JPH0789843A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation containing extracts of a plant of the genus Anthyllis of Leguminosae as active ingredients and having excellent effect on pigmentation after sunburn, stain, ephelis, chloasma, etc. CONSTITUTION:This skin external preparation contains extracts of a plant of the genus Anthyllis of Leguminosae as active ingredients in an amount of 0.005-20wt.% as a dried material based on total amount of cosmetics. This extract is obtained by immersing or heat-refluxing leaves and stems or whole grass of Anthyllis together with an extracting solvent and filtering the extract and concentrating the filtrate. The preparation can be prepared in an agent type of a solubilizing system such as lotion, an emulsification system such as milk lotion or cream or foundation, dispersion or two-layer type lotion. This skin preparation is excellent also in safety.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to Antilith
s) It relates to a skin external preparation having an excellent effect on pigmentation, spots, freckles, melasma, etc. after sunburn by incorporating an extract of a genus plant.

[0002]

BACKGROUND OF THE INVENTION Although there are some unclear points about the mechanism of skin spots and the like, in general, melanin pigments are formed due to hormonal abnormalities and irritation of ultraviolet rays from the sun, and this is the skin. It is thought to be abnormally deposited inside. Such treatments for bruise and bruise include substances that suppress the production of melanin, for example, a method of administering a large amount of vitamin C, a method of injecting glutathione or the like, or kojic acid,
A method of applying L-ascorbic acid, cysteine or the like in the form of an ointment, cream, lotion or the like locally is adopted. In Europe and the United States, hydroquinone preparations are generally used as medicines.

[0003]

However, these compounds, except for hydroquinone, exhibit their effects very slowly, so that the whitening effect is not sufficient. On the other hand, although the effect of hydroquinone has been confirmed, its use is generally limited because of its sensitizing property. Therefore, in order to improve its safety, attempts have been made to use higher fatty acid monoesters or alkyl monoethers, but it is difficult to say that esters are safe because they are decomposed by hydrolytic enzymes in the body. In terms of safety, the type of product has not been sufficiently satisfactory.

[0004]

Therefore, as a result of investigating the whitening effect of various substances as a solution to these problems, the present inventors have found that the conventional folk remedies include raw juice, hot water extract and alcohol. When an extract of a genus Anthyllis genus plant, which has been used for astringent, hemostasis, laxative, antitussive, anti-tumor, detoxification, etc. of pickled tinctures or powders, is added to cosmetics after dyeing. The inventors have found that they have an excellent effect on lightening of deposits, stains, freckles, melasma, and whitening, and have completed the present invention. That is, the present invention relates to a skin external preparation characterized by containing an extract of a plant belonging to the genus Antilis of the family Leguminaceae as an active ingredient.

[0005]

[Detailed Description of Configuration] The configuration of the present invention will be described in detail below. The antilith used in the present invention is a blister family Antiris that grows in dry grasslands and pastures of Europe and the like.
It is a plant of the genus (Anthyllis). The extract used in the present invention is obtained by dipping or heating or refluxing the above leaves and stems or whole plant of Antilis, filtering and concentrating. The extraction solvent used in the present invention may be any solvent that is commonly used for extraction, and particularly alcohols such as methanol and ethanol, and organic solvents such as acetone can be used alone or in combination.

The amount of the Antilith extract in the present invention is 0.005 to 20% by weight as a dry product in the total amount of the cosmetic.
It is preferably 0.01 to 10% by weight. If it is less than 0.005% by weight, the effect of the present invention will not be sufficiently exhibited, and if it exceeds 20% by weight, the formulation will be difficult, which is not preferable. Also, 10
Even if it is blended in an amount of more than wt%, the effect is not significantly improved.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, various components generally used in cosmetics, pharmaceuticals and the like, that is, an aqueous component and a powder component, if necessary, within a range not impairing the effects of the present invention. , Oils, surfactants, moisturizers, thickeners, preservatives, antioxidants, fragrances, coloring agents, agents and the like can be added. Further, the dosage form of the external preparation for skin of the present invention is arbitrary, for example, a solubilizing system such as lotion, an emulsion, a foundation such as cream or a dispersion,
Various dosage forms such as a two-layer lotion can be used.

[0008]

The present invention will be described in more detail with reference to Examples. The present invention is not limited to this. The blending amount is% by weight. Prior to the examples, the effect test method and evaluation method of the present invention will be described.

Test Example 1 (whitening effect) [Test method] 40 subjects exposed to the sunlight in the summer for 4 hours (2 hours a day for 2 days) were exposed to the sunlight on the skin of the inner part of the upper arm. From 5 days after the day, each sample was applied once a morning and evening for 4 weeks. The panel was divided into 10 groups per group and 4 groups were subjected to the test according to the following formulations. (Alcohol phase) 95% Ethyl alcohol 55.0 Polyoxyethylene (25 mol) Hardened castor oil ether 2.0 Antioxidants / preservatives Appropriate amount Perfume Appropriate amount Drug (described in Table 1) 0.1-10.0 (Water phase) Glycerin 5.0 Sodium hexametaphosphate Appropriate amount Ion Exchanged water Residue <Production method> An aqueous phase and an alcohol phase are respectively prepared, and then both are mixed and solubilized.

[Evaluation Method] The lightening effect after use was judged based on the following judgment criteria. <Judgment Criteria > ⊚: When the rate of marked efficacy and efficacy among the subjects is 80% or more ◯: The rate of marked efficacy and efficacy among the subjects is 50 to 8
In the case of 0% △: The ratio of markedly effective or effective among the subjects is 50 to 3
0% ×: When the ratio of markedly effective or effective in subjects is 30% or less

Examples 1 and 2 and Comparative Examples 1 and 2 Samples having the blending composition described in the above test method were prepared, and Table 1
The whitening effect was compared using the described agents. The results are shown in Table 1.

[0012]

[Table 1] ─────────────────────────────────── Drug compounding amount (% by weight) Effectiveness ─ ────────────────────────────────── Comparative Example 1 Additive- × Comparative Example 2 Hydroquinone 1.0 △ Example 1 Antilith 0.1 ○ Example 2 Antilith 1.0 ○ Example 3 Antilith 10.0 ◎ ───────────────────────────────── ───

The antiliths shown in Table 1 were obtained by heating and refluxing whole plants of Antilis sericea in ethanol, filtering and concentrating and drying.

As is clear from Table 1, the effect after exposure to sunlight is greater in Example than in Comparative Example in that excessive deposition of melanin pigment can be prevented and darkening can be prevented. Admitted.

Example 4 Cream (prescription) Stearic acid 5.0 Stearyl alcohol 4.0 Isopropyl myristate 18.0 Glycerin monostearate ester 3.0 Propylene glycol 10.0 Antilis methanol extract 0.01 Caustic potash 0.2 Sodium hydrogen sulfite 0.01 Preservative proper amount Fragrance appropriate amount Ion-exchanged water residual (Production method) Propylene glycol, antilis extract and caustic potash are added to ion-exchanged water, dissolved and heated to 70 ° C (aqueous phase). Mix other ingredients, melt by heating and keep at 70 ℃
(Oil phase). The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is kept for a while to cause the reaction. After that, homogenize with a homomixer and stir well at 30 ° C.
Cool down.

Example 5 Cream (Formulation) Stearyl alcohol 7.0 Stearic acid 2.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol) cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Antilis Ethanol extract 0.05 Perfume Suitable amount Sodium bisulfite 0.03 Ethylparaben 0.3 Ion-exchanged water Residual (production method) Propylene glycol is added to ion-exchanged water and heated to 70 ° C (aqueous phase). Mix other ingredients, heat and melt to maintain at 70 ° C (oil phase). The oil phase is added to the aqueous phase to carry out preliminary emulsification. After homogenizing with a homomixer, cool to 30 ° C while stirring well.

Example 6 Cream (Formulation) Solid paraffin 5.0 Beeswax 10.0 Vaseline 15.0 Liquid paraffin 41.0 Glycerin monostearate ester 2.0 Polyoxyethylene (20 mol) sorbitan monolaurate ester 2.0 Soap powder 0.1 Borax 0.2 Antilis acetone extract 0.05 an Tirith ethanol extract 0.05 Ion-exchanged water Residual fragrance Suitable amount Sodium hydrogen sulfite 0.03 Ethylparaben 0.3 (Production method) Soap powder and borax are added to ion-exchanged water and dissolved by heating and kept at 70 ° C (water phase). Mix other ingredients, heat and melt
Keep at 70 ° C (oil phase). The oil phase is stirred into the water phase and gradually added to carry out the reaction. After completion of the reaction, emulsify uniformly with a homomixer, and after emulsification, cool to 30 ° C while stirring well.

Example 7 Emulsion (formulation) Stearic acid 2.5 Cetyl alcohol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) Monooleate ester 2.0 Polyethylene glycol 1500 3.0 Triethanolamine 1.0 Antilith methanol extract 0.01 Sodium hydrogen sulfite 0.01 Ethylparaben 0.3 Carboxyvinyl polymer (trade name: Carbopol 941) 0.05 BF Goodrich Chemical company Fragrance Suitable amount Ion-exchanged water Residue (production method) Carboxyvinyl polymer is dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine are added to the rest of the ion-exchanged water, and the mixture is heated and dissolved and kept at 70 ° C (aqueous phase). The other ingredients are mixed, melted by heating and kept at 70 ° C (oil phase). The oil phase is added to the aqueous phase for preliminary emulsification, phase A is added and the mixture is homogenized with a homomixer, and after emulsification, cooled to 30 ° C while stirring well.

Example 8 Emulsion (formulation) Microcrystalline wax 1.0 Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate ester 4.0 Polyoxyethylene (20 mol) sorbitan monooleate ester 1.0 Propylene glycol 7.0 Antilis acetone extraction Substance 10.0 Ethyl paraben 0.3 Sodium hydrogen sulfite 0.01 Perfume Suitable amount Ion-exchanged water Residual (production method) Add propylene glycol to ion-exchanged water,
Heat to maintain 70 ° C (aqueous phase). The other ingredients are mixed, dissolved by heating and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase is gradually added to this and the mixture is uniformly emulsified with a homomixer. After emulsification, stir well and cool to 30 ° C.

Example 9 Jelly (formulation) 95% ethyl alcohol 10.0 dipropylene glycol 15.0 polyoxyethylene (50 mol) oleyl alcohol ether 2.0 carboxyvinyl polymer (trade name: Carbopol 940) 1.0 BF Goodrich Chemical company caustic soda 0.15 L- Arginine 0.1 Antilith ethanol extract 7.0 2-Human oxy-4-methoxybenzophenone sodium sulfonate 0.05 Methylparaben 0.2 Ethylenediaminetetraacetate ・ 3 sodium ・ 2 water 0.05 Fragrance A suitable amount Ion-exchanged water Residual (manufacturing) Carbopol 940 is homogeneous in ion-exchanged water While the antilith acetone extract, polyoxyethylene (50 mol) oleyl alcohol ether, is dissolved in 95% ethanol and added to the aqueous phase. Then, after adding other components, the mixture is neutralized with caustic soda and L-arginine to increase the viscosity.

Example 10 Serum (prescription) (Phase A) Ethanol (95%) 10.0 Polyoxyethylene (20) Octyldodecanol 1.0 Methylparaben 0.15 Pantothenyyl ether 0.1 Antilith Methanol extract 1.5 (Phase B) Hydroxylation Potassium 0.1 (Phase C) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 (Product name: Carbopol 940) BF Goodrich Chemical company Purified water Residue (production method) Phases A and C are uniformly dissolved, A to phase C
Add phase and solubilize. Then, phase B is added and filling is performed.

Example 11 Pack (formulation) (Phase A) Dipropylene glycol 5.0 Polyoxyethylene (60 moles) Hydrogenated castor oil 5.0 (Phase B) Antilis methanol extract 0.01 Olive oil 5.0 Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 ( Phase C) Sodium bisulfite 0.03 Polyvinyl alcohol 13.0 (Saponification degree 90, degree of polymerization 2,000) Ethanol 7.0 Purified water Residual (production method) Phase A, Phase B, Phase C are uniformly dissolved, and Phase B is added to Phase A And solubilize. Then, this is added to phase C and then filled.

Example 12 Solid foundation (formulation) Talc 43.1 Kaolin 15.0 Sericite 10.0 Zinc white 7.0 Titanium dioxide 3.8 Yellow iron oxide 2.9 Black iron oxide 0.2 Squalane 8.0 Isostearic acid 4.0 Monooleic acid POE sorbitan 3.0 Isocetyl octanoate 2.0 Antilith ethanol Extract 1.0 Preservative Suitable amount Perfume Suitable amount (Production method) Talc-black iron oxide powder components are thoroughly mixed with a blender, and squalane-isocetyl octoate oil component, antilis ethanol extract, preservative,
Add fragrance and knead well, then fill and mold in a container.

Example 13 Emulsion type foundation (cream type) (formulation) (powder part) titanium dioxide 10.3 sericite 5.4 kaolin 3.0 yellow iron oxide 0.8 red iron oxide 0.3 black iron oxide 0.2 (oil phase) decamethylcyclopentasiloxane 11.5 flow Paraffin 4.5 Polyoxyethylene-modified dimethylpolysiloxane 4.0 (Aqueous phase) Purified water 50.0 1,3-Butylene glycol 4.5 Antilis ethanol extract 1.5 Sorbitan sesquioleate 3.0 Preservative proper amount (fragrance) Suitable amount (production method) Heat aqueous phase After stirring, a powder portion thoroughly mixed and pulverized is added and a homomixer treatment is carried out. Further, the heated and mixed oil phase is added and subjected to a homomixer treatment, and then a fragrance is added with stirring and cooled to room temperature.

[0025]

The external preparation for skin of the present invention is an external preparation for skin which has an excellent effect on lightening of pigmentation, spots, freckles, chloasma, etc. after sunburn and whitening, and is also excellent in safety. .

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Rumiko Kaku 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Stock company Shiseido Daiichi Research Center

Claims (1)

[Claims] 1. A skin external preparation containing an extract of a plant belonging to the genus Antilis of the legume family.