above burner that fell on the floor was wiped off with a moistened towel containing 0.5% liposomes,
Soot was completely removed and the floor was cleaned. In parallel,
Moistening the floor with water only and wiping with a paper tissue only removed a small amount of soot from the floor.

Example 28 A non-woven fabric was moistened with a 0.5% liposome-containing aqueous solution to prepare a moist towel. This towel was used to wipe only the driver side half of the windshield. I drove this car in heavy rain at 90 kph. It was not necessary to use a wiper to see the road through the liposome-side windshield. The raindrops were repelled from the windshield leaving behind small drops of water.

The rest of the windshield was completely covered with a thick film of water and the road could not be seen clearly enough to drive.

Example 29 50 non-woven tissues having a size of 200 × 140 mm were prepared. This sheet is 205 x 145 x 60 mm
I put it in a container of the size. An aqueous solution containing 5% liposomes was prepared according to Example 1A, 150 ml of this solution was poured into the container until all the masters were evenly immersed, and the container was closed. The moistened tissues were removed from the containers one at a time when needed and used to clean kitchen counters and tables, where greasy, dust, and food deposits could be easily removed.

It is to be understood by those skilled in the art that the present invention is not limited to the details of the illustrative embodiments above, and that the invention can be embodied in other specific forms without departing from its essential aspects. Is obvious. It is understood, therefore, that the present embodiments and examples are illustrative in all respects and not limiting, and it is desired to refer to the claims rather than the foregoing description. All changes in meaning and scope equivalent to the claims are intended in the claims.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Echetzkel Barrenholtz, State of Israel 93707, Jerusalem, Nakhwe Shaanan, 18 (72) Inventor Harve Bakovier, State of Israel 94543, Jerusalem, Tiberias Street, 30 (72) Inventor Zvi Elder Gorda Str. 17 Haifa, Israel

Claims (2)

[Claims] 1. A wet adsorbent material for cleaning articles and surfaces, wherein the material is wetted with an aqueous solution containing liposomes having vesicles with a diameter of up to about 100 nm. Wet adsorbent material for cleaning surfaces. 2. A moistening towel for cleaning articles and surfaces, wherein the towel is moistened with an aqueous solution containing liposomes having vesicles having a diameter of about 20-80 nm. Wet towel for cleaning.