JPH0690703A - Antiulcerous food - Google Patents

Abstract

PURPOSE:To obtain the subject readily drinkable low-viscosity food, containing a water-soluble alginate, etc., having a prescribed average-molecular weight, excellent in safety and useful as a healthy beverage, etc. CONSTITUTION:The objective antiulcerous food comprises a water-soluble alginate or an ester having 10000-59000 average molecular-weight at preferably 1-20wt.% concentration and provides an aqueous solution having 1-100cP viscosity.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a food useful for the prevention of ulcer, and more particularly, it is easy to drink even in the case of a high-concentration beverage, and the antiulcer function of alginic acid can be sufficiently exerted. And an anti-ulcer health drink containing alginic acid.

[0002]

2. Description of the Related Art Alginic acid is D-mannuronic acid (hereinafter referred to as M
And L-guluronic acid (hereinafter referred to as G) are bound at various ratios and are filled in cells of brown algae, and their M / G ratios vary between species and seasons. It depends on the part of the alga. Alginic acid is obtained by extracting brown algae with an aqueous solution of sodium carbonate and precipitating it with hydrochloric acid or calcium chloride. Free alginic acid is poorly soluble in water and easily gels, so it is usually converted to alginate in a water-soluble form. used. This aqueous solution has a high viscosity, for example, sizing agents, food processing,
It has many uses such as paint.

Alginic acid is known to have many health benefits. Since it is excreted without being absorbed in the body, it has an effect of regulating intestine and constipation, and also has an effect of suppressing absorption of harmful metals in the body and an effect of excreting sodium. As a health drink utilizing such an effect, a tonic health drink in which high molecular weight alginic acid is dispersedly added to drinking water has been proposed (JP-A-55-28956). Further, it is described in JP-A-1-240175 that alginic acid is used as a gelling agent in a fiber drink in which dietary fiber is dispersed in a dispersion medium.

Alginic acid has been used as a drug substance in the pharmaceutical field. There is an example that it was used for the treatment of gastric / duodenal ulcer as a combination drug with copper chlorophyllin sodium showing an ulcer treatment effect (Kyosei Pharmaceutical Co., Ltd. "Alloid G"), and water-soluble alginic acid having an average molecular weight of 60,000 to 250,000. Antiulcer having anti-pepsin activity with salt as a drug for gastrointestinal tract having gastrointestinal mucosa protection and gastrointestinal tract hemostatic action (JP-A-57-46920) and aluminum alginate (polymerization degree 50 to 1500) as an active ingredient Agent (JP-A-57-16791
It has been proposed to use it in (8) gazette). It is presumed that alginic acid protects the mucous membrane of the digestive tract since it becomes insoluble alginic acid in the body due to gastric acid.

However, in the conventional health drinks and pharmaceuticals as described above, since high molecular weight alginic acid obtained from brown algae is used, even if it is made water soluble as an alginate such as sodium salt, the solubility in water is high. It was very low and could only be used as a dilute solution with a few% concentration. The higher the concentration, the more viscous it becomes and not suitable for drinking. When high concentration is required, it will be used as it is as powder.

[0006]

As described above, alginic acid has various useful functions, but when it is used, it is used as a dilute solution or used as a powder as it is. The powder has the drawback that it is not easy to swallow. Regardless of when it is used as a drug for the treatment of ulcers or the like, a health drink that takes advantage of the health benefits of alginic acid is required to contain alginic acid at a certain concentration or higher and to have a low viscosity and be easy to drink. When alginic acid or alginate is used in a high molecular weight as it is, it has a high viscosity even at a concentration of about 5% by weight and is not suitable for beverages. In addition, if one tries to ingest the amount of alginic acid necessary for exhibiting the health effects, a large amount of low-concentration beverage will be consumed. It is an object of the present invention to provide a food that is easy to take while containing an amount of alginic acid required to exert antiulcer properties, particularly a health drink having low viscosity and easy to drink.

[0007]

Means for Solving the Problems The present inventors have examined the relationship between the quality of alginic acid and the pharmacological action. As a result, alginic acid having a molecular weight in a specific range by lowering its molecular weight has a gastrointestinal mucosal protective effect. The present invention was completed by finding that it is useful for producing health foods suitable for drinking as it is. The gist of the present invention is an anti-ulcer food which is characterized by containing a water-soluble alginate or alginate having an average molecular weight of 10,000 to 59,000.

[0008]

The water-soluble alginate or alginate having an average molecular weight of 10,000 to 59,000 used in the present invention is obtained by hydrolyzing, enzymatically decomposing or hydrolyzing a high molecular weight alginic acid extracted from brown algae with an acid. It is obtained by processing by decomposition or the like. As a method for lowering the molecular weight, pressurized hydrothermal decomposition is preferable because it can be selectively decomposed into a desired average molecular weight.
If the average molecular weight of alginate or ester is less than 10,000, it will not be deposited even if it becomes alginic acid by the action of gastric juice when ingested, and the gastric mucosa protective action cannot be exerted. On the other hand, when the average molecular weight exceeds 59,000, the viscosity is too high to obtain the concentration of alginic acid required to exhibit the antiulcer property, and it becomes unsuitable for drinking. The average molecular weight is a weight average molecular weight measured by liquid chromatography using pullulan as a standard substance.

Examples of the water-soluble alginate include sodium salt, potassium salt, ammonium salt and amine salt of alginic acid, and examples of the water-soluble alginate ester include propylene glycol alginate.

The low molecular weight alginate or ester of the present invention can be used in an aqueous solution having a concentration of 1 to 20% by weight,
The viscosity measured by a rotational viscometer is as low as 1 to 100 centipoise. In the case of a health drink, it is preferable to contain the above-mentioned water-soluble alginate or ester at a concentration of 1 to 20% by weight. When the alginate or ester having an average molecular weight in the above range is contained in this range, the amount necessary for having an antiulcer action can be reasonably taken, and it is useful for preventing ulcer of the digestive tract. By adjusting the molecular weight and concentration of the alginate or ester so that the viscosity of the beverage is measured by a rotational viscometer to be in the range of 1 to 100 centipoise, a drinkable product can be obtained.

In addition to the beverage, when used in the form of jelly, pudding or the like, the amount necessary to exert the health effect without affecting the physical properties of the food can be added. Conventional high molecular weight alginic acid cannot be added in a large amount because it has a large effect on the physical properties of foods when added to jelly or purine even in a small amount. Further, the food containing the low molecular weight alginate or ester of the present invention,
The form of powder is also possible, and it can be dissolved in water or warm water as a stick-shaped food and can be drunk.

Various conventional additives such as sweeteners, flavors, colorants and preservatives can be added to the antiulcer food of the present invention. Further, in order to enhance the function as a health food, it is possible to add one or more kinds of other dietary fibers and health promoting substances (for example, iodine, iron, fructooligosaccharides, etc.). As is clear from the experimental examples described below, the addition of alginate or ester, as well as licorice extract having anti-ulcer properties and chamomile extract having anti-inflammatory effects, further increases the inhibitory effect on stress ulcers.

It has been known that ingestion of a high molecular weight alginate or ester can exert a protective effect on the digestive tract, but in the present invention, even a low molecular weight one which has not been conventionally used has a protective effect on the digestive tract mucosa. Found. Moreover, the low molecular weight alginate or ester is
Solubility in water is remarkably high as compared with the case of high molecular weight, and even at the same concentration, the viscosity of the aqueous solution decreases, so that ingestion at high concentration becomes easy. When the low molecular weight water-soluble alginate or ester used in the present invention is ingested, insoluble alginic acid is produced by the action of gastric juice, which covers the gastrointestinal mucosa and suppresses the mucosal-disrupting action of the ulcer promoting substance. In particular, it is effective if ingested before the stress causing ulcer is applied.

The health drink of the present invention contains an alginate or ester in the molecular weight range which retains the antiulcer property in a concentration effective for exerting the antiulcer action, and by drinking this, the It is effective in preventing gastrointestinal ulcers such as the duodenum. Moreover, the safety of alginate or ester has been confirmed, and it is a non-calorie food.

[0015]

[Examples] The following is an experimental example demonstrating the antiulcer action of the low molecular weight alginate used in the present invention.

Experimental method [Effect on ethanol / hydrochloric acid ulcer] A predetermined amount of the sample was orally administered to 10 rats per group that were fasted for 24 hours.
After 10 minutes, ethanol / hydrochloric acid (60 V / V% ethanol prepared with 150 mM hydrochloric acid) was orally administered at a rate of 5 ml / kg. One hour after the administration of ethanol / hydrochloric acid, the rat was killed by exsanguination under ether light anesthesia, and the stomach was extracted. Inject 8 ml of 2% formalin solution into the excised stomach, and add 1 to the same solution.
The stomach was fixed by soaking for 0 minute. After that, an incision was made along the large bowel, and the length of the ulcer caused in the glandular stomach was measured under a dissecting microscope, and the total sum per animal was calculated. The control group was administered with distilled water in the same volume as the sample.

[Action on water immersion restraint stress ulcer] 2
A predetermined amount of the sample was orally administered to 10 rats per group that were fasted for 4 hours. After 10 minutes, put in a stress tube, water temperature 23 ℃
It was immersed in the water tank up to the height of the xiphoid process and stress was applied. Seven hours later, the rat was pulled up from the water tank, and was exsanguinated to death under ether anesthesia, and the stomach was excised. After that, the same operation as in the ethanol / hydrochloric acid ulcer test was performed.

Experimental Example 1 Sodium alginate having an average molecular weight of 50,000 was dissolved in water.
And 200 mg / kg were administered to rats to examine the effects on ethanol / hydrochloric acid ulcers. The results are shown in Table 1. As is clear from the results in Table 1, sodium alginate significantly suppressed ulcer formation at any dose by pre-administration. Particularly, the administration rate of 200 mg / kg had a high inhibition rate of about 71%.

[0019]

[Table 1]

Experimental Example 2 Sodium alginate having an average molecular weight of 50,000 was 5 W / V%, licorice extract having an anti-ulcer effect was 0.2 W / V%, and chamomile extract having an anti-inflammatory effect was 0.1 W / V%. Formulation mixed in, and peptic ulcer agent "Alloid G"
(Sodium alginate content 5 W / V%) was used to examine the effect on ethanol / hydrochloric acid ulcer. The results are shown in Table 2. As is clear from the results in Table 2, when the same amount of sodium alginate was administered, the inhibition rate of ulcer formation by ethanol / hydrochloric acid by sodium alginate alone, the preparation, and Alloid G was similar.

[0021]

[Table 2]

Experimental Example 3 Sodium alginate having an average molecular weight of 50,000 was dissolved in water,
20, 50 and 200 mg as sodium alginate
/ Kg was administered to rats to examine the effect on water immersion restraint stress ulcer. The results are shown in Table 3. Pretreatment with sodium alginate showed a dose-dependent tendency to suppress ulcer formation.

[0023]

[Table 3]

Experimental Example 4 Sodium alginate having an average molecular weight of 50,000 was 5 W / V%, licorice extract having an anti-ulcer effect was 0.2 W / V%, and chamomile extract having an anti-inflammatory effect was 0.1 W / V%. Formulation mixed in, and peptic ulcer agent "Alloid G"
(Sodium alginate content 5 W / V%) was used to examine the effect on water immersion restraint stress ulcer. The results are shown in Table 4. The preparation markedly suppressed ulcer formation, and the suppression rate was about 50%. Alloid G also showed a tendency to suppress ulcer formation by about 35%, but it was not significant as compared with the control group. Comparing the ulcer formation inhibition rate when alginic acid alone, the preparation, and alloid G as alginic acid were administered in the same amount, the preparation showed the best suppression of ulcer.

[0025]

[Table 4]

[0026]

[Examples] Health drinks having the following formulations were prepared using sodium alginate having various average molecular weights. Example 1 Sodium alginate having a molecular weight of 50,000 50 g Licorice extract 2 g Chamomile extract 1 g Flavor 1 g Water was added to the above to make a total volume of 1000 ml.

Example 2 Sodium alginate having a molecular weight of 50,000 20 g Citric acid 2 g Reduced maltose starch syrup 60 g Fructose glucose liquid sugar 60 g Water was added to the above to make a total volume of 1000 ml.

Example 3 Sodium alginate having a molecular weight of 50,000 50 g Sodium citrate 5 g Apple juice 10 g Honey 5 g Water was added to make the total amount 1000 ml.

Example 4 Sodium alginate having a molecular weight of 30,000 50 g Sodium citrate 5 g Apple juice 10 g Honey 5 g Water was added to the above to make a total volume of 1000 ml.

Example 5 Sodium alginate having a molecular weight of 10,000, 50 g, citric acid, 1 g, sodium citrate, 5 g, orange juice, 10 g, honey, 5 g.

[0031]

EFFECTS OF THE INVENTION The conventional alginic acid-containing beverage cannot be made into a health beverage having an effective concentration because of its high solution viscosity. According to the present invention, a low molecular weight alginate or ester having an average molecular weight of 10,000 to 59,000 may be used to contain alginic acid at a high concentration that is viscous and suitable for drinking and is effective for health. It is possible to provide a health drink that is useful for the prevention of duct ulcers.

Claims (2)

[Claims] 1. An anti-ulcer food comprising a water-soluble alginate or ester having an average molecular weight of 10,000 to 59,000. 2. A water-soluble alginate or ester
The food according to claim 1, which is contained at a concentration of -20 wt% and has a viscosity of 1-100 centipoise when made into an aqueous solution.