JPH0656649A - Bathing agent composition - Google Patents

Abstract

PURPOSE:To provide a bathing agent composition useful for improving the symptoms of atomic dermatitis, containing an inorganic salt, licorice extract powder and an oily component as active ingredients. CONSTITUTION:This bathing agent composition contains 10-95wt.% of an inorganic salt (e.g. sodium bicarbonate), 0.1-10wt.% of licorice extract powder and 0.1-20wt.% of an oily component which is liquid or pasty at normal temperatures (e.g. jojoba oil) as active ingredients. The composition may optionally be incorporated with a surfactant, polymers, organic salts, vitamins, enzymes, etc., and can be prepared in such forms as powder, granules, or tablets. Even general persons other than the patients with atopic dermatitis, this composition gives smooth touch in bathing and adequate humectant feeling after bathing. Also, as the fluidity of this composition in the form of powder is not impaired with time, there are no troubles in its production and the taking out of the bathing agent from the vessel is facilitated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath agent composition effective for ameliorating the symptoms of atopic dermatitis.

[0002]

2. Description of the Related Art Atopy is asthma,
Allergic rhinitis, familial tendency to develop eczema,
It is a type of allergy with characteristics such as hypersensitivity to foreign proteins, high reagin (IgE) level in serum, and eosinophilia in blood. There are several types of clinical features of atopic dermatitis, and the relationship between the form of skin rash and age is not strict, but it is said that there is a certain degree of correlation with age. What is common to skin eruptions is that they are chronic eczema and that they occur bilaterally and universally.

At present, there is no fundamental treatment method for this atopic dermatitis, and it is the present situation that it is unavoidable to rely on the internal use of external steroids and antipruritics. Since the disease of atopic dermatitis has a characteristic of being chronic eczema, it is necessary to continuously use these oral medications.
It is necessary to take internal medicine regularly. However, in practice, it is difficult to take the internal medicine regularly, and there is a problem that the internal medicine is irregularly taken. In addition, there is concern about side effects on body parts other than the diseased part due to the continuous action of the drug itself.

[0004] Therefore, in clinical skin findings of atopic dermatitis, many are dry type, and it is important to improve the dry state of the epidermis. Therefore, if a bath agent that improves the moisturizing ability of the skin is used, bathing is possible. By doing, the symptoms of atopic dermatitis can be improved and the burden on the patient can be removed. It has been desired to develop a bath agent composition having such a purpose.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to provide a bath agent composition which is effective against atopic dermatitis and which meets such a demand.

[0006]

Means for Solving the Problems As a result of intensive studies to obtain the above-mentioned bath agent, the present inventors have found that a bath agent composition containing inorganic salts, licorice extract powder and an oily component,
The inventors have found that the above problems can be solved and completed the present invention. That is, the present invention provides a bath agent composition containing inorganic salts, licorice extract powder, and an oily component which is liquid or paste-like at room temperature. Hereinafter, the present invention will be described in detail.

The inorganic salts used in the present invention include sodium sulfate, sodium hydrogencarbonate, sodium carbonate, sodium sesquicarbonate, sodium chloride, ammonium chloride, sodium nitrate, sodium polyphosphate,
Sodium phosphate, calcium oxide, calcium carbonate,
Magnesium oxide, magnesium sulfate, aluminum sulfate, magnesium carbonate, potassium chloride, potassium sulfide,
Potassium carbonate, alum and the like can be mentioned, and depending on the moisturizing ability of the salt, one kind alone or two or more kinds can be appropriately selected and blended. Of these, sodium hydrogen carbonate, sodium chloride, magnesium sulfate, sodium sulfate, sodium carbonate and sodium sesquicarbonate are preferable, and sodium hydrogen carbonate (sodium bicarbonate) is particularly preferable. The compounding ratio based on the total composition is 10 to 95% (weight), preferably 50 to 95% (weight).

Examples of the oily component used in the present invention include lanolin, liquid lanolin, jojoba oil, squalane, orange laffy oil, petrolatum, liquid paraffin, liquid isoparaffin, olive oil, macadamian nut oil and other natural oils, synthetic oils, silicones. And the like, which may be used alone or in combination of two or more. Also, among these, jojoba oil, squalane, orange ruffy oil,
Rosehip oil is preferred, and jojoba oil is particularly preferred. The compounding ratio to the total composition is 0.1-20%
(Weight), but preferably 1 to 10% (weight). If the blending ratio is too small, the smoothness at the time of bathing and the sufficient moisturizing effect on the skin after bathing cannot be obtained, and if it is too large, the skin becomes sticky, which is not preferable.

The crude drug powder used in the present invention is licorice extract powder, and the extract powder is dried, powdered licorice extract extracted with water, hot water, solvent or the like by a conventional method or the one obtained by further fractionation. It was obtained by converting. Mixing ratio of licorice extract powder to the total composition is 0.1-10%
(Weight), but preferably 0.5 to 10% (weight)
Is. If the compounding ratio is too small, the desired effect is not exhibited, and even if it is excessive, the effect corresponding to the increased amount cannot be expected to be improved.

As for the compounding ratio of the above oily ingredients, the amount of the oily ingredients is 0.005 times to 200 times that of the crude drug extract powder.
Double, preferably 0.2 to 10 times. Further, in addition to the above-mentioned components, surfactants, polymers, organic acids, vitamins, enzymes and the like can be added to the bath agent composition of the present invention, if necessary. Specific examples thereof are shown below.

Examples of the surfactant include sodium lauryl sulfate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene alkyl ether sulfate, lauric acid diethanolamide and polyoxyethylene glycol monostearate. Examples of the polymer include casein, polyethylene glycol, starch, polyvinyl alcohol, tragacanth, polyvinylpyrrolidone and the like.

Organic acids include succinic acid, malic acid, fumaric acid, tartaric acid and citric acid. Examples of vitamins include vitamins A, B, C, D and E. Enzymes include papain, pepsin, trypsin, ficin, pancreatin and the like. In addition, pigments, fragrances, fine powders for cosmetics and the like can be used.

Any mixer can be used as long as it is used for stirring and mixing powders.
Specific examples thereof include a Bad O mixer, a Nauta mixer, a universal mixer and a mixer, a ribbon mixer, and a V-shaped mixer. The mixing time may be any time required for uniformly mixing the components, and when the mixer described in the above example is used, it is usually 5 to 50 minutes. The dosage form of the present invention is not limited to powder, granules and tablets.

[0014]

[Function] Using a bath agent composition of the present invention for patients with atopic dermatitis, a bathing treatment method with continuous bathing for 4 weeks is carried out,
After 4 weeks from the start, clinical skin findings (skin itchiness, skin rash condition, skin dryness) and keratin water content were measured, and keratin water content increased compared to before bathing therapy was administered.
Clinical skin findings also showed good improvement effects on itching, skin rash, and dry skin. Further, since the bath agent composition of the present invention is impregnated with a liquid or paste-like oily component into other components, it is possible to prevent a decrease in fluidity due to the oily component during the production process, and the same effect This makes it possible to maintain a smooth fluidity during storage and use.

[0015]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

Example 1 Jojoba oil 10.0 was added to 83.4 parts by weight of sodium hydrogen carbonate.
After adding a mixture of 1 part by weight, 0.5 part by weight of perfume, and 0.1 part by weight of pigment, 6.0 parts by weight of licorice extract powder was added, and the mixture was stirred uniformly to obtain a desired bath preparation composition.

Example 2 A bath composition for atopic dermatitis having the following composition was produced in the same manner as in Example 1. This bath agent composition also has the same excellent effects as the bath agent composition of Example 1. Sodium chloride 89.4 parts by weight Squalane 6.0 parts by weight Licorice extract powder 4.0 parts by weight Fragrance 0.5 parts by weight Pigment 0.1 parts by weight

Example 3 In the same manner as in Example 1, a bath agent composition for atopic dermatitis having the following composition was produced. This bath agent composition also has the same excellent effects as the bath agent composition of Example 1. Magnesium sulfate 93.4 parts by weight Orange Raffy oil 4.0 parts by weight Licorice extract powder 2.0 parts by weight Fragrance 0.5 parts by weight Pigment 0.1 parts by weight

Example 4 A bath composition for atopic dermatitis having the following composition was produced in the same manner as in Example 1. This bath agent composition also has the same excellent effects as the bath agent composition of Example 1. Sodium sulfate 91.4 parts by weight Rosehip oil 5.0 parts by weight Licorice extract powder 3.0 parts by weight Fragrance 0.5 parts by weight Pigment 0.1 parts by weight

Example 5 (Efficacy test of the bath preparation composition of the present invention against atopic dermatitis) Twenty-one patients with atopic dermatitis were treated with 30 g of the bath preparation composition obtained in Example 1 in 200 liters of bath water. The solution was continuously bathed for 4 weeks by a method in which it was soaked in a bath water of 40 ° C. for 10 minutes. For each patient, a clinical examination and a degree of improvement of subjective symptoms are checked every 2 weeks using a medical inquiry sheet and a case card, and a doctor makes a judgment, and finally a comprehensive judgment is made in the 4th week for atopic dermatitis. The effectiveness was evaluated.

The results are shown in Tables 1, 2 and 3. As shown in Table 1, Table 2 and Table 3, when the bath agent composition of the present invention is used, the amount of keratin water is increased as compared with that before the bathing therapy is performed, and clinical skin findings include pruritus rash, skin rash, It can be seen that there is a good improving effect on dry skin.

Comparative Example 1 As Comparative Example 1, the same test as in Example 5 was conducted using a conventional bath agent composition having the following composition. The results are shown in Tables 4, 5, and 6. The number of panelists in Comparative Example 1 was 2
There were 0 people. Sodium sulfate 94.4 parts by weight Squalane 5.0 parts by weight Perfume 0.5 parts by weight Pigment 0.1 parts by weight

[0023]

[Table 1]

[0024]

[Table 2]

[0025]

[Table 3]

[0026]

[Table 4]

[0027]

[Table 5]

[0028]

[Table 6]

Example 6 (Powder fluidity and sensory evaluation of bath agent composition of the present invention) The fluidity of the bath agent composition obtained in Example 1 was measured by using a powder tester (manufactured by Horikawa Micron Co., Ltd.). Measure
When evaluated according to the following evaluation criteria, the result was ◯ (good fluidity). ○: Good fluidity △: Slight fluffing ×: Poor fluidity and fluffing or solidification

Next, 30 panelists conducted a sensory evaluation on the smoothness during bathing and the moisturizing sensation after bathing when the bath agent composition obtained in Example 1 was used in a bath water at a rate of 30 g / 200 liters. went. The evaluation criteria are as follows. ◯ ... Smoothness and moisturizing feeling are present. △ ... Neither can be said. × …… None The result was ◯.

[0031]

The bath composition of the present invention has the effect of improving the symptoms of atopic dermatitis. Further, even when used by a general person who is not a patient with atopic dermatitis, there is an effect that the feel during bathing is smooth and a sufficient moisturizing sensation is given after bathing. Furthermore, in the bath agent composition of the present invention, even if a large amount of an oily component is blended, the fluidity of the powder is not impaired over time, so there is no trouble during production, and it is also possible to take it out of the container. There is also an effect that it becomes easy.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Daisuke Seki 665-1 Anyobo, Toyama City, Toyama Prefecture (72) Inventor Masaaki Morohashi 64-59 Kureha Mizukami Town, Toyama City, Toyama Prefecture

Claims (3)

[Claims] 1. A bath agent composition comprising an inorganic salt, licorice extract powder, and an oily component which is liquid or paste-like at room temperature. 2. The bath agent composition according to claim 1, wherein the inorganic salt is sodium hydrogen carbonate. 3. The bath agent composition according to claim 1, wherein the oily component is jojoba oil.