JPH0687883B2 - Medical drug supply package - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical package used for injecting antibiotics, powder preparations or other soluble drugs as intravenous drip into a vein or bladder or other internal organs.

[0002]

2. Description of the Related Art Conventionally, aseptic products of antibiotic powders used for drip are filled in glass vials, the mouth of the glass vials is sealed with a rubber stopper, and the mouth is placed over the rubber stopper. The part was completely sealed with an aluminum sheet. On the other hand, a solution for infusion for dissolving these antibiotic powders, that is, a diluting solution is similarly filled in a glass vial, the mouth of the glass vial is sealed with a rubber stopper, and the rubber stopper is placed on the rubber stopper. Therefore, the mouth was completely sealed with an aluminum sheet, or a plastic bag was hermetically filled instead of the glass vial. Then, in use, a doctor or a nurse dissolves the drug by connecting a vial containing the powdered drug and a vial containing the solution or a plastic bag with a separately prepared double-ended needle, or A method of dissolving a drug by injecting a dissolved solution sucked up by a syringe into a drug-containing vial is widely used. However, with such a method, it is difficult to dissolve the drug in an aseptic state because the drug vial and the solution vial are connected in the medical field.
Further, the operation for connecting the drug vial and the solution vial is complicated and requires skill, and further, the operation takes time, which is a big problem particularly in the case of home medical care or emergency medical care. It was.

In order to solve some of these problems, Japanese Patent Application Publication No. 61-501129 discloses that a plastic bag is filled with a diluting solution, and a special stopper is attached to the opening, and the bag is normally closed by the stopper. It is sealed and the diluent is kept aseptic.When using it, by assembling a glass vial containing antibiotics etc. from the aluminum sheet at the mouth part to the top of the stopper and screwing in the glass vial. The rubber stopper of the glass vial is dropped into the bag to open it, and then the diluting solution in the bag is poured into the glass vial, so that the integrated bag and glass vial are now rocked up and down to remove the antibiotic. Disclosed is a drug supply package which can be dissolved in a diluting solution to prepare an infusion solution in this way.

Further, Japanese Patent Application Laid-Open No. 2-1277 discloses a special opening unit for receiving a glass vial containing an antibiotic and the like, which is obtained by tearing off an aluminum sheet at the mouth, and a plastic containing a diluent. It is provided at one end of a bag made of metal, and a metal tube with a sharp tip is fixed to this, a hole is made in the rubber stopper of the glass vial with this metal tube, and the diluent is sent into the glass vial by pressing the plastic bag. A drug supply package has been disclosed.

However, even in these packages, it is impossible to prepare a solution of the antibiotic and the diluent in a completely sterile state because the glass vial is bonded to the opening of the plastic bag on site. In addition, the opening unit of the plastic bag containing the diluting solution becomes large, and the amount of antibiotics used is 50 m, for example.
Despite being extremely small, the glass vial containing this was abnormally large and inconvenient to handle.
Especially in the latter case, the use of sharp metal pipes brings new problems to medical waste treatment plants.

[0006]

Therefore, in the present invention, it is possible to mix a drug and a solution under a completely sterile condition, and the mixing operation is extremely easy and quick, and requires no skill. The present invention provides a medicine supply package for medical use that can be carried out without the use of the medicine and can be easily discarded after use.

[0007]

In order to solve the above-mentioned problems, the present invention similarly seals a preformed antibiotic or the like under a sterile condition in a plastic bag containing a diluent under a sterile condition. The sealed sterilized blister sealed container is enclosed, and the sterile blister sealed container is opened in the plastic bag at the time of use.

[0008]

[Function] A sterile blister sealed container containing antibiotics and the like is contained in a sterile plastic bag containing a diluent, and the sterile blister container is opened in the sterile plastic bag. . Therefore, a solution of a medicine such as an antibiotic and a diluent is prepared under a completely sterile condition.

[0009]

EXAMPLE FIG. 1 shows a medical package 1 constructed according to the present invention.
Indicates 0. The medical package 10 is preferably composed of a tubular bag 12 made of transparent polyethylene so that the internal condition can be visually checked. But bag 12
Depending on the chemicals inside, it may be necessary to improve light stability. In such a case, the bag may be constituted by a colored sheet in which an appropriate coloring agent or the like is mixed instead of the transparent polyethylene sheet, so as to shield the stored chemicals from light. One end of the bag 12 is sealed by a seal portion 14, and a port 16 which is known per se is provided at a substantially central portion thereof.
Is installed in a liquid-tight state. The end of the port 16 is hermetically sealed with a stopper 18 and enters. A connection pipe (not shown) of a drip set is connected to the port 16 and the package 1
Medical liquid from 0 is supplied. A filter is attached to the bag 16 side of the port 16 or the connecting tube side of the drip set in the present invention, if necessary.

Similarly, the other end of the bag 12 is hermetically sealed by a seal portion 20, and a hanger 22 is attached to the seal portion 20. Desirably, the hanger 22 comprises a simple punched opening or bag 1 as shown.
The hook-shaped hanger can be constructed integrally with the 2 and can be pulled out when necessary.

The bag 12 contains a predetermined amount of physiological saline or distilled water 24 which acts as a diluent. A sterile blister container 26, in which necessary chemicals 28 are stored, is suspended in the diluted liquid 24. As shown in FIG. 2, the sterile blister container 26 includes a container body 30 formed of, for example, aluminum foil, and a container body 30.
0 and a lid 32 formed of aluminum foil that completely seals the medicine 28 in a container body 30. In order to hermetically seal the main body 30 and the lid 32, a resin adhesive may be applied between the two as needed. Incidentally, these containers 26
Is made of a corrosion-resistant plastic material such as polyethylene instead of the aluminum foil, and heat seals the lid 32 and the body 30, the body 30 is made of aluminum foil or plastic material, and the lid 32 is made of plastic or aluminum. A part of the main body or lid made of foil, and further aluminum foil or plastic material, can be made of plastic material or aluminum foil.
Furthermore, materials other than these can be used.

In the present invention, the diluent 12 and the sterile blister container 26 are housed together in the bag 12. However, if desired, a pseudo seal portion known per se is provided in the upper and lower intermediate portions of the bag 12. It is also possible to divide the bag 12 into upper and lower chambers by forming the above. In this case, the seal strength of the pseudo seal portion is somewhat weaker than the seal strength of the seal portions 14 and 20 at both ends, but at least the seal strength is sufficient to prevent the liquid from flowing freely. . The pseudo seal portion may be formed over the entire intermediate portion, or only a part of the intermediate portion may be formed and the other portions may be formed to have the same strength as the seal portions at both ends. Then, physiological saline or distilled water 24 is enclosed in one chamber of the bag 12 divided by the intermediate seal portion, and a sterile blister container 26 containing a necessary drug is packaged in the other chamber.

Drug 2 contained in blister container 26
8 is usually a powder, but may be a liquid. The lid 32 is normally sealingly engaged with the container body 30, but a weakened portion is provided in a part of the lid 32, a part of the flange portion 34 of the container body, or a part of the bottom portion of the container body. ,
By operating that portion from the outside of the bag 12 as needed, the container 26 can be easily broken and the drug 28 inside the container can be released from the container 26.

When the drug 28 is a powder, the amount of the drug 28 used in one infusion is usually about 50 mg, and such a trace amount of the powder drug is used in the blister container 2.
Loading the 6 is a daunting task. Therefore, in the present invention, first, a predetermined amount of a predetermined drug is weighed, dissolved in a predetermined amount of distilled water or the like, stirred, and a drug solution of a predetermined concentration is prepared, and this solution is blister container in a predetermined amount. Transfer to 26 and then freeze dry the solution.
According to such a method, the amount of the medicine to be loaded in the blister container 26 can be determined extremely quickly and accurately. This is because those skilled in the art know that it is easier and more accurate to measure a small amount of drug and load it in a liquid state than in a powder state. Furthermore, in the freeze-dried powder, when it comes into contact with a diluent or the like, the powder dissolves extremely quickly. Therefore, it is not necessary to spend a lot of time to dissolve the drug in the diluent as in the past.

An example of the case of manufacturing the package 10 of the present invention will be described. First, the seal portion 14 and the port 16 are preferably integrally provided at one end, for example, transparent or predetermined coloring. A cylindrical bag 12 formed of the applied polyethylene sheet is prepared. Next, the port 16 of the bag 12 is covered with a cap 18 in a sterile room to close the port 16. Then, a predetermined amount of physiological saline or distilled water is supplied from the other end of the bag 12 to the bag 12.
Inject into. After that, a pseudo seal portion is formed in the central portion if necessary. However, this central seal portion is not always necessary. Next, the blister container 26 in which the drug formed in advance in a sterile room is sealed is put in the bag 12, and finally the other end is sealed 20. Here, all the processing for the bag 12 is performed in a sterile room.

When using the medical package 10 of the present invention, first, the lid 32 or the flange portion 34 of the aseptic blister container 26 that is enclosed in the bag 12 is broken. In the case of the single bag as shown without the central pseudo seal, the container 26 floats in the diluting liquid 24, but the destruction of the container 26 can be easily achieved by moving the container 26 to the corner of the bag 12. In the case of a double bag provided with a central seal, it is not necessary to move the container 26 when destroying the container 26.

Next, in the double back, the chamber on the diluent side is strongly pressed to break the intermediate pseudo seal. As a result, the diluent 24 reaches the inside of the blister container 26 and dissolves the drug 28 inside the blister container 26. If necessary, shake the bag 12 several times to make sure the drug 28 is completely dissolved in the diluent 24. In the case where the drug 28 is a freeze-dried powder drug, the diluent 24 just touches the drug 28 and dissolves extremely rapidly. After that, the hanger 22 is hung on a predetermined device, the cap or plug 18 of the port 16 is removed, this is connected to the drip set, and thus the drip administration of the drug solution aseptically dissolved is started.

In FIG. 3, reference numeral 26 is a blister container 26 after the bottom portion of the container body 30 is broken and the medicine 28 inside is dissolved in the diluent 24. For this reason, for example, a cross-shaped weakened portion is provided at the bottom of the blister container 26, or a protrusion made of a corrosion-resistant plastic material is attached to a part of the bottom of the container made of aluminum foil so that the blister container 26 is protected from the outside of the bag. It is possible to easily break the container 26 by hand pressure. In the figure, the blister container 26
Although the bottom portion of the container is shown to be broken, the flange 34 of the container body 30 and the lid 32 itself of the container body 30 can be broken by similar means.

Although the figure shows the form of a single bag, if necessary, a double bag or a triple bag having a double chamber or a triple chamber or multiple chambers with more than one chamber may be provided, and a desired drug such as a vitamin preparation or a nutritional supplement may be provided therein. It is also possible to enclose it and put it on the patient at the same time when the drip is placed.

[0020]

According to the present invention, since the small blister container 26 previously stored in the bag 12 is simply opened in the bag, the operation is extremely simple and the inside of the plastic bag 12 is entirely sterile. Therefore, even under any environment, for example, in a dusty battlefield, a desert area, or an area with poor hygiene, completely sterile drug administration can be rapidly achieved in a short time. If the drug is a lyophilized powder, dissolution in a diluent can be achieved more rapidly. This effect is due to the recent shortage of the absolute number of nurses in the medical field, the need for home medical care due to the rapid increase in the elderly medical population, and further, considering the recent rapid increase in nosocomial infections, the complete aseptic condition of the present case. The demand for a medical package that can rapidly adjust the drug without requiring any skill is enormous, and has been long awaited in many medical fields. In particular, this package can be effectively applied not only to drip injection but also to direct injection of a drug solution into an organ such as bladder washing.

Further, in this package 10, a medicine such as an antibiotic is enclosed in a blister container 26 in a sterile room by, for example, a freeze-drying method, and the blister container 26 thus produced is enclosed in the bag 12 under aseptic conditions. Then the packaging 1
Since 0 is formed, the quality is always constant, it is stable against light and heat, and it can sufficiently withstand long-term storage. In addition, the large glass vials that have been used up to now are no longer necessary, making transportation, storage, and storage extremely easy.

Further, since the package 10 has almost no metal portion, there is almost no problem in treating medical waste.

Further, when the trace amount of the medicine 28 to be filled in the blister container 26 is freeze-dried and filled, the measurement can be performed very quickly and accurately, and the dissolution in the diluent can be achieved very quickly. .

[Brief description of drawings]

FIG. 1 is a diagram showing a medical package before use according to the present invention.

FIG. 2 is a view showing a medical package in use according to the present invention.

FIG. 3 shows a sterile blister container according to the present invention.

[Explanation of symbols]

 10 Medical Package 12 Bag 14 Seal 16 Port 18 Stopper 20 Seal 22 Hanger 24 Diluting Solution 26 Blister Container 28 Drug 30 Container Main Body 32 Lid 34 Flange Part

Claims (6)

[Claims] 1. A bag 1 having a port 16 at one end.
A sterile blister hermetically sealed container 26, which is a container that can be destroyed by hand pressure from the outside of the bag 12 and in which a desired drug 28 is enclosed, is accommodated in the container 2 under aseptic condition together with a diluting solution. A medical drug supply package 10. 2. The medical drug supply package according to claim 1, wherein the drug 28 contained in the sterile blister container 26 is provided by freeze-drying the solution. 3. The sterile blister container 26 is made of aluminum foil.
Alternatively, the medical drug supply package according to item 2. 4. The medical drug supply package according to claim 1, wherein the sterile blister container 26 is made of a corrosion resistant plastic material. 5. The aseptic blister container 26 is made of a combination material of an aluminum foil and a corrosion resistant plastic material.
The medical drug supply package according to [4]. 6. A port 1 provided at one end of the bag 12
6 is equipped with a filter, and the hanger 2 is attached to the other end of the bag 12.
The medical drug supply package according to claim 1, wherein the medical drug supply package is provided with 2.