JPH0742221B2 - Method for producing emulsified composition for cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing an oil-in-water emulsion composition for cosmetics. Specifically, it uses a hydrolyzate of elastin present in animal ligaments such as cattle as an emulsifier. The present invention relates to a method for producing an emulsified composition for cosmetics.

[0002]

2. Description of the Related Art Heretofore, as an oil-in-water type emulsion composition used as a cosmetic, a composition containing various amino acid derivatives, a water-soluble polymer such as polyvinyl alcohol, or a polysaccharide is known.

[0003]

However, the conventional oil-in-water type emulsion compositions described above have excellent moisturizing and water-retaining effects while leaving a refreshing feel, but conversely, they are water-soluble polymers or polysaccharides. When a large amount of the above ingredients is blended, a "slimy feeling" is produced, which is not preferable in terms of feel.

The present invention has been made in view of the above circumstances, and has a high safety, an extremely stable emulsification system, excellent moisturizing properties and water retaining properties, and excellent cosmetic feel. It aims at providing the manufacturing method of the emulsion composition for foods.

[0005]

The present inventors have invented a novel method for producing an emulsion composition for cosmetics based on the finding that the elastin hydrolyzate is excellent in moisturizing, water retaining effect and emulsifying ability. Means for Solving the Problems The first aspect of the invention is to form a surfactant phase by mixing an elastin hydrolyzate or an aqueous solution containing the elastin hydrolyzate and a polyhydric alcohol. The second aspect of the present invention is characterized in that fats and oils are added to this surfactant phase to produce an oil-in-surfactant emulsion type emulsion composition, and then an aqueous phase is added to the emulsion composition. Substance or an aqueous solution containing an elastin hydrolyzate, a polyhydric alcohol, and an ionic substance containing at least one of glycyrrhizin dipotassium salt, casein soda, sodium chloride, and potassium chloride 0.1 5% by weight to form a surfactant phase, oils and fats are added to the surfactant phase to produce an oil-in-water emulsion composition of the surfactant phase, and then the aqueous phase is added to the emulsion composition. Is added.

The elastin hydrolyzate used in each of the above-mentioned inventions is a polypeptide obtained by hydrolyzing elastin present in animal ligaments such as cattle using a protease, and among them, the average Molecular weight 1
Those of about 10,000 to 100,000 are used. This is because those having an average molecular weight of 10,000 or less have poor emulsifying power, and those having an average molecular weight of more than 100,000 have poor solubility themselves,
Particularly, those having an average molecular weight of 50,000 to 100,000 are preferable.

Further, the elastin hydrolyzate is contained in a total amount of 0.001 as a total amount of the polypeptide based on the total weight of the emulsified composition.
It is mixed in a proportion of 1 to 10% by weight, preferably 0.1 to 5% by weight. If it is less than 0.001% by weight, the emulsifying ability cannot be expected, and if it exceeds 10% by weight, the emulsifying ability and the moisturizing and water retaining effects are not improved and it is wasteful, which is economically undesirable. is there.

The elastin hydrolyzate used in the present invention can be obtained, for example, by the following method. That is, 5 l of purified water was added to 1 kg of frozen ligament of fresh beef, pH was adjusted to 10.5 using a diluted sodium hydroxide solution, and the mixture was boiled for 1 to 2 hours and dehydrated using a centrifuge. Then, 5 l of purified water was added to the residue and the pH was adjusted to 2.
After adjusting to 0, it is boiled again for 1 to 2 hours, dehydrated using a centrifuge, washed with a large amount of water, and the pH of the washing solution is made neutral. Next, this is dispersed in 2 liters of water, then stirred with a blender, and a protease is added thereto and partially hydrolyzed at a temperature of 60 ° C. for 6 to 8 hours. Then, this partially decomposed solution is boiled for 1 hour to deactivate the remaining enzyme, and then the insoluble matter is filtered off to obtain a final polypeptide solution.

In the polypeptide solution obtained by the above-mentioned production method, the total amount of polypeptide is 14.0.
16.0 w / v%, and total nitrogen is 2.0 to
Contains 2.5 w / v%. This may be used as it is, or may be used in the form of dry powder.

The thus-obtained elastin hydrolysis alone has excellent emulsifying ability, but when it is used in combination with a polyhydric alcohol or an ionic substance, its emulsifying ability is remarkably improved, It is possible to obtain a very excellent emulsion composition for cosmetics.

The polyhydric alcohol used in each of the above-mentioned inventions has two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1,
3-butylene glycol, glycerin, diglycerin,
Polyethylene glycol, polyglycerin, sorbitol, maltitol, sorbitan, glucose, fructose, sucrose, maltose and the like can be mentioned, and one or a mixture of two or more thereof can be used. Among them, glycerin alone or glycerin and other It is more effective in the case of a mixture with substances.

The polyhydric alcohol content is preferably in the range of 1 to 90% by weight, based on the total weight of the emulsified composition. When a relatively small amount is used within the above range, it is used as an emulsification aid in water. It contributes to the formation of an oil-based emulsion composition.

The ionic substances such as glycyrrhizin dipotassium salt, casein soda, sodium chloride and potassium chloride used in the second invention are used in the form of one kind or a mixture of two or more kinds to improve emulsifying power and emulsification composition. It contributes to improving the stability of objects.

The ionic substance is added in an amount of 0.1 to 5% by weight, preferably 0.5 to 2% by weight, based on the total weight of the emulsified composition. If the amount is less than 0.1% by weight, no effect can be expected, and if the amount is more than 5% by weight, the effect cannot be improved and it is meaningless.

Other emulsifiers usually used for obtaining a wider range of emulsified compositions and expanding the selection range of emulsification methods, such as lecithin, sucrose fatty acid ester, polyglycerin fatty acid ester, and other nonionic surfactants ( It is also possible to use ionic surfactants such as HLB3 to 14) and fatty acid salts as a sub-activator together.

On the other hand, the fats and oils applied to each of the above inventions are not particularly limited, and the fats and oils usually used in cosmetics,
For example, hydrocarbons such as liquid paraffin, ceresin, microcrystalline wax, olive oil, safflower oil, mink oil, animal and vegetable oils such as beef tallow, myristyl myristate, esters such as oleyl oleate, higher alcohols such as cetanol and oleyl alcohol. And higher fatty acids such as myristic acid, palmitic acid, stearic acid, and fragrances, etc., and the respective composition ratios are arbitrarily selected depending on the purposes such as the appearance, usability, and stability of the system.

Next, the surfactant phase emulsification method is applied to the method for producing the emulsion composition for cosmetics of the present invention. That is, first, an elastin hydrolyzate or an aqueous solution containing the same, a polyhydric alcohol and, if necessary, respective appropriate amounts of an ionic substance are mixed, and an elastin obtained by dissolving a polyhydric alcohol formed by adding an oil phase component thereto is dissolved. An oil-in-water emulsion composition of the surfactant phase is obtained by solubilizing or uniformly dispersing the oil phase component in the surfactant phase consisting of the hydrolyzate continuous phase as a microemulsion. Furthermore, an oil-in-water type emulsion composition for cosmetics is obtained by diluting this with an aqueous phase or adding an aqueous phase and uniformly mixing.

However, when the above-mentioned other commonly used auxiliary activator is used in combination, the usual solubilization inversion method or phase inversion temperature emulsification method can be used.

As described above, the cosmetic emulsified composition obtained by the production method of the present invention is highly safe because the elastin hydrolyzate used as the emulsifier is a high molecular weight polypeptide substance, and is itself Because of its gel-forming ability, the emulsion system is extremely stable in combination with the effect of polyhydric alcohol, and it also has excellent moisturizing / water-retaining properties, film feeling, and feel.

Here, p which is generally applied as cosmetics
Table 1 shows the pH stability of the elastin hydrolyzate itself in the H range.
Shown in. In the evaluation of Table 1, "+" is slightly recognized,
"-" Indicates that there is no change.

[0021]

[Table 1]

According to Table 1, it was found that the elastin hydrolyzate was extremely stable in the pH range applied as a cosmetic.

Next, Tables 2 and 3 show the results of evaluation tests carried out on the emulsion composition for cosmetics produced according to the present invention.

Table 2 shows that the emulsified composition (cream) prepared in Example 3 described below and the conventional nonionic activator (instead of 4.5% by weight of the elastin hydrolyzate in Example 3) were used. Tween 60: 2.0 wt% + span 60:
2.5% by weight of cream (Comparative Example 1) and amino acid derivative (N-lauroylglutamic acid polyoxyethylene 2 mol-2-octyldodecyl ether diester: 2.0% by weight + N-lauroylglutamic acid polyoxyethylene 5 mol) Stearyl ether diester:
The results of various comparative evaluation tests with a cream (Comparative Example 2) using 0.6% by weight + polyoxyethylene-added aliphatic ether SAA: 1.9% by weight) as an activator are shown.

Table 3 shows that the emulsion composition (milky lotion) produced in Example 1 described later and the conventional nonionic activity in place of the elastin hydrolyzate (content 1.5% by weight) in Example 1 were used. Agent (Chain 60: 0.7% by weight + Span 6
0: 0.8% by weight) emulsion (Comparative Example 3), and amino acid derivative (polyoxyethylene (2) -2-octyldodecylethergester N-lauroylglutamate: 0.7% by weight + N- Lauroyl glutamic acid polyoxyethylene (5) stearyl ether gestel: 0.2% by weight + polyoxyethylene-added fatty acid group ether SAA: 0.6% by weight) and various emulsions (Comparative Example 4) The result of a comparative evaluation test is shown.

In the evaluations in Tables 2 and 3, ⊚ indicates “excellent”, ◯ indicates “good”, Δ indicates “good or less”, and x indicates “bad”. Also,
Regarding "safety", the positive rate of the 48-hour closed patch test in the inner part of the upper arm conducted for each 20 persons was used as the criterion for judgment, and for "stability", the aging test (-5 to 40 ° C) was carried out on each of 5 samples. After 2 months), the "feel" was evaluated by sensory evaluation of 50 test subjects during a 2-week use test.

[0027]

[Table 2]

[0028]

[Table 3]

According to Tables 2 and 3, the emulsified composition obtained by the present invention has extremely high safety as compared with the conventional emulsified compositions, and the emulsified system is remarkably stable, resulting in excellent feeling. It turns out that

[0030]

EXAMPLES Examples of the present invention will be shown below.

Example 1 (milky lotion)

[Table 4]

Component A is mixed at a temperature of 70 to 80 ° C. to form a surfactant phase, to which component B is gradually added,
Next, the component C and the component D were sequentially added and cooled.

Example 2 (milky lotion)

[Table 5]

Component A is mixed at a temperature of 70 to 85 ° C. to form a surfactant phase, to which component B is gradually added,
Next, the component C and the component D were sequentially added and cooled.

Example 3 (cream)

[Table 6]

Ingredient A was mixed at a temperature of 70 to 85 ° C to form a surfactant phase to which ingredient B was added, followed by ingredient C and cooled.

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Claims (2)

[Claims] 1. A surfactant phase is formed by mixing an aqueous solution containing an elastin hydrolyzate or an elastin hydrolyzate with a polyhydric alcohol, and adding a fat or oil to the surfactant phase to add a surfactant. Producing an oil-in-phase emulsion composition,
Next, a method for producing an oil-in-water type emulsion composition for cosmetics, which comprises adding an aqueous phase to the emulsion composition. 2. An ionic substance 0.1 to 5 comprising an aqueous solution containing an elastin hydrolyzate or an elastin hydrolyzate, a polyhydric alcohol, and at least one of glycyrrhizin dipotassium salt, casein soda, sodium chloride and potassium chloride. % By weight to form a surfactant phase, and oils and fats are added to the surfactant phase to produce an oil-in-water emulsion composition of the surfactant phase, and then an aqueous phase is added to the emulsion composition. A method for producing an oil-in-water emulsion composition for cosmetics, which is characterized in that it is added.