JPH0713715Y2 - Medical capsule - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Industrial field of application) The present invention relates to improvement of a medical capsule that administers a drug or samples a liquid at a predetermined position in a living body.

(Prior Art) Recently, a medical capsule has been developed that can administer a drug or sample a body fluid at a predetermined position in a living body. This medical capsule has a working chamber that seals the medicine inside or takes in body fluid, and if the patient swallows and reaches a predetermined position in the body, releases the medicine inside the working chamber to the outside, The capsule is designed to take in body fluid for sampling.

When this capsule is used for drug administration, the drug can be directly administered to the affected area, there are few side effects, and a high therapeutic effect can be expected, and when it is used for sampling, the body fluid at the desired site can be selected. And take it out,
It will have an excellent function as an auxiliary tool for conducting the inspection.

If this capsule is described in further detail, a conventional medical capsule is, for example, as shown in FIG. 4 (see JP-A-2-36,848 or JP-A-2-36,849),
It has a working chamber A for storing the medicine a or storing a sampled body fluid, and a piston c is slidably provided at one end of the working chamber A.

When this capsule is used as a drug administration capsule, the discharge port d is provided at the end of the working chamber A opposite to the piston c.
The piston c is always fixed by the fixed thread f against the force of the spring g, and the fixed thread f is heated and cut by the filament h to utilize the force of the spring g to move the piston c to the outer cylinder. The medicine a in the working chamber A is ejected to the outside from the ejection port d by sliding in the i.

When used as a sampling capsule, the working chamber A is emptied, and the piston c is slid in the outer cylinder i so that the working chamber A has a negative pressure. The body fluid is taken into the working chamber A through the holes j and k.

When medicine is administered or body fluid is sampled by this medical capsule (hereinafter simply referred to as capsule operation), after the patient swallows the capsule, it is tracked by an external monitoring device such as an X-ray, and this capsule is When reaching a predetermined position, current is sent from the outside,
The filament h is heated, the fixed yarn f is heated and cut, and the piston c is slid in the outer cylinder i by the force of the spring g to perform the capsule operation.

As a means for energizing the filament h, a long-distance electric wire is attached to the capsule as in the above publication, an electric wire connected to the swallowed capsule is guided to the outside of the patient, and an electric current is passed through the electric wire. There are an operating method, an indirect operating method in which the resonance circuit in the capsule is resonated from the outside to energize the filament h, or a method in which a switch is turned on by mechanical vibration.

The above-mentioned drugs include drugs, microorganisms, diagnosis of diseases,
Refers to those used for therapy, treatment or prophylaxis.

(Problems to be solved by the device) However, the conventional direct remote control is preferable because it causes physical pain to the patient because not only the capsule but also the electric wire connected to the capsule must be swallowed. Instead, it is preferable to use an indirect operation method. However, this indirect operation method is not always preferable because the time point of capsule operation differs from the time point of external operation.
When the filament h is heated after detecting that the capsule has reached a predetermined position in the body, and the fixed thread f is cut by heating, the fixed thread f is made of cotton thread or synthetic fiber thread. There is a possibility that some deviation may occur, which may cause the capsule operating position to be inaccurate, and a sufficient therapeutic effect cannot be expected, or an unexpected test result due to insufficient sampling. There is a problem that comes out.

The present invention has been made in view of the drawbacks and problems associated with the above-mentioned conventional techniques, and performs a capsule operation accurately at a predetermined position in the body to exert a predetermined medicinal effect on a drug to be administered, or to ensure a certain drug effect at a desired position. An object of the present invention is to provide a medical capsule capable of performing sampling.

(Means for Solving the Problems) An object of the present invention to achieve the above object is to provide an outer cylinder and a lid attached to both ends of a main body block, and a working chamber formed between the main body block and the outer cylinder. A piston provided slidably in the working chamber, a spring member provided between the main body block for urging the piston toward the distal end side of the outer cylinder, and an elastic force of the spring member. A fixed thread mounted so as to fix the piston to the main body block against heat, a filament that heats and cuts the fixed thread, and a battery that supplies power to the filament. In the medical capsule which is released to the outside from the drug discharge port provided in or to take in body fluid from the outside into the working chamber, a medical capsule characterized in that a flammable material is applied to the fixing thread. is there .

The outer cylinder of the present invention attached to the main body block may have a through hole sealed by a seal film at the tip end so as to seal the drug in the inner working chamber. ,
The inside may be hollow, and the body fluid may be taken in from the outside by the negative pressure generated by the operation of the piston.

It is preferable that the fixing system mounted so as to fix the piston to the main body block is attached in contact with the filament in a predetermined space formed in the main body block, and more preferably, a thread made of polyethylene terephthalate is combustible. It is preferably impregnated with a natural oil.

(Operation) In the present invention configured as described above, when the capsule is operated, the fixed yarn is impregnated with the combustible material, so that the filament is melted by the heat of the filament and the flammable material is ignited at the same time. The fixed yarn is broken, the fixed yarn is instantaneously broken, and the external operation and the piston operation are performed substantially at the same time, and the capsule operation is accurately performed. In particular, since this kind of medical capsule is used in a body with little oxygen, if the fixing thread is attached in contact with the filament in the space of the main body block, the breakage can be performed more quickly. Further, when the fixed thread is impregnated with a flammable oil, the strength of the fixed thread itself is improved, and the trade-off requirements of easiness of breakage and certainty of piston support can be solved at once.

Embodiment An embodiment of the present invention will be described below with reference to the drawings.

FIG. 1 is a sectional view showing an embodiment of the present invention, FIG. 2 is a perspective view of a reed switch, and FIG. 3 is a sectional view showing an operating state of the same embodiment.

The medical capsule 1 is of a type used for drug administration, and as shown in FIG. 1, an outer cylinder 2 and a lid body made of a polycarbonate made of bottomed cylinders at both ends of a main body block 3. 4 is screwed via an O-ring o, and the whole is formed into a substantially elliptical shape. A working chamber A is formed between the main body block 3 and the outer cylinder 2. A piston 5 is provided in the working chamber A, and the piston 5 is urged by a coil spring 26 provided between the piston 5 and the main body block 3 so as to project toward the distal end side of the outer cylinder 2. A space between the piston 5 and the outer cylinder 2 is a drug chamber Y in which a drug is enclosed.

Examples of the drug to be encapsulated in the drug Y include Def curl (trade name: Futraful, Taiho Pharmaceutical KK), anti-neoplastic tumor streptococcus preparation (trade name: Hishibanil, Chugai KK), Kawaratake extract polysaccharide (trade name: Krestin, Kureha Chemistry) KK)
Anti-neoplastic agents such as, and radiopharmaceuticals such as sodium pertechnetate (trade name Technesin Tc-99, Medifix KK), or cefachlor (trade name Kefral, Shionogi KK), cephalexin (trade name Keflex,
Antibiotics such as cephem-based preparations such as Shionogi Pharmaceutical KK) and synthetic penicillin-based preparations such as cloxacillin sodium (trade name Orben, Shionogi Pharmaceutical KK) are used. The drugs are not limited to these.

The outer cylinder 2 and the bottoms 2a and 4a of the lid 4 have dome-shaped outer peripheral surfaces so that they can move smoothly in the body. The bottom portion 2a is provided with a drug discharge port 6 closed by a sealing film m. The seal film m is preferably formed of a thin film that is resistant to chemicals and is easily broken, such as polytetrafluoroethylene, but the present invention is not limited to this.

The outer cylinder 2 has a through hole 9 at the substantially center of its side wall and a piston 5
It is preferable to open a through hole 10 in the middle part of the. By opening these through holes 9 and 10, body fluids and the like flow into the capsule from the outside through the through holes 9 and 10, the negative pressure on the back side of the piston 5 is released, and the piston 5 operates smoothly. become.

However, in order to prevent body fluid from entering from the outside, such through holes 9 and 10 are not provided, and the pressurized air is sealed in the battery chamber C in the lid body 4 and the pressurized air is used. The negative back pressure generated by the movement of the piston may be eliminated.

When such air sealing is performed, for example, the screw portion N with which the main body block 3 and the lid body 4 are screwed together is made long, and when the lid body 4 is screwed in, air is introduced into the battery chamber C. You may make it screw in, pressurizing.

The main body block 3 is also made of polycarbonate, has a recessed portion for accommodating the battery B on the right end side, and has a central hole 3a at the central portion. The center hole 3a is a portion in which the reed switch s is housed. This reed switch
Is a normally open switch, and has two lead wires 11 and 12 connected to two silver batteries B and B (1.5 V each) as shown in FIG. One end of one lead wire 12 is connected to a contact 13, and this contact 13 is housed and held in a glass tube 14 so as not to contact the other contact 15 unnecessarily. contact
The lead wire 11 and the lead wire 11 extend outward from the glass tube 14 and are connected via a filament 16. Contact 13,1
Reference numeral 5 is made of a magnetic material having elasticity, and is sensitive to the magnetic force in the direction of the arrow D in the drawing to turn on, and the current from the battery B is made to flow to the filament 16 to generate heat. Is held in the off state by its elastic force.

In the figure, reference numeral “21” is a pressing spring for pressing the silver battery B.

The piston 5 is a polycarbonate cylindrical body that slides in the outer cylinder 2. A thread stopper cap 22 is detachably press-fitted on the tip side of the piston 5. At the tip of the stopper cap 22, a protrusion 22a is formed so as to penetrate the seal film m. A step portion 24 is formed on the inner peripheral wall of the piston 5, and the step portion 24 and the main body block 3 are formed.
A coil spring 26 is interposed between the step portion 25 on the side and the step portion 25 on the side.

The piston 5 is normally fixed to the main body block 3 by a fixing thread 28 against the elastic force of the coil spring 26. Fixed thread
As 28, one having a high strength and a relatively low melting point (260 ° C) such as polyethylene terephthalate is preferable, but the present invention is not limited to this, and for example, nylon (melting point 200 to 270 ° C) is used. ) Or the like. Both ends of the fixed thread 28 are held by the thread stopper cap 22, and are inserted in a state in which the filament 16 is in contact with the filament 16 in a space 17 having a predetermined volume in the form of a vertical hole formed in the main body block 3. There is.

In particular, in this embodiment, the fixed yarn 28 is coated with a flammable material. As the flammable material, a material having no flash and a low flash point is preferable. Specifically, wax,
In addition to benzene and naphthalene, flammable oil may be used. By applying this flammable material, the fixed yarn 28 is easily ignited and ruptured. Especially, when flammable oil is used, not only is it ignited and ruptured easily, but also the yarn itself. Will also improve the strength of the
It is possible to solve at once a trade-off of the need for certainty in piston support.

Next, the operation will be described.

The medical capsule 1 set in the state shown in FIG. 1 is administered to a patient. The internal position of the capsule 1 is monitored by an external monitoring device such as an X-ray fluoroscopic camera, and when it reaches a predetermined position, the operation switch of the magnetic field generator is turned on and the contacts 13 and 15 of the reed switch s of the capsule 1 are turned on. . Here, in the capsule of the present invention, since the current from the battery B does not flow until both contacts 13 and 15 are turned on, useless consumption of the battery is prevented.

When both contacts 13 and 15 are turned on, an electric current flows through the filament 16 to make it glow red.
The combustible material impregnated in the above is burned to melt the fixing thread 28 fixing the piston 5. As a result, the fixed thread 28
The fusing time is extremely short, and the fixed yarn 28 is blown immediately when the operation switch of the magnetic field generator is turned on, so that the capsule operation can be reliably performed at the predetermined position.

Due to the breaking of the fixing thread 28, the piston 5 is moved leftward in the figure by the elastic force of the coil spring 26. During this movement, at a very early stage, the through hole 9 of the outer cylinder 2 and the through hole 10 of the piston 5 are partially overlapped. As a result, the working chamber A is brought into communication with the outside, and external body fluid or the like flows into the working chamber A through the through holes 9 and 10. This allows the piston 5
Moves smoothly. If the through holes 9 and 10 are not provided, the high-pressure air in the battery chamber C eliminates the negative back pressure of the piston 5 and smoothens the operation of the piston.

Further, although the medicine in the medicine chamber is pressurized by the initial movement of the piston 5, this pressure is absorbed by the deformation of the seal film m, so there is no problem.

Further, when the piston 5 moves, as shown in FIG. 3, the projection 22a of the piston 5 breaks through the seal film m, and all the drug in the drug chamber Y is released to the outside. Even when the overlapping state of the through holes 9 and 10 is completed, the piston 5 is pushed by the spring force, so that the drug does not remain in the capsule.

The capsule 1 for which the drug has been released in this manner is discharged outside the body during defecation.

The communication between the through holes 9 and 10 is finally cut off due to the movement of the piston 5, and the body fluid taken inside is cut off from the outside. Therefore, when the drug is not released, the same capsule can be used for reliable sampling.

It should be noted that the present invention is not limited to the above-described embodiments, but can be modified in various ways. For example, the fixing thread 28 of the present invention does not necessarily have to be provided in a predetermined space, but may be simply inserted into a space such as a through hole.

(Effect of the Invention) As described above, according to the present invention, since the fixed yarn is impregnated with the flammable material, the fixed yarn is instantaneously broken by the heat of the filament, and the capsule operation at the predetermined position is surely performed. become. Also, even when used in a body with little oxygen, if the fixing thread is attached in contact with the filament in the space of the main body block, a certain amount of oxygen is secured,
Breaking occurs more quickly. Furthermore, when the fixed thread is impregnated with oil, the strength of the fixed thread itself is improved,
It is possible to solve all of the trade-off requirements of easy breakage and reliable piston support.

[Brief description of drawings]

1 is a sectional view showing an embodiment of the present invention, FIG. 2 is a perspective view of a reed switch, FIG. 3 is a sectional view showing an operating state of the same embodiment, and FIG. 4 is a conventional medical capsule. FIG. 2 ... Outer cylinder, 3 ... Main body block, 4 ... Lid body, 5 ... Piston, 6 ... Drug discharge port, 9,10 ... Through hole, 16 ... Filament,
17 ... Space part, 26 ... Coil spring, 28 ... Fixing thread, A ... Working chamber, B ... Battery, S ... Reed switch.

Claims (5)

[Scope of utility model registration request] 1. An outer cylinder (2) and a lid (4) attached to both ends of a body block (3), and the body block (3).
And a piston (5) slidably provided in the working chamber (A) formed between the outer cylinder (2) and the outer cylinder (2).
And a spring member (26) provided between the main body block (3) for urging the piston (5) toward the distal end side of the outer cylinder, and an elastic force of the spring member (26). Then, a fixed thread (28) mounted so as to fix the piston (5) to the main body block (3), a filament (16) for heating and cutting the fixed thread (28), and a filament (16) A medical capsule having a battery (B) for supplying power, wherein the fixing thread (28) is coated with a flammable material. 2. The outer cylinder (2) has a through hole (6) sealed by a seal film at a tip end thereof, and a drug is sealed in an internal working chamber (A). The medical capsule according to claim 1. 3. The inside of the working chamber (A) is hollow,
The medical capsule according to claim 1, wherein the body fluid is taken in from the outside by a negative pressure generated by the operation of the piston. 4. The fixing thread (28) is a body block (3).
A first space characterized in that it is mounted in contact with the filament in a predetermined space (17) formed in
The medical capsule according to the item. 5. The medical capsule according to any one of claims 1 to 4, wherein the fixing thread (28) is made of polyethylene terephthalate impregnated with flammable oil. .