JPH0695892B2 - Feed that reduces body fat storage - Google Patents
Feed that reduces body fat storageInfo
- Publication number
- JPH0695892B2 JPH0695892B2 JP2003568A JP356890A JPH0695892B2 JP H0695892 B2 JPH0695892 B2 JP H0695892B2 JP 2003568 A JP2003568 A JP 2003568A JP 356890 A JP356890 A JP 356890A JP H0695892 B2 JPH0695892 B2 JP H0695892B2
- Authority
- JP
- Japan
- Prior art keywords
- feed
- body fat
- vitamin
- amount
- bloace
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、家畜の脂肪代謝を改善し、体脂肪の蓄積量を
減少させる飼料に関するものである。TECHNICAL FIELD The present invention relates to a feed that improves fat metabolism and reduces body fat accumulation in livestock.
近年、畜産動物において、発育促進の目的のために、エ
ネルギー摂取量が多くなってきており、体脂肪の蓄積量
が増大する傾向にある。In recent years, in livestock animals, the amount of energy intake has been increasing for the purpose of promoting growth, and the amount of body fat accumulated tends to increase.
しかし、最近の健康食ブームにより、動物性脂肪を食べ
ないようにする人々が増大し、体脂肪の少ない畜産物を
生産する方法や飼料の開発が広く要望されていた。However, due to the recent boom in healthy eating, the number of people who do not eat animal fat has increased, and there has been a widespread demand for the development of a method and feed for producing livestock products low in body fat.
〔発明が解決しようとする課題〕 しかしながら、このような体脂肪の少ない畜産物を生産
する飼料は、広く要望されているにもかかわらず、有効
なものはほとんど開発されていなかった。わずかに、本
出願人が、蛋白質の構成成分であるある種のアミノ酸を
飼料に強化することにより、体脂肪蓄積量を減少させる
飼料を提案している（特願平1-287395号明細書）。[Problems to be Solved by the Invention] However, although a feed for producing such livestock products having a small amount of body fat has been widely demanded, an effective feed has hardly been developed. The applicant has proposed a feed that reduces the amount of body fat accumulated by fortifying a feed with a certain amino acid that is a constituent of protein (Japanese Patent Application No. 1-287395). .
ところで、ビタミンD3はCa代謝にとって重要な役割をも
つ物質であることはよく知られている。ビタミンD3が小
腸でCaの吸収を促進する働きを持つには、ビタミンD3が
肝臓において25位が水酸化されて25（OH）D3となり、次
に腎臓において１α位が水酸化されて、１α、25(OH)2D
3となる必要がある。この１α、25(OH)2D3は小腸でのCa
の吸収促進作用が最も高く、活性型ビタミンD3と呼ばれ
ている。By the way, it is well known that vitamin D 3 is a substance that plays an important role in Ca metabolism. In order for vitamin D 3 to have a function of promoting Ca absorption in the small intestine, vitamin D 3 is hydroxylated at the 25th position in the liver to become 25 (OH) D 3 , and then at the 1α position in the kidney. 1α, 25 (OH) 2 D
Must be 3 . This 1α, 25 (OH) 2 D 3 is Ca in the small intestine
Has the highest absorption-promoting effect, and is called active vitamin D 3 .
他方、近年、ビタミンD3と脂肪代謝に関する研究が開始
されており、ビタミンD3、特に１α、25(OH)2D3が、前
脂肪細胞の脂肪細胞への分化を阻害する働きを持つこと
や、肝臓での脂肪分解に関与することが試験管内（イン
ビトロ）の実験で報告されている。すなわち１α、25(O
H)2D3は、脂肪細胞の数を減少させ、体脂肪の蓄積量を
減少させる働きがあるものと推測される。On the other hand, in recent years, studies on vitamin D 3 and fat metabolism have been started, and that vitamin D 3 , especially 1α, 25 (OH) 2 D 3 has a function of inhibiting the differentiation of preadipocytes into adipocytes. In addition, it has been reported in an in vitro experiment that it is involved in lipolysis in the liver. That is, 1α, 25 (O
It is speculated that (H) 2 D 3 has a function of reducing the number of adipocytes and reducing the amount of accumulated body fat.
しかし、この点について動物を用いた生体（インビボ）
での試験は実施されておらず、実際に動物に対して体脂
肪の蓄積量を減少させる働きが有るか否か不明である。However, in this regard, living organisms using animals (in vivo)
No studies have been carried out in Japan, and it is unclear whether it actually acts to reduce the accumulation of body fat in animals.
本発明者らは、この点を明らかにするため、ビタミンD3
および１α（OH）D3（本物質は、肝臓ですみやかに25位
が水酸化され、１α、25(OH)2D3となる）をブロイラー
に給与して、体脂肪蓄積量に与える影響を検討した。The present inventors have clarified this point by using vitamin D 3
And 1α (OH) D 3 (this substance is rapidly hydroxylated at the 25th position in the liver to become 1α, 25 (OH) 2 D 3 ) is fed to the broiler, and its effect on the body fat accumulation is investigated. investigated.
その結果、ビタミンD3および１α（OH）D3は、ともに体
脂肪蓄積量を抑制することを見い出した。また、我々
は、体脂肪の蓄積量を減少させる好適な添加量を見い出
し、本発明を完成させた。As a result, both vitamin D 3 and 1α (OH) D 3 were found to suppress body fat accumulation. We have also found a suitable amount of addition that reduces the amount of body fat accumulated, and completed the present invention.
すなわち、本発明の体脂肪蓄積量を減少させる飼料は、
飼料kg当りビタミンD3を750〜2500μｇの範囲に強化す
ることを特徴として構成されている。That is, the feed for reducing the body fat accumulation amount of the present invention is
It is characterized in that vitamin D 3 is fortified within a range of 750 to 2500 μg per kg of feed.
ビタミンD3および１α（OH）D3の添加量が、それぞれ25
0μｇおよび0.25μｇ未満であると、体脂肪蓄積の抑制
効果はない。ビタミンD3および１α（OH）D3の添加量
が、それぞれ2500μｇおよび４μｇを越えると、ビタミ
ンD3および１α（OH）D3の過剰摂取による副作用が出現
し増体面で好ましくない。The amount of vitamin D 3 and 1α (OH) D 3 added was 25 each
When it is less than 0 μg and 0.25 μg, there is no effect of suppressing body fat accumulation. When the added amounts of vitamin D 3 and 1α (OH) D 3 exceed 2500 μg and 4 μg, respectively, side effects due to excessive intake of vitamin D 3 and 1α (OH) D 3 appear, which is not preferable in terms of weight gain.
なお、ビタミンＤと１α（OH）D3は、それぞれ単独で強
化しても、混合して強化してもよい。It should be noted that vitamin D and 1α (OH) D 3 may be fortified individually or may be fortified by mixing.
その他の飼料成分は家畜用の公知の飼料でよく、蛋白
質、エネルギー源、カルシウム源、リン源、ビタミン
類、ミネラル等を含み、NRC要求量を満足する配合のも
のである。蛋白質としては、魚粉、大豆粕、菜種粕、フ
ェザーミール、ミートボーンミル等であり、アミノ酸イ
ンバランスを補うためにDL−メチオニン、Ｌ−トリプト
ファン、Ｌ−スレオニン等のアミノ酸を加えてもよい。
エネルギー源としては、とうもろこし、マイロ、小麦粉
等の穀類と、飼料用油脂、大豆油、粉末油脂等がある。
その他、リン源、ビタミン類、ミネラル等を公知飼料と
同様に含有させる必要がある。成分の含有率は、粗蛋白
質12〜25％、粗脂肪３〜10％程度、カルシウム0.8〜2.0
％程度、ME2700〜3300Kcal/kg程度でよい。The other feed ingredients may be known feeds for livestock, and are those containing protein, energy source, calcium source, phosphorus source, vitamins, minerals, etc. and satisfying the NRC requirement. Examples of the protein include fish meal, soybean meal, rapeseed meal, feather meal, meatbone mill and the like, and amino acids such as DL-methionine, L-tryptophan and L-threonine may be added to supplement the amino acid imbalance.
Examples of energy sources include grains such as corn, milo and wheat flour, and fats and oils for feed, soybean oil and powdered oils and fats.
In addition, it is necessary to add a phosphorus source, vitamins, minerals, etc. as in known feeds. The content of ingredients is crude protein 12-25%, crude fat 3-10%, calcium 0.8-2.0
%, ME2700 to 3300 Kcal / kg.
本発明の体脂肪の蓄積量を減少させる飼料は、ビタミン
D3および１α（OH）D3が体内で１α、25(OH)2D3とな
り、この１α、25(OH)2D3が前脂肪細胞を脂肪細胞へ分
化させる作用を阻害するとともに、脂肪の分解を促進
し、体脂肪の蓄積量を減少させる。The feed for reducing the body fat accumulation of the present invention is a vitamin
D 3 and 1α (OH) 1α D 3 is in the body, 25 (OH) 2 D 3, and this l [alpha], together with the 25 (OH) 2 D 3 inhibits the action of pre-differentiation of adipocytes into adipocytes, fat Promotes the decomposition of and reduces the accumulation of body fat.
〔実施例〕 市販のブロイラー飼料（ブロエースＳおよびブロエース
Ｇ、伊藤忠飼料（株）製品）に、ビタミンD3または１α
（OH）D3を添加し、試験を実施した。[Examples] Vitamin D 3 or 1α was added to commercially available broiler feeds (Bloace S and Bloace G, products of ITOCHU Feed Co., Ltd.).
The test was conducted by adding (OH) D 3 .
試験は５グループを設定し、ブロイラー初生雛180羽
（雄90羽、雌90羽）を用い、１グループ雄18羽（６羽×
３反復）、雌18羽（６羽×３反復）の５グループで49日
齢まで試験を実施した。For the test, 5 groups were set, and 180 broiler chicks (90 males, 90 females) were used, and 18 males per group (6
The test was carried out up to 49 days old in 5 groups of 3 females) and 18 females (6 females × 3 replicates).
試験区分を以下に示す。The test categories are shown below.
１区 対照区 （無添加） ２区 ビタミンD3 強化区（ブロエースS375μg/kgブロ
エースG750μg/kg） ３区 ビタミンD3 強化区 （ブロエースS2500μg/kg ブロエースG5000μg/kg） ４区 １α（OH）D3 強化区 （ブロエースS0.8μg/kg ブロエースG1.6μg/kg） ５区 １α（OH）D3 強化区 （ブロエースS4.0μg/kg ブロエースG8.0μg/kg） 結果を下表に示す。1 ward Control group (no additives) 2 wards Vitamin D 3 fortified group (Bloace S375 μg / kg Bloace G750 μg / kg) 3 wards Vitamin D 3 fortified group (Bloace S2500 μg / kg Bloace G5000 μg / kg) 4 wards 1α (OH) D 3 Strengthened group (Bloace S 0.8 μg / kg Bloace G 1.6 μg / kg) 5th group 1α (OH) D 3 Reinforced group (Bloace S4.0 μg / kg Bloace G8.0 μg / kg) The results are shown in the table below.
ビタミンD3および１α（OH）D3を強化しない飼料で育て
た１区は、腹脂肪量が、他の区分に比して、雄で約25
％、雌で約17％増加している。したがって、ビタミンD3
および１α（OH）D3の強化は体脂肪の蓄積量を減少させ
ることが明らかである。 Compared to the other groups, the 1st group raised on a diet that was not fortified with vitamin D 3 and 1α (OH) D 3 had abdominal fat content of about 25 in males.
%, Females have increased by about 17%. Therefore, vitamin D 3
It is clear that and enhancement of 1α (OH) D 3 reduces body fat accumulation.
また、ビタミンD3の添加量が多い３区は、体重が、２区
および４区に比して、雄および雌とも約６％少ない。In addition, the body weight of the 3 groups, which contained a large amount of vitamin D 3 , was about 6% less in both males and females than in the 2 and 4 groups.
さらに、１α（OH）D3の添加量が多い５区は、体重が、
２区および４区に比して、雄で14％、雌で約９％少な
い。Furthermore, in the 5 wards where the amount of 1α (OH) D 3 added is large,
Compared to the 2nd and 4th plots, males have 14% less and females have approximately 9% less.
したがって、ビタミンD3および１α（OH）D3の添加量を
多くすると、増体面で好ましくないことが明らかであ
る。Therefore, it is clear that increasing the amounts of vitamin D 3 and 1α (OH) D 3 is not preferable in terms of weight gain.
２区および４区は、体重が減少することなく、腹脂肪量
が減少しており、好適であることが明らかである。It is clear that the second and fourth plots are suitable because the abdominal fat mass is reduced without reducing the body weight.
本発明は以上のように構成することにより、生体量に影
響を与えることなく体脂肪の蓄積量を減少させることが
できる。By configuring the present invention as described above, it is possible to reduce the amount of body fat accumulated without affecting the biological amount.
フロントページの続き (56)参考文献 特開 昭63−56254（ＪＰ，Ａ)Continuation of front page (56) References JP-A-63-56254 (JP, A)
Claims (1)
範囲に強化した体脂肪の蓄積量を減少させる飼料1. A feed fortified with vitamin D 3 in the range of 750 to 2500 μg per kg of feed to reduce the accumulation of body fat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003568A JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003568A JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03210156A JPH03210156A (en) | 1991-09-13 |
| JPH0695892B2 true JPH0695892B2 (en) | 1994-11-30 |
Family
ID=11561043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003568A Expired - Fee Related JPH0695892B2 (en) | 1990-01-12 | 1990-01-12 | Feed that reduces body fat storage |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0695892B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| WO2011119610A2 (en) | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | (20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1α,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22- DIMETHYL-1α,25-HYDROXYVITAMIN D3 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA74158B (en) * | 1973-01-10 | 1975-03-26 | Res Inst Medicine Chem | Chemical process |
-
1990
- 1990-01-12 JP JP2003568A patent/JPH0695892B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03210156A (en) | 1991-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |