JPH0644550U - Syringe for container - Google Patents

Abstract

(57) [Summary] [Purpose] It is an object of the present invention to provide a container-combined syringe that does not contaminate the patient or the surroundings or the amount of the drug solution to be injected is insufficient due to the leakage of the injection solution in advance. . [Structure] A medicine is enclosed and stored in an inner chamber (12 to 14) formed between rubber stoppers (7 to 9), and a rubber stopper (9) at a rear end portion of the rubber stopper is pressed and moved forward. At this time, the rubber stopper (7) at the front end moves forward in the glass cartridge to reach the collar portion (21) of the barrel tip (4) fitted into the glass cartridge, and the drug enclosed in the glass cartridge is injected with the injection needle (22). ) Out. The inner wall surface (30) forming the collar portion at the tip of the cylinder is formed in a tapered shape so that the inner diameter of the collar portion becomes gradually narrower toward the front end.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to a container / syringe, and more particularly to a so-called container / syringe in which a glass cartridge is sealed by a plurality of elastic rubber stoppers and a drug or the like is enclosed therein.

[0002]

[Prior art]

 Syringes that also serve as containers can be transported and stored while the drug is filled in the container in advance. There is only one inner chamber for enclosing and storing the drug, and there are two inner chambers. There is a two-chamber type. Japanese Unexamined Patent Publication (Kokai) No. 62-5357 discloses a two-chamber type syringe that also serves as a container.

A known container / syringe 1 of this type will be described with reference to FIG. 6. The front end of the glass cartridge 2 (in this specification, the side to which the injection needle is attached is the front, that is, the right side in FIG. 6). Is defined as the front, and the opposite side is defined as the rear.) A synthetic resin tube tip 4 is tightly fitted to the glass cartridge 2 and a synthetic resin finger grip 5 is tightly fitted to the rear end of the glass cartridge 2. A syringe 6 is composed of 2, the barrel tip 4, and the finger grip 5.

A front rubber stopper 7, an intermediate rubber stopper 8 and a rear rubber stopper 9 are fitted in the glass cartridge 2 in a gas-tight and liquid-tight manner at appropriate intervals. As will be described later, in actual use, these rubber stoppers 7 to 9 slide and move within the glass cartridge 2, but in order to ensure their smooth sliding, the rubber stoppers 7 to 9 have silicone oil on the outer periphery thereof. A lubricant that does not affect the chemicals such as is applied.

A female threaded portion 9 a is formed on the rear surface of the rear rubber stopper 9, and the male threaded portion at the tip of the plunger rod 10 is screwed into the female threaded portion 9 a. At the time of injection, the rubber stopper 9 is pressed by the plunger rod 10.

Inner chambers 12, 13, and 14 are formed between the front rubber stopper 7 and the barrel tip 4 and between the rubber stoppers 7 to 9, respectively. The inner chamber 12 on the front side is a space where the rubber stoppers 7 to 9 move forward as the plunger rod 10 moves forward. As a result of the movement of the rubber stoppers 7 to 9, the inner volume eventually becomes zero. Is the place where Further, a predetermined amount of powdered drug or freeze-dried drug 16 is aseptically enclosed in the intermediate chamber 13 in the middle part, and a predetermined amount of solution 17 is aseptically filled in the rear inner chamber 14. ing.

Further, a bypass groove 20 is formed in the center of the glass cartridge 2 so as to extend in the axial direction due to a part of the wall bulging outward. The length L of the bypass groove 20 is set to be longer than the length M of the intermediate rubber stopper 8.

The barrel tip 4 includes a cylindrical collar portion 21 that is tightly fitted to the outer periphery of the front end portion of the glass cartridge 12, and an injection needle attachment portion 23 to which an injection needle 22 is attached and which has a through hole 23a in the center. It is configured. An inner chamber 24 is formed inside the barrel 4, that is, at a position defined by the front portion of the collar portion 21 and the bottom portion 23b of the injection needle mounting portion 23. The inner chamber 24 is formed on the front side of the cartridge 12. It communicates with the inner chamber 12. The axial length N of the inner chamber 24 is set longer than the length O of the front rubber stopper 7.

At least one or more recessed grooves 21a extending in the axial direction are formed in the inner wall surface of the collar portion 21 of the cylinder tip 4 in the circumferential direction (four in every 90 degrees in the figure). Is communicated with the through hole 23a through a radially extending concave groove 23c formed on the ceiling surface of the bottom portion 23b of the injection needle mounting portion 23. Then, as will be described later, the plunger rod 10 is pressed and the front rubber stopper 7 is moved into the inner chamber 24 of the barrel tip 4 as the pressure of the dissolved solution containing the drug stored in the inner chamber 13 is increased. Even when it is pressed and moved, the through hole 23a of the barrel tip 4 is not sealed by the rubber stopper 7, and the solution containing the drug passes through the recessed grooves 21a and 23b, passes through the through hole 23a, and then the needle tube of the injection needle. It is designed to be discharged from 22.

Further, a luer lock 26 of an injection needle mounting portion 23 having a double thread is projectingly provided on the outer peripheral portion of the bottom portion 23 b of the barrel tip 4 so as to extend in the opposite side to the collar portion 21.

A method of using the container-combined syringe 1 will be described with reference to FIGS. 7A to 7E. When actually injecting using the container-combined syringe 1, first, the injection needle 22 is used. The barrel tip 4 is attached to the injection needle attachment portion 23, and the plunger rod 10 is screwed onto the rear rubber stopper 9 (see FIG. 7A). When the rear rubber stopper 9 is advanced through the plunger rod 10 in this state, the pressure of the dissolved liquid in the inner chamber 14 rises and the intermediate rubber stopper 8 is moved forward. When the pressing force is continuously applied to the plunger rod 10 in this manner, the intermediate rubber stopper 8 moves to a position facing the bypass groove 20 (see FIG. 7B).

Since the length M of the intermediate rubber stopper 8 is set shorter than the length L of the bypass groove 20, the dissolved liquid is a space formed between the bypass groove 20 and the intermediate rubber stopper 8. To flow into the inner chamber 13 through.

Further, when the rear rubber stopper 9 is further advanced, the rear rubber stopper 9 finally comes into close contact with the intermediate rubber stopper 8, and all the dissolved liquid in the inner chamber 14 is transferred to the inner chamber 13 (FIG. 7 ( C))). In the middle of this operation, the front rubber stopper 7 moves forward in the inner chamber 12 as the pressure in the inner chamber 13 rises (see Fig. 7 (c)), but the way of this movement is gradual. It is not a physical thing, and so to speak, it moves in a state of jumping into the inner chamber 12 at once. This state is recognized in both the one-chamber type and the two-chamber type, but in comparison with the one-chamber type in which the rubber stopper is pressed and moved through the liquid whose volume does not change, in the case of the two-chamber type, the inner chamber is In addition to the powdered drug and the like being enclosed in 13, a space 13a necessary for the dissolution liquid to flow into the chamber is provided. Therefore, the front rubber stopper 7 is located in the space 13a in the internal chamber 13. It is pressed by mediating gas such as air and inert gas. Therefore, since the air in the inner chamber 13 is compressed and the pressing energy is accumulated, the above phenomenon is conspicuous.

Next, the syringe 6 is lightly shaken to suspend the powdered drug in the inner chamber 13 with a solution to prepare an injection solution. Then, the rear rubber stopper 9 is advanced again via the plunger rod 10. Then, the rubber stoppers 9 and 8 integrally move forward, the front rubber stopper 7 is moved forward through the injection liquid in the inner chamber 13, and finally fitted into the inner chamber 24 of the barrel tip 4 (Fig. 7 (D)).

Thereafter, as the rear rubber stopper 9 is further advanced, the injection liquid existing in the inner chamber 13 passes through the inner grooves 21 a and 23 c of the barrel tip 4 to reach the through hole 23 a, and is pushed out to the injection needle 22. Be done. That is, injection is carried out (see FIG. 7 (e)).

In the above-described two-chamber type syringe that also serves as a container, the powder and the like and the liquid can be separately stored in the inner chambers 13 and 14 of the cartridge 2. However, it is possible to obtain an advantage that it can be stored in a stable state for a long period of time by, for example, performing freeze-drying or the like to obtain a powder.

[0017]

[Problems to be solved by the device]

 By the way, there are still some problems to be solved in the practical application of the container-combined syringe having the above structure.

The above-mentioned rubber stoppers 7 to 9, especially the front rubber stopper 7, are located on the front side of the glass cartridge 2, and a change in pressure increase in the inner chamber of the glass cartridge 2 due to the forward movement of the plunger rod 10 is caused. Even if it occurs, it has a role of sealingly storing the injection drug in the syringe 6 until just before use. Therefore, the glass cartridge 2 is tightly fitted. On the other hand, since the injection liquid in the glass cartridge 2 needs to be released at the time of injection, the front rubber stopper 7 and the like also have appropriate slidability with respect to the glass cartridge 2.

Here, in consideration of the case where the plunger rod 10 is moved forward in use,

2. Description of the Related Art As the pressure in the inner chamber 14 in the syringe 6 increases, the intermediate rubber stopper 8 advances, causing the pressure in the inner chamber 13 to rapidly increase. As a result, the pressing force on the front rubber stopper 7 also suddenly rises, and when the pressing force exceeds the above-mentioned frictional force between the front rubber stopper 7 and the glass cartridge 2, the front rubber stopper 7 suddenly suddenly moves forward. Moving. Moreover, the injection liquid in the syringe 6 passes through the recessed grooves 21a and 23c of the barrel tip 4 through the through hole 23a before the injection action, though a small amount of the injection liquid in the syringe 6 due to the abrupt pressure change that occurs at this time. There is a risk of leaking out through the.

As a result, there are problems that the leakage of the injection liquid stains the patient and the surroundings, the liquid medicine adheres to the periphery of the syringe 6, and the amount of the liquid leaked out causes an insufficient amount of the liquid medicine to be injected. This problem hinders the commercialization of this type of container-use injector regardless of whether it is a single-chamber type or a double-chamber type.

In order to avoid such a problem, the front rubber stopper 7 should be inserted as far as possible from the cylinder tip 4 so that the front rubber stopper 7 does not reach the inner wall 24 of the cylinder tip 4 at a stretch. Can also be considered. However, in this solving means, the relationship between the pressure in the inner chamber 13 and the strength of the frictional force between the front rubber stopper 7 and the glass cartridge 2 is not uniform, so that the front rubber stopper 7 and the barrel tip 4 are It is difficult to preset the size of the gap provided between the syringes, and if such a space is made large, the syringe 2 must have an extra length, which makes the handling of the syringe 6 difficult. It is not a realistic solution because it creates a new problem that makes injection difficult.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a container / syringe which can solve the above-mentioned conventional problems.

[0023]

[Means for Solving the Problems]

 In order to achieve such an object, in the invention according to claim 1, the inner wall surface forming the collar portion of the cylinder tip is formed in a taper shape so that the inner diameter of the collar portion becomes gradually narrower toward the front end. did.

Further, in the invention as claimed in claim 2, a tapered rib extending in the axial direction of the color portion and gradually increasing in height toward the front end is provided on the inner wall surface forming the collar portion of the cylinder tip. A plurality is formed in the direction.

[0025]

[Action]

 Since the inner wall surface of the collar part at the tip of the cylinder is tapered, or the inner wall surface of the collar part is provided with tapered ribs, when the rubber stopper moves inside the collar part, the gap between the collar part and the rubber stopper is The friction that occurs on the road gradually increases toward the front. Therefore, even if a sudden pressure is applied to the rubber stopper, the rubber stopper does not move to the front end of the collar at a stroke and gradually moves.

[0026]

【Example】

 An embodiment of the present invention will be described below with reference to FIGS. In the following embodiments, the same components as those described in the conventional example are designated by the same reference numerals and the description thereof will be omitted.

First Embodiment FIGS. 1 and 2 show a first embodiment of the present invention. In this embodiment, a part of the inner wall surface 30 constituting the collar portion 21 of the barrel tip 4, specifically, the inner wall surface portion 30a facing the inner chamber 20 of the barrel tip 4, has an inner diameter of the collar portion 21 increasing toward the front end. It is formed in a taper shape so that it becomes gradually narrower.

As described above, according to the container / syringe in which the inner wall surface 30 of the collar portion 21 is formed in a tapered shape, the injection liquid in the glass cartridge 2 is opened to the outside via the injection needle 22. As a preparatory work, when the rear rubber stopper 9 is pushed forward through the plunger rod, the pressure of the inner chamber 13 inside the syringe 6 rises, and the front rubber stopper increases as the pressure inside the inner chamber 13 rises. When the pressing force also rises, and the pressing force exceeds the frictional force between the rubber stopper 7 and the glass cartridge 2, the rubber stopper 7 is released from the close fitting force and is moved to the inner chamber 24 in front of the barrel tip 4. Start moving towards.

Here, since the inner wall surface 30 of the collar portion 21 is formed in a tapered shape as described above, the thrust force of the front rubber stopper 7 is weakened, so that it is not possible to jump into the collar portion 21 at once. Absent. Moreover, since the frictional force between the rubber stopper 7 and the glass cartridge 2 becomes larger as it goes forward, the movement of the rubber stopper 7 gradually moves forward without increasing the speed above a certain value and finally reaches the inner chamber. It reaches a predetermined position at the back of 24.

As described above, the phenomenon of the rush due to the pressure applied to the front rubber stopper 7 which is seen in the conventional product is controlled by the inner wall surface 30 having the taper. Thus, if the forward movement of the plunger rod 10 is stopped at the time when the front rubber stopper 7 has finished moving to the inner part of the inner chamber 20 of the barrel tip 4, it is easy to remove air bubbles in the injection solution, which is generally performed. In particular, in the case of the two-chamber type, the freeze-dried drug in the inner chamber 13 is surely dissolved or suspended. Then, after confirming that all the preparations for injection have been completed, and pushing the plunger rod again, the injection liquid passes through the concave grooves 21a and 23c of the barrel tip 4 and the through hole 23a for the first time and is stored in the injection needle 22. It is possible to realize safe, hygienic and economical injection.

The taper angle θ of the inner wall surface 30 and the detailed shape of the inner wall surface 30 which is the contact surface with the front rubber stopper 7 are determined by the strength of the pressing force applied to the front rubber stopper 7 and the front rubber stopper 7. Since it depends on the elasticity of the stopper 7 and the strength of the front rubber stopper 7 fitted to the glass cartridge 2, the front rubber stopper 7 can be prevented from thrusting and abrupt pressure change. The stopper moving speed is not particularly limited as long as it can be controlled, and various design changes can be made. For example, the surface of the inner wall surface 30 of the collar portion 21 may be provided with fine irregularities, or the inner wall surface 30 of the collar portion may be provided with a taber portion only on the front half.

Second Embodiment FIGS. 3 and 4 show a second embodiment of the present invention. In this embodiment, a part of the inner wall surface 40 forming the collar portion 21 of the cylinder tip 4, specifically the inner wall surface portion 40a facing the inner chamber 24 of the cylinder tip 4, extends in the axial direction of the collar portion 21 and has a front end. A plurality of taper-shaped ribs 41 are formed in the circumferential direction, the height of which gradually increases toward the bottom. The rib 41 is arranged in the middle portion of the recessed grooves 21a so as to avoid the recessed grooves 21a serving as a passage for the injection liquid.

Even with such a configuration, the same effect as that of the first embodiment, that is, the phenomenon of the rush due to the pressure applied to the front rubber stopper 7 is changed by the tapered ribs 41. Since it is controlled, it is possible to achieve effects such as removal of air bubbles in an injection solution that is generally performed, and reliable dissolution and suspension of a freeze-dried drug in the inner chamber 13 in particular.

The taper angle, the number, the length, etc. of the ribs 41 are not limited to those in the embodiment, and the front rubber stopper 7 has a speed sufficient to prevent the thrust of the front rubber stopper 7 and the abrupt change in the pressure. If the moving speed of the stopper 7 can be controlled, the design can be changed appropriately.

In addition, in each of the above embodiments, an example in which the present invention is applied to a two-chamber type container / syringe is described, but the present invention is not limited to this, and the present invention is also applied to a one-chamber type container / syringe. The proposal is applicable, and in the case of a two-chamber type syringe that also serves as a container, the glass cartridge is composed of two, that is, as shown in FIG. It is also applicable to a container-combined syringe in which the glass cartridges 50 and 51 are separately configured, and the glass cartridges 50 and 51 are connected in series by a connector 52 made of a material having appropriate elasticity, for example, a synthetic resin material.

[0036]

[Effect of device]

 As described above, according to the present invention, since the inner wall surface of the collar portion at the tip of the cylinder is tapered or the inner wall surface of the collar portion is provided with the tapered rib, when the rubber stopper moves inside the collar portion, The friction generated between the collar portion and the rubber stopper can be gradually increased toward the front. Therefore, even if a sudden pressure is applied to the rubber stopper, the rubber stopper can move the collar part gradually without moving to the front end at a stroke, and as a result, prevent a rapid change in the pressure in the cartridge. Without the leakage of injection liquid, there is no problem such as contamination of the patient or the surroundings, adhesion of liquid medicine around the syringe, and lack of the amount of liquid medicine to be injected due to the leaked liquid volume. Moreover, it has an excellent effect such that the preparatory step for injection can be carried out hygienically and smoothly.

[Brief description of drawings]

FIG. 1 is a sectional view of a front portion of a syringe that also serves as a container according to a first embodiment of the present invention.

FIG. 2 is an enlarged cross-sectional view of a main part of the container-combined syringe.

FIG. 3 is a cross-sectional view of the front part of the container / syringe according to the second embodiment of the present invention.

FIG. 4 is an enlarged perspective view of the main part of the container / syringe.

FIG. 5 is a cross-sectional view showing another embodiment of the present invention.

FIG. 6 is a cross-sectional view showing a conventional example of a syringe that also serves as a container.

7 (a) to (e) are cross-sectional views showing the movement of the conventional container / syringe in the same example.

[Explanation of symbols]

 1 Container and Syringe 2 Glass Cartridge 4 Tube Tip 5 Finger Grip 6 Syringe 7 Rear Rubber Stopper 8 Middle Rubber Stopper 9 Front Rubber Stopper 12 Inner Chamber 13 Inner Chamber 14 Inner Chamber 16 Drug 17 Dissolved Liquid 21 Collar 21a Recessed Groove 22 Injection needle 23 Injection needle mounting portion 23c Recessed groove 24 Inner chamber 30 Inner wall surface 41 Rib

Claims (2)

[Scope of utility model registration request] 1. A glass tip is fitted to one end of an outer periphery of a glass cartridge, and a finger grip is fitted to the other end of the glass cartridge. At least two rubber stoppers are arranged in the glass cartridge with a space between them. When the medicine is enclosed and stored in the inner chamber formed in the above, and the rubber stopper at the rear end of the rubber stopper is pushed and moved forward, the rubber stopper at the front end moves forward in the glass cartridge to move the glass stopper. A container that reaches the inside of the collar portion of the barrel tip that fits into the cartridge, and the drug in the glass cartridge is pushed out from the injection needle fitted to the barrel tip through the groove formed in the inner wall surface of the collar portion of the barrel tip. In the dual-purpose syringe, the inner wall surface forming the collar portion of the barrel tip is tapered so that the inner diameter of the collar portion gradually narrows toward the front end. Combined container-syringe is characterized in that it is formed in the over shape. 2. A glass tip is fitted to one end of the outer circumference of the glass cartridge, and a finger grip is fitted to the other end thereof, and at least two rubber stoppers are arranged in the glass cartridge with a space therebetween, and between the rubber stoppers. When the medicine is enclosed and stored in the inner chamber formed in the above, and the rubber stopper at the rear end of the rubber stopper is pushed and moved forward, the rubber stopper at the front end moves forward in the glass cartridge to move the glass stopper. A container that reaches the inside of the collar portion of the barrel tip that fits into the cartridge, and the drug in the glass cartridge is pushed out from the injection needle fitted to the barrel tip through the groove formed in the inner wall surface of the collar portion of the barrel tip. In the dual-purpose syringe, the inner wall surface forming the collar portion of the barrel tip extends in the axial direction of the collar portion, and the height gradually increases toward the front end. Combined container-syringe, wherein the tapered ribs are formed with a plurality of circumferentially made.