JPH0742409Y2 - Laboratory animal harness - Google Patents

Description

[Detailed description of the device]

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a harness for laboratory animals which holds a catheter protector for inserting a catheter.

[0002]

2. Description of the Related Art Continuous dialysis, administration of continuous high-calorie liquid and the like are performed through a catheter that penetrates the skin of a living body. When performing these studies with laboratory animals, the catheter is permanently worn through the skin. However, it is difficult to fix the catheter directly to the skin due to the movement of the experimental animal. There is also a problem that when the experimental animal moves around, infection and inflammation due to bacteria may occur in the vicinity of the portion where the catheter penetrates the skin.

A method of inserting a catheter into a body by using a catheter protector formed of a coil spring, sewing the tip of the catheter protector to the epidermis of an experimental animal, and inserting the catheter into the catheter protector Is also being done. However, even with this method,
Since the catheter protector is sewn on the epidermis, it cannot follow the movement of the experimental animal sufficiently, and the problems such as infection and inflammation cannot be completely solved.

More recently, rodent jackets have been put on the market for fixing the catheter protector formed by the coil spring. By attaching this jacket to the experimental animal, the movement of the experimental animal is easily allowed.

[0005]

[Problems to be Solved by the Invention] However, the conventional Rodent jacket is difficult to wear on a laboratory animal, and since the body surface is made of a simple woven fabric, The surface of the woven fabric is irritating to the skin of the laboratory animal, and the laboratory animal is apt to be damaged by scratching or biting the jacket,
Therefore, it could not withstand long-term use. In addition, the attachment work was complicated because there was an operation to tie it up with a string.

The present invention solves the above-mentioned problems of the prior art, is easy to attach to an experimental animal, and is easy to attach a catheter protector. Furthermore, even if the experimental animal moves relatively freely, the catheter can be attached. It is an object of the present invention to provide a harness for experimental animals that can be reliably fixed to the skin and that is unlikely to cause irritation or discomfort to the skin of the experimental animals.

[0007]

A harness for an experimental animal according to the present invention is provided with a harness main body having a hole for inserting a leg of the experimental animal and wound around the experimental animal, and provided between both ends of the harness main body. And a holding piece that is fastened to both ends of the harness body by fasteners, and a catheter protector for inserting a catheter can be removably attached to a through hole formed in the holding piece. It is what

Further, it is preferable that the harness body is mounted so that the fastener surface thereof faces the skin side of the laboratory animal.

Further, the surface layer and the back layer are separated at the portion where the through hole is formed in the holding piece, and the flange portion at the tip of the catheter protector is sandwiched between the surface layer and the back layer. It is possible to

[0010]

In the above means, the harness body is wound around the laboratory animal by inserting, for example, the forefoot of the laboratory animal into the hole of the harness body. Further, the holding piece to which the catheter protector is detachably attached is set on the epidermis of the experimental animal, and both ends of the harness main body are joined to the holding piece by fasteners. Therefore, it is very easy to attach the harness body and the holding piece. The catheter is inserted into the catheter protector, penetrates the skin of the experimental animal, and is inserted into the carotid artery or the like. Since the harness main body and the holding piece can be firmly fixed to the experimental animal by the fastener joining, the catheter can be reliably held.

Further, when the fastener surface of the harness body is attached to the skin side of the laboratory animal, even if the laboratory animal moves freely due to the small protrusions of the fastener surface being entangled in the hair of the laboratory animal, the harness body is not easily displaced. Become. Further, since the fine protrusions on the fastener surface hit the epidermis of the experimental animal, irritation and discomfort to the skin of the experimental animal is relieved, and damage due to scratching or biting is less likely to occur.

Further, by sandwiching the flange portion of the catheter protector between the front layer and the back layer of the holding piece, the work for attaching and detaching the catheter protector is simplified.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to the drawings. Figure 1
4 is a perspective view showing a state in which the harness for experimental animals of the present invention is attached to an experimental animal, FIG. 2 is a developed plan view of the harness body seen from the inner side, FIG. 3 is a partial sectional view of the harness body, FIG.
Is a developed plan view of the holding piece viewed from the outside, and FIG.
-V line sectional view, FIG. 6 is a partially enlarged view of FIG. 5, FIG. 7 is a perspective view showing the appearance of the catheter protector, and FIG. 8 is an enlarged sectional view showing a state in which the catheter protector is attached to the holding piece. . The harness for experimental animals is a harness body 1 shown in FIG.
And a holding piece 2 shown in FIG. 4 and a catheter protector 3 shown in FIG.

The inner surface of the harness main body 1 (the surface facing the skin side of the laboratory animal) is the fastener surface 1a, and the outer surface of the holding piece 2 (the surface opposite to the skin side of the laboratory animal) is the fastener surface 2a.
Is. The fastener surface 1a of the harness body 1 is provided with a large number of resin monofilament loops 11 as shown in FIGS. 3 and 9A, and the fastener surface 2a of the holding piece 2 is provided.
6 is provided with a large number of protrusions 21 having a hook-like hook structure as shown in FIG. 6 and FIG.
As shown in FIG. 9, a and 2a are faced to each other and pressed against each other, so that the loop 11 and the protrusion 21 are hooked to each other, and the harness body 1 and the holding piece 2 are joined by a fastener.

The fastener structure provided on the fastener surfaces 1a and 2a is not limited to the combination of the loop 11 and the protrusion 21 shown in FIGS. 3, 6 and 9, but may be provided on the harness body 1 side as shown in FIG. 10 (A). A large number of dense loop groups 1
1a may be provided, and a large number of protrusions 21a having a mushroom-shaped hook structure may be provided on the holding piece 2 side. The fastener structure is not limited to the one described above, and may have any shape as long as it has a generally used shape. In the illustrated embodiment, the loop 11 or 11a is provided on the harness body 1 side and the projection 21 or 21a is provided on the holding piece 2 side. However, a hook-like or mushroom-shaped hook structure projection is provided on the harness body 1 side. A loop may be provided on the holding piece 2 side. However, in order not to cause irritation or discomfort to the skin of the experimental animal, the loop 11 or 11a is formed on the fastener surface 1a of the harness body 1 side.
Is preferably provided.

Further, the loops 11 or 11a on both fastener surfaces 1a and 2a, and the projections 21 and 21a having a hook structure of a hook or mushroom shape are made of polyamide, polyester,
It is made of a plastic material such as polyoxymethylene, polyethylene or polypropylene.

As shown in FIG. 2, in the center of the harness body 1, there are two holes 1b for inserting the front legs of an experimental animal.
1b is bored. At both ends of the harness body 1, 12 parts indicated by broken lines are cut out, and the remaining parts are joining pieces 1c and 1d. As shown in FIG. 1, the harness body 1, the hole 1b of the forefoot of the experimental animals, in a state of being inserted in 1b, but wound toward the neck from the body portion toward the fastener surface 1a inward, this time, both Joining piece 1c
A distance w of about 4 mm or more is maintained between the distances 1 and 1d, and the catheter protector 3 can be positioned in the middle of the distance w.

By projecting the joining pieces 1c and 1d from the both ends of the harness body 1 with predetermined lengths La and Lb, as shown in FIG. Therefore, the harness body 1 and the holding piece 2 can be securely attached to the experimental animal. Further, by making the lengths La and Lb long to some extent, the fastener joining area between the joining pieces 1c and 1d and the holding piece 2 can be secured even if the size of the experimental animal is different, and the harness body 1 having the same size can be obtained. Can be commonly used for experimental animals of various sizes.

The joining pieces 1c and 1d may not be projected at both ends of the harness body 1. In this case, it suffices if there is an overlapping area that allows sufficient fastener joining between the both ends of the harness body 1 and the holding piece 2. Further, in order to allow the harness main body 1 of the same size to be commonly worn by laboratory animals of different sizes, an elastic body such as a rubber band is provided in the central portion OO of the harness main body 1 to elastically change the length. It may be adjustable. In addition, the rubber band may be provided at one or two arbitrary positions within the range indicated by D in the circumferential direction of the harness body 1.

As shown in the sectional view of FIG. 3, the harness body 1 has a structure in which a front layer 13 and a back layer 14 are laminated. Of these, the back layer 14 is the loop 11 of the fastener surface 1a.
The support is, for example, a woven or knitted fabric of a fibrous plastic material, or those reinforced by a sheet of plastic or the like. The surface layer 13 is a woven or knitted fabric of a fibrous plastic material, a plastic sheet, or a cloth sheet, and the surface layer 13 and the back layer 14 are joined by sewing or adhesion so as not to separate from each other. Alternatively, the back layer 14 may be thickened and the surface layer 13 may be omitted.

As shown in FIG. 4, the holding piece 2 is rectangular or square. However, the planar shape of the holding piece 2 is not limited to a rectangular shape, and may be any shape as long as it can be joined by fasteners to the joining pieces 1c, 1d of the harness body 1.

As shown in FIGS. 5 and 6, the holding piece 2 has a two-layer structure in which a front layer 23 and a back layer 24 are laminated. Surface layer 2
Reference numeral 3 denotes a support body that supports, for example, fishhook-shaped protrusions 21 on the fastener surface 2a, and is, for example, a woven or knitted fabric of a fibrous plastic material, or those reinforced by a sheet of plastic or the like. The backing layer 24 is a woven or knitted fabric of a fibrous plastic material, a plastic sheet, or a cloth sheet. As shown in FIG. 1, since the backing layer 24 contacts the epidermis with respect to the experimental animal, it is preferable to use a woven fabric or knitted fabric of a plastic material that causes less irritation to the skin and a sense of discomfort. Also, the loop may be in the back layer 24.

The front layer 23 and the back layer 24 are joined to each other within a range indicated by E on both sides so as not to be separated from each other by sewing or adhesion, and in the strip portion indicated by F in the center, the front layer 2
3 and the back layer 24 are not joined and can be separated in the front-back direction. A catheter through hole 2b penetrating the surface layer 23 and the back layer 24 is formed at the center of the holding piece 2 and at the center of the strip portion indicated by F. Further, the surface layer 23 is formed with a notch 2c extending from the catheter through hole 2b to the edge of the holding piece 2.

As shown in FIG. 7, the catheter protector 3
Is for covering the catheter in a state where the catheter is inserted, and is composed of a coil spring and a flange portion 3b fixed to the tip of the coil spring. The catheter protector 3 is detachably attached to the holding piece 2. At the time of attachment, the flange portion 3b is inserted from the direction of arrow G at the portion indicated by F of the holding piece 2, and the flange portion 3b is sandwiched between the surface layer 23 and the back layer 24 of the holding piece 2. When it is pushed in the direction of arrow G as it is, the protective body 3 passes through the inside of the cut 2c, and the flange portion 3b is sandwiched between the surface layer 23 and the back layer 24 with the protective body 3 inserted to the position of the catheter through hole 2b. It is held and the protector 3 fits into the catheter through hole 2b. In this state,
The catheter can be inserted into the experimental animal through the inside of the protective body cylinder a, the central hole of the flange portion 3b and the inside of the catheter through hole 2b of the holding piece 2.

Next, a method of using the harness for experimental animals according to the above embodiment will be described. As experimental animals, small animals such as mice, rats, hamsters, guinea pigs and rabbits are used. As shown in FIG. 1, the front legs of the experimental animal are inserted through the two holes 1b, 1b of the harness body 1,
With the fastener surface 1a facing the skin side of the experimental animal, the harness body 1 is covered from the torso to the neck of the experimental animal.
Further, as shown in FIG. 8, the holding piece 2 in which the flange portion 3b of the catheter protector 3 is sandwiched between the surface layer 23 and the back layer 24 in advance is used, with the fastener surface 2a of the holding piece 2 facing outward. Place it from the back to the neck. In the joining pieces 1c and 1d of the harness main body 1, the fastener surface 1a faces inward, and the holding piece 2 has the fastener surface 2a facing outward. Therefore, the harness body 1 and the holding piece 2 are securely fixed to each other by fastener joining by overlapping the joining pieces 1c and 1d of the harness body 1 on the upper surface of the holding piece 2 and crimping the fastener surface 1a and the fastener surface 2a. It

The catheter protector 3 extends substantially vertically outward from the middle of the gap w between the joining pieces 1c and 1d of the harness body 1. The catheter is inserted into the catheter protector 3, passes through the central hole of the flange portion 3b, and the holding piece 2
Through the catheter through hole 2b, further penetrates the skin of the experimental animal and is subcutaneously inserted into the jugular vein or the like.

The catheter protector 3 and the upper end of the catheter inserted therein are swivels (not shown) for infusion.
Connected to. When the experimental animal moves around, the swivel rotates in response to this movement, and the twist of the catheter and the catheter protection body 3 is corrected. Therefore, no load is applied to the catheter at the skin penetrating portion of the experimental animal, and since the catheter is securely fixed to the experimental animal by the holding piece 2, it is possible to prevent infection and inflammation by skin bacteria. , The experimental animals can be continuously infused for a long period while freely moving in the cage.

In the example shown in FIG. 1, the joining piece 1 of the harness body 1 is attached to the fastener surface 2a which is the outer surface of the holding body 2.
Although the fastener surfaces 1a on the inner surfaces of c and 1d are overlapped from above to join the fasteners, conversely, the joining piece 1 of the harness body 1 is joined.
A fastener surface may be provided on the outer surfaces of c and 1d, and the inner surface side of the holding body 2 may be used as the fastener surface, and the holding piece 2 may be installed on the joining pieces 1c and 1d to fasten the two.

(Example 1) The harness for experimental animals of the present invention was attached to 250 g of rats. The dimensions of the harness body 1 and the holding piece 2 shown in FIGS. 2 and 4 were as follows. -Dimensions of harness 1 Width Wa of central part ... 4.2 cm Width of center line Lc ... 11.0 cm Lengths of joining piece La, Lb ... 2.5 cm Width Wb of joining piece ... 1.4 cm Base of notch Wc ... 1.8 cm-Dimensions of the holding piece 2 Short side width Wd ... 2.8 cm Long side width We ... 5.5 cm-The harness body 1 is a plain woven fabric in which both the surface layer 13 and the back layer 14 are made of nylon fiber. , Fastener layer 1 of back layer 14
For a, the one provided with a large number of nylon single-woven loops 11 was used. The holding piece 2 is a plain woven fabric made of nylon fiber for both the front layer 23 and the back layer 24, and the fastener surface 2 of the front layer 23
A large number of protrusions 21 having a hook-like hook structure made of nylon monofilament were provided in a, and the surface layer 23 and the back layer 24 were bonded to each other with an epoxy adhesive at a portion E.

The catheter protector 3 used was a coil spring having an outer diameter of about 4 mm and provided with a flange portion 3b having an outer diameter of 13 mm and a center hole having an inner diameter of 4 mm at its tip. The flange portion 3b of the catheter protector 3 is sandwiched between the surface layer 23 and the back layer 24 at the portion F of the holding piece 2, and the protector 3 is vertically upward from the catheter through hole 2b on the surface layer side of the holding piece 2. I attached it to.

The catheter was passed through the catheter protector 3, passed through the central hole of the flange 3b and the catheter through hole 2b on the back layer side of the holding piece 2, penetrated the skin of the rat, and was subcutaneously inserted into the jugular vein. . The upper end of the catheter and the catheter protector 3 were connected to a swivel. A high calorie solution was conjunctively administered through a catheter and the animals were raised for 30 days. Rats were free to move in their cages. No inflammation or bacterial infection was found in the epidermis of the rat where the catheter penetrated. Rats were bred well, and neither scratching nor biting of the harness body 1 by the rat was observed.

[0032]

As described above, according to the present invention, the legs of an experimental animal are inserted into the harness body, and the holding piece to which the catheter protector is detachably attached and the harness body are attached by fasteners. Therefore, the mounting work is easy. Further, the harness main body and the holding piece are securely attached to the experimental animal by fastener joining and the catheter can be firmly held, so that the skin portion through which the catheter penetrates is prevented from being inflamed or infected by bacteria.
Further, since the harness main body and the holding piece are mutually fixed by the fastener joining, the harness main body and the holding piece can be surely attached to the experimental animal even if the size of the animal is different.

According to the second aspect of the present invention, since the fastener surface of the harness main body faces the skin side of the experimental animal, there is little irritation or discomfort to the skin, and therefore the harness can be scratched or bitten. Without, it can be used for a long time. Further, since the protrusions and loops provided on the fastener surface are entangled with the hair of the experimental animal, the harness body is prevented from being displaced, and the catheter can be reliably held.

According to the third aspect of the invention, since the flange portion of the catheter protection body is sandwiched between the front layer and the back layer of the holding piece, the catheter and the holding body can be easily assembled and separated.

[Brief description of drawings]

FIG. 1 is a perspective view showing a use state of a harness for experimental animals according to the present invention,

FIG. 2 is a developed plan view of the harness main body as viewed from the inner side,

FIG. 3 is an enlarged cross-sectional view of the harness body,

FIG. 4 is a developed plan view of the holder seen from the outer surface side,

5 is a sectional view taken along line VV of FIG.

6 is an enlarged view of the central portion of FIG.

FIG. 7 is an external perspective view of a catheter protector,

FIG. 8 is a partially enlarged cross-sectional view showing a state in which a catheter protector is attached to a holding piece.

9A and 9B are enlarged side views showing a combination of fastener surfaces,

10 (A) and 10 (B) are enlarged side views showing other combinations of fastener surfaces,

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Harness main body 1a Fastener surface 1b Holes 1c, 1d Joint piece 2 Holding piece 2a Fastener surface 2b Catheter through hole 2c Notch 3 Catheter protector 3b Flange portion 13 Harness main body surface layer 14 Harness main body back layer 23 Holding piece surface layer 24 Back layer of holding piece

Claims (3)

[Scope of utility model registration request] 1. A harness main body having a hole portion through which a leg of an experimental animal is inserted and wound around the experimental animal, and provided between both ends of the harness main body and joined to both ends of the harness main body by fasteners. Harness for experimental animals, characterized in that a catheter protector for inserting a catheter can be removably attached to a through hole formed in the holder. 2. The harness for a laboratory animal according to claim 1, wherein the harness body is mounted so that the fastener surface thereof faces the skin side of the laboratory animal. 3. The surface layer and the back layer are separated at the portion of the holding piece where the through hole is formed, and the flange portion at the tip of the catheter protector is sandwiched between the surface layer and the back layer. The harness for experimental animals according to claim 1.