JPH06501402A - Apparatus and method for disinfection of contact lenses and detection of oxidizing disinfectants - Google Patents

Abstract

An apparatus and method useful for disinfecting a contact lens are disclosed. The apparatus includes a color indicator element comprising a redox polymer containing a repeating unit which has a stable oxidized state and a stable reduced state. This color indicator element provides a color indication of the presence of the oxidative disinfectant, e.g., hydrogen peroxide, in the liquid medium.

Description

[Detailed description of the invention] Basketball for holding contact lenses in liquid medium within cup means, 7-piece Dan: and providing a first color indication indicating the presence of an oxidizing contact lens disinfectant in the liquid medium; at least partially in the liquid medium within the cup means for serving. A method of color indicator that shows stable oxidation state and stable reduction state. Repeat unit with original state (repeat unit is cationic in stable oxidation state) So, chatter, unit of nium and quinrylene groups). A device comprising:

23 One means of color indicator is an oxidizing quencher for contact lenses in a liquid medium. Claims that can provide another color indication to indicate the substantial absence of a toxic agent 23. The device according to 22.

24 A method for disinfecting contact lenses, which involves contact lenses to be disinfected and acid. contact lenses with a disinfectant-containing liquid medium under conditions that effectively disinfect contact lenses. This contact is effective in providing a color indication of the presence of oxidizing disinfectant in the liquid medium. Redox having a repeating unit with a stable oxidation state and a stable reduction state in an amount of a method comprising carrying out in the presence of a copolymer.

25. The method of claim 24, wherein the repeating Tosa is cationic in its oxidized state.

26. The method of claim 24, wherein the oxidizing disinfectant is hydrogen peroxide.

27 The repeating unit is a repeating unit containing bipyrinonium Tosa in the cationic oxidation state. The method according to claim 24.

28. The method of claim 24, wherein the redox polymer is oxidized during the contacting.

29 Oxidizing disinfectant may be separated to provide a liquid medium substantially free of oxidizing disinfectant. 25. The method of claim 24, further comprising: decoding.

30. The decomposition step consists of substantially oxidizing disinfectant in a liquid medium substantially free of oxidizing disinfectant. Redo in the reduced state is effective in providing different color indications to indicate the absence of 30. The method of claim 29, which also serves to provide a base polymer.

31. An effective amount of the reducing component decomposes to provide the redox polymer in a reduced state. 30. The method of claim 29, wherein the method is present during the step.

32. Liquid medium substantially free of oxidizing disinfectant and redox polymer in reduced state The peroxidase component is present during the degradation process in an amount effective to provide The method according to claim 29.

33 The redox polymer in the reduced state is a liquid medium substantially free of oxidizing disinfectants. to provide different color indications to indicate the substantial absence of oxidizing disinfectant in the 33. The method of claim 32, which is effective.

34. The redox polymer of claim 24, wherein the redox polymer is substantially insoluble in the liquid medium. Method.

35. The redox polymer according to claim 24, wherein the redox polymer is substantially soluble in the liquid medium. Method.

36. The redox polymer is combined with a matrix material that is substantially insoluble in the liquid medium. 25. The method of claim 24.

37. The redox polymer is combined with a cation exchange resin that is substantially insoluble in the liquid medium. 36. The method of claim 35.

38. A contact lens disinfection method, which involves contact lenses to be disinfected and contact lenses with an aqueous liquid medium containing hydrogen oxide under conditions that effectively disinfect contact lenses. contact, and this contact results in a repeating unit having a stable oxidation state and a stable reduction state. (The repeating unit is cationic in stable oxidation state, bipyridinium unit and a redox polymer containing quinrylene groups), Redox polymers have a primary color indicator that indicates the presence of hydrogen peroxide in an aqueous liquid medium. is present in an oxidized state during this contact, and then the aqueous liquid The carrier and the hydrogen peroxide decomposition component are brought into contact, and the hydrogen peroxide decomposition component is dissolved in an aqueous liquid medium. A redox polymer that decomposes virtually all hydrogen peroxide in the body and is in a reduced state. A first method that demonstrates the substantial absence of hydrogen peroxide in an aqueous liquid medium by providing present in an amount effective to provide a color indication of 2.

Specification - Apparatus and method for disinfection of contact lenses and detection of oxidizing disinfectants background The present invention relates to devices and methods useful for disinfecting contact lenses. The present invention In particular, the presence, and preferably the substantial absence, of an oxidizing disinfectant The present invention relates to the apparatus and method for instructing. Contact lens users should wear contact lenses. Preventing infections or other adverse effects on eye health that may be associated with wearing lenses Therefore, contact lenses should be disinfected regularly. I am currently using it outside of wearing hours. There are several different systems and methods by which users can disinfect contact lenses. There is a law. Such conventional cleaning and disinfection systems use "hot J and" It can be classified as a cold system. For high temperature systems, contact lenses Requires the use of heat for disinfection; cryogenic systems require the use of heat at ambient temperature to disinfect the lens. Use chemical disinfectants.

Within the range of low-temperature disinfection systems are disinfection systems based on oxidizing disinfectants (particularly hydrogen peroxide). Ru. Disinfecting hydrogen peroxide solution eliminates bacteria and fungi that can contaminate contact lenses. Effective for sterilization. However, hydrogen peroxide remaining on disinfected contact lenses may be harmful to the eye unless removed, i.e., decomposed, neutralized, inactivated or chemically reduced. may cause irritation, burning or other trauma. Therefore, disinfected contact lenses In order to ensure safe and comfortable wearing of contact lenses, it is necessary to insert disinfected contact lenses. It is necessary to remove residual hydrogen peroxide in the liquid medium.

Prevents eye trauma caused by oxidizing disinfectants present on or within the lens. It would be advantageous if the presence of an oxidizing disinfectant could be indicated to avoid this. Furthermore, oxidative disinfection disinfected lenses, e.g. It would be advantageous if it were found to be safe even when injected into the eyes.

Effectively disinfect contact lenses and indicate the presence of oxidizing disinfectant to remove disinfected lenses. Contact lens care systems that enable safe and comfortable wearing of lenses remain essential. It is essential.

A novel device and method for disinfecting and preferably cleaning contact lenses I found it. The system of the invention uses an oxidizing disinfectant (particularly hydrogen peroxide) in the lens disinfecting medium. ) provides a clear, positive indication of the existence of This instruction is for lens users , warns against putting lenses in the eye that have been removed from media containing oxidizing disinfectants.

Importantly, the means to provide this instruction will allow the decomposition of residual oxidizing disinfectants to is safe (preferably useful) when used alone (e.g. catalase); It is said that it does not interfere with disinfection and does not have any substantial harmful effects on the lenses being disinfected. That's true. Furthermore, the indicator of the present invention can be used multiple times. is preferable (i.e., an economical method for improving the safety of contact lens disinfection). ).

The present invention broadly includes a cup means and a color indicator means. This invention relates to a device useful for disinfecting contact lenses. Cup means contact Contains a liquid medium containing an oxidizing lens disinfectant (particularly hydrogen peroxide) be. The color indicator means that the liquid medium at least partially within the cup The presence of an oxidizing disinfectant for contact lenses in a liquid medium adjusted to be located in It provides color instructions. One means of color indicator is stable oxidation contains redox polymers with repeating units that have a stable reduced state and a stable reduced state. It consists of

The present invention also broadly provides a method of disinfecting contact lenses. This person The law requires contact lenses to be disinfected under conditions that effectively disinfect contact lenses. contact with a liquid medium containing an oxidizing disinfectant (particularly hydrogen peroxide). consists of This contact indicates the presence of oxidizing disinfectant in the liquid medium by color in the presence of an effective amount of a redox polymer (as described herein).

Detailed description of the invention The present invention requires periodic disinfection using an oxidizing disinfectant (particularly hydrogen peroxide). is useful when disinfecting any lenses (e.g. contact lenses). be. Such lenses, such as conventional contact lenses, especially soft contact lenses, Tact lenses are suitable for use with any suitable disinfectant that is not substantially adversely affected by oxidizing disinfectants. may be manufactured from any suitable material or combination of materials; It may have a shape.

Oxidative disinfection that can effectively disinfect contact lenses and oxidize redox polymers Although any of the oxidizing disinfectants can be used, a particularly preferred oxidizing disinfectant is hydrogen peroxide, especially It is an aqueous solution containing hydrogen peroxide.

The lens disinfection device of the present invention comprises a cup means, preferably a substantially transparent cup means. , and a color indicator.

The cup means is operative to receive a liquid medium containing an oxidizing contact lens disinfectant. has. Such cup means are resistant to the action of oxidizing disinfectants and are Any suitable material that does not have a substantially deleterious effect on the poisoning lens (e.g. glass, polymeric materials, etc.). Useful construction materials Examples include polymethyl methacrylate, polysulfone, acrylonitrile/butylene Examples include gen/styrene terpolymer and polyphenylene oxide. preferably The cup means or or a portion thereof is substantially transparent.

The color indicator means is at least partially associated with the liquid medium within the cup means. In the middle! Tone like that! do. One means of color indicator is the color of the liquid in the liquid medium. Color indication indicating the presence of an oxidizing disinfectant for contact lenses, and preferably in a liquid medium A different color indication indicating the substantial absence of oxidizing disinfectant (more preferably a contact while the lens is in the liquid medium). color index One means for the quantifier includes repeating units having a stable oxidation state and a stable reduction state. comprising a redox polymer having Such redox polymers It may be soluble or substantially insoluble in the liquid medium in which it is used. useful one In embodiments, the redox polymer itself has a high solubility in the liquid medium. However, it can be combined with a matrix material that is substantially insoluble in the liquid medium (e.g., a cationic exchanger). (e.g. by bonding, gluing or bonding). ) to form a color indicator composite material that is substantially insoluble in the liquid medium.

In any case, such redox polymers add substantially It is preferred that penetration or otherwise not be substantially affected.

Redox polymers useful in the present invention function as described herein. can be selected from available redox polymers. As used herein, "redox polymer" is a material having multiple repeating units, each repeating unit being oxidized and/or or reduce, preferably one or more moieties capable of being reversibly oxidized and reduced. means the material having above. Redox polymers are for example ion exchange or other Directly from the polymerization process rather than by ion addition or conjugation or post-polymerization steps It is preferable to induce In other words, redox polymers useful in the present invention The redox properties of polymers are important to the nature of the polymer rather than being added to it after it has been formed. It is preferable that the property is The redox polymer of the present invention is substantially metallic. It can be free of certain metals (particularly transition metals), e.g. impregnated, ionized. exchanged, combined and/or otherwise incorporated into one or more polymers. can impart useful properties. For example, metal-containing ions may themselves have different oxidation states and The metal-containing ions are combined with the useful redox polymers of the present invention because they change color and color. In combination, a clear color indication of the presence and/or substantial absence of an oxidizing disinfectant provision can be promoted. When using such metal-containing ions, Such ions leave the redox polymer and contaminate the lens being processed. Care should be taken to avoid this possibility.

- In embodiments, the repeating units of useful redox polymers are cationic in the oxidized state. It is on-type. Redox polymers can be oxidized by oxidizing disinfectants in liquid media. (i.e., can oxidize the repeating units of the redox polymer to the oxidized state) is preferable.

Any suitable redox polymer may be used, but the repeating units in the oxidized state is bipyridinium unit Preferred are polymers containing. In particular, the included bipyridinium units have the following structure: Has a structure: Preferably, such repeating units further include a xylylene group. like that Polymers may be soluble or insoluble and are described by F actor et al. No. 3,694,384, which is described in more detail and incorporated herein by reference in its entirety. shall be incorporated herein by reference.

Polymers such as those mentioned above are quinrylene nolide (commonly quinrylene chloride or quinrylene chloride). is easily synthesized by reacting quinrylene bromide) with bipyridyl. Can be done. Xylylene halide is 0-1■- or p-xylylene halide. It may be any of the three isomers.

The reaction between quinrylene civalide and dipyridyl proceeds at room temperature. This reaction is It is convenient to carry out in a solvent which dissolves the reactants but not the polymer.

The specific solvent used is not critical, but acetonitrile is a convenient solvent. It is. Other solvents can of course also be used. Acetonitrile is a non-reactive agent for reactants. Always a good solvent, the polymer precipitates and is recovered by filtration of the reaction mixture be able to. Since there are no other products, the filtrate does not need to be purified (used in the next reaction). Can be used as a solvent. The polymer synthesized in this way is a polysalt. Yes, the anion is xy1lungino\lide used for polymer synthesis)\ It is a halide anion corresponding to a ride, and the cation is, for example, It is a bilinonium cation.

The synthesized polymers are in oxidized form and are soluble in water and various aqueous media. It dissolves easily to form a colorless solution, but is yellow in solid state. like that A reducing agent such as sodium dithionite or zinc powder is added to the aqueous solution containing the polymer. When added, a deep to blue-purple color occurs depending on the concentration of the polymer. reduced cation In the polymeric form, the polymer has repeating units of the formula Since it is a leaving group, formula D1. The resonance structure conveniently indicated by A and I[IH It is recognized that With a strong reducing agent, such as sodium metal, the formula Complete reduction can occur to a red, dynamic polymer with repeating units of Ru.

The aqueous solution containing the reduced polymer of formula ■ or ■ is shaken in the presence of air. Then, the polymer is oxidized and returns to a form with the following nest positions, rapidly Bleaching: If it is desired that the polymer is not water soluble, two methods can be used. Wear. In one method, some or all of the quinolyl halide is Replace with (halomethyl)benzene, e.g. mesityltrino\lide. this In this case, crosslinking occurs due to the trifunctionality of the trihalo compound. the other one method is a completely different method of polymer synthesis. In this method, xylylene dino-1ride is reacted with 4-cyanopyrinone. Forms the 4-sene anopyrinnium salt. This salt, sodium dithionite Reduction with a reducing agent such as formula II [A and IfB having repeating units] Synthesize a polymer that Some cross-linking seems to occur, and the polymer is not water-soluble. A side reaction occurs.

Other redox polymers that may be used are ruthenium-containing vinyl-substituted pyridine polyesters. polymer, vinyl ferrocene polymer, vinyl pyridinium polymer, vinyl pyridinium polymer, vinyl ferrocene polymer, vinyl pyridinium polymer, vinyl pyridinium polymer, polymers derived from Nium derivatives, and mixtures thereof.

If the redox polymer itself has substantial solubility in the liquid medium, A substantially soluble redox polymer such as a substantially insoluble matrix in a liquid medium. in combination with a redox material to keep the redox polymer in a separate phase from the liquid medium It is preferable to do so. This means that the redox polymer can be in both oxidized and reduced states. Especially if it is a charged species in either state, it is cationic or It is particularly useful when it is anionic or anionic. For example, the bipyridinium unit The polymer is cationic in both oxidized and reduced states. Ru. Soluble cationic polymers, e.g. polymers with bipyridinium units , coupled to conventional water-insoluble cation exchange resins using conventional ion exchange methods, e.g. can do. Such water-insoluble cation exchange resins are cationic and Exchange the Sox polymer with cations on the resin to create a cationic redox bonded to the resin. The lens has the ability to retain the polymer during contact lens disinfection. In this specification has the functions described in , and has a substantially adverse effect on lens disinfection or the lens to be disinfected. Any suitable cation exchange resin may be used as long as it does not have any adverse effects.

Useful cation exchange resins include anionic groups, especially acid groups, preferably Select from sulfonic acid group, phosphonic acid group, phosphinic acid group, carboxylic acid group, etc. Substantially water-insoluble organic polymeric materials having acid groups, and mixtures thereof are mentioned. can be lost.

Examples of cation exchange resins useful in the present invention include cross-linked polystyrene, cross-linked tyrene/divinylbenzene copolymers, insoluble perfluoropolymers [e.g. - I DuPont de Nemours & Company (E, 1. duPo ntde Nemours & Co.) to Nafion (Namours & Co.) Products commercially available under the names of Examples include tyrene, crosslinked polyacrylic acid, etc., and mixtures thereof. those Of course, the resin may be appropriately substituted or modified to make it an effective cation exchange resin. (e.g. by acid groups as described above). Insoluble redox polymers and redox The insoluble matrix material carrying the xpolymer preferably has sufficient porosity. or have transparency. Thereby, oxidative disinfection in liquid media (in particular in liquid media) agents) and redox polymers (e.g. color indicators) away from the outer surface of the means. (located on the inside of the The color indication provided can be visually observed.

A color indicator is used to disinfect contact lenses during use. placed in a liquid medium. That is, one color indicator means is a cup means. (i.e. the space containing the liquid medium inside the cup means), be adjustable to move freely in the liquid medium within the cup means, or It can be a component.

For example, if the color indicator means is fixed inside the cup means, the color - The indicator means may be a strip or other material adhesively or otherwise secured to the cup means. or other pieces of material. Color indicator means cup means separately, e.g. in the form of a disc or tablet or a plurality of particles. could be. - In embodiments, the color indicator is in the form of small particles. If the holding means, e.g. a screen element or an ion-permeable membrane, The cup means is provided within a stage to hold the particles in place and allow the liquid medium within the cup means to freely absorb the particles. You can make contact with.

The color indicator means may be a component of the cup means. That is, For example, the cup means may at least partially serve as a color indicator. It can be manufactured from the materials used. In one particularly useful embodiment, manufacturing the cup means The materials and color indicators used for the redox polymer and the physical and processed (e.g., molded) to form the cup means.

The device of the invention comprises a bath for holding a contact lens in a liquid medium within a cup means. Preferably, the device further includes a cage means. Basketball Color Indicator Means The basket means may be fixed to the basket means or may be a component of the basket means. bus The cup means may be made of the same or different material used in the manufacture of the cup means. can be built. The basket means may be substantially opaque rather than transparent. preferable.

The cup means may have a removable cover. The cover is used in the manufacture of cup means. It may be made of the same or different material used and need not be transparent.

In the present invention, the liquid medium used to disinfect contact lenses has a disinfecting amount of oxidation Preferably it contains a poisonous agent, especially hydrogen peroxide. Preferably an oxidizing disinfectant The disinfection amount means the amount that reduces the amount of microorganisms by 1 log in 3 hours. even more Preferably, the hydrogen peroxide concentration reduces the microbial load by an order of llog per hour. This is the concentration to lower. Reduces microbial load by llog units in 10 minutes or less Particularly preferred are hydrogen peroxide concentrations. Aqueous hydrogen peroxide solution, preferably hydrogen peroxide Aqueous solutions containing about 0.2% or about 0.5% to about 6% (W/V) are It is known to be an effective disinfectant solution for lenses. Such a solution is Effective in killing bacteria or fungi that may be present in contact lenses. Usually liquid The amount of hydrogen peroxide used in the medium is the amount required to effectively poison contact lenses with I'I4. is the fourth remainder than the quantity. Lens disinfection can be completed within a reasonable time Use a substantial excess of hydrogen peroxide as needed.

The liquid medium used has no substantial adverse effect on the lenses being treated and is compatible with the lenses of the present invention. Select one that enables (and preferably facilitates) lens processing. Liquid media are preferred Preferably, it is water-based. Particularly useful aqueous liquid media include saline solutions, e.g. Induced from liquid. During disinfection contact, the pH of the aqueous liquid medium is preferably between about 3 and 9, and so on. It is preferably about 6 to 8. A liquid medium, e.g. an aqueous liquid medium, has a p It is preferred to contain an amount of buffering agent effective to maintain H in the predetermined range. buffering agent may be present in and/or introduced into the liquid medium. can be used Suitable buffering agents are commonly used in contact lens care products! 1 Contains buffering agent do. Examples of useful buffers include carbonate-functional, bicarbonate-functional, and carbonate-functional. Buffers with sphate functionality, porate functionality, etc. and mixtures thereof include. Buffers include alkali metal salts and alkaline earth metal salts, especially sodium can be lium and potassium salts.

- In an embodiment, an oxidative disinfectant decomposition component (oxidative disinfectant decomposition component) ctant destroying component: Hereinafter referred to as ○DDC ) into a solid composition (e.g. tablet, capsule, one or more solid particles) etc.). This solid composition introduces the lens to be disinfected into a liquid medium. is preferably introduced into the liquid medium at about the same time. Such a solid composition is , one or more ○DDCs are removed from the oxidized material remaining in the liquid medium after lens disinfection. Decomposes all disinfectant and preferably color indicator based redox Contains an amount effective to reduce the polymer to a reduced state. In some cases, A redox polymer as an indicator of oxidizing disinfectants in a liquid medium May act to promote degradation.

That is, a preferred solid composition as described above (substantially simultaneously with the lens to be disinfected) , preferably begins contact with an oxidizing disinfectant-containing liquid medium) is an effective lens Disinfection and also effective separation of residual oxidizing disinfectants in liquid media containing oxidizing disinfectants. remove the disinfected lens from the liquid medium and place it directly in the eye to safely store it. Can be worn completely and comfortably. Such a composition may be used as a color indicator. Although it is preferable to also carry out reduction of the redox polymer to a reduced state, such In some cases, substantially no oxidizing disinfectant is present while the contact lens is in the liquid medium. A second color indication is provided to indicate the absence and the lens can be removed from the liquid medium and disinfected. This will more reliably demonstrate to the user the safety of wearing the lens. the Preferred compositions such as or larger solid particles); such solids may be coated with a core, such as a core tablet, and a barrier component. coated The part containing ○DDC. The barrier component is transferred from the coated area to the liquid medium. to delay the release of 0DDC for a period of time, preferably a period sufficient for lens disinfection. It works. Preferably, the barrier coating substantially envelops the portion being coated. surround

The systems of the present invention, disinfected lenses, and disinfectant amounts have a substantially negative effect on lens wearers. Any suitable 0DDC may be used as long as it does not affect helpful ○DDC includes oxidizing disinfectant reducing agent, peroxidase (including catalase) and mixtures thereof. One important advantage of the system of the present invention is that the oxidative quenching If peroxidase is used to degrade poisonous agents, peroxidase becomes a redox molecule. There is no need to use other reducing agents as it also reduces reamers. It is. In some other redox systems, the peroxidase used is a reducing virtually ineffective in providing redox materials in the state. In such a system, A major disadvantage is that a separate reducing agent must be used.

Examples of oxidizing disinfectant reducing agents useful in the present invention include alkali metals, especially thiosulfate of sodium), thiourea, alkali metals (especially sodium) Sulphites, thioglycerols, formates of alkali gold IE (especially sodium) , pyrupic acid and pyruvate, N-acetylcysteine, ene-diolation compounds, such as ascorbic acid compounds, reductin acid compounds, isoascorbic acid Compounds, glyoxylic acid compounds, squaric acid compounds, dihydroxymaleic oxidation compounds, dihydroxy/fumaric acid compounds and mixtures thereof. The engine Examples of all-compounds are such acids themselves (e.g. ascorbic acid), such Ophthalmically acceptable salts of uric acid (e.g. sodium ascorbate), such ophthalmically acceptable esters of uric acid (e.g. ascorbyl palmitate), and other ophthalmically acceptable derivatives of such acids (e.g. (that maintains the molecular structure), and mixtures thereof. Particularly useful peroxy Dase is catalase. Peroxidase, especially catalase, is a liquid About 1 minute to 12 hours, preferably about 5 minutes to 1 hour after initiation of release into the medium Substantially removes hydrogen peroxide from the liquid medium in a reasonable amount of time, such as on the order of It is very useful in the present invention.

The amount of 0DDC used is such that it eliminates all the oxidizing disinfectant present in the liquid medium into which it is introduced. sufficient to decompose and preferably reduce the redox polymer to a reduced state. Preferably, the amount is ODDC may be used in excess. Especially over 0DDC. If used in excess, ODDC itself may compromise the safety of disinfected lenses and/or their wear. Such should be avoided as it may cause safety and comfort problems.

When catalase is used as part of 0DDC, preferably about 100-100 Q, more preferably about 150-700 catalase activity units/rnl of liquid medium Use with. For example, in an aqueous solution containing about 3% cW of hydrogen peroxide, If catalase is used, use it in an amount of approximately 520 catalase activity units/ml solution. It is particularly effective to do so.

Delayed release of 0DDC into a liquid medium can be achieved by a number of suitable methods, many of which are conventional. This can be accomplished by any of the methods well known in the art. For example, Bali a component (e.g. a coating), which includes 0DDC. core tablets or other particles with expelled degradable coating material (finally completely, or only partially soluble in the liquid medium) or 0D Incorporating DCs into a matrix (from which ODDCs can be gradually leached) done by. The matrix can also be coated with an expulsion-degradable material for sustained release. The start may be delayed. The delayed release form of 0DDC means that there is no substantial release during the delay time. If no release occurs and at the end of the delay period, substantially all of the ODDC is released in a short period of time. It is preferable that the Coating the 0DDC with an expulsion-repellent coating Such a result can be obtained depending on the following.

Barrier components suitable as coatings or matrices include water-soluble vinyl polyesters. polymers such as polyvinylpyrrolidone, polyvinyl alcohol and polyethylene Glycols: water-soluble proteins, polysaccharides and cellulose derivatives, e.g. Methyl cellulose, hydroxypropyl methyl cellulose, sodium carbo oxymethylcellulose; alginic acid, its salts and other derivatives, etc.; It includes a mixture of these. Mixtures of the above materials may be used.

If the barrier component functions as described herein, the amount of barrier component used will be Not important to the invention. The barrier component is approximately 1 to 20% by weight of 0DDC. % or more may be appropriate.

Solid compositions can be prepared in a number of suitable ways, many of which are conventional and well-known in the art. It can be manufactured using any of the following methods.

The solid composition may contain other ingredients such as excipients, binders, tonicity agents, contact lenses, etc. It may contain conditioning/wetting agents, buffering agents, lubricants, etc. If you use them, it Each can be used in an effective amount to achieve the desired function. Examples of such various ingredients are: Conventional and known to those skilled in the art. Therefore, details about these ingredients are No detailed explanation will be given.

In a particularly useful embodiment, the contact lens is cleaned of dirt from the contact lens. It may be subjected to the action of at least one enzyme effective for removal. during normal use. The types of stains that occur on contact lenses include protein-containing stains and mucin-containing stains. There are lipid-containing stains and carbohydrate-containing stains. one or more types of Stain can be present on one contact lens.

The enzyme used is peroxide, which is traditionally used for enzymatic cleaning of contact lenses. may be selected from physically active enzymes. For example, U.S. Reissue Patent No. 3 of Huth et al. No. 2672 and Karageozian et al. Many of the enzymes disclosed in No. 3,910,296 are useful in the present invention.

These patents are incorporated by reference in their entirety. Useful enzymes include Ta There are selections from proteolytic enzymes, lipases and mixtures thereof.

Preferred proteolytic enzymes include sulfhydryl groups or disulfide bonds. It is an enzyme that has virtually no substances (which can react with the active oxygen of poisonous agents and impair enzyme activity). Ru. 2IilIi metal ions such as Cal7ium, Magne/Rum or Zinc. Metalloproteases bound to proteins may also be used.

A more preferred group of proteolytic enzymes are serine proteases, especially Obtained from fungi of the genera Kebacillus, Streptomyces and Ascorbillus. It is. The more preferred enzymes from this group are commonly referred to as subtilinone enzymes. It is an alkaline protease. Deayl, L. Moser, P. W. and Wildy, B. ・Varnish (Wildi.

B, S,), -Broteases of the Nnas Bacillus ■Alcalai Proteases of the Genus Bac illus, U, to1kalineP roteases>j, biotech Bio-technology and B ioengineering), Volume ■, pp. 213-249 (19 70), Nnoninoyon of Alkaline Proteases Form Ba Chirs Speens (Djfferentiation of Alkali ne Proteases form Bacillus Species) 2, Biochemical and Biofinical Research Communications (Biochemical and Biophysical Re5earc h Com11. ), Vol. 34, No. 5, pp. 600-604 (1969) Sansho.

Subtilinone enzymes are divided into two subclasses: subtilisin A and subtilinone It is classified as ricin B. The enzyme subtilinone is produced by Bacillus subtilis (B , 5ubtilis), Bacillus licheniformis (B. licheni) species such as B. formis) and B. pumilis obtained from. This subclass of bacteria produces little or no neutral protease or amylase. Little or no production. Subtilisin B subclass is Bacillus subtilis Squirrel, Bacillus subtilis amylosalacalyticus (B, 5ubtilis) var, amylosacchariticus), Bacillus amylolique B. amyloliquefaciens and Bacillus bacterium It consists of enzymes obtained from bacteria such as S. subtilis NRRLB3411. these Microorganisms produce neutral proteases at levels roughly comparable to alkaline protease production. It also produces amylase and amylase. Subtilisin, one species belonging to subclass He or more enzymes are particularly useful.

Still other preferred enzymes include pancreatin, trypsin, collagenase, Keratinase, carbokinlase, aminopeptidase, elastase, asbe lugirobebutidase A and B, pronase E [Streptomyces griseus (S, obtained from Bacillus griseus)] and dispase [obtained from Bacillus poly It is obtained from Bacillus polymyxa.

When such enzymes are used, they are preferably used in effective amounts. like that The amount refers to at least one type of stain due to normal wear, for an appropriate period of time (e.g. overnight). This is the amount that is substantially all removed from the lens. This standard is based on lens dirt accumulation patterns. Concerning contact lens wearers with a normal course The dirt deposition rate was so high that cleaning every 3 days was preferable. This does not apply to a very small number of people.

The amount of enzyme required to produce an effective leaner depends on the enzyme's inherent activity and the amount of enzyme present. It is determined by several factors including its degree of interaction with hydrogen peroxide.

As a basic rule, the working solution should be approximately 0,000 oz to 3 a Anson units, preferably fishing 01 to 1 Anson units of activity are obtained. It should contain enough enzyme to more or less enzymes may be used.

Enzyme activity is pH dependent, and some enzymes have specific pH values at which they function best. There is a range. The range can be easily determined by known methods.

The solid composition containing lens cleaning enzymes as described above is suitable for the release of enzymes in a liquid medium. Any substance that is effective under conditions in the body to exert a cleansing action as described herein. For example, the enzyme may be present in a liquid medium with which the composition is in contact, relative to the other components of the composition. It may be configured to be released at any time. In one particularly useful embodiment, solid The cleaning enzyme is released into the liquid medium substantially immediately after introducing the composition into the liquid medium. Ru.

For contact lenses in liquid media, if stain-removing enzymes are present, , dirt can also be effectively cleaned. This cleaning action is performed before disinfecting the lens. , to occur at the same time as disinfecting the lens, or after disinfecting the lens. I can do it.

The disinfecting contact is preferably carried out at a temperature that keeps the liquid medium substantially liquid. . The contact temperature is preferably about 0-100°C, more preferably about 10-60°C, more More preferably, the temperature is in the range of about 15 to 30°C. At ambient temperature or its temperature It is very convenient and effective to make contact. This contact is preferably treatment for a period of time until the lens is substantially completely disinfected. Such contact time is , for a period of about 1 minute to 12 hours or more.

After such contact, the liquid medium is preferably substantially free of residual oxidizing disinfectant. Remove the sterilized lens from the liquid medium and place it directly in the eye for safe and comfortable use. Can be worn properly. However, if the liquid medium is one or more ” If they contain enzymes, rinse the disinfected lenses with saline, for example, to remove the enzymes. It is preferable to wear it directly on the eye.

Brief description of the drawing FIG. 1 is a partially sectional front view illustrating one embodiment of the device of the present invention. .

FIG. 2 is a front view, partially in section, illustrating another embodiment of the device of the present invention; Ru.

FIG. 3 is a front view, partially in section, illustrating another embodiment of the device of the present invention; Ru.

FIG. 4 is a front view, partially in section, illustrating yet another embodiment of the device of the invention; It is.

FIG. 5 is a partially cutaway illustration of another embodiment of the lens basket of the device of the invention; FIG.

Brief description of the drawing First of all, referring to FIG. 1, the lens disinfection device, generally designated 10, is It has a lens container 12, a cover 14, and a lens basket 16.

Lens container 12 is made of a transparent thermoplastic polymer material (e.g., polymethyl methacrylate). manufactured as a single piece (e.g. molded in a conventional manner). Re Lens container 12 has a bottom wall 18 and side walls 20. The upper part 22 of the side wall 20 is It spreads to the sides. The top 24 of the sidewall 20 has a threaded outer surface 26. Re The bottom of container 12! The cross section parallel to 18 is typically circular. The lens container 12 is , defining an internal space 28 containing an aqueous liquid medium containing hydrogen peroxide.

A color indicator band 32 is provided on the inner surface 30 of the side wall 20 within the interior space 28. is fixed. Color indicator band 32 is based on Factor et al. Quinrylene-4゜4 synthesized according to the method of Example 3 of Patent No. 3694384 ′-Bipyridinium unit-containing water-insoluble redox polymer. Ru. Moreover, the color indicator band 32 is made of water-insoluble cation exchange resin, For example, cross-linked sodium poly(styrene sulfonate) and the rice of Factor et al. Bipyridinium unit-containing water as described in Example 4 of National Patent No. 3694384 from soluble redox polymers, e.g. by conventional ion exchange methods. It may be written down. In any case, the color indicator band 32 is It is virtually insoluble in liquid media and yellow in color in the presence of hydrogen peroxide.

The color indicator hand 32 is typically in the shape of a right cylinder, allowing liquid to flow freely. The through space 34 that can be circulated is limited. Band 32 is glued to inner surface 30 Contact lenses can be fixed by hydrogen peroxide-containing aqueous liquid during disinfection. It is conveniently located within the interior space 28 so as to be fully immersed in the medium.

The cover 14 has a mud wall 36 and a downwardly facing side wall 38. The cover 14 is Opaque thermoplastic polymer materials, such as those made from polyphenylene oxide It is. The upper part 36 is typically circular, and the cross section of the side wall 38 parallel to the earthen wall 36 is also typically circular. It is circular. The side wall 38 has a threaded inner surface 40, the threads being threaded. The cover 14 is engaged with threads on the outer surface 26 to secure the cover 14 to the lens container 12. hippopotamus -14 also has a circular hollow protrusion 42 in the center, which connects the cover 14 to the lens container. 12, it protrudes downward into the lens container 12. In the hollow space of the protrusion 42 attaches the attachment element 44 of the lens basket 16 by, for example, gluing, interference fitting, etc. Fix it by etc. This fixes the lens basket 16 to the cover 14. do. A pair of foamed polymer sealing elements 46 and 48 are placed around protrusion 42. Attach it to the bottom of the cover 14. Sealing elements 46 and 48 hold cover 14 in place. provides a substantially leak-tight seal when secured to the lens container 12.

Lens basket 16 is made of an opaque thermoplastic polymer material, such as polyphenylene. It is manufactured from carbon oxide. The lens basket 16 and the lens container 12 and cover 14, may be manufactured (eg, molded) in a conventional manner. As mentioned above In other words, the lens bath Kent 16 has an attachment element 44 that is fixed to the cover 14. has. The basket body 50 attached downwardly from the attachment element 44 is It has a left lens mount 52 and a right lens mount 54. basket body 50 has a series of through holes (not shown) that allow liquid to pass through the basket body. can flow freely inside.

Both the left basket cover 56 and the right basket cover 58 cover the basket. It is fixed to the body 50 with a hinge, and the left lens mount 5 can be attached as needed. 2 and the right lens mount 54 and "snap" it closed to remove the left lens. The structure forms a compartment 60 and a right lens compartment 62. It is constructed. The hasget covers 56 and 58 cover the lens basket 16. It is manufactured separately from other ingredients. Basket covers 56 and 58 are Each has a series of through holes through which liquid can freely flow. However, those through holes When lens covers 56 and 58 are closed, lens compartment 60 and and 62 are sized so that the contact lenses in them do not fall out. left basket The cover 56 is marked with rLJ to indicate that it is for left contact lenses. Ru.

Similarly, the right basket cover 58 is marked with r indicating that it is for right contact lenses. You will get an indication of RJ.

Lens disinfection device 10 may be used as follows. Place the cover 14 on the lens container 1 2 and remove the contact lenses to be disinfected from the left and right lens mounts 52 and 54, and then remove the left and right basket covers 56 and 58. Closed by napping.

A certain amount, for example, about 10 ml of 3% (W/V) hydrogen peroxide aqueous solution is poured into the lens container 12. The band 32 is fully immersed in the inner space 28 of the band 32. Add hydrogen peroxide solution , the band 32 takes on a yellow color, indicating the presence of hydrogen peroxide in the interior space 28. . Cover 14 is placed on lens container 12 and secured in place. lens compartment men The contact lenses in containers 60 and 62 are fully immersed in the hydrogen peroxide solution. be Enable contact lenses for a period of time, for example on the order of about 4 hours. disinfect. But band 32 is still yellow and hydrogen peroxide is still present Show that.

At this point, remove the cover 14 from the lens container 12 and remove any remaining hydrogen peroxide in the solution. Sufficient force is applied to decompose and bring the redox polymer in band 32 into a reduced state. Add the tablet containing talase to the solution and re-secure the cover 14 to the lens container 12 do.

After a further period of time, for example about 1 hour, the band 32 takes on a bluish-purple color and the interior space 28 The solution is shown to be substantially free of hydrogen peroxide. Therefore, contact lenses removed from lens compartments 60 and 62, rinsed with saline solution, It can be placed directly in the eye and worn safely and comfortably.

Contact lens disinfection (and cleaning) using device 10 involves several different methods. method is also possible. For example, a contact lens starts coming into contact with a solution containing hydrogen peroxide. Substantially at the same time as adding the delayed release coated catalase. Can also be done. Band 32 has a yellow color indicating the presence of hydrogen peroxide. after a certain time , the delayed release coating dissolves, releasing the catalase into solution. There is more After a period of time, the band 32 assumes a blue-purple color and the solution in the interior space 28 has substantially no hydrogen peroxide. Indicates that it does not contain any Rinse disinfected contact lenses with saline solution. It can be placed in the eye and worn safely and comfortably.

In yet another method, at least one soil (e.g. a protein-containing soil) with an amount of a hydrogen peroxide active enzyme (e.g. subtilisin A enzyme) effective to remove , covering said delayed release coating. In this embodiment, the delayed release coating contact lenses contain hydrogen peroxide, which contains an enzyme/catalase combination that It can be added into the solution substantially simultaneously with the initial contact with the solution. van 32 exhibits a yellow color indicating the presence of hydrogen peroxide. Over a period of time, hydrogen peroxide Active enzymes remove protein-containing dirt from contact lenses and The torrents are effectively disinfected and the delayed release coating then dissolves the catalase. Release into liquid. After a further period of time, the band 32 takes on a bluish-purple color and the interior space 28 Indicates that the solution is substantially free of hydrogen peroxide. Cleaned and disinfected contours Lenses can be safely rinsed with saline to remove the subtilisin A enzyme and placed in the eye. And it can be worn comfortably.

FIG. 2 illustrates another aspect of the invention. Unless otherwise specified in this specification This lens disinfection device! (110 as a whole) is similar to the lens disinfection device 10. Has structure and function. Components of device 2110 that correspond to components of device 10 include: Add 100 to the corresponding number.

The main difference between device 110 and device 10 is that device 110 has a color indicator. Because it does not have a color indicator band like the color indicator band 32, be. Instead, device 110 is similar to color indicator band 32. The color indicator disk 70 is made of a material of. In other words, The color indicator disk 70 is made of a water-insoluble redox polymer or a water-insoluble redox polymer. Manufactured from a composite material of soluble redox polymer and water-insoluble cation exchange resin . The color indicator disk 70 is a contour in the lens basket 116. While disinfecting or cleaning and disinfecting the lens, the interior space 128 of the device 110 Put it in.

Color indicator disc 70 exhibits a yellow color to indicate the presence of hydrogen peroxide. , exhibiting a bluish-purple color indicating the substantial absence of hydrogen peroxide.

FIG. 3 illustrates another aspect of the invention. Unless otherwise specified in this specification This lens disinfection device (210 as a whole) is similar to the lens disinfection device 10. Has structure and function. The components of device 210 that correspond to the components of device 10 include 2 The corresponding number is given by adding 00.

The main difference between device 210 and device 10 is that device 210 has a color indicator. Because it does not have a color indicator band like the color indicator band 32, be. Instead, device 210 is located at or near the bottom of interior space 228. It has a plurality of color indicator beads 72 placed on it. of the lens container 212 A screen insert 74 is attached to the interior wall 230. The screen element 74 is , the liquid material within the interior space 228 can freely flow through the screen element 74. It has multiple pores of similar size. However, those holes are and the bottom of the lens container 212 . It is not so large that the color indicator bead 72 can escape.

Color indicator bead 72 is the same as color indicator band 32. Manufactured from similar materials. That is, the color indicator beads 72 are Soluble redox polymer or water-soluble redox polymer and water-insoluble cation Manufactured in composite material with exchangeable resin. The color indicator beads 72 are An opening for disinfecting or cleaning and disinfecting the tactile lens, the screen element 74 and the lens and the bottom of the container 212 . color index The indicator beads 72 exhibit a yellow color to indicate the presence of hydrogen peroxide, and a blue-purple color. shows the substantial absence of hydrogen peroxide.

If desired, the screen element 74 can be removed from the lens container 212 to remove the color image. The indicator beads 72 can be replaced. For example, lens disinfection device 1 One important advantage of lens disinfection device 210 compared to The Decatur beads 72 remain in place within the device 210 even when not in use. Therefore, it is difficult to lose it. Color indicator of lens disinfection device 110 The data disk 70 can be taken out when not in use, so it can be lost. .

FIG. 4 illustrates yet another aspect of the invention. Special mention in this specification Otherwise, this lens disinfection device (310 as a whole) is identical to lens disinfection device 10. It has a similar structure and function. The components of device 310 that correspond to the components of device 10 include: , 300 plus the corresponding number.

The main difference between device 310 and device 10 is that device 310 has a color indicator. Because it does not have a color indicator band like the color indicator band 32, be. Instead, device 310 includes polymethyl methacrylate and device 10. Color-indicating materials made from physical mixtures with relatedly described redox polymers It has a lens container 80. The polymers are physically mixed and then virtually A transparent lens container 80 is formed. The lens container turns yellow in the presence of hydrogen peroxide. Enough redox polymer is included so that it has a cloudy appearance.

Lens container 80 has an interior space 82 for containing an aqueous liquid medium containing hydrogen peroxide. .

Lens container 80 has substantially the same shape as lens container 12. Lens container 8 0 indicates hydrogen peroxide in the aqueous liquid medium of the interior space 82 by yellowish cloudiness. indicates the presence of hydrogen peroxide and exhibits a blue-purple color, indicating the substantial absence of hydrogen peroxide in the aqueous liquid medium. show.

FIG. 5 illustrates another embodiment of the lens basket of the present invention. Specification Unless otherwise noted in the book, this lens basket (416 in total) does not contain any lenses. It has the same structure and function as the basket 16. Ingredients of lens basket 16 The component of the lens basket 416 corresponding to 400 is added to the corresponding number. attach

The main difference between lens basket 416 and lens basket 10 is that the lens basket This is due to the construction material used for the socket 416. That is, the lens basket 416 is polyethylene oxide and the redox described with respect to the lens disinfection device 10. Manufactured from a physical mixture with a polymer. Lens basketball in the presence of hydrogen peroxide Sufficient redox polymer is contained so that the entire dot 416 appears yellow.

The lens basket 416 can also be used as a lens basket with a hydrogen peroxide color scheme. It can also be effectively used as an indicator. In particularly useful embodiments, the lens In the disinfection device 110, a lens basket is used instead of the lens basket 116. 416 to remove the color indicator disk 70. In this manner When the lens basket 416 is yellow, indicating the presence of hydrogen peroxide, the lens basket 416 becomes blue-purple. A color appears to indicate the substantial absence of hydrogen peroxide.

The following examples illustrate some aspects of the invention and illustrate some aspects of the invention. It is not limited.

Example 1 This example illustrates the lens cleaning/disinfection aspect of the present invention, with particular reference to FIG. It is something that

Water-insoluble, prepared according to Example 3 of Factor et al., U.S. Pat. No. 3,694,384. Beads 72 (approximately 1 g) made of a redox polymer are placed at the bottom 78 of the internal space 228. Put it in.

A pair of contact lenses with protein-containing dirt are placed in the lens basket 21. Put it in 6. Salt solution containing 23% (w/v) H2O and 03% by weight boric acid 10 ml of liquid is placed in the internal space 228 and contacted with the solution in the lens container 212. Lens basket 216 is arranged so that the lenses are fully immersed. The pH of the solution is It is approximately 7°5. At this point, beads 72 take on a yellow color.

A layered delayed release tablet is placed in the solution within the lens container 212. The central core of the tablet is , contains 2.0 mg of crystalline catalase. The outer layer of the tablet contains subtilisin A enzyme 0. Contains ゜4mg. A delayed release layer between such inner and outer layers is After being exposed to the solution in the container 212, the catalase is sufficiently dissolved in the solution within 2 hours. Constructed and designed to emit

When the tablet is placed in a solution, the outer layer dissolves, releasing subtilisin A into the solution.

Enzymes in the outer layer act on the protein-containing stains on the lens and begin to remove it. Ta Substantially all protein-containing soil is removed from the lens. In addition, contact The lenses are effectively disinfected. Two hours after putting the layered tablets into the solution, Katara is released into the solution, decomposing the residual hydrogen peroxide in the solution and decomposing the redox in the beads 72. reduce the xpolymer to a reduced state. At this point, bead 72 turns blue-purple. do. The lens user should check the blue-purple color of the bead 72 and remove the cleaned/sterilized lens. Remove from solution, rinse with physiological saline to remove subtilisin A enzyme, and attach to the do. Effectively disinfects contact lenses and cleans protein-containing stains. I can see that it was. Wearing contact lenses that have been disinfected and cleaned in this way and aqueous solution as described in Example 4 of Factor et al., U.S. Pat. No. 3,694,384. complex redox polymer and cross-linked sodium poly(styrene sulfonate). Beads made from composite materials can be used in place of water-insoluble redox polymer beads. Example 1 is repeated, except that:

Similar to Example 1, the beads take on a yellow color in the presence of hydrogen peroxide and are free from residue in the solution. When the distilled hydrogen peroxide is decomposed and the redox polymer is reduced to its reduced state, it produces a blue-purple color. change color. Lens users check the blue-purple color of the beads and remove them from cleaned/disinfected lenses. Remove the lens from the solution, rinse with saline to remove the subtilisin A enzyme, and apply to the eye. Installing. Effectively disinfects contact lenses and cleans protein-containing stains. What was said to be changed. Wearing contact lenses disinfected and cleaned in this way does not cause discomfort or eye irritation.

Example 3 The inner layer of the tablet contains 3.0 mg of N-acetylnstein and contains catalase. Example 1 is repeated except that no.

After the beads change color from yellow to blue-purple, remove the cleaned/disinfected contact lens from the solution. The tube is removed from the eye, rinsed with physiological saline to remove subtilisin A enzyme, and placed on the eye.

The contact lenses were effectively disinfected and protein-containing stains were cleaned. and change. By wearing contact lenses that have been disinfected and cleaned in this way, No pleasure or eye irritation occurs.

Example 4 The inner layer of the tablet contains 3.0 mg of N-acetylnstein and contains catalase. Example 2 is repeated except that no.

After the beads change color from yellow to blue-purple, remove the cleaned/disinfected lens from the solution. , rinse with physiological saline to remove subtilisin A enzyme, and place on the eye. contact The result was effective disinfection of the lens and cleaning of protein-containing dirt. . Wearing contact lenses that have been disinfected and cleaned in this way may cause discomfort or discomfort. No eye irritation occurs.

Although the invention has been described with respect to several specific embodiments and embodiments, the invention It is understood that the invention is not limited to these, but may be implemented in various ways within the scope of the claims below. Should.

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Claims (38)

[Claims] 1. An oxidizing disinfectant for contact lenses that is useful for disinfecting contact lenses. cup means for containing a liquid medium containing a poisonous agent; and for providing a color indication of the presence of an oxidizing contact lens disinfectant in a liquid medium; a collar adapted to be at least partially located within the liquid medium within the cup means; an indicator means having a stable oxidation state and a stable reduction state A device comprising means containing a redox polymer having repeating units. 2. 2. The device of claim 1, wherein the repeating unit is cationic in the oxidized state. 3. The repeating unit is a bipyridinium unit in the cationic oxidation state ▲ Mathematical formula, chemical formula There are tables, etc.▼ 3. The device according to claim 2, comprising: 4. The bipyridinium unit is ▲Contains mathematical formulas, chemical formulas, tables, etc.▼ 4. The device according to claim 3. 5. 4. The device of claim 3, wherein the repeating unit further contains xylylene groups. 6. Redox polymers are oxidizable by oxidizing disinfectants in liquid media. The device according to claim 1. 7. 2. The device of claim 1, wherein the redox polymer is affixed to the cup means. 8. The device of claim 1, wherein the redox polymer is substantially insoluble in the liquid medium. . 9. The device of claim 1, wherein the redox polymer is substantially soluble in the liquid medium. . 10. Redox polymers are combined with matrix materials that are substantially insoluble in liquid media. 2. The apparatus of claim 1. 11. Redox polymers are combined with cation exchange resins that are substantially insoluble in the liquid medium. 10. The device according to claim 9. 12. 2. The device of claim 1, wherein the redox polymer is disposed within the cup means. 13. 13. The device of claim 12, wherein the redox polymer is in the form of a single solid. 14. 13. The device of claim 12, wherein the redox polymer is in the form of a plurality of particles. 15. for retaining a plurality of particles within the cup means when discharging liquid from the cup means; 15. The cup means of claim 14 further comprising screen means disposed within the cup means of. Device. 16. The screen means is disposed within the cup means and directs the plurality of particles into the cup means. 16. The device of claim 15, further operative to suspend. 17. A basket for holding contact lenses in a liquid medium within a cup means. 2. The apparatus of claim 1, further comprising means for attaching. 18. 15. The apparatus of claim 14, wherein the redox polymer is fixed to the basket means. . 19. 16. The redox polymer is a component of the basket means. equipment. 20. The cup means is substantially transparent and has a removable cover means. The device according to claim 1. 21. The color indicator means contains an oxidizing agent for contact lenses in a liquid medium. Claims that can provide another color indication to indicate the substantial absence of a toxic agent 1. The device according to 1. 22. A device useful for disinfecting contact lenses, the oxidizing device for contact lenses substantially transparent cup means for receiving a liquid medium containing a disinfectant; Basket means for holding a contact lens in a liquid medium within a cup means ;and providing a first color indication indicating the presence of an oxidizing contact lens disinfectant in the liquid medium; and positioned at least partially within the liquid medium for serving. A tailored color indicator means that indicates a stable oxidation state and a stable reduction state. Repeat unit with original state (repeat unit is cationic in stable oxidation state) So, bipyridinium unit ▲Contains mathematical formulas, chemical formulas, tables, etc.▼ and xylylene groups). A device comprising: 23. The color indicator means contains an oxidizing agent for contact lenses in a liquid medium. Claims that can provide another color indication to indicate the substantial absence of a toxic agent 23. The device according to 22. 24. A method of disinfecting contact lenses, in which contact lenses to be disinfected and acid are used. contact lenses with a disinfectant-containing liquid medium under conditions that effectively disinfect contact lenses. This contact is effective in providing a color indication of the presence of oxidizing disinfectant in the liquid medium. Redox having a repeating unit with a stable oxidation state and a stable reduction state in an amount of a method comprising carrying out in the presence of a copolymer. 25. 25. The method of claim 24, wherein the repeat unit is cationic in the oxidation state. 26. 25. The method of claim 24, wherein the oxidizing disinfectant is hydrogen peroxide. 27. The repeating unit is a bipyridinium unit in the cationic oxidation state ▲ Formula, Chemistry There are formulas, tables, etc.▼ 25. The method according to claim 24, comprising: 28. 25. The method of claim 24, wherein the redox polymer is oxidized during the contacting. 29. The oxidizing disinfectant is separated to provide a liquid medium that is substantially free of the oxidizing disinfectant. 25. The method of claim 24, further comprising: decoding. 30. The decomposition process consists of substantially oxidizing disinfectant in a liquid medium that is substantially free of oxidizing disinfectant. Redo in the reduced state is effective in providing different color indications to indicate the absence of 30. The method of claim 29, which also serves to provide a base polymer. 31. An effective amount of the reducing component is decomposed to provide the redox polymer in a reduced state. 30. The method of claim 29, wherein the method is present during the step. 32. Substantially oxidizing disinfectant-free liquid medium and redox polymer in reduced state The peroxidase component is present during the degradation process in an amount effective to provide The method according to claim 29. 33. The redox polymer in its reduced state is a liquid medium that is virtually free of oxidizing disinfectants. to provide different color indications to indicate the substantial absence of oxidizing disinfectant in the 33. The method of claim 32, which is effective. 34. 25. The redox polymer is substantially insoluble in the liquid medium. Method. 35. 25. The redox polymer is substantially soluble in the liquid medium. Method. 36. Redox polymers are combined with matrix materials that are substantially insoluble in liquid media. 25. The method of claim 24. 37. Redox polymers are combined with cation exchange resins that are substantially insoluble in the liquid medium. 36. The method of claim 35. 38. A method of disinfecting contact lenses, which includes contact lenses to be disinfected and contact lenses with an aqueous liquid medium containing hydrogen oxide under conditions that effectively disinfect contact lenses. contact, and this contact results in a repeating unit having a stable oxidation state and a stable reduction state. (The repeating unit is cationic in stable oxidation state, bipyridinium unit ▲Contains mathematical formulas, chemical formulas, tables, etc.▼ and xylylene groups), Redox polymers have a primary color indicator that indicates the presence of hydrogen peroxide in an aqueous liquid medium. present in an oxidized state during this contact; and then an aqueous liquid The carrier and the hydrogen peroxide decomposition component are brought into contact, and the hydrogen peroxide decomposition component is dissolved in an aqueous liquid medium. A redox polymer that decomposes virtually all hydrogen peroxide in the body and is in a reduced state. A first method that demonstrates the substantial absence of hydrogen peroxide in an aqueous liquid medium by providing present in an amount effective to provide a color indication of 2.