JPH07265299A - Measuring method of thyroid gland iodine quantity - Google Patents
Measuring method of thyroid gland iodine quantityInfo
- Publication number
- JPH07265299A JPH07265299A JP6082298A JP8229894A JPH07265299A JP H07265299 A JPH07265299 A JP H07265299A JP 6082298 A JP6082298 A JP 6082298A JP 8229894 A JP8229894 A JP 8229894A JP H07265299 A JPH07265299 A JP H07265299A
- Authority
- JP
- Japan
- Prior art keywords
- iodine
- value
- iodine concentration
- thyroid
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title claims abstract description 78
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 78
- 239000011630 iodine Substances 0.000 title claims abstract description 78
- 210000001685 thyroid gland Anatomy 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 9
- 238000009826 distribution Methods 0.000 claims abstract description 10
- 238000000926 separation method Methods 0.000 claims abstract description 4
- 230000002308 calcification Effects 0.000 claims description 23
- 230000003902 lesion Effects 0.000 claims description 5
- 238000003384 imaging method Methods 0.000 claims description 4
- 210000003679 cervix uteri Anatomy 0.000 claims description 2
- 150000002496 iodine Chemical class 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 19
- 238000000516 activation analysis Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 208000024770 Thyroid neoplasm Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 208000013076 thyroid tumor Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000009828 non-uniform distribution Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003325 tomography Methods 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 206010058900 Thyroid mass Diseases 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 230000002902 bimodal effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は生体での甲状腺内ヨウ素
量を測定し、診断に役立てるための甲状腺ヨウ素量の測
定方法に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for measuring the amount of iodine in the thyroid in a living body, which is useful for diagnosis.
【０００２】[0002]
【従来の技術】ヒト甲状腺にはヨウ素が特異的に濃縮し
ている。そしてヨウ素含有量と甲状腺の機能及び疾患と
の関連が意味をもつことがわかって以来、各種のヨウ素
測定方法が提案されている。一般に、生体での甲状腺内
ヨウ素量の測定方法としては、蛍光Ｘ線法が使用されて
いる。この原理は、頚部にＸ線を照射すると甲状腺内に
含まれるヨウ素がこのＸ線を吸収すると同時に、よりエ
ネルギーの低い特定の波長を持った蛍光Ｘ線を放出す
る。2. Description of the Related Art Iodine is specifically concentrated in human thyroid gland. Various methods for measuring iodine have been proposed since it became clear that the relationship between iodine content and thyroid function and diseases was significant. Generally, a fluorescent X-ray method is used as a method for measuring the amount of iodine in the thyroid in a living body. According to this principle, when the cervix is irradiated with X-rays, iodine contained in the thyroid gland absorbs the X-rays and, at the same time, emits fluorescent X-rays having a specific wavelength with lower energy.
【０００３】そして、この蛍光Ｘ線量がヨウ素含有量と
比例することを利用して甲状腺ヨウ素含有量を測定する
ものである（これを蛍光Ｘ線分析法と称す）。実際には
Ｘ線を正面から頚部に照射し、側方又は斜め前方から放
出される蛍光Ｘ線を測定しヨウ素量に換算する方式をと
っている。The thyroid iodine content is measured by utilizing the fact that this fluorescent X-ray dose is proportional to the iodine content (this is called a fluorescent X-ray analysis method). In practice, X-rays are applied to the neck from the front, and fluorescent X-rays emitted from the side or diagonally forward are measured and converted into iodine amount.
【０００４】[0004]
【発明が解決しようとする課題】上記した従来の蛍光Ｘ
線分析法は、空間分解能が非常に悪く、周囲の甲状腺組
織を分離できないため、甲状腺全体に含まれるヨウ素量
を測定することはできるが、甲状腺の一部分だけを限っ
てヨウ素量を測定することはできない。ましてや甲状腺
腫瘤のヨウ素量を正確に測定することは不可能である。
又、測定方式から言って、患者の頚の形態の違いによっ
ても測定値に大きな誤差があった。DISCLOSURE OF THE INVENTION The conventional fluorescent X described above
Since the line analysis method has a very poor spatial resolution and cannot separate the surrounding thyroid tissue, it is possible to measure the amount of iodine contained in the entire thyroid, but it is not possible to measure the amount of iodine in only a part of the thyroid. Can not. Furthermore, it is impossible to accurately measure the amount of iodine in a thyroid mass.
Further, in terms of the measurement method, there were large errors in the measured values due to the difference in the morphology of the patient's neck.
【０００５】更に又、従来方法にあっては甲状腺あるい
は被測定部分を限定して特定することができないため、
甲状腺患者の診断の決め手となるヨウ素濃度をも求める
ことはできなかった。更には専用機であるため他に転用
ができないこと等のため、価格的にも問題があった。Furthermore, in the conventional method, the thyroid gland or the part to be measured cannot be limited and specified.
It was not possible to determine the iodine concentration, which is the decisive factor in the diagnosis of thyroid patients. Furthermore, since it is a dedicated machine, it cannot be diverted for other purposes, so there was a problem in terms of price.
【０００６】本発明は上記課題を解決するためになされ
たものであり、甲状腺組織のヨウ素濃度は勿論のこと、
測定部分の体積も併せて測定ができ、かつ患者の頚の形
態によっても殆んど誤差の生じない甲状腺ヨウ素量の測
定方法を提供することを目的としている。The present invention has been made to solve the above-mentioned problems, and not only the iodine concentration in thyroid tissue,
It is an object of the present invention to provide a method for measuring the amount of iodine in thyroid, which can measure the volume of a measurement portion together and causes almost no error depending on the morphology of the neck of a patient.
【０００７】[0007]
【課題を解決するための手段】基本的な考え方を説明す
る。本発明者らは、石灰化を伴なわない甲状腺組織にお
いて、そのヨウ素濃度が０．０２ｍｇ／ｇ以上でそのＣ
Ｔ値とヨウ素濃度との間には直線的な相関があり、ヨウ
素濃度は（１）式で表わされることを既に報告している
（Ｊｏｕｒｎａｌｏｆ Ｃｏｍｐｕｔｅｒ Ａｓｓｉｓ
ｔｅｄ Ｔｏｍｏｇｒａｐｈｙ，１５：２８７−２９
０，１９９１．）。[Means for Solving the Problem] The basic idea will be described. In the thyroid tissue without calcification, the present inventors have found that when the iodine concentration is 0.02 mg / g or more, the C
It has already been reported that there is a linear correlation between the T value and the iodine concentration, and the iodine concentration is represented by the equation (1) (Journalof Computer Assistis).
Ted Tomography, 15: 287-29
0, 1991. ).
【数１】 ヨウ素濃度＝（ＣＴ値−６５）／１０４ ………（１）## EQU00001 ## Iodine concentration = (CT value-65) / 104 ... (1)
【０００８】しかし、甲状腺腫瘍はしばしば石灰化を持
ち、この石灰化がＣＴ値に大きな影響を与えることがわ
かっている。したがって石灰化に影響されることなく、
甲状腺ＣＴ値からヨウ素濃度を算出しようとしている。However, it is known that thyroid tumor often has calcification, and this calcification has a great influence on the CT value. Therefore, without being affected by calcification,
I am trying to calculate the iodine concentration from the thyroid CT value.
【０００９】患者を仰臥位でＣＴ（ｃｏｍｐｕｔｅｄ
ｔｏｍｏｇｒａｐｈｙ）装置の台に寝かせ、一定のスラ
イス厚（通常は５ｍｍ）、連続ピッチ（通常は５ｍ
ｍ）、一定の撮影条件（管電圧１２０ＫＶ，管電流１５
０ｍＡ，撮影時間２秒）で全甲状腺を撮影する。撮影さ
れた全てのスライスに対して、ヨウ素濃度・体積・総ヨ
ウ素量を測定しようとする部位に関心領域（ＲＯＩ）を
設定する。各々のスライスに対して関心領域内のＣＴ値
のヒストグラムを作成する。CT (computed) of a patient in a supine position
lay on a table of tomography device, constant slice thickness (usually 5 mm), continuous pitch (usually 5 m)
m), constant shooting conditions (tube voltage 120KV, tube current 15)
The whole thyroid gland is photographed at 0 mA and a photographing time of 2 seconds. A region of interest (ROI) is set in a region where the iodine concentration, volume, and total iodine amount are to be measured for all the taken slices. Create a histogram of CT values in the region of interest for each slice.
【００１０】このヒストグラムでは石灰化を伴なわない
甲状腺組織では図１に示すように、ＣＴ値が正規分布に
近い分布（一峰性又は二峰性）を示すが、石灰化を伴な
う甲状腺組織では図２に示すように、ＣＴ値が正規分布
に近い分布に加えてＣＴ値の高い側に平坦な分布を持
つ。In this histogram, the thyroid tissue without calcification shows a CT value distribution close to a normal distribution (unimodal or bimodal) as shown in FIG. 1, but thyroid tissue with calcification Then, as shown in FIG. 2, in addition to the distribution in which the CT value is close to the normal distribution, the CT value has a flat distribution on the higher CT value side.
【００１１】ここで測定しようとする甲状腺組織に石灰
化がある場合にのみ、正規分布に近い分布とＣＴ値の高
い側の平坦な分布との分離点をヒストグラム上で指定
し、この分離点より高いＣＴ値は次のヨウ素濃度計算か
ら除外し、以下に示す（３）式にてヨウ素濃度を算出す
る。Only when the thyroid tissue to be measured has calcification, the separation point between the distribution close to the normal distribution and the flat distribution on the high CT value side is designated on the histogram. The high CT value is excluded from the next iodine concentration calculation, and the iodine concentration is calculated by the following equation (3).
【００１２】これは、石灰化部分を除く甲状腺組織につ
いてのみ、Ｘ線ＣＴの最小単位面積である各々のピクセ
ルのＣＴ値に対して、そのＣＴ値がｔc ＨＵ以上の時に
はそのＣＴ値を以下に示す一般式(2) に代入してヨウ素
濃度を求める。なお、（２）式は（１）式の一般式であ
る。This is because only for the thyroid tissue excluding the calcified part, when the CT value is t c HU or more with respect to the CT value of each pixel which is the minimum unit area of X-ray CT, the CT value is The iodine concentration is obtained by substituting it into the general formula (2) shown in. The expression (2) is a general expression of the expression (1).
【数２】 ヨウ素濃度（ｍｇ／ｇ）＝（ＣＴ値−ｔc ）／ｔd ……（２） 但し、ｔc は切片定数，ｔd は傾き定数であって、ＣＴ
装置、特にＸ線管のターゲットに含まれる金属の組成に
よって決まり、発明者らの使用しているＣＴ装置の場合
では、実測値からｔc ＝６５，ｔd ＝１０４が最適と考
えられた。この数値を入れた式が（１）式である。## EQU2 ## Iodine concentration (mg / g) = (CT value−t c ) / t d (2) where t c is an intercept constant and t d is a slope constant, and CT
It is determined by the composition of the apparatus, particularly the metal contained in the target of the X-ray tube, and in the case of the CT apparatus used by the inventors, t c = 65 and t d = 104 were considered optimal from the measured values. The equation containing this numerical value is the equation (1).
【００１３】このヨウ素濃度にピクセルの面積とスライ
ス厚を乗じて求めた体積を乗じてボクセル内の総ヨウ素
量を求める。又、そのＣＴ値がｔc ＨＵ未満の時にはそ
のピクセル内のヨウ素濃度及びボクセル内の総ヨウ素量
を各々０ｍｇ／ｇ及び０ｍｇとする。これら全てのボク
セル内の総ヨウ素量を合計し、これを石灰化部分を除く
全てのボクセル内の体積の合計で除したものをその組織
のヨウ素濃度として算出したことに相当する。The iodine concentration is multiplied by the volume obtained by multiplying the pixel area and the slice thickness to obtain the total amount of iodine in the voxel. When the CT value is less than t c HU, the iodine concentration in the pixel and the total iodine amount in the voxels are 0 mg / g and 0 mg, respectively. This is equivalent to calculating the iodine concentration of the tissue by summing the total amount of iodine in all these voxels and dividing this by the total of the volumes in all voxels excluding the calcified portion.
【００１４】[0014]
【数３】 [Equation 3]
【００１５】ｘ：ヒストグラム上のあるＣＴ値。 ａx ：あるＣＴ値（ｘ）を持つピクセル全体の面積。 ａix：あるスライス（ｉ）におけるあるＣＴ値（ｘ）を
持つピクセル全体の面積。 ｂ：ヒストグラム上での石灰化成分の分離点のＣＴ値。 ｌ：ヒストグラム上での算出のＣＴ値。 ｔc ：切片の定数。 ｔd ：傾きの定数。 ｉ：関心領域（ＲＯＩ）を描いた全てのスライス（但
し、アーティファクトの多いスライス及び両上下端のス
ライスを除く。）。X: A certain CT value on the histogram. a x : Area of the whole pixel having a certain CT value (x). a ix : Area of the whole pixel having a certain CT value (x) in a certain slice (i). b: CT value of the separation point of the calcification component on the histogram. l: CT value calculated on the histogram. t c : intercept constant. t d : slope constant. i: All slices that depict the region of interest (ROI) (excluding slices having many artifacts and slices at both upper and lower ends).
【００１６】更に、石灰化部分を含めた関心領域の面積
とスライス厚の積の全てのスライスにおける和（（４）
式）から測定しようとする甲状腺組織の体積を算出す
る。この体積と先程求めたヨウ素濃度の積を測定しよう
とする甲状腺組織の総ヨウ素量とする。Further, the sum of the product of the area of the region of interest including the calcified portion and the slice thickness in all slices ((4)
The volume of the thyroid tissue to be measured is calculated from the formula). The product of this volume and the iodine concentration obtained above is the total amount of iodine in the thyroid tissue to be measured.
【００１７】[0017]
【数４】 ｘ：ヒストグラム上のあるＣＴ値。 ａix：あるスライス（ｉ）におけるあるＣＴ値（ｘ）を
持つピクセル全体の面積。 ｓ：スライス厚さ（ｃｍ）。 ｉ：関心領域（ＲＯＩ）を描いた全てのスライス（但
し、アーティファクトの多いスライス及び両上下端のス
ライスを含む。）。[Equation 4] x: A certain CT value on the histogram. a ix : Area of the whole pixel having a certain CT value (x) in a certain slice (i). s: slice thickness (cm). i: All slices depicting the region of interest (ROI), including the slices with many artifacts and the slices at the upper and lower ends.
【００１８】なお、ＣＴ値からヨウ素濃度への換算をＣ
Ｔ画素の最小単位であるピクセル及びボクセルで行なっ
たことにより、微量でしかも不均一な分布を示すヨウ素
濃度もより正確に測定できる。例えばｔc 及びｔd が夫
々６５及び１０４で、甲状腺右葉及び左葉が同じ体積
で、ＣＴ値が夫々６０ＨＵと７０ＨＵだったとする。甲
状腺全体の平均ＣＴ値は６５ＨＵでヨウ素濃度は０ｍｇ
／ｇとなってしまうが、ヨウ素濃度を右葉と左葉で別々
に計算すると各々０ｍｇ／ｇ及び０．０４８ｍｇ／ｇと
なり、実際には甲状腺全体のヨウ素濃度の平均は０．０
２４ｍｇ／ｇである。このようにＣＴ値からヨウ素濃度
への換算単位が小さければ小さいほど微量でしかも不均
一な分布を示すヨウ素濃度をより正確に測定できる。The conversion from CT value to iodine concentration is C
By carrying out with pixels and voxels, which are the minimum units of T pixels, it is possible to more accurately measure the iodine concentration, which is a trace amount and has a non-uniform distribution. For example, suppose that t c and t d are 65 and 104, respectively, the right and left lobes of the thyroid have the same volume, and the CT values are 60 HU and 70 HU, respectively. Average CT value of the entire thyroid is 65 HU and iodine concentration is 0 mg
However, when the iodine concentration in the right lobe and that in the left lobe are calculated separately, they are 0 mg / g and 0.048 mg / g, respectively. Actually, the average iodine concentration in the entire thyroid is 0.0
It is 24 mg / g. Thus, the smaller the conversion unit from the CT value to the iodine concentration is, the more accurately the iodine concentration exhibiting a non-uniform distribution can be measured more accurately.
【００１９】[0019]
【実施例】以下実施例を説明する。使用器具はＣＴ装置
として東芝製ＴＣＴ−９００Ｓを使用し、撮影条件はス
ライス厚５ｍｍ，連続ピッチ５ｍｍ，管電圧１２０Ｋ
Ｖ，管電流１５０ｍＡ，撮影時間２秒，画像ｍａｔｒｉ
ｘ ５１２×５１２とし、ヨウ素濃度換算係数はｔc＝
６５，ｔd ＝１０４とした。対象は手術前に上記の条件
で甲状腺ＣＴ検査が行なわれ、手術によって摘出標本が
得られた５１病変（ＣＴ上石灰化のない２９病変，ＣＴ
上石灰化のある２２病変）について行なった。EXAMPLES Examples will be described below. The equipment used is a TCT-900S manufactured by Toshiba as a CT device, and the imaging conditions are: slice thickness 5mm, continuous pitch 5mm, tube voltage 120K.
V, tube current 150mA, shooting time 2 seconds, image matri
x 512 x 512, and the iodine concentration conversion coefficient is t c =
65, and a t d = 104. Thyroid CT examination was performed on the subject under the above conditions before surgery, and 51 lesions (29 lesions without calcification on CT, CT
(22 lesions with upper calcification).
【００２０】放射化分析（Ｎｅｕｔｏｒｎ Ａｃｔｉｖ
ａｔｉｏｎ Ａｎａｌｙｓｉｓ）について。手術で摘出
した標本は分析を行なうときまでホルマリン溶液内に保
存された。この標本から５〜２００ｍｇの大きさのサン
プルを１〜４個切り出し、正確に重さを測定してからポ
リエチエンシートで密封し、一定量の標準物質（ＮＨ4
Ｉ）と共に原子炉（ＴＲＩＧＡ Ｍａｒｋ II）にて一
定時間中性子を照射した後、サンプル及び標準物質から
放出されるγ線を測定し、これによって各々のサンプル
のヨウ素濃度を算出した。複数個のサンプルを切り出し
た場合はそれらの平均ヨウ素濃度を標本のヨウ素濃度と
した。ＣＴ上石灰化のある標本ではできる限り石灰化の
ない部分をサンプルとした。Activation analysis (Neutorn Activ)
ation Analysis). The surgically excised specimens were stored in formalin solution until the time of analysis. From this specimen, 1 to 4 samples of 5 to 200 mg in size were cut out, the weight was accurately measured, and the sample was sealed with a polyethylene sheet, and a fixed amount of standard substance (NH 4
After irradiating neutrons together with I) in a nuclear reactor (TRIGA Mark II) for a certain period of time, the γ-rays emitted from the sample and the standard substance were measured, and thereby the iodine concentration of each sample was calculated. When a plurality of samples were cut out, the average iodine concentration thereof was used as the iodine concentration of the sample. In a specimen with calcification on CT, a portion without calcification was used as a sample.
【００２１】結果は図３に示される。なお、図３は放射
化分析によるヨウ素濃度とＣＴで測定されたヨウ素濃度
との関係を、石灰化を伴なわない甲状腺組織と石灰化を
伴なう甲状腺組織とに分け、夫々を対比して示したもの
である。又、図４はＣＴにより算出されたヨウ素濃度と
放射化分析により測定されたヨウ素濃度との相関図であ
り、白丸が石灰化を伴なわないもの、黒丸が石灰化を伴
なうものを夫々示す。The results are shown in FIG. Note that FIG. 3 shows the relationship between the iodine concentration by activation analysis and the iodine concentration measured by CT, divided into thyroid tissue without calcification and thyroid tissue with calcification, and comparing them. It is shown. FIG. 4 is a correlation diagram between the iodine concentration calculated by CT and the iodine concentration measured by activation analysis. White circles are not accompanied by calcification and black circles are accompanied by calcification. Show.
【００２２】図からわかるように、放射化分析によって
測定されたヨウ素濃度と、ＣＴによって測定されたヨウ
素濃度との間には非常に良い相関（ｙ＝０．００６４８
＋０．９９９ｘ，ｎ＝５１，ｒ＝０．９６）が認められ
た。しかも石灰化のない甲状腺組織と石灰化のある甲状
腺組織との間で、その相関に有意差は認められなかった
（共分散分析でｐ＞０．１）。したがって、甲状腺組織
内のヨウ素濃度は石灰化の有無に拘らず非常に正確に測
定されているものと考えられた。As can be seen from the figure, there is a very good correlation (y = 0.00648) between the iodine concentration measured by activation analysis and the iodine concentration measured by CT.
+ 0.999x, n = 51, r = 0.96) was recognized. Moreover, there was no significant difference in the correlation between non-calcified thyroid tissue and calcified thyroid tissue (covariance analysis p> 0.1). Therefore, it was considered that the iodine concentration in thyroid tissue was measured very accurately regardless of the presence or absence of calcification.
【００２３】[0023]
【発明の効果】以上説明したように、本発明によれば検
出されたＣＴ値からヨウ素濃度への換算をＣＴ画素の算
出単位であるピクセル及びボクセルで行ない、かつ、Ｃ
Ｔ値のヒストグラムで石灰化のＣＴ値を除外するように
したので、以下列挙する効果を奏する。 ＣＴ装置は全国的に汲まなく普及しているため、生
体内の甲状腺組織のヨウ素濃度が簡単に、かつ短時間で
測定できる。 ＣＴは空間分解能が非常に優れているので、周囲の
甲状腺組織に影響されることなく特定の部分のヨウ素濃
度などが簡単に測定できる。 ＣＴはＸ線吸収率を測定しているため、原子番号が
非常に大きいヨウ素原子に対して非常に感度が良く、し
かも頚の形態に殆んど影響されない。 石灰化の影響を受けることなくヨウ素濃度などを正
確に測定できる。 ＣＴを用いることによって、ヨウ素濃度のみならず
同時に体積をも測定できるので、甲状腺全体，甲状腺腫
瘍など関心領域（ＲＯＩ）で自由に選択した部分の体
積，ヨウ素濃度，総ヨウ素量を一度に求めることができ
る。 特に病変部のヨウ素濃度は、びまん性甲状腺疾患に
おける診断・手術適応の判定・治療効果の判定などに非
常に役立ち、又、甲状腺腫瘤における診断及び良悪性の
判定・経過観察及び手術適応の判定などに非常に役立
つ。 特定のＣＴ値を持つ部分の面積・体積を簡単に測定
できることから、肥満評価のための内臓脂肪・皮下脂肪
などの面積・体積の測定などにも応用できる。As described above, according to the present invention, the detected CT value is converted into the iodine concentration by the pixel and voxel which are the calculation units of the CT pixel, and C
Since the CT value of calcification is excluded from the T value histogram, the following effects are achieved. Since CT devices are widely used nationwide, it is possible to easily measure the iodine concentration of thyroid tissue in a living body in a short time. Since CT has a very good spatial resolution, it is possible to easily measure the iodine concentration at a specific portion without being affected by the surrounding thyroid tissue. Since CT measures X-ray absorptance, it is very sensitive to iodine atoms, which have a very large atomic number, and is almost unaffected by the morphology of the neck. The iodine concentration can be measured accurately without being affected by calcification. By using CT, not only the iodine concentration but also the volume can be measured at the same time. Therefore, the volume, iodine concentration, and total iodine amount of the entire thyroid gland, thyroid tumor, etc. selected freely in the region of interest (ROI) can be obtained at once. You can In particular, the iodine concentration in the lesion area is very useful for diagnosing diffuse thyroid disease, determining the indication for surgery, determining the therapeutic effect, etc., and diagnosing thyroid tumors, determining whether benign or malignant, observing and determining the indication for surgery. Very helpful to. Since the area / volume of a portion having a specific CT value can be easily measured, it can be applied to the measurement of the area / volume of visceral fat / subcutaneous fat for evaluating obesity.
【図１】石灰化を伴なわない甲状腺組織のＣＴ値のヒス
トグラムを整理して示す図。FIG. 1 is a diagram showing an organized histogram of CT values of thyroid tissue without calcification.
【図２】石灰化を伴なった甲状腺組織のＣＴ値のヒスト
グラムを整理して示す図。FIG. 2 is a diagram showing an organized histogram of CT values of thyroid tissue with calcification.
【図３】実際に使用した甲状腺資料について、放射化分
析とＣＴにて測定されたヨウ素濃度の対比図。FIG. 3 is a comparison diagram of iodine concentration measured by activation analysis and CT for thyroid data actually used.
【図４】図３の測定結果からヨウ素濃度について作成し
た相関図。FIG. 4 is a correlation diagram created for iodine concentration from the measurement results of FIG.
Claims (1)
定する甲状腺ヨウ素量の測定方法において、全甲状腺を
一定のスライス厚，連続ピッチ及び一定の撮影条件にて
Ｘ線ＣＴを撮影し、病変のある全てのスライスに対して
関心領域を設定すると共に、各スライスに対し、関心領
域内のＣＴ値のヒストグラムを作成し、甲状腺に石灰化
がある場合はＣＴ値の高い側の平坦な分布との分離点を
ヒストグラム上で指定して次のヨウ素濃度計算から除外
するようにし、石灰化を除く甲状腺組織についてのみＸ
線ＣＴの最小単位面積である各々のピクセルのＣＴ値に
対して、そのＣＴ値が所定値以上である時には所定の計
算式を用いてヨウ素濃度を求め、このヨウ素濃度にピク
セルの面積とスライス厚を乗じて求めた体積を乗じてボ
クセル内の総ヨウ素量を求め、全てのボクセル内の総ヨ
ウ素量を合計し、かつ石灰化部分を除く全てのボクセル
内の体積の合計で除して当該組織のヨウ素濃度とするこ
とを特徴とする甲状腺ヨウ素量の測定方法。1. A method for measuring the amount of iodine in a thyroid gland, which measures the amount of iodine by imaging an X-ray CT of a cervix, by imaging the whole thyroid gland with a constant slice thickness, continuous pitch and constant imaging conditions. Set a region of interest for all slices with lesions, create a histogram of CT values in the region of interest for each slice, and if there is calcification in the thyroid gland, flatten the side with higher CT values. The separation point from the distribution is specified on the histogram so that it is excluded from the next iodine concentration calculation, and only the thyroid tissue excluding calcification is X
For the CT value of each pixel, which is the minimum unit area of the line CT, when the CT value is greater than or equal to a predetermined value, the iodine concentration is calculated using a predetermined calculation formula, and the iodine concentration is used to determine the pixel area and the slice thickness. The total amount of iodine in the voxel is multiplied by the volume obtained by multiplying the total iodine amount in all voxels, and divided by the total volume in all voxels excluding the calcified part A method for measuring the amount of iodine in thyroid, which is characterized in that
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6082298A JP2630911B2 (en) | 1994-03-29 | 1994-03-29 | Measurement device for iodine in thyroid gland |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6082298A JP2630911B2 (en) | 1994-03-29 | 1994-03-29 | Measurement device for iodine in thyroid gland |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07265299A true JPH07265299A (en) | 1995-10-17 |
| JP2630911B2 JP2630911B2 (en) | 1997-07-16 |
Family
ID=13770650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6082298A Expired - Lifetime JP2630911B2 (en) | 1994-03-29 | 1994-03-29 | Measurement device for iodine in thyroid gland |
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| Country | Link |
|---|---|
| JP (1) | JP2630911B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011524754A (en) * | 2008-02-13 | 2011-09-08 | キットウェア インク | Method and system for measuring cell damage and disease risk |
| KR20200090288A (en) * | 2019-01-18 | 2020-07-29 | 고려대학교 산학협력단 | System and Method for Classifying Thyroid Lesions Using Dual-Energy CT Iodine Quantification |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3544511A4 (en) * | 2016-11-23 | 2020-08-19 | Mayo Foundation for Medical Education and Research | System and method for quantifying luminal stenosis using multi-energy computed tomography imaging |
-
1994
- 1994-03-29 JP JP6082298A patent/JP2630911B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011524754A (en) * | 2008-02-13 | 2011-09-08 | キットウェア インク | Method and system for measuring cell damage and disease risk |
| KR20200090288A (en) * | 2019-01-18 | 2020-07-29 | 고려대학교 산학협력단 | System and Method for Classifying Thyroid Lesions Using Dual-Energy CT Iodine Quantification |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2630911B2 (en) | 1997-07-16 |
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