JPH07507812A - Screening method for epithelial cancer and kit for the screening - Google Patents
Screening method for epithelial cancer and kit for the screeningInfo
- Publication number
- JPH07507812A JPH07507812A JP6516458A JP51645894A JPH07507812A JP H07507812 A JPH07507812 A JP H07507812A JP 6516458 A JP6516458 A JP 6516458A JP 51645894 A JP51645894 A JP 51645894A JP H07507812 A JPH07507812 A JP H07507812A
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- Prior art keywords
- preselected
- screening
- reagents
- kit
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/0413—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section formed by folding or erecting one or more blanks, e.g. carton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B2050/005—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover
- A61B2050/0051—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover closable by rotation
- A61B2050/0056—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover closable by rotation about a lateral axis in the lid plane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
- A61B50/31—Carrying cases or bags, e.g. doctors' bags
- A61B2050/311—Cases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
(57)【要約】本公報は電子出願前の出願データであるため要約のデータは記録されません。 (57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.
Description
【発明の詳細な説明】 この発明は、上皮癌について患者をスクリーニングする改良された方法に関する 。[Detailed description of the invention] This invention relates to an improved method of screening patients for epithelial cancer. .
他の点においては、この発明は、発生が見込まれる上皮癌（ｐｏｓｓｉｂｌｅ ｅｐｉｔｈｅｌｉａｌ ｃａｎｃｅｒ）を検出するための患者のスクリーニング に用いられるキットに関する。In other respects, the present invention is applicable to epithelial cancers that are likely to occur. Screening of patients to detect epithelial cancer The present invention relates to a kit used for.
特には、上皮癌についての患者のスクリーニングに用いられるキットであって、 医療関係者が高度に専門化した訓練を受けることなく使用することが可能なキッ トに関する。In particular, a kit for use in screening patients for epithelial cancer, comprising: A kit that can be used by medical personnel without highly specialized training. Regarding
さらに別の点においては、この発明は、上皮癌についての患者のスクリーニング に用いられるキットであって、時間を浪費し、もしくは繁雑である混合−保存一 分配一計墓工程を必要とすることなく、必要な材料の全てを、臨床医が即座に意 のままに使用できる“調製済み（ｒｅｘｄ７−Ｉｏ−ｕｓｅ）”の形態にするキ ットに関する。In yet another aspect, the invention provides methods for screening patients for epithelial cancer. kits used for mixing and storage that are time consuming or complicated. Clinicians can instantly obtain all necessary materials without the need for a dispensing process. The key is in “prepared (rexd7-Io-use)” form that can be used as is. Regarding the cut.
上皮癌についての患者のスクリーニング、特に口腔粘膜のような粘膜上の癌及び 前癌か疑われる部位の検出の種々の手順が知られている。そのような手順は、一 般に、癌及び前癌状態の特徴として認識されているＲＮＡリッチの組織（ＲＮＡ −ｒｉｃｈ ｔｉｓｓｕｅ ）を優先的に染色する染料を用いる。例えば、Ｍａ ｓｈｂｅｒｇの米国特許４．３２１．２５１号はそのような手順を開示する。Ｍ ｉｓｈｂｕｇの手順には、口腔粘膜の癌及び前癌状態を検出するために、連続的 な洗浄、リンス、並びに水、希釈酢酸及びトルイジンブルーＯ染料の塗布が含ま れる。この、洗浄−リンス−塗布−リンスー洗浄め手順は、疑わしい部位が検出 された場合には、偽陽性の数を減らすために、繰り返される。Screening patients for epithelial cancers, especially cancers on mucous membranes such as the oral mucosa and Various procedures for detecting suspected precancerous sites are known. Such a procedure is Generally, RNA-rich tissues (RNA A dye that preferentially stains -rich tissue is used. For example, Ma US Pat. No. 4,321,251 to Shberg discloses such a procedure. M The ishbug procedure includes continuous Includes thorough cleaning, rinsing, and application of water, dilute acetic acid, and Toluidine Blue O dye. It will be done. This wash-rinse-apply-rinse procedure is used to detect suspicious areas. If detected, it is repeated to reduce the number of false positives.
歯医者に歯の掃除に訪れるような型通りの検診（ｒｏｕｔｉｎｔｏｆｆｉｃｓ ｖｉｓ日Ｓ）の間に、全ての患者を上皮癌についてスクリーニングすることは非 常に有益なことであろう。しかしながら、Ｍａｓｈｂｅ＋ｇの手順のような上皮 癌のスクリーニング法では、型通りの使い方は達成されていない。これは、一部 には、必要な溶液を混合し、計量し、分配することが、歯医者によって各患者に 対して行なわれるには時間がかかり過ぎ、そのような手順が、幾らかの訓練と専 門職補助員（助手）が通常有する経験を越える経験を要求するためである。Routine checkups like visiting the dentist for teeth cleaning It is not possible to screen all patients for epithelial cancer during the It will always be beneficial. However, epithelial as in the Mashbe+g procedure Routine use has not been achieved in cancer screening methods. This is partly The necessary solutions are mixed, measured, and dispensed by the dentist to each patient. It is too time consuming to perform this procedure, and such procedures require some training and expertise. This is because they require experience that exceeds that normally held by assistants.
それ故に、簡略化され、患者か他の理由で診療所又は歯医者に普通に訪れること に付随するものとしての型通りのスクリーニングの助長に特に適合する、上皮癌 についての患者のスクリーニングの改良された方法を提供することが望まれる。Therefore, a normal visit to a clinic or dentist by a patient or for other reasons is simplified. epithelial cancers, particularly amenable to routine screening as an adjunct to It would be desirable to provide improved methods of screening patients for.
したがって、この発明の第１の目的は、上記改良されたスクリーニング法を提供 することにある。Therefore, a first object of the present invention is to provide the above-mentioned improved screening method. It's about doing.
この発明のさらに別の目的は、従来医療もしくは歯科専門職による上記の型通り の試験を阻止していた、時間及び繁雑さを最小にすることによって、上記の型通 りの試験を助長する装置を提供することにある。Yet another object of the invention is to provide the above-mentioned methods by the conventional medical or dental profession. By minimizing the time and complexity that was hampering the testing of The purpose of this invention is to provide a device that facilitates testing.
この発明のこれらの、及び他の、より以上の特定の目的は、この発明の一態様の 原理に従って組み立てられる要素のキットを説明する以下のこの発明の詳細な説 明から、図面と共に考慮して、当業者には明らかであろう。These and other specific objects of the invention are one aspect of the invention. The following detailed description of this invention describes a kit of elements assembled in accordance with the principles. This will be apparent to those skilled in the art when considered in conjunction with the drawings.
簡潔に述べると、この発明に従って、私は上皮癌について患者をスクリーニング するための方法及び装置を提供する。Briefly, in accordance with this invention, I screened patients for epithelial cancer. A method and apparatus for doing so are provided.
私の方法は、予め選択された濃度の少なくとも２種類の液体試験試薬を癌又は前 癌が疑われる部位に予め選択された容量連続的に塗布する工程を含む従来のスク リーニング法の改良である。私の改良された方法は、投与する臨床医に上記試薬 を予め包装された形態で提供して、さらなる混合もしくは計量工程なしに、スク リーニングの手順に従って用いられる包装から各々の試薬を直接投与することを 可能にすることを包含する。ここで、臨床医に提供される試薬の各々は、それら の予め選択された容量が予め選択された濃度で含まれるように包装されている。My method involves administering at least two liquid test reagents at pre-selected concentrations to cancer or cancer patients. A conventional screen that involves sequentially applying a preselected volume to the suspected cancer site This is an improvement on the leaning method. My improved method allows clinicians to administer the above reagents. is provided in pre-packaged form to allow for screening without further mixing or metering steps. Administer each reagent directly from the packaging used according to the cleaning procedure. Includes enabling. Here, each of the reagents provided to the clinician is The packaged product is packaged to contain a preselected volume of at a preselected concentration.
この発明の他の態様に従って、私は、発生が見込まれる上皮癌を検出する型通り のスクリーニング手順を行なうための診断キットを提供する。この手順には、予 め選択された濃度の少なくとも２種類の試験試薬の予め選択された容量を、癌又 は前癌が疑われる部位に連続的に塗布する工程が含まれる。In accordance with other aspects of this invention, I provide a method for detecting epithelial cancer that is likely to occur. The present invention provides a diagnostic kit for performing a screening procedure. This step includes preselected volumes of at least two test reagents at concentrations selected for The method involves continuous application to areas suspected of having precancerous cancer.
このキットは、各試験試薬の個別の包装を具備する。この包装の各々には、予め 選択された濃度の試薬が、予め選択された容量含まれる。The kit includes separate packaging for each test reagent. Each of this packaging includes Reagents at selected concentrations are included in preselected volumes.
図は、この発明の原理に従って構築され、この場合には、Ｍａｓｈｂｅｒｇのス クリーニング手順を行なうためのキットを示す。The diagram is constructed according to the principles of the invention, in this case Mashberg's A kit for performing a cleaning procedure is shown.
このキットは、１個の箱１０内に都合よく収容することができ、これは−人の患 者を口腔上皮癌についてスクリーニングするに必要な全ての要素を収容している 。この要素には、単一用途のカップと共に、３本のボトルＩＩ、 １２及び１３ が含まれる。The kit can be conveniently housed in one box 10, which is suitable for human patients. Contains all the elements necessary to screen people for oral epithelial cancer . This element contains three bottles II, 12 and 13, along with a single-use cup. is included.
ボトルＩＩには、高校のｐＨＦｌ整及び食物粒子等の洗い流しに用いられる、酢 酸の１％溶液の予備すすぎ液（ｐτｅ−ｒｉｎｓｅ ）１０ｃｃが収容されてい る。ボトル１２には、トルイジンブルー０の１％溶液１０ｃｃか収容されている 。ボトル１３には、口から余分のトルイジンブルー〇染料を除去するために用い られる、１％酢酸溶液後すすぎ液（ｐｏｓｔ−ｒｉｎｓｅ）が収容されている。Bottle II contains vinegar, which is used in high schools to adjust pHFl and wash away food particles. Contains 10 cc of pre-rinse solution (pτe-rinse) of 1% acid solution. Ru. Bottle 12 contains 10 cc of a 1% solution of toluidine blue 0. . Bottle 13 contains a bottle of toluidine blue used to remove excess toluidine blue dye from the mouth. A 1% acetic acid solution post-rinse is contained.
この好ましい態様に従い、私は、後の参考のために臨床医が疑わしい癌部位を記 録することができる口腔ダイアグラムシート、患者の前掛け１５、洗浄水を与え るためのカップ１６及びこの手順の有効性の確認に用いられる臨床情報応答カー ド１７のような他の任意の要素もキットに含めた。In accordance with this preferred embodiment, I would like the clinician to note the suspected cancer site for later reference. Provide an oral diagram sheet that can be recorded, an apron for the patient15, and water for irrigation. a clinical information response card used to confirm the effectiveness of this procedure. Other optional elements such as code 17 were also included in the kit.
当業者には明らかであるように、私の発明は特定の治療法又は特定の溶液に限定 されるものではない。その代わりに、一般に、複数の試験試薬を用いるいかなる 上皮癌検出法にも、用いられる特定の試験試薬に限定を加えることなく、適用可 能である。As will be clear to those skilled in the art, my invention is not limited to specific treatments or specific solutions. It is not something that will be done. Instead, any test using multiple test reagents is generally recommended. Applicable to epithelial cancer detection methods without any restrictions on the specific test reagents used. It is Noh.
以上、私の発明は、当業者が理解し、それを実施することが可能な用語で記述さ れ、それらの好ましい態様が検証された。My invention has been described in terms that will enable those skilled in the art to understand and put it into practice. and their preferred aspects were verified.
ＦＩＧ、 ／FIG, /
Claims (2)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002131164A CA2131164A1 (en) | 1993-01-14 | 1993-01-14 | Method and kit for epithelial cancer screening |
| PCT/US1993/000352 WO1994016325A1 (en) | 1993-01-14 | 1993-01-14 | Method and kit for epithelial cancer screening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07507812A true JPH07507812A (en) | 1995-08-31 |
Family
ID=25677465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6516458A Pending JPH07507812A (en) | 1993-01-14 | 1993-01-14 | Screening method for epithelial cancer and kit for the screening |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0636246A1 (en) |
| JP (1) | JPH07507812A (en) |
| AU (1) | AU696368B2 (en) |
| CA (1) | CA2131164A1 (en) |
| WO (1) | WO1994016325A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004504615A (en) * | 2000-07-20 | 2004-02-12 | ジラ・インク | Improved diagnostic method for detecting dysplastic epithelial tissue |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882627A (en) * | 1996-01-16 | 1999-03-16 | Zila Pharmaceuticals, Inc. | Methods and compositions for in-vivo detection of oral cancers precancerous conditions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3743088A (en) * | 1971-01-18 | 1973-07-03 | R Henkin | Diagnostic device and method of treatment |
| US4321251A (en) * | 1979-12-19 | 1982-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse |
| US4977177A (en) * | 1985-04-30 | 1990-12-11 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents |
| US5018531A (en) * | 1989-09-07 | 1991-05-28 | Hartman William B | Skin blemish measuring and recording system and method |
| US5116328A (en) * | 1990-07-16 | 1992-05-26 | Oclassen Pharmaceuticals, Inc. | Diagnostic kit for the detection of atypical epithelia |
-
1993
- 1993-01-14 CA CA002131164A patent/CA2131164A1/en not_active Abandoned
- 1993-01-14 AU AU34740/93A patent/AU696368B2/en not_active Ceased
- 1993-01-14 WO PCT/US1993/000352 patent/WO1994016325A1/en not_active Application Discontinuation
- 1993-01-14 JP JP6516458A patent/JPH07507812A/en active Pending
- 1993-01-14 EP EP93903503A patent/EP0636246A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004504615A (en) * | 2000-07-20 | 2004-02-12 | ジラ・インク | Improved diagnostic method for detecting dysplastic epithelial tissue |
Also Published As
| Publication number | Publication date |
|---|---|
| AU696368B2 (en) | 1998-09-10 |
| AU3474093A (en) | 1994-08-15 |
| CA2131164A1 (en) | 1994-07-21 |
| EP0636246A4 (en) | 1995-03-08 |
| EP0636246A1 (en) | 1995-02-01 |
| WO1994016325A1 (en) | 1994-07-21 |
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