JPH08117342A - Internal medicine injecting system - Google Patents

Abstract

PURPOSE: To bring about a lasting effect due to daily dosing of a medicine by providing an internal medicine injecting system with a main body including a medicine retaining portion, a medicine discharging portion and faces contacting a patient's gingiva or oral cavity, so as not to bind the patient at all when the medicine is injected. CONSTITUTION: An internal medicine injecting system body 1, which has a shape like a full set of dentures, to be used in injecting a medicine such as nutrient, insulin, or anticancer agent little by little for long hours, comprises an artificial gingiva 2 where artificial dental crowns 3... are arranged, and a medicine retaining portion 6 surrounded by faces 4, 5. In the face 5 a plurality of apertures 7 are formed as medicine discharging portions. When this injecting system 1 is set within a patient's mouth like a full set of dentures, it is fixed so that the patient's gingiva and the inside of the artificial gingiva 2, the upper palate and the face 4 are respectively brought into close contact. And by making the medicine retaining portion 6 discharge a medicine corresponding to an object of a treatment into the mouth little by little, the medicine is absorbed in the body when the patient drink it.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device for gradually and continuously injecting a drug into the body.

[0002]

2. Description of the Related Art When a drug such as a nutritional supplement, insulin, or an anticancer drug is slowly infused into the body over a long period of time, a method by devising a formulation such as encapsulation or solidification of a bulking agent Another method is to use a continuous infusion device such as a syringe with a cylinder pump.

[0003]

With the former method of formulation, which is a conventional method, it is difficult to inject the drug into an appropriate place of the patient, and it is necessary to uniformly control the formulation depending on the drug. However, the drug efficacy may change over time. On the other hand, in the latter method, the patient must install a continuous infusion device outside the body, and no matter how small the device is, the discomfort of a continuous infusion device fixed outside the body must be completely eliminated. I couldn't. What's more, do not break the device or remove it from your body,
Since we had to be careful, there was a problem that during the injection, we could not exercise as we expected, and sometimes it had a serious effect on social life such as work. In addition, the injection of the drug sometimes expands the damage on the blood vessel. Therefore,
An object of the present invention is to provide a drug injecting device that does not restrain the patient at the time of injecting the drug and can administer the drug daily to exert a continuous effect.

[0004]

According to another aspect of the present invention, there is provided a drug injecting device, which comprises a drug holding part, a drug releasing part, and
A body with a surface for contacting the patient's gums or the oral wall is removable. The invention according to claim 2 is characterized in that the main body of the above invention is provided with a fixing aid for fixing the main body to the teeth. The invention of claim 3 is characterized in that a micro pump is provided inside the main body. The invention according to claim 4 is characterized in that the drug holding portion is made of a porous material.

[0005]

The drug gradually released from the drug holding portion of the injection device installed in the patient's mouth is absorbed into the body from the mucous membrane of the mouth or the esophagus via the throat or the mucous membrane of the stomach. This device has a surface that comes into contact with the gingiva of the patient or the inner wall of the mouth, and the body is fixedly installed in close contact with the inside of the mouth.
In addition, the fixing is further strengthened by using a fixing aid for fixing to the teeth. Micropumps within the body accurately control the rate of drug release. When the drug holding part is made of a porous material, the drug is held in the porous part of the drug holding part, and at the same time, is gradually released from this part.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The first embodiment shown in FIGS. It is composed of an artificial gingiva 2 in which artificial dental crowns 3 are arranged and a drug holding portion 6 surrounded by surfaces 4 and 5, and the surface 5 serves as a drug releasing portion.
A drug release hole 7 is formed. When this device 1 is installed in the patient's mouth like a denture, the patient's gingiva and the inside of the artificial gingiva 2 and the upper palate and the surface 4 are in close contact and fixed.
Then, the medicine holding section 6 is filled with medicine according to the purpose of treatment. The retained drug is released into the mouth from the release hole 7 and is absorbed into the body by swallowing. The second embodiment shown in FIG. 3 is the same as the first embodiment except that a part of the surface 4 that comes into close contact with the upper palate is formed of the osmotic membrane 8 and that the surface 5 has no discharge hole. The osmotic membrane 8 forms a drug release portion, and the drug released so as to ooze out therefrom is permeated and absorbed from the mucous membrane of the upper palate and absorbed into the body. In this embodiment, the drug releasing portion is formed of the osmotic membrane 8, but the release hole may be formed as in the first embodiment.

[0007] Depending on whether the drug is absorbed in the mouth or absorbed in the stomach for the purpose of the drug, it may be selected whether the drug releasing portion is closely attached to the mucous membrane of the mouth or opened in the mouth. The rate of drug release can be controlled by the size and number of pores. Further, the drug holding portion 6 may be formed on any part of the main body. 4 and 5
The third embodiment shown in is a drug injection device main body 1 having a shape of a partial denture. An artificial dental crown 3 and an artificial gingiva 2 which are fitted to two places with lower teeth lost due to caries etc. are connected by a bridge fitting 9. As shown in FIG. 6, the artificial gingiva 2 is shaped so as to be placed on a patient's toothless gingiva. Then, the drug holding portion 6 is provided inside the artificial gingiva 2.
, A drug release hole 7 is formed in the artificial dental crown 3, and the bridge metal fitting 9 is aligned with the inner curve of the lower jaw of the patient,
When installed behind the front teeth, it fits snugly and is fixed.
The process of injecting the drug into the body by the device is similar to that in the above-described embodiment, and the drug released from the release hole 7 of the artificial dental crown 3 is absorbed in the mouth or absorbed in the stomach. It is done. Even with the same outer shape as in this embodiment, the drug release hole 7 can be provided in the artificial gingiva 2, and the drug holding portion can be formed in the crown 3 portion.

In the fourth embodiment shown in FIG. 6, a drug holding portion 6 is formed on the artificial dental crown 3, and a micro pump 12 is provided in the middle of the drug releasing hole 7. Whatever the overall shape, the position of the drug holding portion 6, etc.,
With the provision of, it is possible to accurately control the release amount of the drug. The artificial gingiva 2 and the artificial dental crown 3 used in the above embodiments are known ones used when a tooth is lost due to tooth extraction. A fifth embodiment shown in FIG. 7 is a lower denture type injection device main body 1 below, in which the artificial gingiva 2 is made of a porous material having pores 11, and the pores 11 hold a drug holding portion. And also serves as a discharge part, and operates similarly to the first to third embodiments. The sixth embodiment shown in FIGS. 8 and 9 is a type without artificial teeth, and FIG. 8 shows the injection device main body 1 having the drug holding portion 6 surrounded by the surfaces 4 and 5 as the upper palate. It is the figure which looked up from the inside of the installed state, and FIG. 9 is sectional drawing. In addition, 13 and 14 are the crown 13 and the gingiva 14 of the patient himself. The surface 4 is fixed in close contact with the upper palate, and the drug held in the drug holding portion 6 is released from the drug release hole 7 formed in the surface 4 and absorbed in the body.

In a seventh embodiment shown in FIG. 10, the injection device main body 1 of the sixth embodiment is provided with a fixing aid 10.
The main body 1 is securely fixed by hooking the metallic fixing aid 10 on the back teeth of the patient. The injection device main body 1 has a surface that comes into contact with the surface inside the mouth, and can be fixed in the mouth by bringing the surface into close contact and providing a curve that conforms to the shape of the jaw. For more reliable fixing, it is advisable to use a commercially available denture adhesive or use a fixing aid as in the seventh embodiment. Further, if the fixing aid 10 is used for fixing, the overall shape of the main body 1 and the degree of freedom in setting the installation place are increased. If the drug is administered to the human body as described above, the drug in the drug holding portion 6 will naturally disappear, but at that time, the main body 1 is removed from the mouth to replenish the drug. If the capacity of the medicine container 6 is increased, the frequency of medicine replenishment can be reduced, but it is convenient if the medicine replenishment mouth and lid are provided. In addition, it is a device such as a denture that the patient himself can attach and detach by himself, and the medicine can be replenished if necessary, so that the number of hospital visits can be reduced.

Once this drug injecting apparatus is installed, drug administration is continued until the drug holding portion 6 becomes empty. Therefore, the drug will be administered daily, and a sustained effect can be expected. Moreover, since the drug injection device body 1 is completely stored in the mouth as in the embodiment, it is possible to treat the drug administration without affecting daily life such as having no effect on daily eating habits. . The injection device body 1 used in the present invention may be made of any material such as hard or soft resin as long as its safety is confirmed. Further, the medicine to be put in the medicine holding unit 6 may be one encapsulated with a gelatin film, for example. In this case, the gelatin film is melted and passes through the drug releasing part together with the drug. Drug release hole 7
Is for setting the diameter, the number, and the position of the passage in accordance with the type of the medicine to be injected and the injection amount.

[0011]

According to the device for injecting a drug in the body of the present invention,
The patient is not restrained at the time of injecting the drug, and the drug can be administered daily to exert a sustained effect. Therefore, a drug that needs to be infused over a long period of time, which is used for the treatment of chronic diseases, can be infused continuously for a long period of time with a single installation, and even if the drug is infused, it may interfere with social life. There is no such thing. Moreover, since the patient can attach and detach the device and replenish the medicine, the number of hospital visits can be reduced. In particular, for a patient using dentures, which also serves as dentures, there is almost no new discomfort due to mounting of the injection device. Further, by using the fixing aid of the second invention, the injection device main body can be fixed more securely in the mouth. According to the in-vivo drug injection device of the third aspect of the invention, the drug can be positively injected by the micropump, so that the injection amount per unit time can be arbitrarily and accurately controlled.

[Brief description of drawings]

FIG. 1 is a perspective view of a first embodiment.

FIG. 2 is a sectional view taken along the line II-II in FIG.

FIG. 3 is a sectional view of a second embodiment.

FIG. 4 is a perspective view of a third embodiment.

5 is a sectional view taken along line VV of FIG.

FIG. 6 is a partial sectional view of a fourth embodiment.

FIG. 7 is a perspective view of a fifth embodiment.

FIG. 8 is a plan view of the sixth embodiment.

9 is a sectional view taken along line IX-IX in FIG.

FIG. 10 is a plan view of a seventh embodiment.

[Explanation of symbols]

 1 Main Body 4 Surface 6 Drug Retaining Part 7 Drug Release Part 10 Fixing Aid 11 Pore 12 Micro Pump

Claims (4)

[Claims] 1. An injecting device for a drug, wherein a main body including a drug holding part, a drug releasing part, and a surface contacting the gingiva or the inner wall of the mouth of a patient is removable. 2. The drug injecting device according to claim 1, wherein the main body is provided with a fixing aid for fixing the main body to the teeth. 3. The drug injecting device according to claim 1, further comprising a micropump inside the main body. 4. The drug injecting device according to claim 1, wherein the drug holding portion is made of a porous material.