JPH0725734A - Liquid composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a liquid dentifrice useful for children and women having weakness in irritation, having low stimulation, proper foaming and a refreshing feeling and a liquid dentifrice having neither bitternessin addition of cetylpyridinium chloride nor reduction in antimicrobial effect in addition of cetylpyridinium chloride. CONSTITUTION:A composition for oral cavity containing ethanol and a slightly water-soluble spice is mixed with 1.5(w/v) of ethanol or further with 0.01-0.1(w/v)% of cetylpyridinium chloride to give a liquid composition for oral cavity.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition for cleaning the oral cavity, that is, teeth and gums and preventing bad breath.

[0002]

2. Description of the Related Art There are bacteria in the oral cavity, and the growth of these oral bacteria is promoted by sugars contained in food waste and foods, and secretes acidic substances that aggravate tooth decay and diseases around the teeth to cause tooth decay. Causes disease around the teeth. However, oral bacteria cannot completely kill, but various compounds for effectively preventing the growth of harmful bacteria are known, and oral compositions containing these as active ingredients are used as a mouse composition. Toothpastes such as wash, liquid toothpaste, liquid toothpaste and toothpaste, mouthwash and mouthwash (gargle) are prescribed. In particular, liquid oral compositions such as mouthwash and liquid toothpaste (hereinafter referred to as "liquid toothpaste") have been launched in recent years and have become a habit.

This liquid toothpaste contains a germicide such as cetylpyridinium chloride, triclosan, and chlorhexidine gluconate as a component for suppressing the growth of oral bacteria. In addition to this, menthol and other substances are used to obtain a refreshing feeling. The poorly water-soluble flavor is added. further,
A large amount (about 15%) of ethanol is added in order to give a refreshing sensation called "feeling of use" by giving an appropriate stimulus.

On the other hand, the establishment of liquid toothbrushing in the habit has increased the age group of users, and individual tastes have become the motive for purchasing products. For this reason, there is a need for liquid toothpaste that has a refreshing feeling and is less irritating, and is a non-alcoholic oral composition that does not contain ethanol, which has been used to give a "feeling of use" among the constituents of liquid toothpaste. Things are also being considered. For example, Japanese Patent Application Laid-Open No. 1-275521 discloses a dry mouthwash which comprises a surfactant, a foaming agent, sodium saccharin and a spray-dried fragrance and is used by dissolving it in water. In particular, it has been shown that "volatile oil, that is, a sparingly water-soluble fragrance can be used as a spray-dried fragrance, in which case it is dispersed in a solution with a sufficient amount of a surfactant". However, the surfactant is a component necessary to disperse the poorly water-soluble component in the liquid toothpaste, but if it is added more than necessary, it foams abnormally during use of the liquid toothpaste, making it difficult to use.

Further, as a liquid toothpaste for children, a product containing 7% of ethanol, which is less than half the amount of ethanol in the products that have been released before, has been released. But,
According to the inventors' examination, children are still very stimulating,
It turned out to be difficult to use.

[0006]

Therefore, the inventors of the present invention have little irritation for children or women who are vulnerable to irritation.
Liquid toothpaste was investigated for the purpose of obtaining a liquid toothpaste with proper foaming and a refreshing feeling. Another object of the present invention was to easily disperse a poorly water-soluble fragrance in a liquid toothpaste regardless of the blending amount of a surfactant when preparing a liquid toothpaste.

Still another object of the present invention is to provide a liquid toothpaste containing cetylpyridinium chloride even if a surfactant for the purpose of properly foaming at the time of use is added, and the liquid toothpaste has no bitterness, and The purpose was to obtain a liquid toothpaste whose antibacterial effect does not decrease.

[0008]

The above object is achieved by a liquid oral composition comprising the following (a) and (b) of the present invention. That is, (a) a liquid oral composition comprising ethanol and a sparingly water-soluble fragrance, wherein ethanol is added in an amount of 1.5 (w / v)% or less. (B) In an oral composition containing ethanol and a poorly water-soluble fragrance, ethanol is blended in an amount of 1.5 (w / v)% or less, and cetylpyridinium chloride 0.01 to 0.1
(w / v)% blending composition for liquid oral cavity.

The ethanol in the present invention includes not only hydrous ethanol and anhydrous ethanol which are generally called, but also alcohols modified with various denaturants. For example, geraniol modified alcohol, octaacetylated sucrose modified alcohol, phenylethyl alcohol modified alcohol, brucine modified alcohol, linalool modified alcohol, diethyl phthalate modified alcohol, linalool acetate modified alcohol, benzyl acetate modified alcohol and 10% denatonium benzoate alcohol solution Denatured alcohol etc. can be illustrated.

The sparingly water-soluble fragrance in the present invention includes:
-Menthol, dl-menthol, acetophenone, anethole, anisaldehyde (Anisaldehy
de), anisyl alcohol, benzyl acetate, borneol, butyl acetate, butyl butyrate, citral, citronellol, p-cresyl acetate, cumin aldehyde, damascenone diphenyl oxide, ethyl caproate Eight (Ethyl caproate), eugenol (Eugenol), geraniol, limonene, linary acetate (Linaly acetate), bromelia (Bromelia) and their one or more compounds selected from optical isomers and geometric isomers An example is a fragrance.

In the present invention, the content of ethanol in liquid toothpaste is 1.5% or less. In general, the expression "containing 1.5% or less" includes non-alcohol (containing no ethanol), but in the present specification, "1.
"5% or less" does not include non-alcohol. And the blending amount of ethanol is 1.5 (w / v)%
(Hereinafter, “%” is described as w / v unless otherwise specified.) If it is more than that, children or some women feel irritation, and therefore, a lesser amount is preferable. Further, a general prepared flavor is prepared by adding a minor component based on the poorly water-soluble flavor. Then, although some of the prepared fragrances are added with a large amount of ethanol, the present invention also applies to liquid toothpaste having an ethanol content of 1.5% or less in a liquid toothpaste prepared by adding the prepared fragrance ethanol solution. Including.

In the present invention, the surfactant is optional including those listed in the Japanese Pharmacopoeia and the standards for cosmetic raw materials, but when cetylpyridinium chloride is used,
A substance that does not inhibit the antibacterial activity of the cetylpyridinium chloride is preferable, and for example, the average number of moles of addition of polyoxyethylene polyoxypropylene glycol and ethylene oxide is 40.
Examples include polyoxyethylene hydrogenated castor oil of -100. Furthermore, considering that the point of taste of the present invention, that is, bitterness is not present and foaming is appropriate, polyoxyethylene polyoxypropylene glycol is preferable, and polyoxyethylene (160) polyoxypropylene glycol (30) is particularly preferable. Also, polyoxyethylene (160) and polyoxypropylene glycol (30) are preferable from the viewpoint of good pH stability. Further, the amount of the surfactant blended may be an amount of foaming during use, and may be in the range of 0.01 to 1.0%.

In the present invention, the content of cetylpyridinium chloride in the liquid toothpaste varies depending on the kind of the surfactant. For example, polyoxyethylene (160) polyoxypropylene glycol (30) (trade name Pronone 208) described above is used. When used, the concentration of cetylpyridinium chloride in liquid toothpaste is 100 ppm, ie 0.01%.
When it is below, the antibacterial activity is significantly reduced. Cetylpyridinium chloride may be usually added in an effective amount, but since it has bitterness, its content is preferably low, and in this case, the upper limit is 0.1%.

In the present invention, as a method for solubilizing the poorly water-soluble fragrance in liquid toothpaste, it is preferable to dissolve the poorly water-soluble fragrance in ethanol and then mix it with other components. This is because, in the manufacturing stage, when the poorly water-soluble fragrance is uniformly dispersed in the liquid toothpaste, not only the time spent for the stirring operation is short but also it can be dissolved in almost the same manufacturing process even at a low temperature. In some cases, modifying the ethanol with a sparingly water-soluble flavor may lead to the possibility of using an inexpensive raw material.

As other components of the present invention, appropriate components are used depending on the kind of the oral composition. For example, a thickener, a sweetener, a pH adjuster and the like can be added, and as its components, sodium N-acyl-L-glutamate, ascorbic acid, sodium alginate, aloe extract, disodium edetate, tetrasodium edetate dihydrate. Salt, zinc chloride, sodium chloride, alkyldiaminoethylglycine hydrochloride, eugenol, augon extract, γ-oryzanol, brown algae extract, carrageenan, carboxyvinyl polymer, carboxymethylcellulose sodium, licorice extract, agar, dilute hydrochloric acid, xanthan gum, sodium citrate, glycerin. , Glycyrrhizic acid and its salts, Gunjou, cinnamic alcohol, cinnamic aldehyde, crystalline cellulose, saccharin, sodium saccharin, aluminum oxide, shikon extract, heavy carbonate Cium, tartaric acid, distilled peppermint water, sucrose fatty acid ester, sodium hydroxide, sodium N-stearoyl-L-glutamate, stevia extract, sage extract, sodium cetyl sulfate, gelatin, sodium fibrin glycolate, sorbit, sodium hydrogen carbonate, Copper chlorophyllin sodium, sodium lactate, lactose, glycerin, sucrose, toothpaste calcium hydrogen phosphate, hydroxyethyl cellulose, calcium pyrophosphate, glucose, propanol, propylene glycol, sodium polyacrylate, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 150
0, polyethylene glycol 6000, sodium polyphosphate, d-borneol, microcrystalline wax, maltitol, beeswax, myristic acid diethanolamide, anhydrous citric acid, methyl cellulose, liquid paraffin, sodium monohydrogen phosphate, sodium dihydrogen phosphate, phosphorus Sodium acid, citric acid, calcium hydrogen phosphate, magnesium phosphate and the like can be mentioned.

[0016] In particular, a preservative can be blended because it has a weaker preservative property (suppressive effect on the growth of various bacteria) than a liquid toothpaste having an ethanol content of about 15% or more, which is conventionally sold. When using chlorhexidine such as cetylpyridinium chloride, triclosan and chlorhexidine hydrochloride, and fragrances having a high phenol index such as hinokitiol, it is not necessary to intentionally mix them. Examples of the preservatives include isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate and Examples thereof include sodium dehydroacetate, and sodium benzoate or sodium salicylate, which causes less irritation during use, is preferable.

Further, in the present invention, cetylpyridinium chloride is used as an active ingredient and / or other active ingredients are replaced with dextranase, a lytic enzyme (lysozyme chloride, etc.), mutanase, chlorhexidine hydrochloride, chlorhexidine gluconate, sorbin. Acid, alexidine, hinokitiol, alkylglycine, triclosan, alkyldiaminoethylglycine salt, β-aminocaproic acid, tranexamic acid, vitamin E, sodium monofluorophosphate, sodium fluoride, fluorinated first
Copper, a water-soluble primary or secondary phosphate, a quaternary ammonium compound, etc. can also be added. As an amount to be blended, an effective amount may be blended, usually 10% or less 0.001
% Or more, preferably 5% or less and 0.005% or more.

[0018]

As described above, the present invention mixes liquid toothpaste with ethanol in an amount not more than one-tenth that of conventional liquid toothpaste, that is, 1.5% or less, so that it is almost irritating to children or women who are vulnerable to irritation. In addition to a liquid toothpaste free of ethanol, ethanol plays a sufficient role as a solubilizing aid even in dissolving a sparingly water-soluble fragrance.

[0019]

EXAMPLES The present invention will be described in detail below with reference to test examples and examples, but the present invention is not limited to these examples.

Examples 1 to 7 The components were mixed in the proportions shown in Tables 1 and 2 below, and the pH was adjusted to between 7.7 and 5.4. As the sparingly water-soluble fragrance, 1-menthol (made by Takasago fragrance),
FL-87204 (fragrance A), FL-87206 (fragrance B), FL-87380 (fragrance C), FL-86923
(Fragrance D), FL-90282 (Fragrance E), FL-96
040 (fragrance F; all manufactured by Inabata Koryo Co., Ltd.) and the like, and as the surfactant, polyoxyethylene (160) polyoxypropylene glycol (30) (pronone 20
8), polyoxyethylene hydrogenated castor oil (100) (trade name HCO-100), etc. were used.

[0021]

[Table 1]

[0022]

[Table 2]

Test Example 1 (Ethanol Concentration) The liquid toothpaste of the formulation of Example 4 and Comparative Example 1 (pH 6.
Using 4), a sensory test was conducted on 28 children (6 kindergarten children, 10 elementary school lower grades and 12 elementary school upper grades) and 30 females in their 20s.

The test method was as follows: Example 4 and Comparative Example 1 were separately conducted twice a day, morning and evening, and 5 to 10 m each time.
It was carried out by a method of use in which 1 was contained in the mouth, rinsed, exhaled, and then brushed, and continued for about 2 weeks.
Then, the questionnaire was asked to answer once every two days, and the aggregates were used to observe the feelings of each child and woman.
The results are shown in Table 3 as a ratio (%) of the felt persons to the whole subjects. The survey items were bitterness and irritation.

[0025]

[Table 3]

Test Example 2 (concentration of cetylpyridinium chloride) As a test sample, ethanol 1 (v / v)%, concentrated glycerin 10%, sodium monohydrogenphosphate 0.25%, sodium dihydrogenphosphate 0.132 %, Saccharin 0.00
5%, pronone 208 1% basic sample to which 0.01, 0.008, 0.006 and 0.004% of cetylpyridinium chloride was added and the basic sample were used (samples of each concentration were measured from the front to C100). , C80, C60, C40 and C0). As a test method, Streptococcus pre-cultured in BHI (Difco) liquid medium
Mutant MT8148R suspension or subject A
100 μl of saliva of each of the above was put into a sterilized 3 ml test tube, 400 μl of C100, C80, C60, C40 or C0 was added to each test tube, and the mixture was left to stand for about 30 seconds after stirring with a vortex mixer (manufactured by Scientific Inc.). I was Then, each sample is 1000% with 0.8% saline.
Dilute twice and 50 μl of it is SCD in a 10 cm Petri dish.
It was applied to the surface of an LP medium (manufactured by Nippon Pharmaceutical Co., Ltd .; mixed with 3% agar), cultured at 37 ° C. for 2 days, and the number of colonies was measured. The results are shown in Table 4 by obtaining the number of mutans bacteria or the number of miscellaneous bacteria (cell / sheet) in 1 ml of the stock solution or the treated sample from the dilution ratio.

[0027]

[Table 4]

[0028]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, when the ethanol concentration is 1.5 (w / v)% or less, a liquid toothpaste without resistance can be prepared when used by a child or a woman who is irritated by irritation. At the same time, the sparingly water-soluble fragrance can be easily and easily dissolved in liquid toothpaste, and can be prepared in a short time even during manufacturing.

Claims (2)

[Claims] 1. A liquid oral composition comprising ethanol and a sparingly water-soluble fragrance, wherein ethanol is incorporated in an amount of 1.5 (w / v)% or less. 2. An oral composition containing ethanol and a sparingly water-soluble fragrance, containing not more than 1.5 (w / v)% of ethanol and 0.01 to 0.1 (w / v) cetylpyridinium chloride. % Composition for liquid oral cavity.