JPH0733624A - Agent for treating and preventing acne - Google Patents

Abstract

PURPOSE:To provide an acne-treating and preventing agent containing a specific biphenyl compound having a strong antibacterial action against Propionibacterium acnes as an active ingredient, and capable of being added to cosmetics, quasi-drugs and medicines. CONSTITUTION:An acne-treating and preventing agent containing a biphenyl compound of the formula (R is H, 1-8C linear or branched chain saturated hydrocarbon) as an active ingredient. The biphenyl compound exhibits a strong antibacterial action against Propionibacterium acnes in a low concentration. The biphenyl compound used herein is partially known.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention relates to pharmaceuticals, quasi drugs,
The present invention relates to a specific biphenyl compound that is incorporated into cosmetics and has a strong antibacterial action against Propionibacterium acnes.

[0002]

BACKGROUND OF THE INVENTION Although the etiology of acne has not yet been elucidated, hypersecreted sebum associated with increased hormonal activity during puberty fills the immature hair funnel, causing obstruction of the pilosebaceous sebaceous gland, resulting in anaerobic It is considered that the abnormal growth of the sex bacterium Propionibacterium acnes is involved. Therefore, as an anti-acne treatment or preventive agent, antibiotics such as erythromycin, tetracycline, and clindamycin, and sulfur, camphor, and sulfa drugs, which are expected to cure acne naturally, have been used.

However, it is known that antibiotics such as erythromycin, tetracycline and clindamycin show strong side effects such as gastrointestinal disorders. on the other hand,
The stripping action of sulfur, camphor, sulfa, etc. causes irritation to the skin around the acne by repeated application, and there are large individual differences in the therapeutic effect, and it cannot be said that there is a sufficient therapeutic and preventive effect.

[0004]

In view of the above circumstances, the present inventors have made extensive studies on compounds having a strong antibacterial activity against Propionibacterium acnes. As a result, it was found that a specific biphenyl compound has a strong antibacterial action against Propionibacterium acnes.

Therefore, an object of the present invention is to provide a compound having a strong antibacterial action against Propionibacterium acnes.

[0006]

Means for Solving the Problems That is, the present invention has the following general formula:

[0007]

[Chemical 2]

The present invention relates to an agent for treating and preventing acne, which comprises a biphenyl compound represented by a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms.

A part of the biphenyl compound used in the present invention contains known substances, and a method for synthesizing the same has been reported (Japan Chemical Journal Vol. 87, No. 6, p. 603,
1966). Further, other compounds can be obtained by the same synthetic method.

The acne treatment and prevention agent of the present invention can be incorporated into, for example, pharmaceuticals, quasi drugs, cosmetics and the like.

The blending amount depends on the system used,
Although it cannot be said to be unequivocal, as will be apparent from the following examples, an existing substance of this type may be used.

Next, examples for clarifying the effect of the antibacterial action against Propionibacterium acnes by the biphenyl compound of the present invention will be shown.

[0013]

EXAMPLES Examples will be described below. The names of the biphenyl compounds in the examples are abbreviated as follows depending on the difference in R in the general formula. Biphenyl compounds 1 (R = CH _3), biphenyl compounds _{2 (R = C 2 H 5} ), biphenyl compounds 3 (R =
C ₃ H ₇ ), biphenyl compound 4 (R = iso-C ₃ H
_7), biphenyl compounds _{5 (R = C 8 H 17} ), biphenyl compounds 6 (R = H). In addition, dehydrodioigenol and dehydrodicresol, which are biphenyl compounds having different structures, were used as controls.

[Test Method for Antibacterial Action] As a method for testing the antibacterial action against Propionibacterium acnes, the paper disc method was used. Propionibacterium cultivated separately in the same liquid medium on the agar medium
Mix Acnes culture solution (0.1 ml / 100 ml medium)
Then, 10 ml was dispensed and solidified in a petri dish. A paper disk was placed in the center of the petri dish, and 50 μl of a sample absolute ethanol solution (volume%, abbreviated as%) was dropped. After standing at 5 ° C. for 24 hours, it was cultured at 32 ° C. for 48 hours.
The antibacterial activity was investigated by measuring the diameter of the inhibition circle formed around the paper disc. The sample concentrations used for the measurement were 1.25, 0.625, 0.313 and 0.156%.

[0015]

[Table 1]

From the results shown in Table 1, it was found that the biphenyl compound of the present invention has a concentration-dependent antibacterial action against Propionibacterium acnes and is effective even at low concentrations.

[0017]

As described above, since the present invention has a strong antibacterial action against Propionibacterium acnes at a low concentration, it can be applied to cosmetics, quasi-cosmetics and drugs for treating or preventing acne. It is possible to mix
It is clear to provide useful acne treatment and prevention agents.

Claims (1)

[Claims] 1. A therapeutic and prophylactic agent for acne comprising a biphenyl compound represented by the following general formula. [Chemical 1] (However, R is a hydrogen atom or a linear or branched saturated hydrocarbon group having 1 to 8 carbon atoms)