JPH07102459A - X-ray contrasting nonwoven fabric - Google Patents

Abstract

PURPOSE:To provide a medical nonwoven fabric giving a contrast image by X-ray as a whole, having antibacterial property by itself and easily disposable by incineration and biodegradation after use. CONSTITUTION:This nonwoven fabric is produced by exclusively using a hydrophilic fiber containing 15-50wt.% of barium sulfate and having a fineness of 1-7de and interlocking and integrating the fibers by high-pressure water jet. The nonwoven fabric is imparted with antibacterial property by adding an antibacterial agent to the fiber raw material, the fiber or the nonwoven fabric.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a gauze or sponge that absorbs bleeding during a surgical operation, and a non-woven fabric used as a gauze drain for drainage or tamponade for removing blood and the like accumulated in a body cavity.

[0002]

2. Description of the Related Art During surgery, a large amount of gauze or sponge is used to absorb blood that has bleeded. In the medical field, great care is taken in the management of these so that they will not be left in the body after surgery.
However, gauze and sponges that have absorbed blood are difficult to distinguish, and there are many cases in which they remain in the body.

Therefore, conventionally, in the medical field, a gauze in which a radiopaque element such as an X-ray contrasting thread is incorporated so that even if these gauze or sponge are left in the body, they can be detected by X-ray. Or using a sponge. Previously, X made of vinyl chloride mixed with barium sulfate
Gauze woven with a line contrast thread was used, but there was a problem that thread loss or breakage occurred and only that part remained in the body. Therefore, recently
No. 44, JP-A-2-307446, and Japanese Utility Model Laid-Open No. 2-109.
As disclosed in Japanese Patent No. 616, etc., a tape has been proposed in which an X-ray contrast yarn and a tape containing a radiopaque substance are overlapped with a web, and these are firmly fixed and integrated by hydroentanglement or the like.

[0004] Gauze and sponge are also used in medical treatment such as drainage and tamponade. These are treatments such as laparotomy that remove bleeding and body fluids retained in the body cavity without opening the affected area largely. At that time, what is called a gauze drain in which an antibiotic is applied to gauze or sponge is used. Drainage refers to the act of pushing this gauze drain into the affected area with a probe, exposing a part of the gauze drain to the outside of the body, and using capillarity to discharge blood and the like out of the body. Tamponade refers to the act of pushing a gauze drain into the affected area and allowing the gauze drain to absorb blood etc. to remove them. In either case, it is necessary to insert the gauze drain accurately into the affected area, but the reality is that this work depends exclusively on the experience and intuition of the doctor. However, this work is a delicate work, and it is difficult even for a skilled doctor to insert the gauze drain accurately into a place where blood or the like is accumulated.

[0005]

As described above, recently, sponges and the like in which an X-ray contrast yarn or the like and a non-woven fabric are integrated are being widely used. Regarding these, although thread loss or breakage does not occur, if the X-ray contrasting thread is left in the body in the state of being hidden in the shadow of the bone or the like, the X-ray contrast may not be recognized and may remain as it is. As a result, adhesion to organs occurs and causes secondary diseases. Furthermore, since gauze and sponge are generally disposable and become waste after use, they contain a large amount of heat when incinerated and synthetic polymers such as polyester, which has poor biodegradability. This is not preferable from the environmental aspect.

Further, it is considered that the gauze drain can be accurately inserted into the affected area by using these gauze or sponge which is contrasted by X-ray as a gauze drain and performing drainage or tamponade while confirming with an X-ray image or the like. However, a sponge containing a thick and hard X-ray contrasting thread is difficult to push and is difficult to handle, and even if X-ray imaging is performed, only a part of the sponge, that is, the portion of the X-ray contrasting thread is imaged, and the accurate position of the gauze drain is known. I can't. In other words, when it is necessary to accurately know the position of the gauze drain such as drainage, the conventional gauze partially containing the X-ray contrast yarn is not sufficient, and the one in which the whole is imaged by X-ray is used. desirable.

[0007] In addition, in the case of drainage, a part of the gauze drain is out of the body so that it is likely to become a hotbed of infectious bacteria. For that reason, antibiotics are applied in advance, but abuse of antibiotics leads to the creation of new resistant bacteria, so it is necessary to refrain as much as possible.

Therefore, the present inventor has solved these problems,
The present invention has been accomplished as a result of studying to obtain a nonwoven fabric that is soft and easy to handle, the whole is imaged by X-rays, the nonwoven fabric itself has antibacterial properties, and can be easily incinerated and biodegraded even when it becomes waste. .

[0009]

That is, according to the present invention, a hydrophilic fiber such as rayon containing barium sulfate which is a radiopaque substance is made into a web by a usual method, and then the fibers are entangled and integrated by a high-pressure water stream. The above-mentioned problem was solved by using this non-woven fabric as a gauze or sponge.

Since the non-woven fabric of the present invention is a hydroentangled non-woven fabric consisting of only hydrophilic fibers containing barium sulfate, the non-woven fabric is soft and the whole is imaged by X-rays, and when used as a gauze drain, an X-ray image, etc. The exact position can be easily determined with. Moreover, since the manufacturing method is the same as the manufacturing method of a usual non-woven fabric and can be easily manufactured, it is very suitable for disposable medical gauze and sponge. Less than,
The configuration of the present invention will be described in detail.

The fiber used in the present invention has hydrophilicity,
In addition, there is no particular limitation as long as barium sulfate can be contained in the manufacturing process. Examples include rayon, chitosan, cupra, vinylon and the like. Of these, rayon and chitosan are particularly preferable from the viewpoint of ease of disposal such as incineration after use and safety in the body. Moreover, you may mix and use these fibers as needed. However, even in that case, all fibers must contain barium sulfate. X when the fiber containing barium sulfate and the fiber not containing barium sulfate are mixed
This is because the imaging with lines is insufficient and accurate position determination cannot be performed.

In the present invention, barium sulfate is used as the radiopaque element. In the present invention, fibers obtained by wet spinning or melt spinning a fiber raw material to which barium sulfate is added or kneaded are used. For example, viscose having a cellulose concentration of 8 to 10% by weight to which barium sulfate is added and mixed is spun into a coagulation bath to make rayon.

Barium sulfate is 15% by weight or more in the fiber and 5
It is desirable that the content be 0% by weight or less. 15% by weight
If it is less than 50% by weight, contrast with X-rays is insufficient, and if it exceeds 50% by weight, although the contrast property is good, the strength of the obtained fiber becomes small and fiber molding becomes difficult, which is not preferable.

Further, when the nonwoven fabric of the present invention is provided with antibacterial properties, it becomes a desirable nonwoven fabric especially for gauze drain. Examples of means for imparting antibacterial properties to the non-woven fabric include a method in which an anti-bacterial agent is added and the mixed fiber raw material is used to form fibers into a non-woven fabric, or a method in which the anti-bacterial agent is added after forming fibers or non-woven fabrics. . In order to enhance the antibacterial property, a method of applying an antibacterial agent after forming the fiber or nonwoven fabric is preferable, but from the viewpoint of cost, a method of adding the antibacterial agent to the fiber raw material and then forming the fiber is preferable.
As the antibacterial agent to be added to and mixed with the fiber raw material, a cationized antibacterial agent having a high molecular weight is most desirable in order to prevent elution from the fiber, and specifically, UX101 (trade name: manufactured by Yatasha Yushi Kogyo Co., Ltd.) is used. This is the case. As the antibacterial agent added after forming the fiber or the non-woven fabric, cathionone UK (trade name: manufactured by Yatasha Yushi Kogyo Co., Ltd.) or the like is preferably used. In any method, the content or addition amount of the antibacterial agent is preferably 1% by weight or more and 10% by weight or less per fiber. If it is less than 1% by weight, the antibacterial property of the nonwoven fabric is insufficient, and if it exceeds 10% by weight, the antibacterial property does not change.
This is because it only leads to higher costs.

Generally, the larger the fiber fineness is, the more the contrast property by X-ray is improved, but the fineness of the fiber used in the present invention is preferably 1 denier or more and 7 denier or less. If it is less than 1 denier, a soft non-woven fabric can be obtained, but the contrast property by X-ray is poor, and spinning becomes difficult. When it exceeds 7 denier, the contrast property by X-ray is improved, but the flexibility of the nonwoven fabric is deteriorated, which is not preferable.

The basis weight may be determined according to the application, but is preferably 50 g / m ² or more and 150 g / m ² or less.
If it is less than 50 g / m ² , the contrast property due to X-rays becomes poor and 1
This is because if it exceeds 50 g / m ² , the flexibility is poor and the thickness is large, making it difficult to handle. If thick ones are needed, thin ones can be stacked and used.

The nonwoven fabric of the present invention is obtained by opening the above-mentioned fibers by a usual method to form a web, and injecting a high-pressure water stream onto the web to entangle and integrate the fibers. The pressure of the water stream is preferably 30 kg / cm ² or more and 150 kg / cm ² or less. If the weight is less than 30 kg / cm ² , the fibers are not sufficiently entangled with each other, and the fibers may come out and remain in the body.
If it exceeds / cm ² , the texture of the web is disturbed, which is not preferable.

[0018]

In the present invention, hydrophilic fibers such as rayon exclusively contribute to absorption of blood and the like, and barium sulfate contained in the fibers enables detection by X-ray. Further, when the hydrophilic fiber contains an antibacterial agent, the antibacterial agent imparts antibacterial property to the entire nonwoven fabric and prevents nosocomial infection.

[0019]

The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples. In the examples,% means% by weight unless otherwise specified.

(Example 1) Barium sulfate was added to viscose (cellulose concentration 9 to 10%) in which cellulose was dissolved, and the mixture was thoroughly stirred to be exfoliated, and then in a coagulation bath by an ordinary wet spinning method. Then, a rayon containing barium sulfate was obtained. The amount of barium sulfate added was 10%, 30%, 40%, 60% and 80% based on the weight of cellulose.
The content of barium sulfate in the obtained fiber was 9 each.
%, 23%, 29%, 37%, 44% (by ash measurement). Further, each rayon has a fineness of 5 denier and a fiber length of 51 mm. Each of these fibers is opened by a usual method and then 40 to 8 depending on the web and the basis weight.
A high pressure water flow of 0 kg / cm ² is applied several times to make a basis weight 30 to 15
A non-woven fabric of 0 g / m ² was prepared. Then, the X-ray contrast property of each non-woven fabric was evaluated. The evaluation was made by placing a non-woven fabric on an acrylic phantom with a thickness of 15 cm, setting the distance between the X-ray source and the phantom to 120 cm, and then using 80 k
It was performed by irradiating X-rays at V, 70 mA for 0.4 to 0.5 seconds. The results are shown in Table 1.

[0021]

[Table 1]

Further, the heat of combustion when each non-woven fabric was incinerated was measured. As a result of measurement by the pump calorimeter method, the combustion heat of all the non-woven fabrics is about 4500 cal / g
And was almost the same as paper.

Example 2 The barium sulfate content is 37.
%, A fineness of 5 denier, and a fiber length of 51 mm were prepared in the same manner as in Example 1. This is opened by a normal method, and the web is removed, and a high-pressure water stream with a water pressure of 80 kg / cm ² is applied 7 times to entangle and integrate the fibers to give a basis weight of 100 g / m ²
The non-woven fabric was prepared, and its water absorption and water retention properties were evaluated.
5 denier without barium sulfate, 51
A non-woven fabric (blank) having a basis weight of 100 g / m ^{2 made} of mm rayon was prepared by the same method, and its water absorption and water retention were also evaluated. Water absorption is based on the Bayrec method (J
IS L1096 6.26.1B method), that is, 2.5c
The m × 20 cm sample was immersed in physiological saline for 1 cm from the lower end of the test piece and evaluated by measuring the height of water increased by capillary action after 1 minute, 5 minutes, and 10 minutes. Further, the water retention property is obtained by immersing a 10 cm × 10 cm sample in physiological saline for 1 minute, then taking it out, suspending it for 30 seconds, measuring its weight, and determining the difference from the weight before immersion in physiological saline. It was evaluated by calculating the amount of water. The results of evaluation of water absorption and water retention are shown in Tables 2 and 3.

[0024]

[Table 2]

[0025]

[Table 3]

(Example 3) An antibacterial test of a nonwoven fabric provided with an antibacterial agent was conducted. The test was conducted using a nonwoven fabric made of fibers spun by adding and mixing an antibacterial agent to the fiber raw material (nonwoven fabric kneading the antibacterial agent), a non-woven fabric having an antibacterial agent added by post-processing after fiber molding (post-processing non-woven fabric), and an antibacterial agent. The non-woven fabric (blank) that was not applied was used. Each nonwoven fabric was created by the following method.

Nonwoven fabric kneaded with antibacterial agent In viscose, barium sulfate was added to 6 parts by weight of cellulose.
0% and UX-101 (trade name: manufactured by Yatasha Yushi Kogyo Co., Ltd.) as an antibacterial agent were added in an amount of 5% and 10% based on the weight of cellulose, and after sufficiently stirring, in a coagulation bath by a usual wet spinning method. By spinning, rayon containing barium sulfate was obtained. The content of barium sulfate in the obtained fiber was about 35 per fiber.
%, And the content of the antibacterial agent is 3% and 5%, respectively, per fiber. The fiber fineness of each rayon is 5 denier,
The fiber length is 51 mm. Each of the fibers was opened by a usual method to form a web, and a high-pressure water stream having a water pressure of 80 kg / cm ² was applied 7 times to entangle and integrate the fibers to form a nonwoven fabric.

Post-Processed Nonwoven Fabric Barium sulfate was added to and mixed with 60% of the weight of cellulose in viscose, and 5 denier and 51 mm rayon were prepared by the same method as described above without adding an antibacterial agent. This rayon was dipped in an aqueous solution in which 15 g of potassium hydroxide per liter and 50 ml of cathionone UK (trade name: manufactured by Yatasha Yushi Kogyo Co., Ltd.) were dissolved, and 80
The reaction was carried out at 30 ° C. for 30 minutes. After washing with water and drying, a hydroentangled nonwoven fabric having a basis weight of 100 g / m ² was prepared by the same method as described above.

Blank Barium sulphate and an antibacterial agent were not added, and 5 denier and 51 mm rayon were prepared by a conventional method, and this was made into a hydroentangled nonwoven fabric having a basis weight of 100 g / m ^{2 by} the same method as described above.

The antibacterial properties of these non-woven fabrics were evaluated by the following method. The non-woven fabric is cut into 1 cm x 1 cm samples to obtain the minimum inhibitory concentration (MIC).
100r or more of methicillin-resistant Staphylococcus aureus 10 ⁶ ~
10 ⁸ were dropped together with physiological saline. Then, the number of viable bacteria on the sample after a certain period of time was counted to evaluate the antibacterial property. The result is shown in FIG. Except for the blank, in all cases, 10 ⁶ or more bacteria were reduced to 10 ³ or less, which was 1/1000 of that after 24 hours, showing excellent antibacterial properties.

[0031]

Since the nonwoven fabric of the present invention is composed of only hydrophilic fibers containing barium sulfate, it has excellent absorbability of blood and the like and can be detected by X-ray. And since it is composed entirely of fibers made of barium sulphate, if it is left in the body after surgery or drainage etc.
When performed under a line image, the whole is imaged by the X-ray, and the position in the body can be accurately known.
Furthermore, when this hydrophilic fiber is provided with antibacterial properties, it is possible to prevent nosocomial infection due to MRSA or the like, which is also beneficial from the viewpoint of infection prevention. Further, a non-woven fabric made of a fiber material such as rayon or chitosan into cellulose or polysaccharide is easy to incinerate and biodegradable, so that it is easy to treat as waste. In addition, the non-woven fabric of the present invention can be economically obtained by an ordinary non-woven fabric manufacturing method, and thus can be said to be particularly suitable for a disposable type sponge and the like.

[Brief description of drawings]

FIG. 1 is a graph showing the antibacterial property of the nonwoven fabric of the present invention.

Claims (2)

[Claims] 1. A unit weight of 50 g / m ² or more and 150 g / m ^{2 which} comprises hydrophilic fibers having a fineness of 1 denier or more and 7 denier or less containing barium sulfate in an amount of 15% by weight or more and 50% by weight or less, and the fibers are entangled and integrated by a high-pressure water stream. X-ray contrast non-woven fabric of ² or less. 2. The X-ray contrast nonwoven fabric according to claim 1, which is provided with antibacterial properties.