JPH08143602A - Production of hollow and porous carrier using starch and its use - Google Patents
Production of hollow and porous carrier using starch and its useInfo
- Publication number
- JPH08143602A JPH08143602A JP6290979A JP29097994A JPH08143602A JP H08143602 A JPH08143602 A JP H08143602A JP 6290979 A JP6290979 A JP 6290979A JP 29097994 A JP29097994 A JP 29097994A JP H08143602 A JPH08143602 A JP H08143602A
- Authority
- JP
- Japan
- Prior art keywords
- starch
- particles
- hollow
- enzyme
- porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、内部に中空部を有する
湿熱処理澱粉粒子に、澱粉分解能を有する酵素を作用さ
せ中空多孔性となし、当該粒子の中空部及び孔部に、目
的物質を担持する機能を持つ中空多孔性澱粉粒子よりな
る中空多孔性担体及びその製造方法並びに当該中空多孔
性担体を用いた製剤及びその製造方法に関する。本発明
の中空多孔性担体に担持した製剤は、制御可能な安定
性、持続性、除放性などの機能を付与されているため、
医薬品、農薬、香料、肥料などの分野において、優れた
効果並びに経済性を発揮することができる。BACKGROUND OF THE INVENTION The present invention relates to a heat-moisture treated starch particle having a hollow portion inside, which is made hollow by making an enzyme having a starch-decomposing action act to make it hollow, and a target substance is provided in the hollow portion and the pore portion of the particle. The present invention relates to a hollow porous carrier composed of hollow porous starch particles having a supporting function, a method for producing the same, a preparation using the hollow porous carrier, and a method for producing the same. The formulation supported on the hollow porous carrier of the present invention is provided with functions such as controllable stability, sustainability, and sustained release,
It can exert excellent effects and economical efficiency in the fields of pharmaceuticals, agricultural chemicals, fragrances, fertilizers, and the like.
【０００２】[0002]
【従来の技術】従来より、香料、色素、医薬、農薬、肥
料など目的物質の保護、安定化、効力の持続あるいは所
定の条件で放出させる手段として、マイクロカプセル中
に包接、イオン交換樹脂に結合、ワックス中に分散する
などの技術がある。更に、小型化を目指した方法とし
て、特開平１−１５９０４７では、澱粉粒子を架橋し、
この内部を生澱粉分解酵素により分解しマイクロカプセ
ルとしている。また、特開平５−１１２４６９では、澱
粉に生澱粉分解酵素を作用させた多孔性澱粉粒よりなる
多孔性担体を用いて、目的物質を該多孔性担体の孔部に
担持させている。2. Description of the Related Art Conventionally, as a means for protecting, stabilizing, sustaining the effect of a target substance such as a fragrance, a dye, a medicine, an agricultural chemical, and a fertilizer, or releasing it under a predetermined condition, an encapsulation in a microcapsule, an ion exchange resin There are techniques such as binding and dispersing in wax. Further, as a method aiming at downsizing, in Japanese Patent Laid-Open No. 1-159047, cross-linking starch particles,
The inside is decomposed by a raw starch degrading enzyme to form a microcapsule. Further, in JP-A-5-112469, a target substance is supported in the pores of the porous carrier by using a porous carrier composed of porous starch granules obtained by reacting raw starch with a raw starch degrading enzyme.
【０００３】しかしながら、上記した従来の技術のう
ち、マイクロカプセル、イオン交換樹脂およびワックス
を用いる方法は、効力の持続性や放出条件の制御が難し
い。また、特開平１−１５９０４７の方法、すなわち澱
粉粒子を架橋した後、生澱粉分解酵素で中空部をつくる
方では、架橋反応という煩雑な処理が必要であり、人体
に対する架橋剤の毒性も危惧される。さらに、特開平５
−１１２４６９では、酵素により未処理の生澱粉を生澱
粉分解酵素により分解する結果、多孔性になった澱粉粒
子は非常にもろくなり、加熱あるいは撹拌により粒子が
崩壊してしまうため、多孔性担体として使用しがたい。However, among the above-mentioned conventional techniques, the method of using microcapsules, ion-exchange resins and wax is difficult to control the sustainability of the effect and release conditions. Further, in the method disclosed in JP-A-1-159047, that is, in the case of forming a hollow portion with a raw starch degrading enzyme after cross-linking starch particles, a complicated treatment of a cross-linking reaction is necessary, and the toxicity of the cross-linking agent to the human body is concerned. . Furthermore, JP-A-5
In -112469, as a result of decomposing raw starch that has not been treated with an enzyme with a raw starch degrading enzyme, the starch particles that have become porous become very brittle, and the particles disintegrate due to heating or stirring. Hard to use.
【０００４】[0004]
【発明が解決しようとする課題】本発明は、第１に、内
部に中空部を有する湿熱処理澱粉粒子に、澱粉分解能を
有する酵素を作用させ多孔性となし、当該粒子の中空部
及び孔部に、目的物質を担持する機能を持つ中空多孔性
澱粉粒子よりなる中空多孔性担体を提供することを目的
とする。SUMMARY OF THE INVENTION The present invention is, firstly, that a moisture-heat-treated starch particle having a hollow portion inside is made porous by allowing an enzyme having a starch degrading action to act to make it porous. Another object of the present invention is to provide a hollow porous carrier composed of hollow porous starch particles having a function of supporting a target substance.
【０００５】第２に、内部に中空部を有する湿熱処理澱
粉粒子に、澱粉分解能を有する酵素を作用させ多孔性と
なし、当該粒子の中空部及び孔部に、目的物質を担持す
る機能を持つ中空多孔性澱粉粒子とすることで製造する
中空多孔性担体の製造方法を提供することを目的とす
る。Secondly, an enzyme having a starch decomposing property is made to act on the heat-moisture treated starch particles having a hollow portion inside so as to make it porous, and it has a function of supporting a target substance in the hollow portion and the pore portion of the particle. It is an object of the present invention to provide a method for producing a hollow porous carrier produced by making hollow porous starch particles.
【０００６】第３に、内部に中空部を有する湿熱処理澱
粉粒子に、澱粉分解能を有する酵素を作用させ多孔性と
なし、当該粒子の中空部及び孔部に、目的物質を担持さ
せた製剤を提供することを目的とする。[0006] Thirdly, a preparation in which a moisture-heat-treated starch particle having a hollow portion inside is made porous by the action of an enzyme having a starch degrading property, and the target substance is supported in the hollow portion and the pore portion of the particle. The purpose is to provide.
【０００７】第４に、内部に中空部を有する湿熱処理澱
粉粒子に、澱粉分解能を有する酵素を作用させ多孔性と
なし、当該粒子の中空部及び孔部に、目的物質を担持さ
せることで製造する製剤の製造方法を提供することを目
的とする。Fourthly, the moisture-heat-treated starch particles having a hollow inside are made porous by the action of an enzyme having a starch-decomposing ability, and the target substance is carried in the hollows and pores of the particles. It is an object of the present invention to provide a method for producing a pharmaceutical preparation.
【０００８】[0008]
【課題を解決するための手段】本発明は、(a)澱粉粒子
を湿熱処理することにより澱粉の中空粒子を得る工程；
および(b)得られる中空湿熱澱粉粒子に澱粉分解能を有
する酵素を作用させて多孔性ととする工程；を包含する
中空多孔性担体の製造方法を提供するものであり、その
ことにより上記目的が達成される。The present invention comprises: (a) a step of subjecting starch particles to wet heat treatment to obtain hollow starch particles;
And (b) a step of causing an enzyme having a starch-decomposing ability to act on the obtained hollow moist heat starch particles to make them porous; and a method for producing a hollow porous carrier, which provides the above object. To be achieved.
【０００９】澱粉粒子を担体として、使用する場合の有
利な点は、その粒子サイズがミクロン単位と小さいこ
と、更に、その粒径分布はアマランサス澱粉の約１μｍ
から馬鈴薯澱粉の約１００μｍと広く、澱粉の種類を選
択することにより保持時間、放出時間の調節が可能なこ
とである。その上、澱粉、特に薬品などで処理されてい
ない澱粉には食品あるいは医薬などの用途において安心
して使用できる利点がある。The advantage of using starch particles as a carrier is that the particle size is as small as micron, and the particle size distribution is about 1 μm of amaranth starch.
The range is about 100 μm for potato starch, and the retention time and release time can be adjusted by selecting the type of starch. In addition, starch, particularly starch that has not been treated with chemicals, has the advantage that it can be used safely in applications such as food and medicine.
【００１０】更に、湿熱処理澱粉粒子を使用する場合の
有利な点として、本発明者らが発見し、第３４回澱粉研
究懇談会、資料集、２７頁（１９９４年６月）で報告し
ている下記の事実を挙げることができる。通常の澱粉粒
子の内部が、澱粉分子で完全に充填され、空隙、空洞が
存在しないのに反し、適当な条件で湿熱処理された澱粉
粒子の内部には、ほぼ中心部に澱粉粒子の直径の約２分
の１以上の大きさの直径を持つ真球状の中空部が存在す
ることである。この中空部の空間は目的物の担持にとっ
てきわめて有利なものである。従って、澱粉分解酵素を
作用させ、澱粉粒子の表面から中空部にまで到達する孔
を造り、孔部を経て目的物質を粒子の中空部にまで導く
ことにより、孔部及び中空部に効率よく大量に充填する
ことができる。Furthermore, as an advantage of using the heat-moisture treated starch particles, the present inventors have discovered and reported it in the 34th Starch Research Conference, Data Book, page 27 (June 1994). The following facts can be mentioned. While the inside of normal starch particles is completely filled with starch molecules and there are no voids or cavities, the inside of starch particles that have been heat-moisture treated under appropriate conditions is That is, there is a hollow portion having a spherical shape with a diameter of about one half or more. The space of the hollow portion is extremely advantageous for supporting the target object. Therefore, a starch-degrading enzyme acts to form pores that reach the hollow portion from the surface of the starch particles, and the target substance is guided to the hollow portions of the particles through the pores, so that the pores and the hollow portions can be efficiently mass-produced. Can be filled.
【００１１】更に、本発明者らは、湿熱処理澱粉粒子
は、内部が空洞化した分だけ、外側の構造が強化されて
いることも見出している。例えば、湿熱処理されたコー
ンスターチの場合、通常、水中、１００℃、強い撹拌下
に数１０分の加熱により、やや膨潤するが、崩壊、糊化
することはない。一方、未処理のコーンスターチでは、
９５℃、２０分の加熱により容易に膨潤、糊化するほど
澱粉粒子は脆い。このような澱粉粒子の欠点を改良する
ため、特開平１−１５９０４７では、エピクロロヒドリ
ン、トリメタリン酸ナトリウムなどで架橋し粒子構造の
強化を計っている。Furthermore, the present inventors have also found that the moisture-heat-treated starch particles have the outer structure strengthened by the amount of the hollowed inside. For example, in the case of corn starch that has been heat-moisture treated, it usually swells slightly in water for several tens of minutes under strong stirring at 100 ° C., but does not disintegrate or gelatinize. On the other hand, in untreated cornstarch,
The starch particles are so brittle that they are easily swollen and gelatinized by heating at 95 ° C. for 20 minutes. In order to improve such a defect of the starch particles, JP-A-1-1549047 attempts to strengthen the particle structure by crosslinking with epichlorohydrin, sodium trimetaphosphate and the like.
【００１２】しかしこれらの薬品は人体に対する安全性
に問題があり好ましくない。他方、湿熱処理澱粉は、水
と熱のみの処理で得られる、天然物と同様な澱粉であ
り、その上、優れた耐熱性、機械耐性を備えている。従
って、湿熱処理澱粉粒子から多孔性担体を製造し、目的
物質を担持さすことは、きわめて有意義なことである。However, these chemicals are not preferable because they have a problem in safety for human body. On the other hand, heat-moisture treated starch is a starch similar to a natural product obtained by treatment with only water and heat, and further has excellent heat resistance and mechanical resistance. Therefore, it is extremely significant to produce a porous carrier from the heat-moisture treated starch particles and carry the target substance.
【００１３】湿熱処理澱粉粒子は、熱的並びに機械的特
性が改善されている反面において、澱粉分解性酵素に対
する消化性は向上している。例えば、１２５℃、３０
分、水分２５％で湿熱処理した澱粉のα-アミラーゼ消
化性は、スピターゼＬＨを用い、４０℃、２時間反応
後、７０％であるのに対し、未処理のコーンスターチ
は、同一条件で６％の消化性しか示さなかった。湿熱処
理澱粉粒子におけるこのようなアミラーゼ消化性の飛躍
的向上は、生澱粉を用いる従来法では、生澱粉分解酵素
しか使用が許されなかったのに反し、すべての澱粉分解
性酵素の使用が可能であり、酵素の使用量も削減するこ
とができ工業上きわめて有利である。更に、湿熱処理澱
粉粒子の有利な点は、既に述べたように、粒子の外殻構
造が強化されている分だけ、内部は中空部以外の部分も
脆くなっているため、酵素による分解も起こり易く、粒
子内部の中空部体積は増加し易い。結果として、粒子表
面には少ない数の小さい孔を造り、粒子の外殻構造を強
固に保ったままで、粒子内部の有効保持体積を増加さす
ことができる。The heat-moisture treated starch particles have improved thermal and mechanical properties, but on the other hand have improved digestibility to starch degrading enzymes. For example, 125 ℃, 30
The α-amylase digestibility of starch subjected to heat-moisture treatment with water content of 25% is 70% after reaction for 2 hours at 40 ° C using spitase LH, whereas untreated cornstarch is 6% under the same conditions. It showed only digestibility. Such a dramatic improvement in the digestibility of amylase in heat-moisture treated starch particles allows the use of all starch degrading enzymes, whereas the conventional method using raw starch only allowed the use of raw starch degrading enzymes. Therefore, the amount of enzyme used can be reduced, which is extremely advantageous industrially. Further, the advantage of the heat-moisture treated starch particles is that, as already described, the outer shell structure of the particles is strengthened, so that the inside is also fragile in parts other than the hollow part, so that decomposition by enzymes also occurs. It is easy to increase the volume of the hollow part inside the particles. As a result, a small number of small holes are formed on the surface of the particle, and the effective holding volume inside the particle can be increased while maintaining the outer shell structure of the particle firmly.
【００１４】本発明で使用する澱粉の種類については、
特に制限はなく、通常の澱粉例えばコーンスターチ、ハ
イアミロースコーンスターチ、馬鈴薯澱粉、小麦澱粉、
米澱粉などが挙げられる。Regarding the types of starch used in the present invention,
There is no particular limitation, and normal starch such as corn starch, high amylose corn starch, potato starch, wheat starch,
Examples include rice starch.
【００１５】本発明で使用する湿熱処理条件について
は、特に制限はないが、通常、温度９０から１５０℃、
水分１５から４０％、時間１０分から１５時間の範囲で
澱粉を処理する。処理条件が弱い場合には、内部の中空
部が形成できないか、できてもその体積が小さい。従っ
て、澱粉の種類を考慮した上で、十分大きな中空のでき
る条件を選ぶことが肝要である。The wet heat treatment conditions used in the present invention are not particularly limited, but usually, a temperature of 90 to 150 ° C.,
The starch is treated with a water content of 15 to 40% and a time of 10 minutes to 15 hours. When the treatment conditions are weak, the internal hollow portion cannot be formed, or even if it is formed, its volume is small. Therefore, it is important to consider the type of starch and to select the conditions that allow a sufficiently large hollow.
【００１６】本発明に用いる澱粉分解酵素としては、湿
熱処理澱粉の酵素消化性は格段に向上しているので、上
記のように生澱粉分解酵素に限定されることなく、通常
のα-アミラーゼ、グルコアミラーゼなど澱粉分解酵素
のいずれもが使用できる。As the starch-degrading enzyme used in the present invention, since the enzyme digestibility of heat-moisture treated starch is remarkably improved, it is not limited to the raw starch-degrading enzyme as described above, but a normal α-amylase, Any starch degrading enzyme such as glucoamylase can be used.
【００１７】本発明の中空多孔性担体に目的物質を担持
させる方法は、特に制限されるものではないが、目的物
質が液体の場合には、中空多孔性担体に含浸、混合して
担持させる。固体の場合には、粉末にして混合後、ボー
ルミル、ハイブリダイザー（商品名：（株）奈良機械製
作所製）などのような機械的方法で担持させることがで
きる。また、溶媒に溶解し、吸収後、溶媒を蒸発乾燥
し、担持させる方法などがある。The method of supporting the target substance on the hollow porous carrier of the present invention is not particularly limited, but when the target substance is a liquid, it is impregnated into the hollow porous carrier, mixed and supported. In the case of a solid, it can be supported by a mechanical method such as a ball mill and a hybridizer (trade name: manufactured by Nara Machinery Co., Ltd.) after being mixed into powder. Further, there is a method of dissolving in a solvent, absorbing the solvent, and then evaporating and drying the solvent to carry it.
【００１８】更に、目的物質を担持した担体を、適当な
コーティング材で被覆し安定化することもできる。コー
ティング材としては、特に制限はなく通常のコーティン
グ材が用いられるが、例えば、蛋白、多糖類、天然樹脂
などが例示される。Further, the carrier carrying the target substance can be coated with a suitable coating material to be stabilized. The coating material is not particularly limited and a common coating material is used, and examples thereof include proteins, polysaccharides and natural resins.
【００１９】[0019]
【実施例】次に実施例を挙げて本発明を詳しく説明する
が、本発明はこれらの実施例にのみ制限されるものでは
ない。EXAMPLES The present invention will now be described in detail with reference to examples, but the present invention is not limited to these examples.
【００２０】実施例１ 中空部を有する湿熱処理コーンスターチ粒子の作成 コーンスターチ１０００gを２リットルの耐圧反応層に
充填し、撹拌下に真空ポンプで３０mmHgまで減圧にし、
ついで過熱スチームを導入し、温度１２５℃で６０分間
加熱後、再度１００mmHgまで減圧にし冷却する。得られ
た湿熱処理澱粉粒子をパラフィンワックスで固定し、マ
イナス４０℃でマイクロトームにより切断し、走査電子
顕微鏡で観察した結果、中心部に澱粉粒子の直径の約２
分の１の直径の真球状の中空部が認められた。また、本
方法で得られた湿熱処理澱粉は９５℃、３０分以上の撹
拌下の加熱においても、粒子の崩壊、糊化は認められな
かった。 Example 1 Preparation of wet heat-treated cornstarch particles having a hollow portion 1000 g of cornstarch was filled in a pressure resistant reaction layer of 2 liters, and the pressure was reduced to 30 mmHg with a vacuum pump while stirring,
Then, superheated steam is introduced, and after heating at a temperature of 125 ° C. for 60 minutes, the pressure is reduced again to 100 mmHg and cooled. The obtained heat-moisture treated starch particles were fixed with paraffin wax, cut with a microtome at -40 ° C, and observed by a scanning electron microscope. As a result, the diameter of the starch particles was about 2
A true spherical hollow portion having a diameter of one-half the diameter was observed. Further, the heat-moisture treated starch obtained by this method was not disintegrated or gelatinized even when heated at 95 ° C. for 30 minutes or more with stirring.
【００２１】実施例２ α-アミラーゼによる多孔化 実施例１で得られた中空部を有する湿熱処理コーンスタ
ーチ粒子を、以下の条件で酵素分解した。湿熱処理コー
ンスターチ濃度０．４％、ＢＬＡ（長瀬産業（株）製結
晶細菌液化型アミラーゼ）０．００２％、酢酸緩衝液
０．０２M(pH ４．８）、温度３５℃、２４時間、撹拌
下に反応させた。酵素を失活後、濾過、水洗、乾燥して
中空多孔体を得た。顕微鏡観察により、澱粉粒子１個あ
たり数１０個以上の孔が認められた。フェノール−硫酸
法によって測定した可溶化率は５０％であった。 Example 2 Porosification with α-amylase The wet heat-treated corn starch particles having a hollow portion obtained in Example 1 were enzymatically decomposed under the following conditions. Heat-moisture treatment Corn starch concentration 0.4%, BLA (Nagase Sangyo Co., Ltd. crystalline bacterium liquefied amylase) 0.002%, acetate buffer 0.02M (pH 4.8), temperature 35 ° C, 24 hours, with stirring To react. After deactivating the enzyme, it was filtered, washed with water and dried to obtain a hollow porous body. Microscopic observation revealed several tens or more holes per starch particle. The solubilization rate measured by the phenol-sulfuric acid method was 50%.
【００２２】実施例３ ペパーミントオイルの中空多孔性担体への担持 実施例２で得られた中空多孔性担体１００部に対し十分
に乾燥した条件下で、ペパーミントオイル１００部を加
え、１０分間室温で撹拌し、ペパーミントオイルを中空
多孔性担体へ担持した製剤を得た。なお、本担体へ担持
できる目的物質は、ペパーミントオイルに限られず、医
薬、農薬、肥料なども担持が可能である。安定保持時間
も数か月以上と長く、十分に実用用途へ適応できるもの
であった。 Example 3 Support of Peppermint Oil on Hollow Porous Carrier 100 parts of the hollow porous carrier obtained in Example 2 was added to 100 parts of peppermint oil under sufficiently dry conditions, and at room temperature for 10 minutes. The mixture was stirred to obtain a preparation in which peppermint oil was supported on a hollow porous carrier. The target substance that can be loaded on the carrier is not limited to peppermint oil, but can be loaded on drugs, agricultural chemicals, fertilizers, and the like. The stable holding time was as long as several months or more, and it was sufficiently adaptable to practical use.
【００２３】実施例４ 大豆油の中空多孔性担体への担持 実施例２で得られた中空多孔性担体１００部に対し十分
に乾燥した条件下で、大豆油７００部を加え、１０分間
室温で撹拌し、大豆油を中空多孔性担体へ担持した製剤
を得た。 Example 4 Support of Soybean Oil on Hollow Porous Carrier 700 parts of soybean oil was added to 100 parts of the hollow porous carrier obtained in Example 2 under sufficiently dry conditions, and the mixture was kept at room temperature for 10 minutes. After stirring, a soybean oil-supported hollow porous carrier was obtained.
【００２４】実施例５ 中空部を有する湿熱処理馬鈴薯澱粉粒子の作成 馬鈴薯澱粉１０００gを２ の耐圧反応層に充填し、撹
拌下に真空ポンプで６０mmHgまで減圧にし、ついで過熱
スチームを導入し、温度１３０℃、水分２５％で６０分
間加熱後、再度１００mmHgまで減圧し冷却する。得られ
た湿熱処理澱粉粒子の切断面の走査電子顕微鏡写真は、
中心部に澱粉粒子の直径の約２分の１の直径の真球状の
中空部を示した。 Example 5 Preparation of moist-heated potato starch particles having a hollow portion 1000 g of potato starch was filled in 2 pressure-resistant reaction layers, the pressure was reduced to 60 mmHg with a vacuum pump under stirring, and then superheated steam was introduced to bring the temperature to 130. After heating for 60 minutes at 25 ° C and a water content of 25%, the pressure is reduced again to 100 mmHg and cooled. The scanning electron micrograph of the cut surface of the obtained heat-moisture treated starch particles is
In the center, there was shown a spherical hollow portion having a diameter of about ½ of the diameter of starch particles.
【００２５】実施例６ グルコアミラーゼによる多孔化 実施例５で得られた中空部を有する湿熱処理馬鈴薯澱粉
粒子を、実施例２と同様の条件でグルコアミラーゼ（天
野製薬株式会社、グルクザイムＡＦ６）により分解し
た。但し、反応時間は１４４時間、撹拌下に行った。酵
素を失活後、濾過、水洗、乾燥して中空多孔体を得た。
顕微鏡観察により、澱粉粒子には無数の孔が認められ
た。フェノール−硫酸法によって測定した可溶化率は４
５％であった。 Example 6 Porosification by Glucoamylase The moist heat-treated potato starch particles having a hollow portion obtained in Example 5 were decomposed by glucoamylase (Amano Pharmaceutical Co., Ltd., Gluczyme AF6) under the same conditions as in Example 2. did. However, the reaction time was 144 hours, and the reaction was performed with stirring. After deactivating the enzyme, it was filtered, washed with water and dried to obtain a hollow porous body.
Microscopic observation revealed numerous pores in the starch particles. The solubilization rate measured by the phenol-sulfuric acid method is 4
5%.
【００２６】実施例７ 実施例６で得られた中空多孔性担体１００部に対し十分
に乾燥した条件下で、ペパーミントオイル８０部を加
え、１０分間室温で撹拌し、ペパーミントオイルを中空
多孔性担体へ担持した製剤を得た。 Example 7 To 100 parts of the hollow porous carrier obtained in Example 6, 80 parts of peppermint oil was added under a sufficiently dried condition, and the mixture was stirred at room temperature for 10 minutes to add peppermint oil to the hollow porous carrier. A formulation supported on
【００２７】[0027]
【発明の効果】本発明の湿熱処理澱粉粒子を用いた中空
多孔性担体は、人体に対し安全で、しかも担持容量が大
きく、熱的、機械的性質にも優れている。本中空多孔性
担体を用いる目的物質の担持方法は簡単、高効率であ
る。その製剤は安定し、効力の持続性、放出の制御性に
優れている。INDUSTRIAL APPLICABILITY The hollow porous carrier using the heat-moisture treated starch particles of the present invention is safe for the human body, has a large carrying capacity, and is excellent in thermal and mechanical properties. The method of supporting the target substance using the present hollow porous carrier is simple and highly efficient. The formulation is stable, has long-lasting efficacy and excellent controlled release.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ１２Ｐ 19/20 7432−4Ｂ // Ａ０１Ｎ 25/10 Ａ６１Ｋ 47/36 Ｂ Ｃ Ｃ０５Ｇ 3/00 １０３ 7537−4Ｈ (72)発明者 蔵橋 嘉樹 大阪府大阪市阿倍野区丸山通１−５−29─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 6 Identification code Internal reference number FI technical display location C12P 19/20 7432-4B // A01N 25/10 A61K 47/36 B C C05G 3/00 103 7537 -4H (72) Inventor Yoshiki Kurahashi 1-5-29 Maruyama-dori, Abeno-ku, Osaka-shi, Osaka
Claims (1)
澱粉の中空粒子を得る工程；および(b)得られる中空湿
熱澱粉粒子に澱粉分解能を有する酵素を作用させて多孔
性ととする工程；を包含する中空多孔性担体の製造方
法。1. A step of (a) obtaining a hollow starch particle by subjecting the starch particle to wet heat treatment; and (b) a step of causing an enzyme having a starch decomposing activity to act on the obtained hollow wet heat starch particle to make it porous. A method for producing a hollow porous carrier, including:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29097994A JP3638645B2 (en) | 1994-11-25 | 1994-11-25 | Production and use of hollow porous carrier using starch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29097994A JP3638645B2 (en) | 1994-11-25 | 1994-11-25 | Production and use of hollow porous carrier using starch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08143602A true JPH08143602A (en) | 1996-06-04 |
| JP3638645B2 JP3638645B2 (en) | 2005-04-13 |
Family
ID=17762900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP29097994A Expired - Lifetime JP3638645B2 (en) | 1994-11-25 | 1994-11-25 | Production and use of hollow porous carrier using starch |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3638645B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005005484A1 (en) * | 2003-07-11 | 2005-01-20 | Asahi Kasei Chemicals Corporation | Functional starch powder |
| JP2007153882A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid formulation to control elution of active ingredient to sustained-release |
| JP2007153886A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid formulation to control elution of active ingredient to sustained-release |
| JP2007153884A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Multi-layered solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2007153883A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2007153885A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Nucleated solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2008189702A (en) * | 2007-01-31 | 2008-08-21 | Daio Paper Corp | Porous starch, aromatic composition, coated paper product and method for coating aromatic composition |
| CN105384831A (en) * | 2015-12-13 | 2016-03-09 | 熊小芳 | Preparation method of crosslinked starch containing 3-chloro-1,2-epoxypropane |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3853335A1 (en) * | 2018-09-21 | 2021-07-28 | The Procter & Gamble Company | Active agent-containing matrix particles and processes for making same |
-
1994
- 1994-11-25 JP JP29097994A patent/JP3638645B2/en not_active Expired - Lifetime
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005005484A1 (en) * | 2003-07-11 | 2005-01-20 | Asahi Kasei Chemicals Corporation | Functional starch powder |
| JPWO2005005484A1 (en) * | 2003-07-11 | 2006-10-26 | 旭化成ケミカルズ株式会社 | Functional starch powder |
| JP4959191B2 (en) * | 2003-07-11 | 2012-06-20 | 旭化成ケミカルズ株式会社 | Functional starch powder |
| US9101155B2 (en) | 2003-07-11 | 2015-08-11 | Asahi Kasei Chemicals Corporation | Functional starch powder |
| JP2007153882A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid formulation to control elution of active ingredient to sustained-release |
| JP2007153886A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid formulation to control elution of active ingredient to sustained-release |
| JP2007153884A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Multi-layered solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2007153883A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2007153885A (en) * | 2005-11-11 | 2007-06-21 | Asahi Kasei Chemicals Corp | Nucleated solid pharmaceutical preparation controlling elution of active ingredient to sustained release property |
| JP2008189702A (en) * | 2007-01-31 | 2008-08-21 | Daio Paper Corp | Porous starch, aromatic composition, coated paper product and method for coating aromatic composition |
| CN105384831A (en) * | 2015-12-13 | 2016-03-09 | 熊小芳 | Preparation method of crosslinked starch containing 3-chloro-1,2-epoxypropane |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3638645B2 (en) | 2005-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5489401A (en) | Method for entrapment of active materials in chitosan | |
| Campos et al. | Polysaccharides as safer release systems for agrochemicals | |
| JP5048690B2 (en) | Agricultural treatment agent with delayed effect, especially for seed germination and plant development | |
| EP1458472B1 (en) | Method of preparing functional microcapsule incorporating silver nanoparticles | |
| US3242051A (en) | Coating by phase separation | |
| Denkbaş et al. | Norfloxacin-loaded chitosan sponges as wound dressing material | |
| EP1473992A1 (en) | A sustained-releasing agricultural chemical and the method for producing thereof | |
| JPH0310372B2 (en) | ||
| Riseh et al. | Increasing the efficiency of agricultural fertilizers using cellulose nanofibrils: a review | |
| JPH08143602A (en) | Production of hollow and porous carrier using starch and its use | |
| RU2008120633A (en) | ACTIVE SUBSTANCE NANOPARTICLE COMPOSITIONS | |
| Franca et al. | Spray-dried cellulose nanofibrils microparticles as a vehicle for enhanced efficiency fertilizers | |
| Vinceković et al. | Release of Trichoderma viride spores from microcapsules simultaneously loaded with chemical and biological agents | |
| JPH0716409B2 (en) | Method of immobilizing enzyme | |
| EP2740532A1 (en) | Method of producing a starch-containing material | |
| Ma et al. | Fabrication of polydopamine reduced CuO nanoparticle–alginate composite nanogels for management of Pseudomonas synringae pv. tabaci in tobacco | |
| Guo et al. | Enzyme and pH dual-responsive CAP@ CS@ PLGA microcapsules for controlled release antibacterial application | |
| HU214917B (en) | Granular formulation containing microorganisms, a process for the preparation and use thereof | |
| KR100654233B1 (en) | Preparation of microcapsules and prolonged release microcapsules thereby | |
| CN104801247A (en) | Controlled release type yeast cell microcapsule product and preparation method thereof | |
| NO127792B (en) | ||
| CN111700065B (en) | Avermectin nano slow-release body and preparation method and application thereof | |
| Gumus et al. | Drug loading of tannic acid crosslinked hydroxyapatite/gelatin composites via spray dryer and kinetic studies | |
| Zhang et al. | Immobilization of β-galactosidase on tamarind gum and chitosan composite microspheres | |
| SU1112056A1 (en) | Method for preparing microincapsulated lipase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20041221 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20050112 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080121 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090121 Year of fee payment: 4 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100121 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100121 Year of fee payment: 5 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313117 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100121 Year of fee payment: 5 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100121 Year of fee payment: 5 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110121 Year of fee payment: 6 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20110121 Year of fee payment: 6 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20120121 Year of fee payment: 7 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130121 Year of fee payment: 8 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130121 Year of fee payment: 8 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140121 Year of fee payment: 9 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |