JPH0738878B2 - Medical materials - Google Patents
Medical materialsInfo
- Publication number
- JPH0738878B2 JPH0738878B2 JP61119574A JP11957486A JPH0738878B2 JP H0738878 B2 JPH0738878 B2 JP H0738878B2 JP 61119574 A JP61119574 A JP 61119574A JP 11957486 A JP11957486 A JP 11957486A JP H0738878 B2 JPH0738878 B2 JP H0738878B2
- Authority
- JP
- Japan
- Prior art keywords
- fibroblast
- action
- hemostatic
- proliferating
- wound healing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Description
【発明の詳細な説明】 （産業上の利用分野） 本発明は、局所止血作用と創傷治癒促進作用を有する新
規な医療材料を提供するものである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention provides a novel medical material having local hemostatic action and wound healing promoting action.
（従来技術） 従来より、外科的に使用される縫合糸、ガーゼ等の医療
材料に対してはトロンビン、カルシウム化合物、各種蛋
白質等の加工が行われている。(Prior Art) Conventionally, medical materials such as sutures and gauze used surgically have been processed with thrombin, calcium compounds, various proteins and the like.
しかしながら、かかる加工によるものは、上記のような
局所止血作用と創傷治癒促進作用等の点においてなお改
善の余地があった。However, there is still room for improvement in the above-mentioned processing in terms of the above-mentioned local hemostatic action and wound healing promoting action.
（発明が解決しようとする問題点） 本発明はかかる点において従来にない優れた効果を有す
る医療材料を提供するものである。(Problems to be Solved by the Invention) The present invention provides a medical material having excellent effects that have not been obtained in the past in these points.
（問題を解決するための手段） しかるに、その構成において、生体吸収性材料であるポ
リグリコール酸の表面、もしくはその内部に線維芽細胞
増殖内質を有することを特徴とする医療材料に関する。(Means for Solving the Problem) However, the present invention relates to a medical material characterized in that, in its constitution, polyglycolic acid, which is a bioabsorbable material, has a fibroblast-proliferating substance on the surface or inside thereof.
以下、これについて具体例を挙げて説明する。Hereinafter, this will be described with a specific example.
（実施例１） 線維芽細胞増殖物質を有機溶剤にとかし、その中に生体
吸収性材料であるポリグリコール酸にて製造された手術
用の縫合糸を一定時間浸漬して繊維内部に線維芽細胞増
殖物質を浸入させた。これを浴より引き上げて乾燥し本
発明品とした。(Example 1) A fibroblast-proliferating substance was dissolved in an organic solvent, and a surgical suture made of polyglycolic acid, which is a bioabsorbable material, was immersed therein for a certain period of time to immerse the fibroblast inside the fiber. The growth material was infiltrated. The product was taken out of the bath and dried to obtain the product of the present invention.
これを外科手術に適用したところ止血作用と創傷治癒促
進作用において従来と異なる顕著な効果が認められた。When this was applied to a surgical operation, remarkable effects different from conventional ones were observed in hemostatic action and wound healing promoting action.
（実施例２） ポリグリコール酸繊維を紡糸する際に、予じめポリマー
原料に線維芽細胞増殖物質を混入せしめこれを溶融紡糸
した後編成して止血用ガーゼとした。これを前記のよう
に外科手術に適用したところ特に優れた止血効果と創傷
治癒促進効果を示した。(Example 2) When a polyglycolic acid fiber was spun, a fibroblast-proliferating substance was mixed in advance with a polymer raw material, which was melt-spun and knitted to obtain a hemostatic gauze. When this was applied to a surgical operation as described above, it exhibited a particularly excellent hemostatic effect and wound healing promoting effect.
尚、かかる処理に用いる線維芽細胞増殖物質としては、
F13を例示することができる。In addition, as the fibroblast proliferation substance used in such treatment,
F13 can be exemplified.
（作用） 本発明により繊維中に混入、もしくは表面処理された線
維芽細胞増殖物質は、前記のように生体中で、局所止
血作用創傷治癒促進作用の２つの効果を発揮する。(Action) The fibroblast-proliferating substance mixed into the fiber or surface-treated according to the present invention exerts two effects of local hemostatic action and wound healing promoting action in the living body as described above.
即ち、局所止血作用とは、繊維内に混入せしめられた線
維芽細胞増殖物質は止血機構の最終段階に働いてフィブ
リン分子とフィブリン分子とをクロスリンクさせること
により、強固で安定したフィブリン網が作られる作用で
あり、また、創傷治癒促進作用とは、線維芽細胞増殖物
質のクロスリンク反応によって形成されたフィブリン網
は、組織修復の主役である線維芽細胞が増殖する足場と
なる作用で、このように線維芽細胞増殖物質は止血機構
と創傷治癒促進作用のかけ橋の役割を果す作用を有す
る。That is, the local hemostatic action means that the fibroblast-proliferating substance mixed in the fiber acts at the final stage of the hemostatic mechanism to crosslink the fibrin molecule with the fibrin molecule, thereby forming a strong and stable fibrin network. Also, the wound healing promoting action means that the fibrin network formed by the cross-linking reaction of fibroblast-proliferating substances serves as a scaffold for proliferating fibroblasts, which is the main component of tissue repair. As described above, the fibroblast-proliferating substance has an action of bridging the hemostatic mechanism and the action of promoting wound healing.
（効果） 以上のように、線維芽細胞増殖物質で適用した医療材料
は、外科的に用いられる医療材料例えば、止血メッシュ
あるいは縫合糸等としてより一層組織の癒合を早め確実
な組織修復に役立つ格段の効果を有する。(Effects) As described above, the medical material applied with the fibroblast-proliferating substance is a medical material used surgically, for example, as a hemostatic mesh or suture, which is much more useful for accelerating the fusion of tissues and for reliable tissue repair. Have the effect of.
即ち、現在市販の生体吸収性組織を用いた縫合糸あるい
は止血メッシュに比べると、より生体に近く、なおかつ
傷の修復が早くなるという特徴を有し、その上かかる作
用は胃腸管、腸に吻合、及び胆管手術においての縫合不
全を起しにくくなることを意味しており、市販縫合糸に
比べると格段にすぐれた特徴を有することとなる。That is, compared with currently available commercially available sutures or hemostatic meshes using bioabsorbable tissue, it has a characteristic that it is closer to the living body, and the repair of wounds is quicker. In addition, it means that suture failure is less likely to occur in bile duct surgery, and has significantly superior characteristics to commercially available sutures.
特に、その用途において前記の例のように手術時に体内
に埋め込みする物質で、且つその素材が生体吸収性材料
である場合に適用して前記のようなすぐれた効果を発揮
するものである。In particular, it is a substance to be implanted into the body during surgery as in the above example in its application, and when the material is a bioabsorbable material, it exerts the above excellent effects.
以上のように本発明は従来にない優れた特徴を有するも
のである。As described above, the present invention has excellent features that have never been obtained.
Claims (1)
表面、もしくはその内部に線維芽細胞増殖物質を有する
ことを特徴とする医療材料。1. A medical material comprising a bioabsorbable material, polyglycolic acid, having a fibroblast-proliferating substance on the surface or inside thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61119574A JPH0738878B2 (en) | 1986-05-24 | 1986-05-24 | Medical materials |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61119574A JPH0738878B2 (en) | 1986-05-24 | 1986-05-24 | Medical materials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62275468A JPS62275468A (en) | 1987-11-30 |
| JPH0738878B2 true JPH0738878B2 (en) | 1995-05-01 |
Family
ID=14764719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61119574A Expired - Fee Related JPH0738878B2 (en) | 1986-05-24 | 1986-05-24 | Medical materials |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0738878B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5128799B2 (en) * | 2006-08-24 | 2013-01-23 | 株式会社アイ・ティー・オー | A bioactive composition containing a thioctic acid derivative. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61253065A (en) * | 1985-05-02 | 1986-11-10 | 片倉チツカリン株式会社 | Medical composite material of chitosan derivative and collagen and its production |
-
1986
- 1986-05-24 JP JP61119574A patent/JPH0738878B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62275468A (en) | 1987-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |