JPH0712797A - Mass spectrograph - Google Patents

Abstract

PURPOSE:To provide a mass spectrograph equipped with a sample evaporation section capable of coping with a change in a solvent composition for sample solution. CONSTITUTION:Ions generated under the atmospheric pressure pass a differential exhaust section separated with the first nozzle 6, the second nozzle 7 and a skimmer 8 and, then, are introduced to a quodrupole for mass analysis. In generating the ions under the atmospheric pressure, a change in the composition of a solvent for sample solution is detected with an ultraviolet absorbance meter 27, and a data processing device 21 changes the operating condition of a sample evaporation section, depending upon a solvent. Thus, an optimum ion generation condition can be set through the sample evaporation section capable of changing the operating condition, and measurements can be undertaken without a substantial change in ionic strength.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention relates to a mass spectrometer,
In particular, the present invention relates to a mass spectrometer suitable for ionizing a sample existing in a liquid and introducing it into a mass spectrometer.

[0002]

2. Description of the Related Art At present, LC / MS is regarded as promising in the field of analysis as a new separation analysis method for volatile or non-volatile compounds. LC / MS is liquid chromatography / mass spectrometry (Liquid Chromatogra
PHY / Mass Spectrometry).

In LC / MS, one component, a liquid chromatograph, handles a sample in a solution, while the other component, a mass spectrometer, handles ions in a vacuum. Interface technology for connecting the elements of is important. As a typical interface technology that has been conventionally proposed, for example, Japanese Patent Laid-Open No. 60-1
Atmospheric pressure chemical ionization method as described in No. 27453,
There is a method of generating ions under atmospheric pressure, which is represented by the electrospray method as described in JP-A-60-41747 and JP-A-60-41748, that is, an atmospheric pressure ionization method.

In the atmospheric pressure chemical ionization method, as shown in FIG. 12, the sample solution eluted from the liquid chromatograph 1 is introduced into an atomizer 44 which is vaporized by using gas or heat,
The vaporized sample is ionized by corona discharge using the corona discharge needle electrode 5, or ionized by an ion-molecule reaction that occurs after the corona discharge. The generated ions pass through the orifice 43 and the skimmer 8 and are introduced into the mass spectrometric section 15 under high vacuum for mass spectrometric analysis.

On the other hand, in the electrospray method, for example, a device as shown in FIG. 13 is used. In this apparatus, first, the sample solution eluted from the liquid chromatograph 1 is introduced into the capillary 3 held by an appropriate capillary holder 46. Usually this capillary 3
Is made of metal and is covered with a cover 45. When a voltage of several kV is applied between the capillary 3 and the counter electrode 48, the sample solution becomes a cone state at the tip of the capillary 3 and an electrostatic spraying phenomenon occurs in which a large number of microdroplets are generated from the tip. Reference numeral 47 denotes a counterflow gas introduction port, and when a gas such as dry nitrogen is introduced from this port, the gas ejected from the hole formed in the counter electrode side 48 vaporizes the fine droplets, and ions are generated in the process. The ions pass through the orifice 43 and the skimmer 8 and are introduced into the mass spectrometric section 15 under high vacuum for mass spectrometric analysis.

In the conventional LC / MS, when the optimum solvent for introducing the sample into the MS is not known in advance, it is necessary to measure several kinds of solvents while changing the combination or the ratio of the sample and the solvent. However, if the solution flowing out from the LC contains solvents with different vaporization conditions,
The evaporation of the solvent is insufficient, and as a result, it becomes difficult to measure the sample with high sensitivity.

[0007]

As mentioned above, the LC
In the / MS method, when the solvent composition of the solution flowing out from the LC changes, there is an optimum vaporization condition for each solvent, so it is necessary to change the vaporization conditions according to the composition change of the solvent.

An object of the present invention is to provide a mass spectrometer capable of coping with LC / MS in which the solvent composition of the solution flowing out from the LC changes, and easily attaining optimum measurement conditions suitable for the solvent composition of the outflowing solution. To provide.

[0009]

In order to achieve the above object, in the present invention, a sample vaporization section for vaporizing a solution supplied from a sample supply section (LC) and introducing it into a mass spectrometric section (MS), A detection unit for detecting the type or composition of the solvent contained in the solution supplied from the sample supply unit to the sample vaporization unit, and optimal vaporization conditions for a plurality of types of solvents are stored in advance, and by the detection unit, Depending on the type or composition of the solvent detected, it has a command unit for commanding the optimum vaporization conditions to the sample vaporization unit, the sample vaporization unit is a vaporization condition according to the command given from the command unit. Is characterized in that the solvent is vaporized.

The sample vaporization section comprises, for example, a capillary placed between the LC and the MS, and a heating section provided around the capillary or in the vicinity of the ejection hole of the capillary. The solvent is vaporized under the optimum conditions by controlling the operation of (1) according to the above command.

The vaporization condition is controlled by, for example, supplying an inert gas along the axial direction of the capillary and changing the supply amount or temperature to change the vapor pressure of the solvent in the vicinity of the capillary ejection hole. You can

Further, the vaporization control and the heating control may be combined.

[0013]

According to the present invention, when the solvent composition of the sample solution flowing into the sample vaporization section changes, the amount of heat applied to the sample vaporization section is changed to sufficiently vaporize the solvent of different type or composition. be able to. Therefore, the optimum measurement conditions can be achieved in accordance with the change in the solvent of the sample solution flowing in from the liquid chromatograph.

[0014]

Embodiments of the present invention will now be described in detail with reference to the drawings.

FIG. 1 shows an embodiment of the device according to the present invention. Liquid chromatograph 1 for atmospheric pressure chemical ionization
The sample solution eluted from the sample is passed through the ultraviolet absorptiometer 27 and the pipe 2 and then introduced into the capillary 3. Droplets of the sample solution are generated from the tip of the capillary 3, and when the droplets pass through the desolvation chamber 4, the solvent is vaporized.

In order to promote the vaporization, the temperature of the capillary 3 or the desolvation chamber 4 may be raised. The temperature of the capillary 3 can be controlled by a ceramic heater provided around the capillary, but in order to enhance the responsiveness of this temperature, it is preferable to energize the capillary 3 itself as shown in FIG. The temperature of the desolvation chamber 4 can be controlled in the same manner as in the case of the capillary, and in order to improve the responsiveness, the desolvation chamber 4 may be heated by energizing it.

The above vaporized sample is ionized, for example, by corona discharge by the corona discharge needle electrode 5 or by an ion-molecule reaction that occurs after the corona discharge,
After passing through the first nozzle 6, the second nozzle 7, and the skimmer 8,
It is introduced into the quadrupole mass spectrometer 15 under high vacuum. The ionized sample is detected by the detector 17, and the amplification converter 20
After being amplified by and converted into digital information, it is input to the data processing device 21 via a signal line. The data processing device 21 displays the input detection information as a mass spectrum.

FIG. 2 is an enlarged view of the differential evacuation section and the sample vaporization section of FIG. When heating the capillary 3 and the desolvation chamber 4, the power control device 25 (25A, 25B) connected to the data processing device 21 supplies electric power to heat by energization.

FIG. 3 is a block diagram of a mass spectrometer equipped with a liquid chromatograph for pretreatment using a switching valve. The sample trap solvent extruded by the LC pump 34 from the solvent reservoir 33 (33A, 33B, 33C) is agitated when passing through the mixer 35. The sample trapping solvent extruded from the solvent reservoir 33 may be one kind or plural kinds, and in the case of plural kinds, it is mixed by the mixer 35. The sample trapping solvent introduced from the mixer 35 to the autosampler 36 is mixed with the sample sampled by the autosampler 36, moved to the analysis column 37, and separated and processed in the analysis column 37. The sample solution flowing out from the analytical column 37 is introduced into the ultraviolet absorption meter 27, and the ultraviolet absorption information of the sample solution is measured. Data processing device 2 for the ultraviolet absorbance information of the sample solution
1, and information processing is performed. When the data processing device 21 determines that the sample solution contains a sample to be mass analyzed, the data processing device 21 operates the switching valve 39 via the valve control device 52 to send the sample solution to the pretreatment column 40. Then, the sample is trapped in the pretreatment column 40. When the data processing device 21 determines from the ultraviolet absorbance information that the solution does not contain the sample to be mass analyzed,
The switching valve 39 is arranged so that the sample outflow solvent flows from the sample outflow solvent reservoir 50 into the pretreatment column 40.
Switch. When the switching operation is performed, the switching valve 39 supplies the solution flowing out of the pretreatment column 40 to the mass spectrometer 41 using the atmospheric pressure ionization method. Therefore, the sample trapped in the pretreatment column 40 is eluted by the sample outflow solvent, and the mass spectrometer 4
1 and mass spectrometric analysis.

As is clear from the above analysis flow, the sample trapping solvent that normally traps the sample in the pretreatment column 40 and the sample eluting solvent that elutes the sample trapped in the pretreatment column 40 are different. As an example, when the sample trap solvent is water and the sample elution solvent is methanol, FIG. 4 shows a change in the composition of the solvent entering the mass spectrometer 41. With the function of the switching valve 39, until the solvent for sample outflow is switched so as to flow into the pretreatment column 40, the methanol as the solvent for sample outflow is converted into the mass spectrometer 4.
Flow into 1. Next, when the switching valve 39 is switched, the water contained in the pretreatment column 40 is flown into the mass spectrometer 41, and then methanol is flowed in.

When water having a boiling point higher than that of alcohol flows into the sample vaporization section in a state where the sample vaporization section is set to an operating condition suitable for methanol, the temperature of the sample vaporization section lowers and the evaporation of the solvent becomes insufficient. As a result, the measured ionic strength decreases. Therefore, when water is flowing into the mass spectrometer 41, it is necessary to change the operating condition of the sample vaporization section to an operating condition suitable for water, and to control the operating condition suitable for methanol when methanol is introduced. There is.

As described above, in order to automatically change the operating conditions of the sample vaporizing section according to the solvent, in the present invention, the solvent type or mixing ratio and the control amount of the sample vaporizing section are previously set for a plurality of types of solvents. The relationship with is stored in the memory 54,
When the type or mixing ratio of the solvent changes, the control amount corresponding to the change is obtained from the memory 54, and the sample vaporizing unit is operated with the obtained control amount. In the case of the sample vaporization section shown in FIG. 2, the energization amount of at least one of the capillary 3 and the desolvation chamber 4 is made variable, and is changed according to the composition change of the solvent, for example, as shown as the input electric power amount in FIG.

According to the configuration of the above-described invention, even if the kind of the solvent flowing into the mass spectrometer 41 changes rapidly, the solvent is sufficiently vaporized and the measured ionic strength is not significantly reduced. Mass spectrometry can be performed.

In the case of a mass spectrometer equipped with a liquid chromatograph for performing analysis by changing the solvent composition of the sample solution such as gradient analysis, the sample outflow solvent reservoir 5 of FIG.
0, LC pump 51 for sample outflow, and switching valve 3
9 is omitted, and the solution flowing out from the ultraviolet absorptiometer 27 is directly introduced into the mass spectrometer 41 through the nozzle 3. Solvent reservoir 3
A plurality of kinds of solvents are extruded by the LC pump 34 from 3 and sent to the mixer 35, and the pump control device 53 changes the amount of the solvent extruded by the LC pump 34 to control the mixing ratio of the plurality of kinds of solvents. The plurality of kinds of solvents whose mixing ratios are controlled are agitated and mixed when passing through the mixer 35. The mixed solvent is introduced into the auto sampler 36, mixed with the sample sampled by the auto sampler 36 to become a sample solution, and moved to the analytical column 37,
Separation processing is performed in the analysis column 37. The sample solution flowing out from the analytical column 37 is introduced into the ultraviolet absorption meter 27, and the ultraviolet absorption information of the sample solution is measured. The ultraviolet absorbance information of the sample solution is sent to the data processing device 21 for information processing.

The sample solution flowing out from the ultraviolet absorptiometer 38 is introduced into the mass spectrometer 41 and mass analyzed. On this occasion,
As the mixing ratio of the sample solution introduced into the mass spectrometer 41 changes, a control amount suitable for the change is obtained from the memory 54, and the operating condition of the sample vaporization unit is changed. In the case of the sample vaporization section shown in FIG. 2, the operating conditions of the sample vaporization section are changed by controlling the energization amount between the capillary 3 and the desolvation chamber 4. The electric power to be supplied is supplied and controlled from the electric power control device 25 connected to the data processing device 21. In this case, the energization amount of either the capillary 3 or the desolvation chamber 4 may be controlled.

As an example, FIG. 5 shows changes in the solvent composition of the sample solution flowing out from the liquid chromatograph for performing the gradient analysis, and the amount of electric power input to the sample vaporization section. When a large amount of water with a high boiling point is contained, a large amount of electric power is input, and when a large amount of methanol with a low boiling point is included, the input electric power amount is reduced.

According to the configuration of the above-mentioned invention, even if the composition ratio of the solvent of the sample solution flowing into the mass spectrometer 41 changes,
The solvent is sufficiently vaporized, and mass spectrometry can be performed without greatly reducing the measured ionic strength.

FIG. 6 shows a cross section of an ion source of a mass spectrometer using a method of ionizing a sample solution sprayed from an infrared-heated capillary by corona discharge, as a modification of the mass spectrometer 41 shown in FIG. The figure is shown. In this case, the wire heater 28 such as a Kanthal wire is used to rapidly heat the capillary using infrared heating. Electrical insulation between the wire heater 28 and the capillary 3 is performed by providing an insulating material 13 such as quartz that allows infrared rays to pass therethrough. L
When optimizing the operating conditions of the sample vaporization unit according to the change in the solvent composition of the sample solution flowing out from C, the capillary 3
It can be performed by changing at least one of the heating amounts of the solvent removing chamber 4 and the solvent removing chamber 4.

FIG. 7 shows another modification of the mass spectrometer 41 shown in FIG. 3, in which mass analysis is carried out by a method of ionizing a sample solution atomized with a spray gas and a make-up gas by corona discharge. The sectional view of the ion source of the meter is shown.
In this case, the sample solution flowing in from the LC passes through the pipe 2 and is sprayed from the tip of the capillary 3 with a gas such as dry nitrogen. For atomization, two types of gas that have passed through the atomization gas chamber 29 and the makeup gas chamber 30 are used. The gas that has passed through the atomizing gas chamber 29 is flown from around the capillary 3, and the capillary 3
The sample solution flowing out from the tip of the sample is atomized, and the gas passing through the make-up gas chamber 30 promotes vaporization of the solvent of the atomized sample solution.

When the type or composition ratio of the solvent of the sample solution changes, a wire heater 28 such as a nichrome wire is provided in the make-up gas chamber 30 so that the contact area with the gas is as large as possible, and the heating of the gas is performed. The amount is rapidly changed, and at the same time, the heating amount of the desolvation chamber 4 is also changed. The heating amount is controlled by controlling the electric power supplied from the power control device 25, and the operating conditions of the sample vaporizing unit are optimized in accordance with the change in the type or composition ratio of the solvent of the sample solution. In this case, a wire heater may be provided in the atomizing gas chamber 29 to energize the wire heater to heat the atomizing gas and the capillary 3 to optimize the operating conditions of the sample vaporizing section. Further, the operating conditions of the sample vaporizing section may be optimized by changing the flow rates of at least one of the above two gas systems.

FIG. 8 shows, as a further modification of the mass spectrometer 41 shown in FIG. 3, an ion source of a mass spectrometer using a system in which a sample solution atomized by a spray gas is ionized by corona discharge. A sectional view is shown. A wire heater 28 such as a Kanthal wire is installed in the make-up gas chamber 30 to heat the gas and the capillary 3 at the same time. A substance having a high electric insulation property, such as quartz, which allows infrared rays to pass therethrough may be installed between the wire heater 28 and the capillary 3.

The heating amount is controlled by controlling the electric power supplied from the electric power control device 25, and the operating conditions of the sample vaporizing section are optimized in accordance with the change in the type or composition ratio of the solvent of the sample solution. . In this case, at least one of the heating amounts of the wire heater 28 and the desolvation chamber 4 is controlled to optimize the operating conditions of the sample vaporizing section. Further, the operating conditions of the sample vaporizing section may be optimized by changing the flow rate of the spray gas.

FIG. 9 shows another example of the mass spectrometer 41 shown in FIG. 3, which is an ion source of a mass spectrometer using an electrospray method for ionizing a sample solution atomized by electrostatic spraying. A sectional view is shown.

A wire heater 28 such as a Kanthal wire is installed in the make-up gas chamber 30 to heat the make-up gas and the capillary 3 at the same time.
The heated capillary 3 and the opposing electrode 48 are several k apart.
A voltage of V was applied, the sample solution became a cone state at the tip of the capillary 3, a large number of microdroplets were generated from the tip by the electrostatic spraying phenomenon, and the solvent of the sample solution that became microdroplets was heated. Vaporization is promoted by the make-up gas. In this case, an insulating plate 13 having a high electric insulating property such as quartz that allows infrared rays to pass therethrough may be installed between the wire heater 28 and the capillary 3.

Further, the counter flow gas heated by the wire heater 28 provided in the passage of the counter flow gas is blown from the counter flow outlet 42 toward the generated minute liquid droplets to vaporize the liquid droplets. Promote.

Ions are generated in the vaporization process of the minute liquid droplets, and these ions enter the differential exhaust unit surrounded by the first nozzle 6 and the skimmer 8 and exhausted by the roughing vacuum pump 23, and the ions are generated in the skimmer 8. After passing through, it is introduced into the mass spectrometric section 15 under high vacuum, and mass spectrometric analysis is performed.

When the type or composition ratio of the solvent of the sample solution changes, the wire heater 28 provided in the passage for the make-up gas and the counter flow gas is energized to make the make-up gas, the counter flow gas, and the capillary 3. Rapidly change the amount of heating. The heating amount is controlled by controlling the electric power supplied from the power control device 25, and the operating conditions of the sample vaporizing section are optimized in accordance with the change in the type or composition ratio of the solvent of the sample solution. In this case, at least one of the makeup gas, the counterflow gas, and the capillary 3 may be heated. Alternatively, the makeup gas outflow mechanism may be omitted and at least one of the counterflow gas and the capillary 3 may be heated. Further, the operating conditions of the sample vaporizing section may be optimized by changing the flow rate of the gas.

FIG. 10 shows another modification of the mass spectrometer 41 shown in FIG. 3, which uses an electrospray method for ionizing a sample solution which is atomized electrostatically from a heated capillary and ionized. The sectional view of the ion source of the meter is shown.

When the type or composition ratio of the solvent of the sample solution changes, a wire heater 28 is provided in the make-up gas chamber 30 and the spray gas chamber 29 to make up the make-up gas, the counterflow gas, and the capillary 3. Rapidly change the amount of heating. The heating amount is controlled by controlling the electric power supplied from the power control device 25, and the operating conditions of the sample vaporizing unit are optimized in accordance with the change in the type or composition ratio of the solvent of the sample solution. in this case,
Either the wire heater 28 in the make-up gas chamber 30 or the spray gas chamber 29 may be electrically heated. Further, the operating conditions of the sample vaporizing section may be optimized by changing the flow rates of the two types of gas.

FIG. 11 shows a modified example of the mass spectrometer 41 shown in FIG. 3 in which a sample solution sprayed from a heating capillary and atomized is introduced into an electron impact ion source through a differential evacuation unit. Figure 3 shows a cross-section view of an ion source of a mass spectrometer. The measurement sample becomes droplets of the sample solution from the tip of the capillary 3 and vaporizes the solvent when passing through the desolvation chamber 4, passes through the differential evacuation system and the heating pipe 31, and enters the electron impact ion source 32. It is introduced, ionized and mass spectrometrically analyzed.

When the kind or composition ratio of the solvent of the sample solution changes, the capillary 3 and the desolvation chamber 4 are energized and heated. The heating may be performed in the capillary 3 and the desolvation chamber 4 at the same time, or in either one. The heating amount is controlled by controlling the electric power supplied from the power control device 25, and the heating amount is controlled in accordance with the change in the type or composition ratio of the solvent of the sample solution to optimize the operating conditions of the sample vaporizing section.

In FIG. 11, the capillary 3 and the desolvation chamber 4 are shown.
Although the method of electrically heating and is shown, the method of infrared heating as shown in FIG. 6 may be used, or the method of heating spray gas as shown in FIGS. 7 and 8 may be used. Good.

[0043]

As is apparent from the above description, according to the present invention, when the solvent of the sample solution is vaporized in the solvent vaporization section, a device for arbitrarily changing the amount of heat given to the solvent vaporization section is provided, and the boiling point The vaporization conditions suitable for different solvents can be achieved, the change in ionic strength due to the change in composition of the solvent can be minimized, and the optimum measurement condition can be obtained corresponding to the change in composition of the solvent.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing the overall configuration of an LC / MS to which the present invention has been applied.

FIG. 2 is an enlarged cross-sectional view of a sample vaporization section and a differential evacuation section shown in FIG.

FIG. 3 is a configuration diagram of a mass spectrometer equipped with a liquid chromatograph that performs a pretreatment using a switching valve.

FIG. 4 is a diagram showing a relationship between a solvent composition of a sample solution flowing out from a liquid chromatograph which performs a pretreatment using a switching valve and an electric energy input to a sample vaporization section.

FIG. 5 is a diagram showing the relationship between the solvent composition of the sample solution flowing out from the liquid chromatograph having a gradient processing function and the amount of electric power input to the sample vaporization section.

FIG. 6 is an enlarged cross-sectional view showing another embodiment of the sample vaporization section.

FIG. 7 is an enlarged cross-sectional view showing still another embodiment of the sample vaporization section.

FIG. 8 is an enlarged sectional view showing still another embodiment of the sample vaporization section.

FIG. 9 is an enlarged cross-sectional view showing still another embodiment of the sample vaporization section.

FIG. 10 is an enlarged sectional view showing still another embodiment of the sample vaporization section.

FIG. 11 is a diagram showing another embodiment of the present invention in which the sample vaporizing section and the differential pumping section used in the atmospheric pressure ionization method are combined with an electron impact ion source.

FIG. 12 is a diagram showing an interface unit of an LC / MS using a conventional atmospheric pressure chemical ionization method.

FIG. 13 is a diagram showing an interface unit of an LC / MS using an electrospray method according to a conventional technique.

[Explanation of symbols]

1 ... Liquid chromatograph, 2 ... Piping, 3 ... Capillary, 4 ... Desolvation chamber, 5 ... Corona discharge needle electrode, 6 ... First
Nozzle, 7 ... Second nozzle, 8 ... Skimmer, 9 ... First flange, 10 ... Second flange, 11 ... Third flange, 12
... Heater, 13 ... Insulation plate, 14 ... Electrostatic lens, 15 ...
Quadrupole mass spectrometer, 16 ... Chamber, 17 ... Detector,
18 ... Terminal, 20 ... Amplification converter, 21 ... Data processing device, 22 ... High vacuum pump, 23 ... Roughing vacuum pump, 2
4 ... Control line, 25 (25A, 25B) ... Power control device, 26 ... Power control line, 27 ... Ultraviolet absorption meter, 28
... Wire heater, 29 ... Chamber for atomizing gas, 30
… Makeup gas chamber, 31… Heating pipe,
32 ... Electron impact ion source, 33 (33A, 33B, 33
C) ... solvent reservoir, 34 ... LC pump, 35 ... mixer,
36 ... Autosampler, 37 ... Analytical column, 39 ... Switching valve, 40 ... Pretreatment column, 41 ... Mass spectrometer using atmospheric pressure ionization method, 42 ... Counterflow outlet, 43 ... Olefith, 44 ... Atomizer , 45 ... Cover, 46 ... Capillary holder, 47 ... Counterflow gas inlet, 48 ... Counter electrode, 50 ... Sample outflow solvent reservoir, 51 ... Sample outflow LC pump, 52 ... Valve control device, 53 ... Pump control Device, 54 ... Memory, D
(D1, D2, D3) ... Data signal line, C (C1, C
2, C3, C21, C22) ... Control data signal line

Claims (5)

[Claims] 1. A mass spectrometric section, a sample supply section for supplying a sample to be analyzed by the mass spectrometric section as a solution in which at least one solvent selected from a plurality of kinds of solvents is dissolved, and the sample supply. Sample vaporization section that vaporizes the solution supplied from the sample section and introduces it into the mass spectrometric section, and detection for detecting the type or composition of the solvent contained in the solution supplied from the sample supply section to the sample vaporization section. Part and the optimum vaporization conditions for the plurality of types of solvents are stored in advance, and a command for commanding the optimum vaporization conditions to the sample vaporization part according to the type or composition of the solvent detected by the detection part. A mass spectroscope, wherein the sample vaporization section vaporizes the solvent under vaporization conditions instructed by the instruction section. 2. The sample vaporization section variably controls a capillary section for ejecting the solution supplied from the sample supply section toward the mass spectrometric section and the capillary temperature or the space temperature in the vicinity of the capillary ejection hole. The mass spectrometer according to claim 1, further comprising a heating unit for operating the heating unit according to the instructed vaporization condition. 3. The sample vaporization section has a gas ejection section for ejecting an inert gas from at least one of a traveling direction of the solution ejected from the capillary ejection hole and an opposite direction thereof, and the instructed vaporization is provided. 3. The operation of the gas jetting section is controlled according to the condition.
The mass spectrometer according to. 4. The sample vaporization section has a gas ejection section for ejecting an inert gas from at least one of a traveling direction of the solution ejected from the capillary ejection hole and an opposite direction thereof, and the gas ejection section comprises: The mass spectrometer according to claim 2, wherein the temperature of the ejected gas is controlled by a heating unit for variably controlling the capillary temperature or the space temperature in the vicinity of the capillary ejection hole. 5. The sample vaporization section has a gas heating section for heating the gas, and the gas heating section operates according to the instructed vaporization condition. The described mass spectrometer.