JPH08133966A - Warm-heating plaster - Google Patents

Abstract

PURPOSE: To obtain a warm-heating plaster free from the thermal softening of a plaster layer and capable of being repeatedly used at a same lesion. CONSTITUTION: This warm-heating plaster has a heat generator composition layer and a plaster layer containing a plaster base agent comprising polyisobutylene, butyl rubber or styrene-butadiene rubber, a plaster-modifying agent comprising a modified copolymer produced by graft-polymerizing methyl methacrylate to styrene-isoprene-styrene block copolymer, styrene-butadiene- styrene block copolymer or their copolymer, a rosin ester resin, a softening agent, a highly water-absorbing polymer and silicon dioxide.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a thermal patch for direct application to human skin, and more specifically, the heat of a heating element composition laminated in the patch is The present invention relates to a heat transfer patch that is transferred to the skin just below the application site through the body layer, and the heat is maintained for a long time in a safe temperature range where low-temperature burns do not occur, thereby improving blood circulation at the application site.

[0002]

2. Description of the Related Art Hyperthermia is generally used for stiff shoulders, low back pain, arthralgia, myalgia, etc. For a long time, this hyperthermia includes hot bags, liquid paraffin hot baths, and hot pepper extract. It was used in patches and pocket furnaces with red stimulant added. However, the temperature control of these is unstable, so the skin may get low-temperature burns,
Alternatively, there is a defect that the temperature is too low to obtain a sufficient hot compress effect. For these reasons, iron powder,
A thermal patch has been proposed in which a layer of a heating element composition composed of a reaction accelerator, water, carbon black, etc., and a layer of an aqueous type plaster or a layer of an oily type plaster are laminated (Japanese Patent Laid-Open No. Hei 10 (1999) -242242). No. 1-297059, JP-A-3-173815
No.).

[0003]

In the conventional hot-paste patch having a water-based plaster, the adhesive strength of the plaster layer is poor. Therefore, in order to maintain the adhesive layer on the affected area, a separate adhesive tape or the like must be used. In addition to the fact that the plaster layer contains a large amount of water, it has a drawback that a strong cold sensation is perceived when it is applied to the skin. On the other hand, the conventional heat-and-paste patch of which the plaster is oily has a strong adhesive force, so that the stratum corneum of the skin is easily damaged at the time of peeling, and there is a problem that repeated application to the same site becomes difficult, resulting in good thermal fluidity. The hot patch using a plaster has a disadvantage that the plaster exudes from the end of the patch during use.

[0004]

The present invention is a combination of a plaster base comprising a special synthetic polymer compound and a plaster modifier,
A composition containing silicon dioxide, a rosin ester resin, a softening agent, and a super absorbent polymer to form a plaster layer of a heat-and-paste patch allows the conventional water-based and oil-based heat-paste application. The purpose is to eliminate the drawbacks pointed out in the drug all at once. That is, the thermal patch according to the present invention has at least 1 selected from the following group A:
Type plaster base and at least 1 selected from the following group B
Seed plaster modifier, rosin ester resin, softener,
A plaster layer made of a plaster composition containing a superabsorbent polymer and silicon dioxide is provided on one surface of a flexible sheet-shaped support, and the other side of the sheet-shaped support is ventilated. The heat-generating composition is heated in the presence of air and is enclosed in a flat packaging bag having no opening formed with the heat-resistant sheet. Group A: polyisobutylene, butyl rubber and styrene / butadiene rubber Group B: styrene / isoprene / styrene block copolymer (a), styrene / butadiene / styrene block copolymer (b) and block copolymer (a) or ( Modified copolymer obtained by graft polymerization of b) with methyl methacrylate

In the present invention, one or more of polyisobutylene, butyl rubber and styrene-butadiene rubber are used as a plaster base, and the compounding amount thereof is 1 of that of the plaster composition.
It is selected in the range of 0 to 35% by weight. Examples of polyisobutylene include, for example, Vistanex 80, 100, 120,
For example, JSR Butyl 268 (made by Japan Synthetic Rubber) can be used as the butyl rubber. As the styrene-butadiene rubber, for example, SBR1013H, SBR1502 (made by Japan Synthetic Rubber) or the like can be used. The block copolymer or modified copolymer thereof used as a paste modifier contains a segment (styrene) consisting of a crystalline phase and a segment (isoprene or butadiene) consisting of an amorphous phase, and is heated. It is a thermoplastic synthetic rubber that exhibits fluidity and hardens into a semi-solid when cooled to exhibit viscoelasticity. Styrene, isoprene, abbreviated as SIS below
Styrene block copolymer (a) is Califlex T
R1107 and TR1112 are trade names (manufactured by Shell Kagaku), and the styrene-butadiene-styrene block copolymer (b) abbreviated as SBS is Califlex TR1101,
It is available from the market under the trade name TR1102 (same as above). The modified copolymer used as the plaster modifier in the present invention is one obtained by graft-polymerizing methyl methacrylate (MMA) to the above-mentioned SIS or SBS by a radiation polymerization method, and these are hereinafter referred to as SIS-MMA and SB
It is abbreviated as S-MMA. Generally, these modified copolymers may be those obtained by graft-polymerizing MMA in an amount of 10 to 5 parts by weight with 90 to 95 parts by weight of SIS or SBS. The compounding amount of the plaster modifier is selected in the range of 3 to 25% by weight of the plaster composition.

The rosin ester resin functions as a tackifier, and it is preferable to select a resin having a high softening point which is particularly excellent in heat stability. For example, ester gum HG which is one of hydrogenated rosin ester resins is selected. (Arakawa Chemical Industries) is suitable as the rosin ester resin of the present invention. The content of the rosin ester resin is 5 to 30% by weight of the plaster composition.
Is in the range. As the softening agent, conventionally used process oil, liquid paraffin, etc. are used, and the compounding amount thereof is selected within the range of 5 to 30% by weight of the plaster composition.
The high water content polymer functions as a sweat absorbing action, and it is available from the market under the trade names of ALASORP 800 F (Arakawa Chemical Co., Ltd.) and KI gel-201 K-F2 (Kuraray Co., Ltd.). High hydrous polymers can be used. The compounding amount of the high hydrous polymer is 0.5 of the plaster composition.
Is in the range of up to 5% by weight. Silicon dioxide prevents excessive softening when the plaster layer is heated. Silicon dioxide commercially available under the trade name of Aerosil (manufactured by Nippon Aerosil Co., Ltd.) is especially known as Aerosil 200V. Aerosil 380 is preferred. The compounding amount of silicon dioxide is selected in the range of 0.1 to 5% by weight of the plaster composition. Fillers such as zinc white, light calcium carbonate, and titanium dioxide may be added to the plaster composition of the present invention as needed.

The plaster layer of the thermal patch according to the present invention is formed by applying and spreading the above plaster composition on one surface of a flexible sheet-like support. A heating element composition layer is provided on the other surface of the support, and a breathable sheet is laminated on the heating element composition layer. The heating element composition is capable of heating the plaster layer directly applied to the skin at about 42 ° C., which is known in the art to generate heat in the presence of air and water. Any of the above heating element compositions can be used. Among them, iron powder, reaction accelerators (sodium chloride, potassium chloride, magnesium chloride,
It is preferable to use a chemically exothermic cairo type heating element composition prepared by blending iron chloride, etc.), water, a water retention agent (silica gel, alumina, highly water-containing acrylic polymer, etc.), carbon black and the like.

The thermal patch of the present invention constituted as described above is applied to an affected area causing neuralgia, muscle aches, muscular stiffness, stiff shoulders, back pain, muscle fatigue, joint pain, poor blood circulation, gastrointestinal dysfunction, etc. By doing so, an excellent therapeutic effect due to heat is exhibited. In this case, blending ceramics in the plaster layer enables a therapeutic effect by far infrared rays. Furthermore, when an analgesic and anti-inflammatory drug is added to the plaster layer, the medicinal component is percutaneously absorbed by heat, so that a thermal patch having an analgesic and anti-inflammatory effect can be obtained. Examples of the medicinal component in this case include salicylic acid derivatives (methyl salicylate, glycol salicylate), indomethacin, ketoprofen, piroxicam, felbinac, flurbiprofen, and one or more of them form a plaster layer. The content of the plaster composition is 0.1 to 15% by weight. In addition, the paste layer of the heat-sensitive adhesive patch according to the present invention has a monoterpene-based essential oil component (mint oil, l) for the purpose of perceiving a refreshing sensation when the patch is used and assisting percutaneous absorption of the medicinal component. -Menthol, camphor, eucalyptus oil) can be added and these are added in the range of 0.5 to 15% by weight of the plaster composition which is the precursor of the plaster layer. The heat-sensitive adhesive patch of the present invention has a relationship that a special plaster base and a plaster modifier are blended in the plaster layer that is in direct contact with the skin. There is no need to worry about the appearance of symptoms, and the adhesive strength is moderate, so even if it is repeatedly applied to the same site, it does not damage the skin.

[0009]

[Examples] At the compounding ratios shown in Table 1, plaster bases (polyisobutylene, butyl rubber, polystyrene butadiene rubber) and plaster modifiers (SIS, SBS, SIS-MMA, S)
BS-MMA), a softening agent (liquid paraffin), and silicon dioxide having excellent thermal stability are uniformly kneaded by a conventionally known heating and pressure kneading machine, and rosin resin (ester gum HG),
A highly hydrous polymer (Ara soap 800 F) and vitamin E were added to obtain a kneaded product at a temperature of about 100 ° C. This kneaded product was applied on a film and spread, and then cut into a desired size, and this was integrated with a heating element composition to obtain a thermal patch of the present invention. When this was applied to the skin, the feeling of warmth began to be felt in 2 to 3 minutes after the application, and the optimum warmth was maintained for 7 hours or more, and there were no side effects after use.

[Table 1] Patch No. 1 2 3 4 5 6 component (wt%) butyl rubber 20.0 − − 5.0 10.0 − polyisobutylene − − 30.0 5.0 − 10.0 polystyrene butadiene rubber − 20.0 − 5.0 5.0 5.0 SIS (or SIS-MMA) ) 20.0 − 10.0 25.0 25.0 25.0 SBS (or SBS-MMA) − 20.0 − − − − Liquid paraffin 17.5 17.5 17.5 15.0 15.0 15.0 Silicon dioxide 0.3 0.3 0.3 0.6 0.6 0.6 Ester gum HG 40.0 40.0 40.0 42.0 42.0 42.0 ALASORP 800 F 1.2 1.2 1.2 1.4 1.4 1.4 Vitamin E 1.0 1.0 1.0 1.0 1.0 1.0 1.0

Claims (2)

[Claims] 1. At least one plaster base selected from the following Group A, at least one plaster modifier selected from the following Group B, a rosin ester resin, a softening agent, and A plaster layer composed of a plaster composition containing a water-absorbent polymer and silicon dioxide is provided on one surface of a flexible sheet-shaped support, and the other surface of the sheet-shaped support is breathable. A thermal patch comprising a heating element composition enclosed in a flat wrapping bag formed with a sheet and having no opening. Group A: polyisobutylene, butyl rubber and styrene / butadiene rubber Group B: styrene / isoprene / styrene block copolymer (a), styrene / butadiene / styrene block copolymer (b) and block copolymer (a) or ( Modified copolymer obtained by graft polymerization of b) with methyl methacrylate 2. The thermal patch according to claim 1, wherein the plaster composition further contains a medicinal component.