JPH0658931A - Equipment for health care - Google Patents
Equipment for health careInfo
- Publication number
- JPH0658931A JPH0658931A JP4234213A JP23421392A JPH0658931A JP H0658931 A JPH0658931 A JP H0658931A JP 4234213 A JP4234213 A JP 4234213A JP 23421392 A JP23421392 A JP 23421392A JP H0658931 A JPH0658931 A JP H0658931A
- Authority
- JP
- Japan
- Prior art keywords
- sensor
- health care
- saliva
- detecting terminal
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は唾液中に含まれる成分の
濃度を測定することによって健康管理を行うことの出来
る健康管理装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a health care device capable of performing health care by measuring the concentrations of components contained in saliva.
【０００２】[0002]
【従来の技術】バイオセンサを用いて唾液中の成分濃度
を分析する装置は今までになかった。但し、尿中の成分
濃度を分析する技術に関しては例えば下記公報がある。
特公昭63-28188、特公平1-53746、同1-54666、同2-2124
6、実開昭60-134164、同60-134165の各号公報。2. Description of the Related Art There has hitherto been no apparatus for analyzing the concentration of components in saliva using a biosensor. However, there is, for example, the following publication regarding the technique for analyzing the concentration of components in urine.
JP-B-63-28188, JP-B1-53746, ID-54666, ID-2-2124
6, Gazette of 60-134164 and 60-134165.
【０００３】[0003]
【発明が解決しようとする課題】従来、唾液線、顎下
線、口腔の病的異常の検出手段としては、細胞膜の摘
出、Ｘ線検査或いは唾液の分析を行っていたが、前２者
は外的検査であるためこれだけでは判断が出来ず、結局
唾液を採取して定量分析を行わなければならなかった。
しかし、唾液の定量分析は全血等の分析のように自動化
されておらず、一つ一つの項目について手で分析しなけ
ればならなかった。Conventionally, as means for detecting salivary lines, submandibular lines, and pathological abnormalities of the oral cavity, cell membrane extraction, X-ray examination, or saliva analysis has been carried out. Since it was a physical examination, it was not possible to make a judgment with this alone, and it was necessary to collect saliva and perform quantitative analysis.
However, the quantitative analysis of saliva is not automated like the analysis of whole blood, etc., and each item must be analyzed by hand.
【０００４】[0004]
【課題を解決するための手段】上記課題を解決すべく本
発明は、口腔中に含んで唾液と接触させるセンサを先端
に搭載して、これから得られる検査対象物質の濃度変化
を電圧の変位に変換する検出端子と、既知の各検査対象
物質の電位と前記検出端子から発生した電圧とを比較し
て正常値か否かを判断する演算装置と、この判断の結果
を表示するための表示装置とからなる、唾液中の成分を
定量分析して健康状態を調べる健康管理装置を提供する
ものである。In order to solve the above-mentioned problems, the present invention has a sensor mounted in the tip which is brought into contact with saliva contained in the oral cavity, and changes in the concentration of the substance to be inspected obtained from this are converted into changes in voltage. A detection terminal to be converted, an arithmetic unit that compares the potential of each known inspection target substance with the voltage generated from the detection terminal to determine whether it is a normal value, and a display device for displaying the result of this determination. The present invention provides a health management device, which consists of and, which quantitatively analyzes the components in saliva to check the health condition.
【０００５】また、上記のセンサに口腔内温度検知手段
を併設し、使用時の口腔温度或いは不使用時の外気温度
を検知し、これらの信号を使用してセンサのオン・オフ
を行うことのできる、前記健康管理装置をも提供するも
のである。In addition, the above-mentioned sensor is provided with an oral temperature detecting means so as to detect the oral temperature during use or the outside air temperature during non-use, and use these signals to turn the sensor on and off. The health management device is also provided.
【０００６】[0006]
【作用】唾液中の検査対象物質の濃度増減による電位変
化を検出し、これらの数値が正常値であるか否かを判定
する。[Function] The potential change due to the increase or decrease in the concentration of the test substance in saliva is detected, and it is determined whether or not these numerical values are normal values.
【０００７】[0007]
【実施例】以下に本発明の実施例を添付図面に基づいて
説明する。ここで図１は本発明の健康管理装置の一例を
示す概略図である。検出端子１はバイオセンサ等のセン
サ２をその先端に搭載している。このセンサ２は測定対
象物質が変るときには交換することができる。またセン
サ２をＩＳＦＥＴ（感応性電界効果型トランジスタ）の
原理による微小のセンサを複数形成したものとし、複数
の物質を同時に測定することも可能である。センサ２は
口腔内に入れられるため、検出端子１はある程度の長さ
が必要となる。そのために配線部が延長されているが、
この配線部は耐水性のガイド３によって保護されてい
る。またガイド３の端部には耐水性のケーブル保護ケー
ス４が設けられており、ケーブル５を保護している。Embodiments of the present invention will be described below with reference to the accompanying drawings. Here, FIG. 1 is a schematic view showing an example of the health management apparatus of the present invention. The detection terminal 1 has a sensor 2 such as a biosensor mounted on its tip. This sensor 2 can be replaced when the substance to be measured changes. It is also possible to simultaneously measure a plurality of substances by forming the sensor 2 with a plurality of minute sensors based on the principle of ISFET (sensitive field effect transistor). Since the sensor 2 is placed in the oral cavity, the detection terminal 1 needs to have a certain length. Therefore, the wiring part is extended,
This wiring portion is protected by a water resistant guide 3. A water resistant cable protection case 4 is provided at the end of the guide 3 to protect the cable 5.
【０００８】検出端子１から発生した電気信号はケーブ
ル５によって演算装置６に送られる。演算装置６には測
定対象物質の正常値と異常値の境目の値（境界値）が前
もってインプットされており、検出端子１からの信号と
比較する。（表１）に、グルコース、尿酸、ビリルビ
ン、尿素窒素及びアルブミンの各境界値、唾液測定例を
示す。また参考として尿中及び全血中の正常値も示す。The electric signal generated from the detection terminal 1 is sent to the arithmetic unit 6 by the cable 5. The value (boundary value) at the boundary between the normal value and the abnormal value of the substance to be measured is input to the arithmetic unit 6 in advance and compared with the signal from the detection terminal 1. (Table 1) shows each boundary value of glucose, uric acid, bilirubin, urea nitrogen and albumin, and an example of saliva measurement. For reference, normal values in urine and whole blood are also shown.
【０００９】[0009]
【表１】 [Table 1]
【００１０】上記のようにして演算装置６で判定された
結果は表示装置７に示される。また測定対象物質として
は、上記の他に例えばエストロン、エストラジオール、
エストリオール、プレグナンジオール等のホルモン類、
糖尿病患者から検出されるパラセタモール、或いはエタ
ノール、β−オキシ酪酸等が挙げられる。The result determined by the arithmetic unit 6 as described above is displayed on the display unit 7. In addition to the above, the substances to be measured include, for example, estrone, estradiol,
Hormones such as estriol and pregnanediol,
Paracetamol detected from diabetic patients, ethanol, β-oxybutyric acid, etc. may be mentioned.
【００１１】図２は本発明に係る平板型センサ２の一例
を示す概略図である。尿酸センサを形成する例を用いて
本図を説明する。先ず1.5mm厚のＰＥＴ（ポリエチレン
テレフタレート）製基板８上にＰtペーストを印刷して
作用極９及び参照極１０を形成し、これを５０℃の恒温
槽で２時間乾燥してセンサ２とした。Ｐtペーストは、
白金微粉末（平均粒径３μm）９０重量％に対して、ビ
ヒクルとして、酢酸ブチルカルビトール、α−テレピネ
オール、ポリビニルブチラールの合計を１０重量％加え
て混練したものである。上記センサ２を放冷後、口腔内
に入れた際に電極端子部９ａ及び１０ａに唾液が触れな
いように絶縁膜１１を形成した。次にＢＳＡ（Bovine S
erum Albumin）９０重量％及びウリカーゼ１０重量％の
混合物を酵素固定化膜１２として作用極９の先端部に１
０μm厚に塗布し、これを架橋して耐水性を持たせるた
めに、グルタルアルデヒドの蒸気が飽和されているデシ
ケータ中に常温で２時間放置した。FIG. 2 is a schematic view showing an example of the flat plate type sensor 2 according to the present invention. This figure will be described using an example of forming a uric acid sensor. First print the P t paste to form a working electrode 9 and the reference electrode 10 on the 1.5 mm thick PET (polyethylene terephthalate) substrate made 8 and a sensor 2 which was dried for 2 hours in a constant temperature bath at 50 ° C. . Pt paste is
Against fine platinum powder (average particle size 3.mu. m) 90 wt%, as the vehicle, butyl carbitol acetate, alpha-terpineol, is obtained by kneading by adding the total 10% by weight of polyvinyl butyral. After the sensor 2 was left to cool, the insulating film 11 was formed so that saliva did not come into contact with the electrode terminal portions 9a and 10a when the sensor 2 was put into the oral cavity. Next, BSA (Bovine S
erum Albumin) 90% by weight and a mixture of 10% by weight of uricase as an enzyme-immobilized membrane 12 at the tip of the working electrode 9.
0Myu m was coated in a thickness, in order to crosslink this have water resistance, steam glutaraldehyde was allowed to stand for 2 hours at room temperature in a desiccator, which is saturated.
【００１２】図３及び図４は本発明に係る、温度検出手
段としてサーミスタを用いた健康管理装置及びセンサの
例を示したものである。人体の口腔内は、最も安定した
体温を示す場所である。よって、この部分にサーミスタ
を用いた温度検知手段を設け、センサに関するスイッチ
を別体としないことが可能である。例えば図１に示した
健康管理装置においては、図３に部分拡大してに示すよ
うに検出端子１に棒型サーミスタ２０を設置することが
できる。また図２に示した平板型センサ２においては、
図４に示すように参照極１０の一部を覆う平板型サーミ
スタ２１を設置することが出来る。ここで用いるサーミ
スタ２０、２１は、人体の体温と、常温（室温）との差
を定性的に判断できるものであれば何でもよい。これに
よって、自動的にセンシングができるようになり、使い
勝手が向上する。FIGS. 3 and 4 show examples of a health care device and a sensor using a thermistor as the temperature detecting means according to the present invention. The oral cavity of the human body is the place where the most stable body temperature is exhibited. Therefore, it is possible to provide a temperature detecting means using a thermistor in this portion and not separately provide a switch related to the sensor. For example, in the health care device shown in FIG. 1, a rod-type thermistor 20 can be installed in the detection terminal 1 as shown in FIG. Further, in the flat panel type sensor 2 shown in FIG.
As shown in FIG. 4, a flat plate type thermistor 21 that covers a part of the reference electrode 10 can be installed. The thermistors 20 and 21 used here may be any as long as they can qualitatively determine the difference between the human body temperature and the room temperature (room temperature). As a result, it becomes possible to automatically perform sensing, and the usability is improved.
【００１３】上記各例では尿酸のみを検出するセンサ２
を示したが、作用極９及び参照極１０の数を増すことに
よって、複数の物質を同時に測定するセンサ２を形成す
ることもできる。またＩＳＦＥＴ等による微小のセンサ
２を使用し、演算装置６及び表示装置７も小型化するこ
とによって携帯可能な健康管理装置を作ることもでき
る。この場合のバッテリとしては、汎用のＭn電池、ア
ルカリ電池、充電可能なＮi−Ｃd電池、鉛電池等でもよ
いが、放電密度が高く且つ小型で長時間使用の可能なＬ
i電池の使用が好ましい。In each of the above examples, the sensor 2 for detecting only uric acid
However, by increasing the numbers of the working electrode 9 and the reference electrode 10, it is possible to form the sensor 2 that simultaneously measures a plurality of substances. In addition, a portable health care device can be made by using a minute sensor 2 such as an ISFET and downsizing the arithmetic device 6 and the display device 7. In this case, the battery may be a general-purpose Mn battery, an alkaline battery, a rechargeable Ni-Cd battery, a lead battery, or the like, but it has a high discharge density, is small, and can be used for a long time.
The use of i batteries is preferred.
【００１４】図５は本発明に係る電極型センサ２の一例
を示す概略図である。アノード１３及びカソード１４が
納められ、電界液が満たされた円筒形のセンサ２の先端
に、透過膜１６を介して酵素固定化膜１２が取り付けら
れている。本例のセンサ２も上記平版印刷版型と同じく
小型化が可能である。FIG. 5 is a schematic view showing an example of the electrode type sensor 2 according to the present invention. The anode 13 and the cathode 14 are housed, and the enzyme-immobilized membrane 12 is attached to the tip of a cylindrical sensor 2 filled with an electrolytic solution via a permeable membrane 16. The sensor 2 of this example can be downsized as in the planographic printing plate mold.
【００１５】[0015]
【発明の効果】以上に説明した如く本発明の健康管理装
置によれば、唾液中に含まれる成分の定量分析によって
健康管理を行うことができるため、人体を痛めることが
なく、また家庭で使用することも可能である。更に、検
出した電圧の変位と既知の検査対象物質の電位とを比較
して正常値か否かを演算装置によって判断するため、検
査結果をすぐに知ることができる。As described above, according to the health management apparatus of the present invention, it is possible to perform health management by quantitative analysis of the components contained in saliva, so that it does not hurt the human body and is used at home. It is also possible to do so. Furthermore, since the displacement of the detected voltage is compared with the potential of the known substance to be inspected to determine whether the value is normal or not, the inspection result can be immediately known.
【００１６】また、口腔内温度検知手段を併設すること
によって、使用時の口腔温度或いは不使用時の外気温度
を検知し、これらの信号を使用してセンサのオン・オフ
を行うことが可能である。Further, by providing an oral temperature detecting means, it is possible to detect the oral temperature during use or the outside air temperature during non-use, and use these signals to turn on / off the sensor. is there.
【図１】本発明の健康管理装置の一例を示す概略図FIG. 1 is a schematic view showing an example of a health management device of the present invention.
【図２】本発明に係る平板型センサの一例を示す概略図FIG. 2 is a schematic view showing an example of a flat plate type sensor according to the present invention.
【図３】本発明の健康管理装置（温度検出手段としてサ
ーミスタ使用）の一例を示す概略図FIG. 3 is a schematic diagram showing an example of a health care device (using a thermistor as a temperature detecting means) of the present invention.
【図４】本発明に係る平板型センサ（温度検出手段とし
てサーミスタ使用）の一例を示す概略図FIG. 4 is a schematic view showing an example of a flat plate type sensor (using a thermistor as a temperature detecting means) according to the present invention.
【図５】本発明に係る電極型センサの一例を示す概略図FIG. 5 is a schematic view showing an example of an electrode type sensor according to the present invention.
１…検出端子、２…センサ、６…演算装置、７…表示装
置、９…作用極、１０…参照極、１２…酵素固定化膜、
２０、２１…サーミスタDESCRIPTION OF SYMBOLS 1 ... Detection terminal, 2 ... Sensor, 6 ... Arithmetic device, 7 ... Display device, 9 ... Working electrode, 10 ... Reference electrode, 12 ... Enzyme immobilization membrane,
20, 21 ... Thermistor
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｇ０１Ｎ 33/483 Ｅ 7055−2Ｊ ─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 5 Identification code Internal reference number FI Technical display location G01N 33/483 E 7055-2J
Claims (2)
調べる健康管理装置であって、口腔中に含んで唾液と接
触させるセンサを先端に搭載し且つ検査対象物質の濃度
変化を電圧の変位に変換する検出端子と、既知の各検査
対象物質の電位と前記検出端子から発生した電圧とを比
較して正常値か否かを判断する演算装置と、この判断の
結果を表示するための表示装置とからなることを特徴と
する健康管理装置。1. A health management device for quantitatively analyzing components in saliva to check a health condition, comprising a sensor mounted on the tip for contacting saliva contained in the oral cavity, and detecting a change in concentration of a substance to be inspected with a voltage. A detection terminal for converting into a displacement, an arithmetic unit for comparing the potential of each known test object substance with the voltage generated from the detection terminal to determine whether it is a normal value, and for displaying the result of this determination A health care device comprising a display device.
し、この温度検知手段からの信号によってセンサのオン
・オフを行うことを特徴とする請求項１に記載の健康管
理装置。2. The health care apparatus according to claim 1, wherein the sensor is provided with an intraoral temperature detecting means, and the sensor is turned on / off by a signal from the temperature detecting means.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4234213A JPH0658931A (en) | 1992-08-10 | 1992-08-10 | Equipment for health care |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4234213A JPH0658931A (en) | 1992-08-10 | 1992-08-10 | Equipment for health care |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000155185A Division JP2001004622A (en) | 2000-01-01 | 2000-05-25 | Health control device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0658931A true JPH0658931A (en) | 1994-03-04 |
Family
ID=16967472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4234213A Pending JPH0658931A (en) | 1992-08-10 | 1992-08-10 | Equipment for health care |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0658931A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807361A (en) * | 1995-03-09 | 1998-09-15 | Nippon Shokubai Co., Ltd. | Blood-absorbent resin composition and absorbent articles |
| CN1318012C (en) * | 2002-04-05 | 2007-05-30 | 株式会社日本吸收体技术研究所 | Absorber including by-pass channel member and absorber product therefrom |
| WO2015040684A1 (en) * | 2013-09-18 | 2015-03-26 | 株式会社日立製作所 | Reference electrode with thermometer function, lithium-ion secondary battery including reference electrode with thermometer function, lithium-ion secondary battery system including reference electrode with thermometer function, and lithium-ion secondary battery control method |
-
1992
- 1992-08-10 JP JP4234213A patent/JPH0658931A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807361A (en) * | 1995-03-09 | 1998-09-15 | Nippon Shokubai Co., Ltd. | Blood-absorbent resin composition and absorbent articles |
| CN1318012C (en) * | 2002-04-05 | 2007-05-30 | 株式会社日本吸收体技术研究所 | Absorber including by-pass channel member and absorber product therefrom |
| US7521109B2 (en) | 2002-04-05 | 2009-04-21 | Japan Absorbent Technology Institute | Absorber including by-pass channel member and absorber product therefrom |
| WO2015040684A1 (en) * | 2013-09-18 | 2015-03-26 | 株式会社日立製作所 | Reference electrode with thermometer function, lithium-ion secondary battery including reference electrode with thermometer function, lithium-ion secondary battery system including reference electrode with thermometer function, and lithium-ion secondary battery control method |
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