JPH0780724B2 - Method for manufacturing drug-impregnated body - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a method for producing a drug-impregnated body, and more particularly to a method for producing a drug-impregnated body used in a method of evaporating a drug by heating.

[Conventional technology]

Conventionally, a method of evaporating a drug by heating a drug impregnated body has been widely used in fields such as insecticide and deodorant aroma.
An electric mosquito trap and a tape-type continuous evaporation device are known as typical ones of such heating evaporation method.

A continuous manufacturing method has been developed as a method for manufacturing a mosquito repellent mat for an electric mosquito trap (Japanese Patent Publication No. 56-12554,
(Japanese Patent Publication No. 57-61242, etc.), basically, a method in which a chemical is applied drop by drop to each mat, and a method in which roll printing is applied to one of the upper and lower surfaces of the mat is also performed.

On the other hand, the tape-type continuous evaporation method continuously or intermittently transfers a belt-like material (tape) impregnated with a chemical that is volatilized by heating, and directly or indirectly heats it when passing through a heating element. It has been known for a long time how to evaporate the chemicals (Japanese Patent Publication No. 39-16073 and Japanese Utility Model Publication No. 40-19950).
Issue, Jikkou 42-5017, Jikō Sho 48-26931, Jikon Sho 49
-31670, Jitsuko Sho 51-51884, Jitsukai Sho 60-7772, Jitsuko Sho 61-11204, etc.), and recently, a cassette type has been developed.

As a vaporizer used in such a tape-type continuous evaporation apparatus, generally, a tape of paper, cloth, non-woven fabric, or the like is impregnated with a drug solution, and the tape is wound into a cylindrical shape. And, as a method of impregnating the drug, for example, Japanese Patent Publication No. 55-43727 and Japanese Utility Model Publication No. 51-51884,
It describes a method of impregnating a tape having a large impregnating property into a solution prepared by dissolving a drug in a solvent such as alcohol, and then drying the tape.

[Problems to be solved by the invention]

In the method for producing a drug-impregnated body as described above, in the case of a mosquito repellent mat, since the mats are applied one by one, the productivity is poor, and there are problems in terms of quantitative application and uniform application,
Further, there is a problem that the coating equipment per unit processing amount becomes large.

On the other hand, in the case of a tape-shaped impregnated body used in a tape-type continuous evaporation device, from the viewpoint of workability, it is usual to wind the tape into a cylindrical shape and then immerse the tape in a solvent solution of the drug. However, in this case, the total impregnated amount is constant when the cylindrical tape is sufficiently impregnated with the drug solution, and the impregnated amount in each part of the cylindrical tape is uniform, but the solvent alcohol is not used when the tape is dried. Volatilize. Since this volatilization occurs from the entire surface of the cylindrical tape, it tends to volatilize toward the outer circumference of the tape (because the cylindrical body is usually inserted in the inner peripheral surface), and the amount of volatilization from the outer peripheral surface of the cylindrical tape is remarkable. . In this case, first of all, alcohol volatilizes mainly from the outer peripheral portion of the cylindrical tape and the drug remains, but a sufficient amount of the drug solution migrates from the inner side of the cylindrical tape toward the outer peripheral surface for volatilization, and in this migration solution, Only the alcohol evaporates and the drug remains. Since such a phenomenon is repeated, when the alcohol has completely evaporated from the cylindrical tape (at the end of drying), there is a difference in the chemical impregnation amount per unit tape length between the inside and the outside of the cylindrical tape, There was a problem that the concentration became higher toward the outside. Further, once the concentration difference occurs, in a cylindrical tape in which almost no drug remains due to drying, the drug transfer between the inner and outer tapes is almost zero, so the difference in concentration is remarkably eased. slow. Further, since the solvent is volatilized, there is a risk of ignition and the like during the drying process.

Therefore, an object of the present invention is to provide a method for producing a drug-impregnated body capable of uniformly impregnating a drug with good productivity in any impregnated body such as mat type and tape type.

Another object of the present invention is to provide a method capable of impregnating an impregnated body with a chemical agent in a short time and economically without danger of ignition.

[Means for solving problems]

In order to achieve the above-mentioned object, the method for producing a drug-impregnated body of the present invention is characterized in that, in a state in which impregnated bodies having a predetermined shape are stacked, a liquid drug is spray-coated on the surface where each layer is exposed. Is.

[Operation and Mode of Invention]

According to the research conducted by the present inventors, as described above, in a state where the impregnated bodies having a predetermined shape are laminated so that adjacent surfaces are in contact with each other, the liquid chemical agent is spray-coated on one end surface where each layer is exposed. It has been found that the liquid drug permeates the pores in each impregnated body and the voids between each impregnated body layer due to the capillary phenomenon so that the impregnated body is uniformly impregnated with the liquid drug. Moreover, since a liquid chemical is used instead of the conventional volatile organic solvent solution, the drying step is unnecessary, and the concentration difference between the inner part and the outer part of the impregnated body, which is seen during the conventional drying step, is also generated. However, each impregnated body is uniformly impregnated with the drug not only at the time of manufacturing but also after a certain period of time has elapsed after manufacturing.

The method of the present invention is a sheet-like mat, particularly a rectangular mat for an electric mosquito trap, a cylindrical wound strip used in a tape-type continuous evaporation device, and the like, which are substantially planar and can be laminated on each other. It can be applied to various shapes of impregnated bodies. As the material of the impregnated body, various materials such as high molecular resin such as pulp, linter, rayon, polyester, hemp, synthetic paper, cloth (including non-woven fabric), paper can be used, and the width and the thickness are intended for use. It can be designed as desired.

Next, the spray application process of the liquid medicine will be explained. For example, in the case of a rectangular mat such as a mosquito catching mat, the rectangular mat 1 is overlapped with the mats of the mats as shown in FIGS. 1 and 2. The liquid medicine is sprayed from the spray nozzle 3 so that the spray nozzle 3 moves on the upper part (or the lower part) (or each mat moves with respect to the fixed spray nozzle). The arrow indicates the moving direction of the spray nozzle (or rectangular mat). Similarly, in the case of a band-shaped body, if necessary, a core material is used to wind it into a cylindrical shape, and the cylindrical band-shaped body 2 is sprayed on the end face where each layer is exposed as shown in FIGS. 3 and 4. It is arranged so as to face the nozzle 3 (usually in the vertical direction), and the liquid drug is sprayed from the spray nozzle 3 in the same manner as described above. Further, the spray nozzle 3 can be fixed and the cylindrical strip 2 can be rotated, and conversely, the spray nozzle 3 can be rotated. In addition, the elongated strips are erected so that the interlayer exposed surfaces of the long sides face up and down in a state where the respective surfaces are overlapped (the laminated body may be bound using an appropriate device), and the rectangular mat As in the case of 1, the liquid chemical may be sprayed and then rolled into a cylindrical shape, or may be cut and formed into a rectangular mat.

A more preferable spraying process is, for example, as shown in FIG. 5, while conveying the rectangular mat 1 by the conveyor 4 at a constant speed in the direction of the arrow, from the spray nozzle 3 fixedly arranged at a predetermined location on the conveyor 4 at a predetermined height. Spray liquid medication. Reference numeral 5 is a drive roll, and 6 is a driven roll.

In these sprays, the number of spray nozzles may be one or more, but the number and arrangement of spray nozzles may be arbitrarily combined depending on the spray pattern, spray amount, and the like. For example, various impregnated bodies using a large number of spray nozzles can be fixed and sprayed.

Although various devices can be used as a spray treatment device for liquid chemicals, for example, a device described in Japanese Patent Publication No. 56-12554 can be suitably used for quantitative spraying. The basic structure is shown in FIG. The liquid medicine prepared in the preparation tank 10 is pressure-fed by the pump 11 to the relay tank 13 via the filter 12, and then quantitatively fed to the temperature adjustment tank 15 by the metering pump 14. Temperature adjustment tank 15
The liquid chemical whose temperature has been adjusted in (1) is flown into the reserve tank 17 via the heat exchange device (16). In the spare tank 17, the excessively inflowing liquid chemical is caused to flow out to the relay tank 13 side by an overflow method so that the liquid level is maintained constant. The liquid chemical in the reserve tank 17 is discharged under constant pressure by the constant pressure pump 18, and is sprayed under constant pressure from the spray nozzle 3 through the safety valve 19 and further through the fine adjustment valve 20. The liquid medicine discharged from the safety valve 19 is returned to the relay tank 13 side.

Below the spray nozzle 3, a conveyor 4 composed of a net, a belt, a chain, or the like is laid, and the conveyor 4 keeps the impregnated body constant while being stacked as shown in FIGS. 1 to 4. Is continuously conveyed at a speed of (or intermittently depending on the supply mode of the impregnated body) and passes below the spray nozzle 3. At this time, the impregnated body is uniformly impregnated with a certain amount of the liquid chemical sprayed from the spray nozzle 3. The liquid drug that has flowed down without being impregnated in each impregnated body,
Collected by the receiver 21 provided below the conveyor 4,
It is returned to the relay tank 13 via the pump 11 and the filter 12. As the spraying method, various methods such as an ink jet method can be used.

As the liquid medicine used in the present invention, any liquid medicine at room temperature and preferably non-volatile can be used, and for example, in the case of aiming at insecticidal / sterilization, it is aimed at insecticidal / bactericidal agents and deodorant aroma. In this case, it is a deodorant, a fragrance, etc., and various chemicals can be used depending on the purpose of use.

As the insecticide used in the present invention, various (heated) volatile insecticides that have been conventionally used can be used, but in general, a pyrethroid insecticide is preferably used because of its high safety. Is an insecticide such as.

3-allyl-2-methylcyclopent-2-ene-
4-on-1-yl dl-cis / trans-chrysanthemate (generic name arethrin: trade name pinamine: manufactured by Sumitomo Chemical Co., Ltd.) 3-allyl-2-methylcyclopent-2-ene-
4-on-1-yl d-cis / trans-chrysanthemate (trade name Pinamineforte: manufactured by Sumitomo Chemical Co., Ltd.) d-3-allyl-2-methylcyclopent-2-en-4-one-1- Il d-trans-chrysanthate (trade name: Exulin: manufactured by Sumitomo Chemical Co., Ltd.) 3-allyl-2-methylcyclopent-2-ene-
4-on-1-yl d-trans-chrysanthemate (generic name bioallethrin) 2-methyl-4-oxo-3- (2-propynyl)
Cyclopent-2-enyl-chrysanthemate N- (3,4,5,6-tetrahydrophthalimide) -methyl dl-cis / trans-chrysanthemate (generic name phthalthrin: trade name neopinamine: Sumitomo Chemical Co., Ltd.) 5-benzyl-3-furylmethyl d-cis / trans-chrysanthemate (generic name resmethrin: trade name Kryslon Forte: Sumitomo Chemical Co., Ltd.) 5- (5-propargyl) -3-furylmethyl Chrysanthemate (generic name flamethrin) 3-phenoxybenzyl 2,2-dimethyl-3-
(2 ', 2'-Dichloro) vinylcyclopropane carboxylate (generic name permethrin: trade name exmine:
Sumitomo Chemical Co., Ltd.) 3-phenoxybenzyl d-cis / trans-chrysanthemate (generic name Phenothrin: trade name Smithlin: Sumitomo Chemical Co., Ltd.) α-cyanophenoxybenzyl isopropyl-4
-Chlorophenyl acetate (generic name phenvalerate: trade name Sumicidine, manufactured by Sumitomo Chemical Co., Ltd.) (S) -α-cyano-3-phenoxybenzyl (1
R, cis) -3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate (generic name cypermethrin f) (R, S) -α-cyano-3-phenoxybenzyl (1
R, 1S) -cis / trans-3- (2,2-dichlorovinyl) -2,2-dimethylcyclopropanecarboxylate (generic name cypermethrin) α-cyano-3-phenoxybenzyl d-cis /
Trans-chrysanthate (generic name cyphenothrin) 1-ethynyl-2-methyl-2-pentenyl cis /
Trans-chrysanthate (generic name Bepasulin) 3-allyl-2-methyl-cyclopent-2-en-4-one-1-yl-2,2,3,3-tetramethylcyclopropanecarboxylate (generic name teraresulin ) 1-Ethynyl-2-methyl-2-pentenyl 2,2,
3,3-Tetramethylcyclopropanecarboxylate 1-ethynyl-2-methyl-2-pentenyl 2,2
-Dimethyl-3- (2,2-dichlorovinyl) cyclopropane-1-carboxylate [(pentafluorophenyl) -methyl] -1R, 3R
-3- (2,2-Dichloroethynyl) -2,2-dimethyl-cyclopropanecarboxylate (generic name phenfluthrin) (S) -2-methyl-4-oxo-3- (2-propynyl) cyclopenta- 2-enyl (1R) -cis, trans chrysanthemate (generic name Praresulin) Examples of synergists include α- [2- (2-butoxyethoxy) ethoxy] -4,5-methylenedioxy-2-propyl. Toluene (abbreviation piperonyl butoxide), octachlorodipropyl ether (abbreviation S-421), N- (2
-Ethylhexyl) -bicyclo- [2,2,1] -hept-
5-ene-2,3-dicarboximide (abbreviation MGK-26
4), N- (2-ethylhexyl) -1-isopropyl-4-methylbicyclo- [2,2,2] -oct-5-ene-2,3-dicarboximide (abbreviation cynepiline-50)
0), isobornyl thiocyanoacetate (abbreviation IBTA)
Etc. can be used.

In addition, antioxidants, pigments, dyes, fragrances, or paraffins, if necessary, as long as the characteristics are not impaired.
You may mix | blend other additives, such as a bulking agent of ester and glycol.

Examples of the antioxidant include 2,6-di-t-butyl-4
-Methylphenol (BHT), 3-t-butyl-4-hydroxyanisole (BHA), 2,2'-methylenebis (4
-Ethyl-6-t-butylphenol), 2,2'-methylenebis (4-methyl-6-t-butylphenol),
4,4'-butylidene bis (5-methyl-6-t-butylphenol), 4,4'-methylenebis (2-methyl-6)
-T-butylphenol), 4,4'-thiobis (3-methyl-6-t-butylphenol), 4,4'-methylenebis (2,6-t-butylphenol), stearyl-β
-(3,5-di-t-butyl-4-hydroxyphenyl)
Propionate, 1,3,5-trimethyl-2,4,6-tris (3,5-di-t-butyl-4-hydroxybenzylbenzene), 1,1,3-tris (2-methyl-4-hydroxy) -5-t-butyl) butane, tetrakis [methylene (3,
5-di-t-butyl-4-hydroxycinnamate)]
Antioxidants such as methane, dilauryl thiodipropionate and distearyl thiodipropionate can be used, and thermal stability and temporal stability can be further improved by adding an appropriate amount thereof.

Similarly, when used for the purpose of aroma, various natural and artificial flavors can be used, for example, animal or plant natural flavors, hydrocarbons, alcohols, phenols, aldehydes, ketones, lactones, oxides. , Artificial flavors such as esters, etc., and one of these may be used alone, or two or more thereof may be mixed and used. Further, depending on the purpose, various chemicals such as deodorants such as borneol and camphor, and bactericides and repellents can be used as long as they are liquid chemicals.

Further, in order to improve the sticking rate of the chemical to be spray-applied, it is possible to add an aliphatic hydrocarbon, an oil and fat, a silicone oil, a thickener or the like.

〔Example〕

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples.

Example 1 10 mm wide pulp tape with a width of 10 mm, a thickness of 0.15 mm and a length of 10 m
It was wrapped around a φ × 10 mm resin core to obtain an impregnated body. on the other hand,
A stock solution (1800 mg) prepared by mixing and dissolving BHT (200 mg) with pinamine (1600 mg) was prepared and spray-coated on the above impregnated body to prepare a drug-impregnated body.

Comparative Example 1 180 mg of the stock solution used in Example 1 was applied to each of 10 parts of the same cylindrical impregnated body used in Example 1 divided into 10 concentric circles from the inside to the outside at an approximately intermediate distance. , Total 1
A drug-impregnated body was prepared by applying 800 mg of the stock solution.

Comparative Example 2 1800 mg of the stock solution used in Example 1 was made up to 5 ml with hexane,
After applying to the same cylindrical impregnated body used in Example 1,
Hexane was removed by drying to prepare a drug-impregnated body.

Each of the drug-impregnated bodies obtained in Example 1 and Comparative Examples 1 and 2 was prepared for 1 day, and then 50 cm at a distance of 2 m from the outer periphery 1 m.
Each was cut out, the drug was extracted with hexane, concentrated, and then quantitatively analyzed by a gas chromatograph. The results are shown in Table-1.

As is clear from the above results, in the case of the present invention, the drug was uniformly impregnated in each part of the cylindrical impregnated body, but Comparative Example 1
In the cases of Nos. 1 and 2, variations in the amount of impregnation were observed, and particularly in the case of Comparative Example 1, there was a significant difference in the amount of impregnation between the inner portion and the outer portion.

Example 2 10 mm of rayon tape with a width of 12 mm, a thickness of 0.1 mm and a length of 10 m
It was wrapped around a φ × 12 mm resin core to obtain an impregnated body. on the other hand,
400 mg of BHT 200 mg mixed and dissolved in Praresulin 200 mg
Was prepared and spray-coated on the above-mentioned impregnated body to prepare a drug-impregnated body.

Comparative Example 3 400 mg of the stock solution used in Example 2 was made up to 4 ml with hexane and applied to the same cylindrical impregnated body as used in Example 2, and then hexane was removed by drying to prepare a drug impregnated body.

Each of the five drug-impregnated bodies obtained in Example 2 and Comparative Example 3 was allowed to stand at 25 ° C., and 0, 1, 3, 5, 10 days after standing, 4 m from the outer periphery of each drug-impregnated body. 50 cm each was cut at intervals, the drug was extracted with hexane, concentrated, and then quantitatively analyzed by gas chromatography. The results are shown in Table-2.

As is clear from the above results, in the case of Comparative Example 3, the amount of impregnation differs between the outer portion and the inner portion, and it is understood that the drug migrates from the outer portion to the inner portion over time. On the other hand, in the case of the present invention, it can be seen that the chemical impregnation amount is constant in both the outer side portion and the inner side portion of the cylindrical impregnated body, and it is always constant over time.

〔The invention's effect〕

As described above, the method for producing a drug-impregnated body of the present invention is a method in which the liquid drug is spray-coated on the surface where each layer is exposed in a state where the impregnated body having a predetermined shape is laminated. Each impregnated body is uniformly impregnated, and even after a certain period of time, each impregnated body is uniformly impregnated with the drug. The problem of non-uniformity of the impregnated drug in 1. does not occur. Further, since it is applied by spraying, it can be applied to a substantially planar impregnated body of any shape, and since it can be treated in large quantities or continuously, it has high productivity and the treatment time per unit impregnated body can be greatly shortened. It is possible to downsize the coating equipment, which is extremely economically advantageous.

Furthermore, since a liquid chemical is used, it can be uniformly applied and impregnated even with a small amount of chemical treatment, and unlike conventional methods, it does not require a volatile solvent, so that the drying step can be omitted, and the risk of ignition etc. is eliminated. Is obtained.

[Brief description of drawings]

FIG. 1 is a plan view showing a spraying state when the method of the present invention is applied to a rectangular mat, FIG. 2 is a side view thereof, and FIG. 3 is a case where the method is applied to an impregnated body obtained by winding a band-shaped body into a cylindrical shape. FIG. 4 is a side view showing a spraying state of the liquid medicine, FIG. 4 is a side view of the same, FIG. 5 is a side view showing a state of spraying the impregnated body being conveyed, and FIG. The schematic block diagram is shown. 1 is a rectangular mat, 2 is a cylindrical strip, 3 is a spray nozzle,
4 is a conveyor.

Claims (12)

[Claims] 1. A method for producing a drug-impregnated body, which comprises spraying a liquid drug onto a surface where each layer is exposed in a state where an impregnated body having a predetermined shape is laminated. 2. The method according to claim 1, wherein the impregnated body is a thin plate mat. 3. The method according to claim 1 or 2, wherein the impregnated body is a rectangular mat. 4. The first invention according to claim 1, wherein the impregnated body is a belt-shaped body.
The method described in the section. 5. The method according to claim 4, wherein the impregnated body is a strip-shaped body wound in a cylindrical shape. 6. The method according to any one of claims 1 to 5, wherein the liquid drug is an insecticidal fungicide. 7. The method according to any one of claims 1 to 5, wherein the liquid drug is a pyrethroid insecticide. 8. The first claim in which the liquid drug is a fragrance.
Item 8. The method according to any one of Items 7 to 7. 9. The method according to any one of claims 1 to 8, wherein the liquid drug is a deodorant. 10. A liquid medicine is a synergist, an antioxidant, a pigment,
The method according to any one of claims 1 to 9, which comprises at least one kind of dye, extender, thickener and the like. 11. The liquid chemical agent is spray-coated while continuously conveying the impregnated body in a laminated state.
The method described in paragraph 10. 12. The method according to any one of claims 1 to 11, wherein the elongated impregnated body is spray-coated with the liquid chemical and then cut into rectangular mats having a predetermined shape.