JPH06501698A - Oral hygiene dispensing - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Oral hygiene dispensing The present invention relates to an oral hygiene preparation for controlling tartar formation, the preparation containing an effective amount of a physiologically acceptable medium containing a tartar formation inhibiting substance.

As is generally known, 40-95% of adults and even children The tartar that forms is a sign of periodontal disease, an inflammation of the gums and bones to which the teeth are attached. and plays an important role in the process. Tartar interferes with plaque removal and and interfere with the prevention and healing of periodontal disease. Removal of tartar significantly improves the health of periodontal tissues. Studies have shown that clinical periodontal Textbook of C1iC11nicalPeriodon For this reason, tartar formation cannot be inhibited. Research has been carried out on a wide scale to find reagents that can

Anti-calculus reagents that are currently in widespread use are pyrophosphates. however The main disadvantage of pyrophosphates is that they do not selectively inhibit tartar formation and do not inhibit tooth enamel. This is to counteract the remineralization of Mel. This is because the action of pyrophosphates causes crystal growth. (Fleiseh and Lasse) Russell, Journal of Dental Research (J, Den t, Res, ), 51 Appendix 2: 314-332.1972, Mandel del) et al., Compend, Contjn, Educ, Dent, Appendix 8:235-241.1987). Therefore, pyrophosphates are effective for this reason. It is even considered a caries-promoting agent (Ten Cate). and 18-11.9.1989, Abstracts (AI) 5traet), 10 4) For this reason, the general use of pyrophosphates in tooth brushing is a major obstacle. It suits me. For example, sodium fluoride, specific polymers, sodium monofluorophosphate Additives of all types and types such as Much research has been and is still being done to alleviate .

Surprisingly, calcium lactate, a compound that is very different from the pyrophosphates, Double salts of calcium phosphate, calcium lactate, and calcium lactate inhibit tartar formation. I found that it has some use.

The present invention therefore provides an effective amount of calcium lactate, calcium lactophosphate and / or a physiologically acceptable medium containing a double salt of calcium lactate. This invention relates to an oral hygiene preparation for controlling tartar formation.

Regarding the above, the action of calcium lactate as an anti-caries reagent has been demonstrated in animals. It is sufficiently pointed out that it is known as such from experiment. In these studies Calcium lactate was added to the diet of the test animals: McCulch + - (M cCulture) (J, Nutr,, 72.131-136.1960 ), Shrestha et al. (Caries Research) Re5), 16:12-17.1982), van der Haven (va der Hoeven) (Caries Res, ), 19:268-370.1985) and Lembke Pond ( l, St□l1ato1. ．． 85.251-261.1988) . All studies have shown that diets containing calcium lactate do not contain calcium. In the case of a control diet that does not contain caries (Caries Res, ), 16/12-17, (1982)) In vitro studies have shown that the addition of calcium lactate to feed can promote desalination, which promotes caries. It was shown that the demineralization of tooth enamel caused by aggressive foods was delayed. clinical In the standard desalination test, Brudevold et al. Res., 64.24-27 (1985)) shows that 5% by weight of calcium lactate is 1 If added to a 0% by weight sugar solution, relatively little demineralization of tooth enamel occurred. I also found it. The use of calcium lactate for oral administration as a cleaning solution can reduce plaque It has also been found to increase the Ca and P content in Van der Hoeven (Caries Research) ies Res, ), λdan: 146-150, (1989)).

The caries-inhibiting effect of calcium lactate shown above is probably due to the Ca and caries in dental plaque. This could be explained by the increase in P content. As a result, dental plaque The acid-buffering effect of P is increased to prevent the pH drop that causes caries (P CT Application PCT/DE88100778, Knappworst ), ZWR94: 490-496.1985). The tooth surface follows will not demineralize (desalinate).

Furthermore, demineralization of tooth enamel is suppressed by the so-called "common ion" effect (i.e., Brudevold et al., J. Dent, Res., Dan 1. 24-27.1985), Ca and phosphate ions in dental plaque are Estimated to inhibit the dissolution of complex calcium phosphate (namel, cement or dentin) be done.

Regarding the above, in particular, the anti-calculus effect of calcium lactate according to the present invention is due to the fact that P is Based on the increased Ca and P content in dental plaque, which is combined with the organic matrix, Tartar-promoting effects are evident (Ashley, Arehs 0r al Biol, 20 +167-170, 1975), :tL is dental calculus. Wachiite is mainly composed of calcium phosphates, such as calcium hydroxy apatite, phosphate Calcium, whitlockite, plushite and magnesium-containing triphosphate This is because it consists of calcium. The generated tartar is approximately 50% by weight of tartar. Contains Rushite. As tartar ages, the relatively complex calcium phosphate The content of bariums increases. Hydroxyapatite is the final stage of tartar formation (ma ffandel), colnpend, Contin, Edu, Dent, Suppl. 8: 235-241.1987).

The physical consistency of the oral hygiene preparation according to the invention may be fluid, gel-like or solid. I can do it. Examples of oral hygiene preparations include toothpaste, chewies, among others. gum and mouthwash. General information on the composition etc. of preparations of this type Book: Pader M., Oral Hygiene Products and Practice (Oral Hygiene Products and Practice) Hygine Products and Practice) J, 7-Se Le Detzker, New York, 1988.

Among the active substances according to the invention, calcium lactate is advantageously used.

In particular, calcium lactate is a virtually tasteless substance that is highly suitable for use in the oral cavity. be. Moreover, this last-mentioned compound is unquestionable from a pharmaceutical point of view. , and is already used for other pharmaceutical effects. Therefore, calcium lactate is used in calcium tablets for pregnant women.

Furthermore, research conducted by the applicant shows that calcium lactate is Naslundii, A., Odontolyticus, Streptococcus sandeis, Streptococcus mutans Has an adverse effect on streptococci, Cabnocytophaga sp. or Lactobalaras sp. It showed that there was no.

In addition to calcium lactate, calcium lactophosphate and calcium lactate double salts, For example, CaNa double salt lactate can also be used as a tartar formation-inhibiting substance in the preparations according to the invention. can be used.

The amount of active substance in an oral hygiene preparation may be within wide limits, e.g. based on the weight of the total preparation. It can be varied from 0.1% to 99%. Advantageously, based on the total weight of all preparations Amounts of 1-10% are used. On the other hand, the preparations according to the invention may include e.g. It can also have a solid consistency, such as in the form of di- or effervescent tablets, in which the active substance is The amount of is 1-99% based on the total weight of all preparations.

Preparations according to the invention are preferably made of sodium monofluorophosphate (MFP), such as sodium monofluorophosphate (MFP). The reason is that the area of action of the preparation is limited to this type of fluorine compound. This is because it is expanded by the compound. This type of fluorine compound is effective against demineralization. Acts as an additional strengthening agent for hard tooth tissues.

The fluorine compound is preferably present in a concentration of 0.1-1.0% based on the weight of the total preparation. There is.

Besides non-ionic fluorine compounds, e.g. triclosan 2 and chlorohexidine Gingivitis-inhibiting agents such as: Additionally, example Using common additives such as fragrances, numbering agents, coloring agents, preservatives and gelling agents, etc. It can also be used.

The invention will be explained in further detail in the following examples.

In order to suppress the formation of tartar and increase the content of Ca and P in dental plaque, the necessary amount of By dissolving calcium lactate in water, a solution containing 5% by weight of calcium lactate can be obtained. A calcium lactate solution was prepared. 20 test subjects participated in the clinical trial did. All subjects brushed their teeth daily with a commercially available fluoride-containing toothpaste. In the intersection setting, try Subjects were treated with human calcium solution for 12 weeks and water for 12 weeks. Suida. Between the two periods, there was a two-week interval in which the teeth were not rinsed. of each exam period At the beginning, teeth were brushed to remove plaque and tartar. During the experiment, this period is routinely Maintained good oral hygiene. In addition, when you specify the mouth 3 times a day +9.00.13.00 and washed with calcium lactate solution at 2200 hours. Brush your teeth before rinsing I always did this. Rinsing was performed for 20 seconds using approximately 10 ml of mouthwash.

The amount of tartar was measured by two testers working independently of each other, before the experiment and after each experimental period. It was measured by The amount of tartar was measured in the cervical region of the four lower incisors (see Schaeken et al., Caries Research, ), 1990, in press). Tartar preferentially forms at this location. clinical measurements Later, dental plaque was collected from each test person and the Ca and P contents of the samples were determined. It was measured. The calculus scale is shown in Table A. Dental calculus formation in the area (mean ± SD, n = 18 people per group) Baseline 4.7 ± 4 ．． 6 Water 4.6±4.3 Calcium lactate 2.9±3,4** Zero reference line: At the start of the test just before brushing teeth Hayashi = P < 0.05, paired t test On all surfaces measured, the calculus scale was lower than that at the beginning of the test in the calcium lactate group. (baseline) or lower after rinsing with water.

The solids content and Ca and P concentrations of the dental plaque samples are shown in Table B.

expression Solids content (mg) in dental plaque and calcium and Biphosphate content (μg/mg solids) (mean ± SD, n = 36 individuals per group) Solid content Calcium phosphate (P) (μg/mg) (μg/mg) Reference line 1.50±0.10A Zero 10.8±1.7A 5.1t0.5A Water 1 ．． 39±0.108 8.6±0.9＾ 3.9±0.3＾Ca lactic acid 1.56 ±0.16＾　24.6±3.1B　8.6±1゜08 average with the same characters The values are not significantly different (Tsuki test) when water contains calcium lactate. After rinsing with water, the Ca and P concentrations are at baseline or after rinsing with water. It was much higher than after.

Example II The use of calcium lactate in tooth brushing to inhibit tartar formation is shown in Table C. Three types of toothpaste with compositions that are generally accepted according to GMP Manufacturing Practices) der) M, r Oral Hygiene Products and Practice (Oral Hygiene Pr products and Practice) J, v-cell φ decker, new York, 1988).

Table C Composition of experimental toothpaste, grams per kilogram for control Ca lactic acid Ca lactic acid/ Sodium lauryl lactate Glycerol 85% * 130: t20 120 carboxymethyl Cellulose, medium viscosity 30 30 30 Na benzoate 6 6 6 Sodium monofluorophosphate 1 1] Water 482 422 412 CaHP04.2HzO350350350 Honey oil 1ml 1ml 1ml Calcium lactate, 5H20--7070 Na lauryl sulfate---10 85% wt solution in H20 , 5% calcium lactate (considered an anhydrous product) and If so, brush your teeth using a toothpaste containing 1% sodium lauryl sulfate. Ta. The experimental period was three months. Set the experimental scale at the beginning and end of the experimental period. Recorded using the VM tartar index (Volpe et al., periodontitis). Periodontics, 5:184-193.1967). test At the beginning of the test, each person's teeth were thoroughly brushed to remove plaque and tartar. The dental calculus scale is It is shown in the table.

appearance Tartar on the lingual surface of the lower incisors after use of control toothpaste and calcium lactate toothpaste Generation (VM tartar index) Baseline 3 months % decrease For control 1.56 (2,50) 1.33 (2,15) 15 calcium lactate 1.12 (1,99) 0.75 (0,99) 33*Calcium lactate/1. 19 (1,56) 0.72 (0,83) 39 Sodium lauryl sulfate The two lactic acids were significantly different from the control group (P<0.05, paired t test). The amount of tartar in the lucium group was reduced much more than in the control group.

Copy and translation of written amendment) Submission (Article 184-8 of the Patent Law) April 7, 1993

Claims (8)

[Claims] 1. Effective amount of calcium lactate, calcium lactophosphate and/or lactic acid inside containing a physiologically acceptable medium into which a double salt of calcium is introduced; Oral hygiene preparations to control tartar formation. 2. The preparation contains calcium lactate, calcium lactate and/or calcium lactate. containing the double salts of Mu, in an amount of 0.1-99%, based on the total weight of the preparation. Preparation according to claim 1, characterized in that: 3. The preparation contains calcium lactate, calcium lactate and/or calcium lactate. 1-10% of the total weight of the preparation. A preparation as claimed in claim 2. 4. Claims 1-3, characterized in that the preparation contains calcium lactate. Preparations described in paragraph 1 or above. 5. The preparation may contain calcium sodium lactate as a double salt of calcium lactate. Preparation according to one or more of claims 1-3, characterized in that: 6. Claim 1 characterized in that the preparation also contains a non-ionic fluorine compound - Preparations as described in one or more of paragraphs 5. 7. If the preparation contains sodium monofluorophosphate as a non-ionic fluorine compound, 7. Preparation according to claim 6, characterized in that: 8. The preparation contains 0.1-10% fluorine compounds, based on the total weight of the preparation. Preparation according to claim 6 or 7, characterized in that: