JPH0797306A - Primer composition and curable composition - Google Patents

Abstract

PURPOSE:To obtain a primer composition useful for the restoration of a surface coating material for tooth or the restoration of a restorative dental resin. CONSTITUTION:This primer composition contains (A) a curable composition having a viscosity of 100-30,000cP at 37.5 deg.C and containing a polymerizable monomer having acidic group in the molecule, a polymerizable monomer having hydroxyl group in the molecule and a polymerization initiator, (B) a polymerizable monomer having acidic group in the molecule and (C) an organic solvent.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a primer composition which can be surface-treated on a tooth by a simple operation and a curable composition which can be adhered. More specifically, restoration of surface coating materials such as teeth or PMMA resin,
The present invention relates to a primer composition and a curable composition that are advantageously used for restoration of dental restoration resins such as resin cement and composite resin.

[0002]

2. Description of the Related Art An adhesive material for a tooth substance strongly adheres a tooth substance and a restorative material without a gap, and since it is an operation in an oral cavity, it can be completed in a simple and short time as much as possible. desirable. The following three methods are mainly adopted as the tooth surface treatment method for firmly adhering the resin restoration material to the tooth structure. That is, first, a total etching method was performed in which an aqueous solution of phosphoric acid or citric acid was applied to the surfaces of enamel and dentin at the same time for deashing, followed by washing with water and drying, and secondly a total etching method. Total etching-Dentin primer method in which a primer is further applied to the surface of dentin afterwards and dried, and thirdly, enamel etching-Dentin primer method in which a primer is applied to the remaining dentin after etching only enamel Is.

The first total etching method is effective as a bonding method because it involves steps of applying an etching agent, washing with water and drying, but does not require much labor. However, since the dentinal tubules are largely opened, the subsequent application of the adhesive may cause a great pain to the patient. In addition, the adhesiveness to dentin is often lower than that to enamel, which causes a gap at the interface between dentin and the adhesive to induce secondary caries or pulpitis. The second method is a method in which a primer is further applied to dentin and the dentin is dried in order to compensate for the drawbacks of the first method. Although this has made some improvement, it not only causes more pain to the patient because of the increased number of bonding operations, but also makes the treatment time-consuming.
The third method is to reduce the pain given to the patient,
This is a method in which the primer is applied without opening the dentinal tubule by performing etching only on the enamel. Although the purpose of this method was mostly achieved, it did not solve the problem that the etching agent had to be applied only to the enamel part of the small and complicated cavity, which was difficult to apply separately, and the treatment was time-consuming. . This is a problem that occurs because there is no primer that can treat enamel and dentin at the same time and give high adhesion.

On the other hand, in order to strongly adhere the restorative material to the tooth structure, it is considered important to sufficiently penetrate the adhesive material into the tooth structure and surely cure it. Various diffusion-promoting monomers have been proposed for diffusing an adhesive material component into the tooth structure, and a tooth-adhesive composition containing the same has been proposed. Further, as a tooth surface treatment for facilitating the penetration of the adhesive material, an application method such as etching and a composition such as a primer have been proposed. Under the present circumstances, these adhesive materials and primer compositions are set to have relatively low viscosities so that they can be easily penetrated into the dentinal tissue.

Further, in order to seal the adhesive interface with no space, a filler having a higher viscosity than that of the adhesive material (referred to as low-viscosity filler or low-viscosity resin) has been proposed (Japanese Patent Laid-Open No. 63-162705). (See Japanese Patent Publication). The low viscosity filler is
Since it has high viscosity and is sticky, it is effective for improving the sealing property to the adhesive interface, but on the other hand, it has very poor adhesion to the tooth structure due to its low permeability to the tooth structure. Used in combination with materials.

In the prior art, in order to strongly bond the restorative material to the tooth structure without any gaps, the adhesive material is applied to the tooth surface that has been etched and / or primed and cured, and a low viscosity filler is further applied. It has been considered that the most preferable adhesive technique is to cover the tooth surface with, and then fill with a restoration filler such as a composite resin. On the other hand, however, the time required for dental treatment is extremely long, which causes great pain to the patient, and it is a laborious work for the dentist.

With respect to the adhesive performance, many adhesives and adhesive methods have been proposed and improved so far. However, even though the experimental adhesion performances of these proposals are extremely excellent, the performances are not sufficiently exhibited in actual clinical evaluations, which is not satisfactory. It can be inferred that this is due to the difference between the adhesive surface used in the experimental adhesive performance test and the actual adhesive surface in the oral cavity, and in particular, the difference in the dry state of the adhesive surface is pointed out.

[0008] Therefore, in the prior art, when the restorative material is strongly adhered to the tooth structure without any gap, it causes a great deal of pain and labor to the doctor and the patient for a long time, and furthermore, the adhesive material has a sufficiently dry state. In the oral cavity where it is not possible to maintain the adhesiveness, there are serious problems such as insufficient adhesive performance.

[0009]

SUMMARY OF THE INVENTION It is, therefore, an object of the present invention to provide a primer composition which is a tooth surface treatment agent capable of surface-treating a tooth by a simple adhesion operation.

Another object of the present invention is that the enamel and dentin can be surface-treated at the same time, and there is no need to carry out operations such as washing with water, and therefore the dentist's treatment can be reduced. And it is providing the primer composition which can eliminate the pain to a patient.

Still another object of the present invention is to provide a curable composition and a method of using which can be adhered to teeth, particularly dentin, by a simple adhesion operation and can be adhered without a gap even in a wet condition.

Still another object of the present invention is that it has adhesiveness to dentin without acid etching or primer treatment, and at the same time, since the adhesive itself has high viscosity and stickiness, a gap is generated at the adhesive interface. (EN) It is intended to provide a curable composition which has an advantage of not being prevented and which can be adhered without a gap by a simple operation.

Further objects and advantages of the present invention will be apparent from the following description.

[0014]

The above objects and advantages of the present invention are achieved by the primer composition and curable composition of the present invention described in detail below. First, the curable composition will be described.

The curable composition provided by the present invention comprises:
And (A1) (a) a polymerizable monomer having an acidic group in the molecule,
(B) a polymerizable monomer having a hydroxyl group in the molecule and (c) a polymerization initiator, and (a)
Based on the total weight of the components (b) and (c),
The component (a) is 1 to 50% by weight, and the component (b) is 1 to 98%.
99% by weight and (c) component occupy 0.01 to 50% by weight, and (B) the viscosity at 37.5 ° C. is 100 to 30,000 c.
It is in the range of P, It is a curable composition characterized by the above-mentioned.

The curable composition of the present invention simultaneously has wettability, dentin reactivity and dentinal permeability with respect to the surface of the dentin, which contains a large amount of water, and has no gaps in the hard tissue of the living body. Can be easily attached.

When the curable composition of the present invention is used for dentin, particularly dentin, it is preferable to directly contact it with moist dentin in consideration of safety to pulp.
In addition, the tooth surface may be treated with an etching agent such as a phosphoric acid aqueous solution, a citric acid aqueous solution or an EDTA aqueous solution which may contain a metal salt according to the situation before use.

The polymerizable monomer (a) containing an acidic group in the molecule in the curable composition of the present invention has, as a polymerizable group, a (meth) acryloyl group, a styryl group, a vinyl group, an allyl group, etc. A radically polymerizable unsaturated group having a can be mentioned. The polymerizable monomer (a) may contain at least one group selected from the above-mentioned polymerizable groups in one molecule (all the polymerizable groups in the polymerizable monomer described below are It should be interpreted in the same way).

In the curable composition of the present invention, as described above, the component (a) is a polymerizable monomer containing an acidic group in its molecule. Examples of the acidic group in the polymerizable monomer include a carboxylic acid group, a phosphoric acid group, a thiophosphoric acid group, a sulfonic acid group and a sulfinic acid group. The component (a) preferably contains at least one of these acidic groups.

Among the polymerizable monomers that can be used as the component (a), the polymerizable monomer having at least one carboxyl group in one molecule includes monocarboxylic acid, dicarboxylic acid, tricarboxylic acid and tetracarboxylic acid. Acids or their derivatives may be mentioned, for example, (meth) acrylic acid, maleic acid, p-vinylbenzoic acid, 11-
(Meth) acryloyloxy-1,1-undecanedicarboxylic acid (in the case of methacrylate: MAC-10),
1,4-di (meth) acryloyloxyethylpyromellitic acid, 6- (meth) acryloyloxyethylnaphthalene-1,2,6-tricarboxylic acid, 4- (meth) acryloyloxymethyltrimellitic acid and its anhydride,
4- (meth) acryloyloxyethyl trimellitic acid (in the case of methacrylate: 4-MET) and its anhydride (in the case of methacrylate: 4-META), 4- (meth) acryloyloxybutyl trimellitic acid and its anhydride, 4- [2-hydroxy-3- (meth) acryloyloxy] butyl trimellitic acid and its anhydride, 2,3-bis (3,4-dicarboxybenzoyloxy) propyl (meth) acrylate, N, O-di (Meth) acryloyloxytyrosine, O- (meth) acryloyloxytyrosine, N- (meth) acryloyloxytyrosine, N- (meth) acryloyloxyphenylalanine, N- (meth) acryloyl p-aminobenzoic acid, N- (meth) ) Acryloyl O-aminobenzoic acid, N
-(Meth) acryloyl 5-aminosalicylic acid (in the case of methacrylate: 5-MASA), N- (meth) acryloyl 4-aminosalicylic acid, 2 or 3 or 4-
(Meth) acryloyloxybenzoic acid, addition product of 2-hydroxyethyl (meth) acrylate and pyromellitic dianhydride (in the case of methacrylate: PMDM), 2
-Hydroxyethyl (meth) acrylate and maleic anhydride or 3,3 ', 4,4'-benzophenonetetracarboxylic dianhydride (methacrylate: BTDA) or 3,3', 4,4'-biphenyltetracarboxylic acid Addition product of acid dianhydride, 2- (3,4-dicarboxybenzoyloxy) 1,3-di (meth) acryloyloxypropane, N-phenylglycine or N-tolylglycine and glycidyl (meth) acrylate Adduct, 4-
[(2-hydroxy-3- (meth) acryloyloxypropyl) amino] phthalic acid, 3 or 4- [N-methyl N- (2-hydroxy-3- (meth) acryloyloxypropyl) amino] phthalic acid, etc. Can be mentioned. Of these, MAC-10, 4-MET, 4-ME
TA and 5-MASA are preferably used. These polymerizable monomers containing a carboxyl group can be used alone or in combination.

Among the polymerizable monomers that can be used as the component (a), the polymerizable monomer having at least one phosphoric acid group in one molecule is, for example, 2- (meth) acryloyloxyethyl acid phosphate. 2, and 3- (meth) acryloyloxypropyl acid phosphate,
4- (meth) acryloyloxybutyl acid phosphate, 6- (meth) acryloyloxyhexyl acid phosphate, 8- (meth) acryloyloxyoctyl acid phosphate, 10- (meth) acryloyloxydecyl acid phosphate, 12- (meth) acryloyl Oxidodecyl acid phosphate, bis {2-
(Meth) acryloyloxyethyl} acid phosphate, bis {2 or 3- (meth) acryloyloxypropyl} acid phosphate, 2- (meth) acryloyloxyethylphenyl acid phosphate, 2- (meth) acryloyloxyethyl p-methoxyphenyl Acid phosphate etc. can be mentioned. The phosphate group in these compounds can be replaced with a thiophosphate group. Among these, 2- (meth) acryloyloxyethyl phenyl acid phosphate and 10- (meth) acryloyloxydecyl acid phosphate are preferably used. These polymerizable monomers having a phosphoric acid group can be used alone or in combination.

Among the polymerizable monomers that can be used as the component (a), the polymerizable monomer having at least one sulfonic acid group in one molecule is, for example, 2-sulfoethyl (meth) acrylate, 2 or 1-sulfo-1 or 2-propyl (meth) acrylate, 1 or 3-sulfo-2-butyl (meth) acrylate, 3-bromo-2
-Sulfo-2-propyl (meth) acrylate, 3-methoxy-1-sulfo-2-propyl (meth) acrylate, 1,1-dimethyl-2-sulfoethyl (meth) acrylamide and the like can be mentioned. Of these, 2-
Methyl-2- (meth) acrylamidopropanesulfonic acid is preferably used. These polymerizable monomers having a sulfonic acid group can be used alone or in combination. All the above-mentioned components (a) can be used alone or in combination.

In the curable composition of the present invention, the component (b) is a polymerizable monomer having a hydroxyl group in the molecule. Furthermore, these hydroxyl group-containing polymerizable monomers may further contain functional groups such as a carboxyl group, a phosphoric acid group, a sulfonic acid group, a hydroxyl group, an amino group and a glycidyl group in the molecule.

Examples of the polymerizable monomer that can be used as the component (b) include, for example, a monomer having a (meth) acryloyl group, 2-hydroxyethyl (meth) acrylate,
2 or 3-hydroxypropyl (meth) acrylate, 4-hydroxybutyl (meth) acrylate, 5-
Hydroxypentyl (meth) acrylate, 6-hydroxyhexyl (meth) acrylate, 10-hydroxydecyl (meth) acrylate, 1,2- or 1,3- and 2,3-dihydroxypropane (meth) acrylate, diethylene glycol mono (Meth) acrylate,
Hydroxyl group-containing (meth) acrylates such as triethylene glycol mono (meth) acrylate, pentaethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate, dipropylene glycol mono (meth) acrylate; methylol (meth) acrylamide , N- (meth) acryloyl-2,
Hydroxyl group-containing (meth) acrylamides such as 3-dihydroxypropylamine and N- (meth) acryloyl-1,3-dihydroxypropylamine; 2-hydroxy-3-phenoxypropyl (meth) acrylate (HPPM in the case of methacrylate), 2-Hydroxy-3-naphthoxypropyl (meth) acrylate (HNPM in the case of methacrylate) 1 mole of bisphenol A and 2 moles of glycidyl (meth) acrylate (GMA in the case of methacrylate) Addition reaction product (in the case of methacrylate) Examples thereof include addition products of GMA (such as Bis-GMA) and an aliphatic or aromatic polyol (including phenol). These polymerizable monomers can be used alone or in combination.

Of these, it is particularly preferable to use, as the component (b), those having a solubility in water of 0.5 g / 100 cc or more. It is speculated that this plays a role of allowing the curable composition to easily penetrate into the dentinal tissue even at the adhesive interface containing a large amount of water. In the present invention, solubility is defined as follows. That is, the solubility of a monofunctional (meth) acrylate monomer having at least one hydroxyl group in one molecule in water is 0.5 part by weight of the above (meth) acrylate monomer in 100 parts by weight of water. Add the quantity 2
Shake in water at 5 ° C. for 10 minutes. Then 1 at 25 ℃
If the solution is visually phase-separated or turbid for 0 minutes, the solubility is 0.5 g / 1.
The solubility was set to less than 00 cc, and the solubility was set to 0.5 g / 100 cc or more when it was transparently dissolved.

Examples of the component (b) having a water solubility of 0.5 g / 100 cc or more include, for example, 2-hydroxyethyl (meth) acrylate, 2- or 3-hydroxypropyl (meth) acrylate and 4-hydroxybutyl ( (Meth) acrylate, 5-hydroxypentyl (meth) acrylate, 6-hydroxyhexyl (meth) acrylate, 10-hydroxydecyl (meth) acrylate, diethylene glycol mono (meth) acrylate, triethylene glycol mono (meth) acrylate, tetraethylene glycol Mono (meth) acrylate, polyethylene glycol mono (meth) acrylate, dipropylene glycol mono (meth) acrylate, tripropylene glycol mono (meth) acrylate, tetrapropylene glycol Mono (meth) acrylate, polypropylene glycol mono (meth) acrylate, 1,3- or 2,3-dihydroxypropyl (meth) acrylate, N- (meth) acryloyl-2,3
-Dihydroxypropylamine, N- (meth) acryloyl-1,3-dihydroxypropylamine and the like can be mentioned. These monomers can be used alone or in combination. Of these polymerizable monomers, 2
-Hydroxyethyl (meth) acrylate (HEMA in the case of methacrylate) is particularly preferable, and 40 to 98.99 parts by weight as at least a part of the component (b) out of 100 parts by weight of the components (a) to (c) in total. It is preferable to contain in the range.

In the curable composition of the present invention, the component (c) is a polymerization initiator. Examples of such a polymerization initiator include organic peroxides, inorganic peroxides, alkylboranes, partial oxides of alkylboranes, α-diketone compounds, organic amine compounds, organic sulfinic acids, organic sulfinic acid salts, inorganic sulfur compounds and barbites. Mention may be made of tool acids. These may be used alone or in combination of two or more.
These polymerization initiators are, for convenience, normal temperature chemical polymerization type,
A photopolymerization type, or a dual type in which these are combined is included. Examples of the peroxide (polymerization initiator) used in the room temperature chemical polymerization type include diacetyl peroxide, dipropyl peroxide, dibutyl peroxide, dicapryl peroxide, dilauryl peroxide, dilauryl peroxide, and benzoyl peroxide (BP).
O), p, p'-dichlorobenzoyl peroxide, p,
Organic peroxides such as p'-dimethoxybenzoyl peroxide, p, p'-dimethylbenzoyl peroxide, p, p'-dinitrodibenzoyl peroxide and ammonium persulfate, potassium persulfate, potassium chlorate, potassium bromate and perphosphoric acid Inorganic peroxides such as potassium may be mentioned. Of these, BPO is preferred.

Further, the polymerization initiator used in the photopolymerization type is a polymerization initiator which can be photopolymerized by irradiation with ultraviolet rays or visible rays. The polymerization initiator that can be used in such photopolymerization is not particularly limited, but examples thereof include benzyl, 4,4′-dichlorobenzyl, benzoin, benzoin methyl ether, benzoin ethyl ether, benzoin isopropyl ether, benzophenone, 9,10-anthraquinone. , Diacetyl, d,
UV or visible light sensitizers such as diketone compounds such as l-camphorquinone (CQ).

A reducing compound may be used in combination when carrying out the polymerization by a room temperature chemical polymerization or a photopolymerization type. Here, as the organic reducing compound, for example, N,
N-dimethylaniline, N, N-dimethyl p-toluidine (DMPT), N, N-diethyl p-toluidine,
N, N-diethanol p-toluidine (DEPT),
N, N-dimethyl p-tert-butylaniline, N, N
-Dimethylanisidine, N, N-dimethyl p-chloroaniline, N, N-dimethylaminoethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, N, N-dimethylaminobenzoic acid and its alkyl ester , N, N-diethylaminobenzoic acid (D
EABA) and its alkyl esters, aromatic amines such as N, N-dimethylaminobenzaldehyde (DMABAd); N-phenylglycine (NPG), N-
Trilyglycine (NTG), N, N- (3-methacryloyloxy-2-hydroxypropyl) phenylglycine (NPG-GMA) and the like can be used in combination. Among these, DMPT, DEPT, DEABA, DM
ABAd, NPG and NTG can be preferably used.

Particularly, in order to surely cure the curable composition of the present invention and further improve the adhesiveness to the tooth structure, the following general formula (I) is used.

[0031]

[Chemical 3]

Wherein R ¹ and R ² are each independently a hydrogen atom or an alkyl group which may have a functional group or a substituent, and R ³ is a hydrogen atom or a metal atom, or , The following general formula (II)

[0033]

[Chemical 4]

Where R^FourAnd R^FiveAre hydrogen independently of each other
An atom or an alkyl group and R ⁶Is a hydrogen atom
Or may have a functional group or a substituent
An alkyl group or an alkoxyl group,

It is preferable to contain at least one of the amine compounds represented by

Examples of the amine compound contained in the general formula (I) include NPG, NTG and NPG- which have already been described.
GMA etc. can be mentioned. Of these, NPG is particularly preferably used. Examples of the amine compound contained in the general formula (II) include N, N-dimethylaminobenzoic acid and its alkyl ester, N, N-diethylaminobenzoic acid (DEABA) and its alkyl ester, which are already described, and N, N- Aliphatic alkylaminobenzoic acid represented by dipropylaminobenzoic acid and its alkyl ester, N, -isopropylaminobenzoic acid and its alkyl ester, N, -isopropyl-N-methylaminobenzoic acid and its alkyl ester, and the like Alkyl esters; DMABAd, N, N-
Aliphatic alkylaminobenzaldehydes represented by diethylaminobenzaldehyde, N, N-dipropylaminobenzaldehyde, N, -isopropyl-N-methylaminobenzaldehyde and the like; N, N-dimethylaminoacetylbenzene, N, N -Diethylaminoacetylbenzene, N, N-dipropylaminoacetylbenzene, N, -isopropylaminoacetylbenzene, N,-
Examples thereof include aliphatic alkylaminoacetylbenzene represented by isopropyl-N-methylaminoacetylbenzene and aliphatic alkylaminoacylbenzenes. These amine compounds can be used alone or in combination.

Other examples of the reducing compound include benzenesulfinic acid, o-toluenesulfinic acid, p-toluenesulfinic acid, ethylbenzenesulfinic acid, decylbenzenesulfinic acid, dodecylbenzenesulfinic acid, chlorobenzenesulfinic acid, and naphthalene. Aromatic sulfinic acid such as sulfinic acid or salts thereof can be used together.

As the inorganic reducing compound, a reducing inorganic compound containing sulfur can be preferably used. As such a compound, a reducing inorganic compound used as a redox polymerization initiator that can be used when polymerizing a radically polymerizable monomer in a medium such as water or an aqueous solvent is preferable, for example, sulfurous acid, bisulfite, and meta. Examples include sulfite, metabisulfite, pyrosulfite, thiosulfate, dithionous acid, 1,2 thionic acid, hyposulfite, hydrosulfite and salts thereof. Of these, sulfite is preferably used, and sodium sulfite, potassium sulfite, sodium hydrogen sulfite, and potassium hydrogen sulfite are particularly preferable. These reducing inorganic compounds can be used alone or in combination.

The curable composition of the present invention comprises the above (a),
For each of the components (b) and (c), these (a),
Per 100 parts by weight of the total of the components (b) and (c),
1 to 50 parts by weight of component (a) and 1 to 98 parts of component (b).
It is preferable to contain 99 parts by weight and the component (c) in the range of 0.01 to 50 parts by weight. More preferably (a)
The components are used in the range of 1 to 30 parts by weight, the component (b) in the range of 3 to 90 parts by weight, and the component (c) in the range of 0.1 to 20 parts by weight.

The curable composition of the present invention comprises the above (a),
In addition to the components (b) and (c), (d) another polymerizable monomer copolymerizable with the components (a) and (b).
And (e) at least one selected from the group consisting of organic fillers, inorganic fillers and organic composite fillers
At least one of the following types of fillers can be included.

Hereinafter, a composition which does not contain both the components (d) and (e) is referred to as a first curable composition of the present invention,
The curable composition of the present invention containing only the component (d) is referred to as the second curable composition of the present invention. The component (d) is a polymerizable monomer copolymerizable with at least one of the components (a) and (b). Examples of such a polymerizable monomer include a monomer having a radically polymerizable unsaturated group having a (meth) acryloyl group, a styryl group, a vinyl group, an allyl group, or the like. It is sufficient that at least one group selected from these polymerizable groups is contained in one molecule. Furthermore, these polymerizable monomers can contain functional groups such as a carboxyl group, a phosphoric acid group, a sulfonic acid group, a hydroxyl group, an amino group and a glycidyl group in the molecule.

The polymerizable monomer that can be used as the component (d) is, for example, methyl (meth) acrylate or (meth).
Aliphatic esters of (meth) acrylic acid such as ethyl acrylate, propyl (meth) acrylate, butyl (meth) acrylate, neopentyl glycol di (meth) acrylate, trimethylolpropane tri (meth) acrylate; ethylene glycol Di (meth) acrylate, diethylene glycol di (meth) acrylate, triethylene glycol di (meth) acrylate, pentaethylene glycol di (meth) acrylate, nonaethylene glycol di (meth) acrylate, tetradecaethylene glycol di (meth) acrylate, etc. Polyethylene glycol di (meth) acrylates; propylene glycol di (meth) acrylate, dipropylene glycol di (meth) acrylate, tripropylene glycol di (meth) acrylate Rate, polypropylene glycol di (meth) acrylates such as nonapropylene glycol di (meth) acrylate; and (meth) acryloyl group of either one of the above polyethylene glycol di (meth) acrylate and polypropylene glycol di (meth) acrylate Mono (meth) acrylates substituted with a methyl group and an ethyl group; 2- (meth) acryloyloxyethyl isocyanate or 2,2,4-trimethylhexamethylene diisocyanate or 1,3,5-trimethylhexamethylene diisocyanate and 2 -(Meth) acrylates having a urethane bond such as an adduct of hydroxyethyl (meth) acrylate; a product obtained by adding oxyethylene to bisphenol A and further condensing (meth) acrylic acid. It was 2,2
-Bis (4- (meth) acryloyloxypolyethoxyphenyl) propanes; styrene derivatives such as styrene, 4-methylstyrene, 4-chloromethylstyrene, divinylbenzene; vinyl acetate and the like. These polymerizable monomers can be used alone or in combination.

As the component (d), the various polymerizable monomers listed above can be used alone or in combination.

In the second curable composition of the present invention, based on the total weight of these components (a), (b) and (c), 1 to 50% by weight of component (a), (b) ) Component is 1 to 99.99% by weight and component (c) is 0.01 to 50% by weight.
%, And (d) component is (a), (b),
3-5 based on the total weight of components (c) and (d)
Contains 0% by weight.

The first and second curable compositions of the present invention have a viscosity at 37.5 ° C. of 100-30,000 cP.
Must be within the range. The viscosity at 37.5 ° C. is preferably 100 to 20,000 cP,
More preferably, it is 100 to 8,000 cP. By using the composition in this viscosity range, particularly, excellent sealability and adhesiveness are exhibited without a gap at the adhesive interface with the tooth substance. The viscosity of the curable composition in the invention is measured at 37.5 ° C. using an E-type viscometer.

Of the above-mentioned components (d) and (e), the curable composition of the present invention containing only the component (e) is the third invention of the present invention.
Curable composition of.

Of the third curable composition of the present invention,
The component (e) is at least one filler selected from organic fillers, inorganic fillers and organic composite fillers. Examples of the organic filler include a filler of a powder polymer obtained by pulverization or dispersion polymerization of a polymer and a filler obtained by polymerizing a polymerizable monomer containing a crosslinking agent and then pulverizing the polymerized monomer. Here, there is no particular limitation on the polymerizable material as the raw material of the filler that can be used, but the homopolymer or copolymer of the polymerizable monomer exemplified in the component (b) or the component (d) is preferable. Can be mentioned. For example, polymethylmethacrylate (PMMA), polyethylmethacrylate, polypropylmethacrylate, polybutylmethacrylate (PBM)
A), polyvinyl acetate (PVAc), polyethylene glycol (PEG) and polypropylene glycol (PP
G), polyvinyl alcohol (PVA), etc. can be mentioned.

Examples of the inorganic filler include silica,
Examples thereof include silica alumina, alumina, alumina quartz, glass (including barium glass), titania, zirconia, calcium carbonate, kaolin, clay, mica, aluminum sulfate, barium sulfate, calcium sulfate, titanium oxide, calcium phosphate and the like.

Examples of the organic composite filler include the fillers obtained by polymerizing the surface of the above-mentioned inorganic filler with a polymerizable monomer to coat it and then pulverizing it.
Specifically, finely powdered silica or zirconium oxide among the inorganic fillers is polymerized and coated with a polymerizable monomer containing trimethylolpropane tri (meth) acrylate (TMPT) as a main component, and the obtained polymer is A crushed filler (TMPT · f) can be mentioned.

When the curable composition of the present invention is used as a resin cement, particularly preferable component (e) is 40 to 80 parts by weight of zirconium oxide filler having an average particle size of 0.05 to 10 μm and an average particle size of 1 10 to 30 parts by weight of spherical silica filler having an average particle diameter of 1 to 3
It is a filler contained in the range of 10 to 30 parts by weight of 0 μm organic composite filler. Further, the zirconium oxide used here is a polymer which is soluble in the component (b), such as P
A filler having an average particle size of 5 to 30 μm, particularly 1 to 30 μm, which is coated with MMA, polyvinyl acetate (PVAc), or the like, is preferable.

In the third curable composition of the present invention,
Based on the total weight of the components (a), (b) and (c), the component (a) is 1 to 50% by weight and the component (b) is 1 to 9%.
8.99% by weight and 0.01 to 50% by weight of component (c)
The component (e) is 15 to 85% by weight based on the total weight of the components (a), (b), (c) and (e).
Contained.

Furthermore, the curable composition of the present invention can contain both the above-mentioned components (d) and (e). The curable composition of the present invention containing both the components (d) and (e) is referred to as the fourth curable composition of the present invention.

In the fourth curable composition of the present invention,
It should be understood that for components (d) and (e), the explanations corresponding to the second and third curable compositions, respectively, apply as they are.

In the fourth curable composition of the present invention,
Based on the total weight of the components (a), (b) and (c), the component (a) is 1 to 50% by weight and the component (b) is 1 to 9%.
8.99% by weight and 0.01 to 50% by weight of component (c)
Component (d) accounts for 3 to 50% by weight based on the total weight of components (a), (b), (c) and (d), and component (e) comprises (a), ( b), (c), (d)
And 15 to 85% by weight based on the total weight of the component (e).

The viscosity of the third and fourth curable compositions of the present invention can be easily changed by using the component (e), and the viscosity at 37.5 ° C. is 100%.
It can be adjusted within the range of up to 30,000 cP.
However, since it may have different properties in handling from the first or second curable composition, in the case of the third and fourth curable compositions, the (e)
Particular preference is given to the weight range of the components.

The first to fourth curable compositions of the present invention are
The components (a) to (e) can be premixed and applied to the tooth substance. When a mixture of these components changes in shape and performance over a long period of time and there is a risk of impairing the effect of the present invention, each component is stored alone or divided in any combination and stored before being mixed and cured before use. It can be a sexual composition.

The curable composition may be stored, for example, in the case of dividing into a mixture of a / b (/ d / e) component and a C component, a mixture of a / b (/ d / e) component. And b (/
d / e) / c when divided into a mixture of components,
These mixtures can be provided as a product by putting them in separate containers and storing them in a kit. When the component (c) is, for example, two components consisting of BPO or CQ and an amine, a mixture of a / b / c (BPO or CQ) (/ d / e) component and B (/ d / e) / c {amine, eg N, N
-Dimethyl p-toluidine (abbreviated as DMPT)} component and the like. Further, a part or all of the component (c) is contained in advance in a jig used when the curable composition is applied to the tooth surface, and (a), (b), (d) immediately before use. Alternatively, the curable composition may be prepared in situ by bringing the component (e) into contact with a jig and then applied directly to the tooth surface. As the jig to be applied to the tooth surface, a brush, a fiber ball or cloth, a sponge ball or a sponge piece can be preferably mentioned, but the jig is not limited thereto.

That is, according to the present invention, a jig used for applying any of the curable compositions of the present invention to a tooth surface is made to previously contain a part or all of the component (c), and then ( a), (b), optionally (d), and optionally (c) part of the component is brought into contact with the jig to prepare the curable composition on the jig, and immediately after the preparation, the tooth is prepared. Also provided is a method of applying a curable composition that comprises applying to a surface.

By this method, for example, as compared with the method of dividing the curable composition into two containers and mixing them immediately before use, the labor is saved and the curable composition can be directly supplied from the container in a required amount. By only contacting with a jig such as a sponge, it can be economically used without using a mixing container or the like. Tooth restoration is advantageously performed by applying the curable composition of the present invention to the surface of the tooth structure and then applying the dental restoration resin thereon.

Further, according to the present invention, in order to achieve the above object of the present invention, secondly, (a) a polymerizable monomer having an acidic group in the molecule and (f) an organic solvent and water are contained. A primer composition comprising a solvent selected from the group consisting of organic solvents is provided.

The primer composition or the tooth surface treating agent of the present invention is suitable for simultaneously treating the surfaces of enamel and dentin and applying an adhesive to the tooth.

In the tooth surface treating agent of the present invention,
The component (a) is a polymerizable monomer containing an acidic group in the molecule. Examples of the polymerizable group of the monomer include a radical-polymerizable unsaturated group having a (meth) acryloyl group, a styryl group, a vinyl group, an allyl group and the like. It suffices that at least one group selected from these polymerizable groups is contained in one molecule (all the polymerizable groups in the polymerizable monomer described below should be construed in the same manner as this). is there). Furthermore, the polymerizable monomer containing these acidic groups may also contain functional groups such as carboxyl group, phosphoric acid group, sulfonic acid group, hydroxyl group, amino group and glycidyl group in the molecule.

As the polymerizable monomer of the component (a), the same ones as exemplified as the component (a) in the curable composition of the present invention can be exemplified.

In the tooth surface treating agent of the present invention, the component (f) is an organic solvent or a water-containing organic solvent. Examples of the organic solvent include those in which the component (a) or the component (g) described later is uniformly dissolved or dispersed, and those which can be mixed with water are particularly preferably used. For example, methanol, ethanol (EtO
H), alcohols such as propanol; ketones such as acetone and methyl ethyl ketone; ethers such as tetrahydrofuran (THF); amides such as N, N-dimethylformamide. Among these organic solvents, it is particularly preferable to use ethanol or acetone in consideration of toxicity and irritation to dental pulp.

Further, the component (f) can contain water as described above. The water that can be used here is
For example, distilled water, ion-exchanged water, physiological saline, etc. are mentioned, and especially distilled water and ion-exchanged water are preferably used. Therefore, the organic solvent of the component (f) can be used as a mixture with water. In this case, a mixed solution of water and ethanol or a mixed solution of water and acetone is particularly preferably used.

The tooth surface treating agent of the present invention is (a) when the total amount of the above components (a) and (f) is 100 parts by weight.
0.1 to 30 parts by weight of component and 70 to 9 of component (f)
It can be contained in the range of 9.9 parts by weight. More preferably, the component (a) is used in the range of 1 to 20 parts by weight and the component (f) is used in the range of 80 to 99 parts by weight.

The tooth surface treating agent of the present invention comprises, in addition to the above components (a) and (f), (g) a polymerizable monomer copolymerizable with the above component (a) and (c) a polymerizable monomer. It may contain at least one selected from the group consisting of initiators.

The component (g) is a polymerizable monomer copolymerizable with the component (a). The polymerizable monomer is not particularly limited, but for example, methyl (meth) acrylate,
Aliphatic esters of (meth) acrylic acid such as ethyl (meth) acrylate, propyl (meth) acrylate, butyl (meth) acrylate, neopentyl glycol di (meth) acrylate, trimethylolpropane tri (meth) acrylate Ethylene glycol di (meth) acrylate, diethylene glycol di (meth) acrylate, triethylene glycol di (meth) acrylate,
Polyethylene glycol di (meth) acrylates such as pentaethylene glycol di (meth) acrylate, nonaethylene glycol di (meth) acrylate, tetradecaethylene glycol di (meth) acrylate; propylene glycol di (meth) acrylate, dipropylene glycol di Polypropylene glycol di (meth) acrylates such as (meth) acrylate, tripropylene glycol di (meth) acrylate, nonapropylene glycol di (meth) acrylate; the above-mentioned polyethylene glycol di (meth) acrylate and polypropylene glycol di (meth) acrylate Mono (meth) acrylates in which one of the (meth) acryloyl groups is substituted with a methyl group or an ethyl group; 2
-(Meth) acryloyloxyethyl isocyanate or 2,2,4-trimethylhexamethylene diisocyanate or a urethane bond such as an adduct of 1,3,5-trimethylhexamethylene diisocyanate and 2-hydroxyethyl (meth) acrylate (meth) ) Acrylates; 2,2-bis (4- (meth) acryloyloxypolyethoxyphenyl) propanes obtained by further condensing (meth) acrylic acid to a product obtained by adding oxyethylene to bisphenol A; styrene, 4- Examples thereof include styrene derivatives such as methylstyrene, 4-chloromethylstyrene and divinylbenzene; vinyl acetate and the like. These polymerizable monomers can be used alone or in combination.

Similarly, as the polymerizable monomer usable as the component (g), a polymerizable monomer having a hydroxyl group in the molecule can be mentioned. Examples of these polymerizable monomers include, for example, monomers having a (meth) acryloyl group, 2-hydroxyethyl (meth) acrylate, 2
Or 3-hydroxypropyl (meth) acrylate,
4-hydroxybutyl (meth) acrylate, 5-hydroxypentyl (meth) acrylate, 6-hydroxyhexyl (meth) acrylate, 10-hydroxydecyl (meth) acrylate, 1,2- or 1,3- and 2, 3-dihydroxypropane (meth) acrylate,
Hydroxyl group-containing (meth) acrylates such as diethylene glycol mono (meth) acrylate, triethylene glycol mono (meth) acrylate, pentaethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate, dipropylene glycol mono (meth) acrylate 2- (meth) acrylamides having a hydroxyl group such as methylol (meth) acrylamide, N- (meth) acryloyl-2,3-dihydroxypropylamine, N- (meth) acryloyl-1,3-dihydroxypropylamine; 2- Hydroxy-3-
Phenoxypropyl (meth) acrylate (HPPM in case of methacrylate), 2-hydroxy-3-naphthoxypropyl (meth) acrylate (HNPM in case of methacrylate), 1 mol of bisphenol A and 2 mol of glycidyl (meth) acrylate (of methacrylate) In the case of GMA, the addition reaction product (in the case of methacrylate B
Examples thereof include addition products of GMA such as is-GMA) and an aliphatic or aromatic polyol (including phenol). These polymerizable monomers can be used alone or in combination.

Further, regarding the polymerization initiator of the component (c), it should be understood that the description of the polymerization initiator described for the curable composition of the present invention is applied as it is.

In the tooth surface treating agent of the present invention,
0.1 to 30% by weight of component (a), based on the total weight of components (a), (f), (g) and (c), (f)
It is preferable that the component is 70 to 99.9% by weight, the component (g) is 0 to 30% by weight, and the component (c) is 0 to 20% by weight. More preferably, the component (a) is 0.1 to 20% by weight, the component (f) is 50 to 97.95% by weight, the component (c) is 0.05 to 15% by weight and the component (g) is 1 to 1% by weight. 15
Used in the weight% range.

The tooth surface treating agent of the present invention comprises the above (a),
The components (f), (g) and (c) can be premixed and applied to the dentin. When a mixture of these components may change the form or performance over a long period of time and impair the effects of the present invention, each component is stored alone or divided in any combination and stored before being mixed and cured. It can be a sexual composition.

As a method for preserving the tooth surface treating agent, for example, in the case of dividing into a mixture of a / f / g component and a C component, a mixture of a / f / g component and a mixture of f / c component is used. There are cases such as division. The division method is not limited to these combinations. These mixtures and components can be put in separate containers, housed as a kit, and provided as a product. Tooth restoration can be advantageously performed by applying the tooth surface treating agent of the present invention to the tooth surface and then applying the dental restorative resin and / or the tooth-adhesive curable composition thereon. it can.

In the combination of the tooth surface treating agent of the present invention and the curable composition of the present invention, the tooth surface is first treated with the tooth surface treating agent of the present invention, and then the curable composition of the present invention is applied. A method of treating a tooth surface is provided. As such a treatment method, the following two methods are particularly preferable.

A first preferred embodiment is at least one selected from the group consisting of (a ') 4- (meth) acryloyloxyethyltrimellitic acid or its anhydride and N- (meth) acryloylaminosalicylic acid. Three
0% by weight, (f ') at least one selected from the group consisting of water-containing ethanol and water-containing acetone 30-
A primer composition consisting of 90% by weight, 1 to 20% by weight of (meth) acrylate having (g ′) oxyalkylene group and 1 to 20% by weight of (c ′) aromatic sulfinate is applied to the tooth surface, and then ( a ') at least one selected from the group consisting of 4- (meth) acryloyloxyethyltrimellitic acid or its anhydride and N- (meth) acryloylaminosalicylic acid 1 to 30% by weight, (b') 2-hydroxy At least one selected from the group consisting of ethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycerol (meth) acrylate, erythritol (meth) acrylate, and poly (meth) acrylate of a polyepoxy compound of bisphenol 30. ~ 90% by weight, (c ')
A visible light sensitizer, d, l-camphorquinone, and a reducing agent, N-phenylglycine, N, N-dialkylaminobenzoic acid, and at least one selected from the group consisting of aromatic sulfinates. A combination of 0.1 to 5% by weight and (d ') a methacrylic acid having an oxyalkylene group in the molecule of 3 to 20% by weight, and a viscosity at 37.5 ° C of 100 to 30,000.
A method for treating a tooth surface, which comprises applying a visible light curable composition in the range of cP, preferably 100 to 20,000 cP, more preferably 100 to 8,000 cP.

The second preferred embodiment is at least one selected from the group consisting of (a ') 4- (meth) acryloyloxyethyltrimellitic acid or its anhydride and N- (meth) acryloylaminosalicylic acid. Three
0% by weight, (f ') at least one selected from the group consisting of water-containing ethanol and water-containing acetone 30-
90% by weight and a primer composition consisting of 1 to 20% by weight of (meth) acrylate having (g ′) oxyalkylene group is applied to the tooth surface, and then (a ′) 4- (meth) acryloyloxyethyltrimellitic acid or At least one selected from the group consisting of its anhydride and N- (meth) acryloylaminosalicylic acid 1-3
0% by weight of (b ') 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycerol (meth) acrylate, erythritol (meth) acrylate and poly (meth) acrylate of polyepoxy compound of bisphenols At least one selected from the group consisting of 10 to 60% by weight,
(C ′) d, l-camphorquinone, at least one selected from the group consisting of organic peroxides and inorganic oxides, and N-phenylglycine as a reducing agent, N, N-dimethyl-p-toluidine, At least one selected from the group consisting of N, N-diethanol-p-toluidine, N, N-alkylaminobenzoic acid and aromatic sulfinic acid 0.1-10 wt%, (d ') oxy group in the molecule (Meth) acrylate having an alkylene group 10 to 60% by weight and (e ′) zirconium oxide filler having an average particle size of 0.05 to 10 μm 40 to 80% by weight, average particle size 1
10 to 30 μm spherical silica filler 10 to 30% by weight and average particle size 1 to 30 μm organic composite filler 10
Consisting of a filler containing any of ~ 30 wt%,
And viscosity at 37.5 ° C is 100 to 30,000 cP
The method for treating a tooth surface is as follows, wherein a room temperature curable composition in the range is applied.

The present invention will be described in more detail with reference to the following examples. The adhesive strength was evaluated by the following method after preparing the curable composition of the present invention as a bonding material for composite resin or as resin cement.

Fresh bovine lower anterior teeth were removed, frozen and stored in water, and used as a dentin sample. The thawed bovine tooth was poured with a rotary polishing machine ECOMET-III (manufactured by BUEHLER) so that the enamel and dentin were exposed, and ground under water pressure to a water-resistant emery paper # 600 to obtain a smooth surface. Moisture was removed from the ground bovine teeth with an air gun, and cellophane tape with a circular hole having a diameter of 5.1 mm was immediately applied to define the bonding area, and the bovine teeth were immersed again in water.
The bovine tooth immersed in water for at least 1 minute was taken out, and the adhesive surface was lightly wiped off with a cotton ball. There was still some water left on this surface and it was used for the adhesion test as a wet surface.

Application as Bonding Material for Composite Resin The curable composition of the present invention is sponge (Super Bond C &
B accessory, manufactured by Sun Medical Co., Ltd.) and lightly blown with air for about 5 seconds. Visible light irradiator (Tran
The curable composition of the present invention was cured by irradiating with a slux CL, Kulzer) for 20 seconds. Place a 5.1 mm thick cardboard with an adhesive on one side to fix it, and fill this hole with composite resin (Silux Plus, 3M) to a thickness of 50 μm.
Covered with polyester film. The composite resin is cured by irradiating the film with a visible light irradiator (Translux CL, Kulzer) for 40 seconds, peeling off the film, and burying acrylic sticks with Meta First (Sun Medical). Let stand for 15 minutes.

Application as Resin Cement In the third curable composition of the present invention, the liquid component and the powder component are separately stored and mixed in a dappen glass immediately before use, or sufficiently mixed on kneading paper. The mixture was kneaded and applied to the adhesion-regulated surface, an acrylic rod was planted, and allowed to stand for 15 minutes.

The sample prepared by the above method or was immersed in water at 37 ° C. for 24 hours and then subjected to a tensile adhesion test (crosshead speed 2 mm / min).

The gap at the interface between the tooth substance and the composite resin was measured by the following method. However,
It was not measured in the case of resin cement.

In order to confirm the sealing property between the tooth substance and the restoration,
The thawed bovine tooth was poured with water using a rotary polishing machine ECOMET-III (manufactured by BUEHLER) so that the enamel and dentin were exposed, and water-resistant emery paper # 600 was ground under finger pressure to obtain a smooth surface. A φ3 × 3 mm cavity was formed using diamond points under water injection. The curable composition of the present invention is applied to the surface inside the cavity using a sponge and lightly air-blown to expose the visible light from the upper portion of the cavity (Translux CL, Kulze
It was irradiated with light for 20 seconds and cured. Further, the composite resin was filled and similarly irradiated with light for 40 seconds to be cured. The surface was polished to a surface of # 600 under water pouring to make it smooth, then immersed in a basic fuchsin aqueous solution for 1 minute and washed with water. The presence or absence of a gap was determined by visually observing the gap in the dried state with an air gun with an optical microscope and visually confirming the coloration observed in the part where the gap was generated.

The viscosity of the curable composition was measured using a curable composition of 1.0 cc and using an E-type viscometer (Tokyo Keiki) at 37.5 ° C.

[0085]

【Example】

Example 1 A curable composition of the present invention as a bonding material for a composite resin was prepared as follows. 58.5 parts by weight of 2-hydroxyethyl methacrylate (HEM
A), 35 parts by weight of VR90 (Showa High Polymer), 6.5 parts by weight of 4-MET and 0.5 parts by weight of d, l-camphorquinone (CQ) were prepared, and the solution was protected from light. I put it in a bottle. Separately, add 0.3 parts by weight and 0.5 parts by weight of N-phenylglycine (NPG), which is a sponge tip S (φ2 × 3 mm) attached to Super Bond D Liner Plus, in a plastic bag and shake well to sponge the NPG.
Was included. Sponge tip 1 containing NPG containing 1 drop of solution from a dropping bottle in a dappish dish.
The individual was soaked with the solution and applied directly to the dentin surface.
As a result of the adhesion test, the adhesion strength to dentin is 76.
± 38 kgf / cm ² , and formation of a gap was not recognized.

NP which is a monomer component and a polymerization initiator component
By dividing G as described above, the curable composition of the present invention could be stored for a long period of time without morphological change. Moreover, the bonding operation is simple and the working time is short as compared with the conventional method of dividing and storing, mixing immediately before use and coating.

Example 2 As the curable composition of the present invention as a bonding material for composite resin, 45.5 parts by weight of HEMA, 35
Parts by weight VR90, 6.5 parts by weight triethylene glycol dimethacrylate (3G), 6.5 parts by weight 2,2-
Bis (4-methacryloyloxypolyethoxyphenyl) propane (2.6E, Shin-Nakamura Chemical), 6.5 parts by weight of 4-MET, 0.5 parts by weight of CQ and 0.5 parts by weight of N.
PG was mixed and dissolved. As a result of using the adhesive test immediately after preparation, the adhesive strength to dentin is 99 ± 49k.
It was gf / cm ² , and formation of a gap was not recognized. The solution in which NPG was dissolved gelled about 1 day after preparation and became unusable.

Example 3 As a curable composition of the present invention as a bonding material for composite resin, 52.5 parts by weight of HEMA, 12.
5 parts by weight of VR90, 7.5 parts by weight of 3G, 7.5 parts by weight of 2.6E, 7.5 parts by weight of 4-MET, 12.5 parts by weight of polyvinyl acetate (PVAc), 0.5. Part by weight of CQ and 0.5 part by weight of NPG were mixed and dissolved. As a result of performing an adhesion test using it immediately after preparation, the adhesion strength to dentin was 77 ± 18 kgf / cm ² , and formation of a gap was not recognized.

Example 4 As the curable composition of the present invention, 4-M in Example 2 was used.
What changed ET into 4-META was used (viscosity:
280 cP). As a result, the bond strength to dentin is 7
It was 8 ± 18 kgf / cm ² , and formation of a gap was not recognized.

Example 5 The curable composition of the present invention as a resin cement was prepared as a liquid cement.
Min: 60 parts by weight HEMA, 30 parts by weight 2-hydroxy
Ci-3-phenoxypropyl methacrylate (HPP
M), 4 parts by weight of 4-MET, 5 parts by weight of N-methacrylate
Royl 5-aminosalicylic acid (5-MASA) and 1
Weight part benzoyl peroxide (BPO), powder component: 10 layers
% PMMA coated zirconium oxide filler
(ZrO₂, Average particle size 2 μm), 60 parts by weight, average particle size
5 μm spherical silica filler (SiO ₂) 20 weight
Parts, trimetize silica filler with an average particle size of 0.04 μm
Roll propane trimethacrylate (TMPT) beforehand
Polymer-coated and crushed organic composite film with an average particle size of 20 μm
20 parts by weight of Ra (TMPT / f) and 2 parts by weight of N
What consisted of PG was used. 0.09 weight on kneaded Japanese paper
Parts of liquid component and 0.13 parts by weight of powder component are mixed and kneaded.
I made it After 1 minute from the start of kneading, the adhesive test
used. As a result, the adhesion strength to dentin was 57 ±.
22 kgf / cm²Met.

Example 6 In Example 5, TMP was used instead of HPPM as a liquid component.
The same procedure as in Example 5 was repeated except that T was used. As a result, the adhesive strength to dentin is 42 ± 20 kgf / cm.
^{Was 2} .

Example 7 In Example 5, 2,2,
The procedure of Example 5 was repeated except that 1 mol of 4-trimethylhexamethylene diisocyanate and 2 mol of HEMA were used as the addition reaction product (UDMA). As a result, the adhesive strength to dentin was 69 ± 25 kgf / cm ² .

Example 8 In Example 5, VR9 was used instead of HPPM as a liquid component.
Example 5 was repeated except that 0 was used. As a result, the adhesive strength to dentin is 40 ± 8 kgf / cm ²
Met.

Example 9 Example 9 was repeated except that 3G was used instead of HPPM as the liquid component and NPG in the powder was changed to 1 part by weight. As a result, the adhesive strength to dentin was 50 ± 9 kgf / cm ² .

Example 10 The hardenability of the dentin prepared in Example 9 was applied to a dentin surface which had been removed from the dentin surface by etching with a 10% by weight citric acid aqueous solution containing 3% by weight ferric chloride and washing with water, and then removing the water with a cotton ball. The same was done using the composition. As a result, the bond strength to dentin is 1
It was a very high value of 07 ± 15 kgf / cm ² .

[0097]

[Table 1]

The primer of the present invention was applied to a surface having a defined area with a sponge (supplied from Superbond C & B, manufactured by Sun Medical Co., Ltd.) and left standing for 30 seconds. Air was blown with an air gun for about 5 seconds to remove the excess liquid and prepare a treated surface. The curable composition described in Example 2 or Example 9 was used as an adhesive to adhere to the treated surface. An adhesive test was conducted using the curable composition described in Example 2 as a bonding material for a composite resin and Example 9 as a resin cement.

The observation of the open state of the dentinal tubule was performed by the following procedure. That is, in the evaluation method of the adhesive force, after applying the tooth surface treatment agent of the present invention to the ground dentin surface and blowing air to remove excess liquid, the dentin surface is observed with an optical microscope, and dentin tubules The open state of was observed.

Example 11 As a tooth surface treating agent, 20 parts by weight of 4-MET and 80 parts by weight of an ethanol (EtOH) solution were used, and the curable composition described in Example 2 was used. And the adhesive strength to dentin was measured. As a result, bond strength 65 ± 8kgf / cm ² in enamel was 73 ± 15kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 12 As a dentin surface treatment agent, a solution of 20 parts by weight of 4-MET, 20 parts by weight of distilled water (H ₂ O) and 80 parts by weight of EtOH was used. The adhesive composition was used to measure the adhesive strength to enamel and dentin. As a result, the adhesive strength is 96 ± 20 kg for enamel.
f / cm ² and 101 ± 20 kgf / cm ² for dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 13 As a tooth surface treating agent, 15 parts by weight of 4-MET and 5 parts by weight of N-methacryloyl-5-aminosalicylic acid (5
MASA), 20 parts by weight of H ₂ O and 80 parts by weight of EtOH, and the curable composition described in Example 2 was used to measure the adhesion strength to enamel and dentin. As a result, 64 ± 24 kgf of enamel
/ Cm ² and the dentin had an adhesive strength of 90 ± 28 kgf / cm ² . When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Also,
No gap formation was observed.

Example 14 As a tooth surface treating agent, 20 parts by weight of 4-META, 4
Adhesive strength to enamel and dentin was determined using a solution of 2.5 parts by weight H ₂ O and 37.5 parts by weight EtOH using the curable composition described in Example 2. As a result, the adhesive strength is 93 ± 18 kg with enamel
f / cm ² and 111 ± 23 kgf / cm ² for dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 15 As a tooth surface treating agent, 10 parts by weight of 4-MET, 40
Enamel and ivory using the curable composition described in Example 2 using a solution consisting of parts by weight EtOH, 45 parts by weight H ₂ O, 5 parts by weight nonaethylene glycol dimethacrylate (9G). The bond strength to quality was measured. As a result, the adhesive strength is 70 ± 12 kg with enamel
f / cm ² , and dentin was 83 ± 7 kgf / cm ² .
When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 16 As a tooth surface treating agent, 10 parts by weight of 4-MET, 40
Using a solution consisting of parts by weight EtOH, 45 parts by weight H ₂ O, 5 parts by weight polyethylene glycol dimethacrylate (23G) and using the curable composition described in Example 9, enamel and dentin. The adhesive strength to was measured. As a result, the adhesive strength is 102 ± 18 with enamel
kgf / cm ^2, it was 109 ± 33kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed.

Example 17 As a tooth surface treating agent, 10 parts by weight of 4-META, 5
Using a solution consisting of 5 parts by weight of 5-MASA, 40 parts by weight of EtOH, 40 parts by weight of H ₂ O, 5 parts by weight of 23G and using the curable composition described in Example 9, the enamel and The adhesion strength to dentin was measured. As a result, the adhesive strength is 108 ± 32 kgf / cm for enamel.
² and 110 ± 37 kgf / cm ² in dentin. Observation of dentinal tubules by an optical microscope after treatment of dentin showed that
No tubule opening was observed.

Example 18 As a tooth surface treating agent, 20 parts by weight of 4-MET, 20
Adhesive strength to enamel and dentin using the curable composition described in Example 2 using a solution consisting of parts by weight EtOH, 70 parts by weight H ₂ O and 0.05 parts by weight CQ. Was measured. As a result, the adhesive strength was 51 ± 26 kgf / cm ^{2 for} enamel and 62 ± 18 kg for dentin.
It was f / cm ² . When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 19 As a tooth surface treating agent, 5 parts by weight of 4-MET, 45 parts by weight of EtOH, 48 parts by weight of H ₂ O and 2 parts by weight of 3 were used.
G, 0.05 parts by weight of CQ and 0.1 parts by weight of N, N-
A solution consisting of diethylamine benzoic acid (DEABA) was used and the curable composition described in Example 2 was used to measure the adhesion strength to enamel and dentin. As a result, the adhesive strength is 44 ± 14 kgf / cm for enamel.
² and 51 ± 14 kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 20 As a tooth surface treating agent, 10 parts by weight of 4-MET, 40
Parts by weight EtOH, 45 parts by weight H ₂ O, 5 parts by weight 9
Using a solution consisting of G and 0.05 parts by weight of CQ,
The curable composition described in Example 2 was used to measure adhesion strength to enamel and dentin. As a result, bond strength 93 ± 8kgf / cm ² in enamel was 113 ± 13kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 21 As a tooth surface treating agent, 10 parts by weight of 4-MET, 40
Parts by weight EtOH, 45 parts by weight H ₂ O, 5 parts by weight 9
A solution consisting of G, 0.05 parts by weight of CQ and 5 parts by weight of NPG was used to measure the adhesive strength to enamel and dentin using the curable composition described in Example 2. As a result, the adhesive strength is 70 ± 10k for enamel.
The gf / cm ² was 87 ± 21 kgf / cm ² for dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

Example 22 As a tooth surface treating agent, 10 parts by weight of 4-META, 4
An enamel was prepared using the curable composition described in Example 2 using a solution consisting of 0 parts by weight EtOH, 48 parts by weight H ₂ O, 5 parts by weight 9G and 0.05 parts by weight CQ. And the adhesive strength to dentin was measured. As a result, the adhesive strength is 89 ± 15 kgf / c for enamel.
m ² and 99 ± 11 kgf / cm ² for dentin. Observation of dentinal tubules by an optical microscope after treatment of dentin showed that
No tubule opening was observed. Moreover, formation of a gap was not recognized.

Example 23 As a tooth surface treatment agent, 20 parts by weight of 4-MET, 65
A solution consisting of 15 parts by weight of EtOH and 15 parts by weight of H ₂ O, 85 parts by weight of H ₂ O, 10 parts by weight of EtOH and 5 parts by weight of sodium benzenesulfinate (BSN).
The solution consisting of a) is mixed in an equal amount immediately before use,
The curable composition described in Example 9 was used to measure adhesion strength to enamel and dentin. As a result, bond strength 118 ± 38kgf / cm ² in enamel was 115 ± 19kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed.

Example 24 As a tooth surface treatment agent, 20 parts by weight of 4-META, 6
A solution consisting of 0 parts by weight EtOH, 15 parts by weight H ₂ O and 5 parts by weight 23G, 5 parts by weight sodium p-toluenesulfinate (pTSNa), 10 parts by weight E
Adhesion to enamel and dentin using the curable composition described in Example 2 using a solution consisting of tOH, 80 parts by weight H2O and 5 parts by weight 23G mixed in equal amounts just before use. The strength was measured. As a result, bond strength 129 ± 27kgf / cm ² in enamel was 128 ± 16kgf / cm ² in dentin. When the dentin tubules were observed with an optical microscope after the treatment of dentin, no opening of the tubules was observed. Moreover, formation of a gap was not recognized.

[0114]

[Table 2]

Comparative Example 1 Example 1 as a bonding material for composite resin
In, methyl methacrylate (MMA) and UDMA were used without HEMA and VR90. As a result, the test sample was peeled off while immersed in water.

Comparative Example 2 Example 3 as a bonding material for composite resin
In, MMA and UDMA were used without using HEMA and VR90 (viscosity: 230 cP). as a result,
It was peeled off while the test sample was immersed in water.

Comparative Example 3 Example 3 as a bonding material for composite resin
In, a solution (viscosity: 230 cP) that does not use CQ and NPG was used as the polymerization initiator (C) component. As a result, the test sample was peeled off while immersed in water.

Comparative Example 4 Example 3 as a bonding material for composite resin
In, a solution (viscosity: 230 cP) in which the polymerizable monomer (A) component containing an acidic group in the molecule is not used was used. As a result, no gap was found, but the adhesive strength to dentin was 23 ± 13 kgf / cm.
^It was remarkably low as ² .

Comparative Example 5 In Example 5 as a resin cement, HEMA was used as the polymerizable monomer (B) component containing an acidic group in the molecule.
And without HPPM, UDMA was used instead. As a result, the test sample was peeled off while immersed in water.

Comparative Example 6 In Example 6 as a resin cement, an adhesion test was conducted without using the polymerization initiator (c) component. As a result, the curable composition did not cure and was peeled off while the test sample was immersed in water.

Comparative Example 7 In Example 9 as a resin cement, an adhesion test was conducted without using the polymerizable monomer (A) component containing an acidic group in the molecule. As a result, the adhesive strength to dentin was as low as 38 ± 21 kgf / cm ² .

[0122]

[Table 3]

Comparative Example 8 As a tooth surface treatment agent, 4 as a polymerizable monomer containing an acidic group in the molecule from the composition shown in Example 11 was used.
As a result of performing an adhesion test in the same manner as in Example 11 without using MET, the adhesion sample was peeled off during immersion in water in enamel, and was 20 ± 8 gf / cm ² in dentin, which was compared with Example 11. And the formation of gaps was recognized.

Comparative Example 9 When EtOH was not used as the organic solvent from the composition shown in Example 11 as the tooth surface treatment agent, 4-
Since the MET is a solid, no solution could be made and the adhesion test could not be done.

Comparative Example 10 As a tooth surface treatment agent, a solution was prepared from the composition shown in Example 15 without using EtOH as an organic solvent, but 4-MET was not dissolved. I couldn't.

Comparative Example 11 Instead of the tooth surface treatment agent, a commercially available total etching agent was used, and the tooth surface treatment agent was dried with air without washing with water.
The adhesion test was performed according to 1. As a result of using the dentin surface treatment agent (green) attached to Super Bond C & B (manufactured by Sun Medical) as a total etching agent, the dentinal tubules after treatment of dentin were observed with an optical microscope, and almost all the tubules were opened. Was there. In addition, both the enamel and the dentin were dropped out of the test sample in water and were not adhered at all.

Comparative Example 12 An adhesive test was carried out according to Example 11 using a commercially available primer attached to Superbond D Liner Plus (manufactured by Sun Medical) instead of the tooth surface treating agent. As a result, 48 ± 21 kgf / cm ² for enamel,
It was as low as 53 ± 19 gf / cm ² for dentin.
Observation of the dentinal tubules by an optical microscope after the treatment revealed no opening of the tubules. Moreover, formation of a gap was not recognized.

Comparative Example 13 As a tooth surface treatment agent, 4 as a polymerizable monomer having an acidic group in the molecule from the composition shown in Example 18 was used.
-As a result of performing the adhesion test as in Example 18 without using MET, the adhesion sample was peeled off during immersion in water for enamel, and was 18 ± 10 gf / cm ² for dentin, which was compared with Example 18. Fell significantly.

Comparative Example 14 As a tooth surface treatment agent, an attempt was made to exfoliate a solution from the composition shown in Example 18 without using EtOH as an organic solvent, but the solution could not be prepared due to phase separation. It was

Comparative Example 15 As a tooth surface treating agent, CQ was not used as a polymerization initiator from the composition shown in Example 20.
As a result of the same adhesion test as above, 70 ± 1 for enamel
2 gf / cm ^2, in dentin it was lower than is Example 20 in 83 ± 7gf / cm ^2.

Comparative Example 16 As a tooth surface treatment agent, 4 as a polymerizable monomer having an acidic group in the molecule from the composition shown in Example 16 was used.
-Adhesion test carried out in the same way as in Example 16 without the use of MET shows that the adhesive sample peels off during immersion in water for enamel and 52 ± 13 gf / cm ² for dentin, compared with Example 16. Fell significantly.

[0132]

[Table 4]

[0133]

EFFECTS OF THE INVENTION The curable composition of the present invention exhibits good adhesive strength to ground dentin without etching or priming treatment, and since it can bond without gaps, it stimulates dental pulp. The adhesive dental treatment can be performed in a short time with a simple operation. Furthermore, since the curable composition of the present invention exhibits a high adhesive strength to wet dentin, it exhibits stable performance even in actual clinical use. In the present invention, by preliminarily containing a part of the constituent components of the curable composition in the jig or container to be used, a curable composition can be provided in a required amount without impairing storage stability or operability. Provide a usable operating method.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Harumi Tanaka, 571-2 Furutakacho, Moriyama-shi, Shiga Prefecture, Sun Medical Co., Ltd. (72) Goshi Baba, 571-2, Furutakacho, Moriyama City, Shiga Prefecture, Sun Medical Corp.

Claims (23)

[Claims] 1. A composition comprising (A1) (a) a polymerizable monomer having an acidic group in the molecule, (b) a polymerizable monomer having a hydroxyl group in the molecule, and (c) a polymerization initiator. Based on the total weight of the components (a), (b) and (c), the component (a) is 1 to 50% by weight and the component (b) is 1 to 9%.
8.99% by weight and 0.01 to 50% by weight of component (c)
And (B) the viscosity at 37.5 ° C. is 100-30,000 c
A curable composition characterized by being in the range of P. 2. The component (a) contains in the molecule at least one acidic group selected from the group consisting of a carboxylic acid group, a phosphoric acid group, a thiophosphoric acid group, a sulfonic acid group and a sulfinic acid group. 1. The curable composition of 1. 3. The component (b) is at least 0.5 g /
The curable composition of claim 1 having a water solubility of 100 cc. 4. The component (c) is an organic peroxide, an inorganic peroxide, an alkylborane, a partial oxide of an alkylborane, an α-diketone compound, an organic amine compound, an organic sulfinic acid, an organic sulfinic acid salt, and an inorganic salt. At least one selected from the group consisting of sulfur compounds and barbituric acids
The curable composition of claim 1 which is a type of polymerization initiator. 5. The viscosity at 37.5 ° C. is 100 to 8.0.
The curable composition of claim 1 in the range of 00 cP. 6. (A2) (a) a polymerizable monomer having an acidic group in the molecule, (b) a polymerizable monomer having a hydroxyl group in the molecule, (c) a polymerization initiator, and (d) the above. (A),
1 to 50 parts by weight of the component (a), based on the total weight of the components (a), (b) and (c), which is composed of another polymerizable monomer copolymerizable with the component (b). %, (B)
1 to 98.9% by weight of component and 0.01 of component (c)
˜50% by weight, and component (d) is (a),
3-50% by weight, based on the total weight of components (b), (c) and (d), and (B1) a viscosity at 37.5 ° C. of 100-30,000.
Curable composition characterized by being in the range of cP. 7. The viscosity at 37.5 ° C. is 100 to 8.0.
The curable composition of claim 6 in the range of 00 cP. 8. (A3) (a) a polymerizable monomer having an acidic group in the molecule, (b) a polymerizable monomer having a hydroxyl group in the molecule, (c) a polymerization initiator and (e) an organic substance. A filler, an inorganic filler and an organic composite filler, and at least one filler selected from the group consisting of these components, and based on the total weight of these components (a), (b) and (c), the component (a) is 1 to 50% by weight, (b)
1 to 98.9% by weight of component and 0.01 of component (c)
˜50% by weight, and component (e) is (a),
15-85% by weight, based on the total weight of components (b), (c) and (e), and (B1) 37.5 ° C.
The viscosity of the curable composition is in the range of 100 to 30,000 cP. 9. The (e) component has an average particle size of 0.05 to 1
0 μm zirconium oxide filler and containing 40 to 80% by weight, or (e) component is spherical silica filler having an average particle size of 1 to 10 μm and containing 10 to 30% by weight. Or above (e)
The curable composition according to claim 8, wherein the component is an organic composite filler having an average particle size of 1 to 30 μm and containing 10 to 30% by weight of the organic composite filler. 10. The viscosity at 37.5 ° C. is 100 to 8,
The curable composition of claim 8 in the range of 000 cP. 11. (A4) (a) a polymerizable monomer having an acidic group in the molecule, (b) a polymerizable monomer having a hydroxyl group in the molecule, (c) a polymerization initiator, (d) the above (A), (b)
Other polymerizable monomer copolymerizable with the component, and (e) at least one filler selected from the group consisting of an organic filler, an inorganic filler and an organic composite filler,
And of these (a), (b) and (c)
1 to 50% by weight of component (a), 1 to 99.99% by weight of component (b) and (c) based on the total weight of the components.
The component accounts for 0.01 to 50% by weight, the component (d) accounts for 3 to 50% by weight based on the total weight of the components (a), (b), (c) and (d), and ( component e) accounts for 15-85% by weight, based on the total weight of components (a), (b), (c), (d) and (e), and (B1) has a viscosity at 37.5 ° C. 100 to 30,000
Curable composition characterized by being in the range of cP. 12. The average particle diameter of the component (e) is from 0.05 to 0.05.
Is it 10 μm zirconium oxide filler and contains it at 40-80% by weight, or is the above-mentioned component (e) a spherical silica filler having an average particle size of 1-10 μm and contains it at 10-30% by weight. Alternatively, the curable composition according to claim 11, wherein the component (e) is an organic composite filler having an average particle size of 1 to 30 µm and containing 10 to 30% by weight of the organic composite filler. 13. The viscosity at 37.5 ° C. is 100 to 8,
The curable composition of claim 11 in the range of 000 cP. 14. The following formula (I):Where R¹And R²Are hydrogen atoms independently of each other
Or an alkyl which may have a functional group or a substituent
Kill group and R³Is a hydrogen atom or a metal atom
Or the following formula (II):Where R^FourAnd R^FiveAre hydrogen atoms or
Rukiru and R ⁶Is a hydrogen atom or
An alkyl group which may have a functional group or a substituent
Or an alkoxyl group, represented by
The curability according to claim 1, 6, 8 or 11 further containing
Composition. 15. A jig used when applying the curable composition according to claim 1, 6, 8 or 11 to a tooth surface in advance (c).
The curable composition is prepared on the jig by containing 1 part or all of the components, and then contacting the other component and optionally 1 part of the component (c) with the jig, and immediately after the preparation. A method for applying a curable composition, which comprises applying the curable composition to the tooth surface. 16. A primer composition comprising (a) a polymerizable monomer having an acidic group in the molecule and (f) an organic solvent and a solvent selected from the group consisting of water-containing organic solvents. 17. The component (a) is 0.1 to 30% by weight and the component (f) is 70 to 99.9% by weight, based on the total weight of the components (a) and (f). Claim 1
6. The primer composition of 6. 18. The component (a) is a carboxylic acid group in the molecule,
The primer composition according to claim 16, having at least one acidic group selected from the group consisting of a phosphoric acid group, a thiophosphoric acid group, a sulfonic acid group and a sulfinic acid group. 19. The primer according to claim 16, further comprising at least one selected from the group consisting of (g) a polymerizable monomer copolymerizable with the component (a) and (c) a polymerization initiator. Composition. 20. (a), (f), (g) and (c)
Based on the total weight of the components, the (a) component is 0.1 to 3
0% by weight, 70 to 99.9% by weight of component (f), 0 to 30% by weight of component (g) and 0 to 20% by weight of component (c).
The primer composition according to claim 19, which is 21. A tooth surface is coated with the primer composition of claim 16 or 19, and then the composition of claims 1, 6, 8 or 11 is used.
A method for treating a tooth surface, which comprises applying the curable composition described in 1. 22. (a ′) 4- (meth) acryloyloxyethyl trimellitic acid or its anhydride and N-
At least one selected from the group consisting of (meth) acryloylaminosalicylic acid 1 to 30% by weight, (f ')
30-90% by weight of at least one selected from the group consisting of water-containing ethanol and water-containing acetone,
A primer composition comprising 1 to 20% by weight of (g ') oxyalkylene group-containing (meth) acrylate and 1 to 20% by weight of (c') aromatic sulfinate is applied to the tooth surface, and then (a ') 4. -(Meth) acryloyloxyethyl trimellitic acid or its anhydride and N-
At least one selected from the group consisting of (meth) acryloylaminosalicylic acid 1 to 30% by weight, (b ')
At least selected from the group consisting of 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycerol (meth) acrylate, erythritol (meth) acrylate and poly (meth) acrylate of a polyepoxy compound of bisphenol. 30% to 90% by weight of 1 type, (c ′) d, l-camphorquinone which is a visible light sensitizer, and N which is a reducing agent.
-Phenylglycine, N, N-dialkylaminobenzoic acid and a combination with at least one member selected from the group consisting of aromatic sulfinates: 0.1 to 5% by weight, and (d ') an oxyalkylene group in the molecule. (Meth) acrylate having 3 to 20% by weight, and 3
A method for treating a tooth surface, which comprises applying a visible light curable composition having a viscosity in the range of 100 to 30,000 cP at 7.5 ° C. 23. (a ′) 4- (meth) acryloyloxyethyl trimellitic acid or its anhydride and N-
At least one selected from the group consisting of (meth) acryloylaminosalicylic acid 1 to 30% by weight, (f ')
At least one kind selected from the group consisting of water-containing ethanol and water-containing acetone 30 to 90% by weight and (g ') an oxyalkylene group-containing (meth) acrylate 1 to 20% by weight on the tooth surface. And then (a ') 4- (meth) acryloyloxyethyl trimellitic acid or its anhydride and N-
At least one selected from the group consisting of (meth) acryloylaminosalicylic acid 1 to 30% by weight, (b ')
At least selected from the group consisting of 2-hydroxyethyl (meth) acrylate, 2-hydroxypropyl (meth) acrylate, glycerol (meth) acrylate, erythritol (meth) acrylate and poly (meth) acrylate of a polyepoxy compound of bisphenol. 1 type 10 to 60% by weight, at least one type selected from the group consisting of (c ') d, l-camphorquinone, organic peroxides and inorganic oxides, and N- which is a reducing agent.
At least one selected from the group consisting of phenylglycine, N, N-dimethyl-p-toluidine, N, N-diethanol-p-toluidine, N, N-alkylaminobenzoic acid and aromatic sulfinate 0.1 -10% by weight, (d ') (meth) acrylate having an oxyalkylene group in the molecule 10-60% by weight and (e') zirconium oxide filler having an average particle size of 0.05-10 μm 40-80% by weight, average Spherical silica filler having a particle diameter of 1 to 10 μm 10 to 30% by weight and organic composite filler having an average particle diameter of 1 to 30 μm 10 to 30% by weight
Consisting of a filler containing any of, and 37.5
A method for treating a tooth surface, which comprises applying a room temperature curable composition having a viscosity at 100C of 100 to 30,000 cP.