JPH0643297B2 - Patch composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention is a patch composition, more specifically, excellent in shape retention and tackiness, and does not cause oil component exudation and sagging due to heat or sweat. The present invention relates to a patch composition.

[Conventional technology]

Conventionally, hydrophilic patches such as patches, especially poultices, patches, etc., include kaolin, talc, bentonite, titanium dioxide,
Inorganic powder such as zinc oxide is used as an excipient, and gelatin,
Water-soluble polymer substances such as polyacrylic acid, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene oxide, carboxymethyl cellulose, hydroxypropyl cellulose, sodium alginate, natural gums; humectants such as glycerin, sorbitol, polyethylene glycol; The mixture was kneaded with water, the active ingredient, etc., and kneaded into a paste.

However, such a patch is apt to drip due to heat, sweat, etc., so that the patch may be crosslinked with a polyvalent metal ion (Japanese Patent Laid-Open Nos. 53-15413 and 54-17113).
No. 54-26326, No. 54-92618, etc.), urea is added to form a urea-gelatin complex (JP-A Nos. 45-5278 and 45-1231).
No. 4, etc.) or a cross-linking gel with an organic cross-linking agent such as dialdehyde starch (JP-A-51-91318 and JP-A-51-51318).
101119, 51-104027, 52-1
No. 43223, No. 54-143517, No. 56-78.
974, No. 57-21317, etc.), and insolubilization by forming a polymer-polymer complex (Japanese Patent Laid-Open No. Sho 5).
2-38016) to improve heat resistance and water resistance and prevent sagging.

[Problems to be solved by the invention]

However, as described above, heat resistance and water resistance are increased,
When trying to prevent sagging, there is a problem that the gel contracts, the active ingredient exudes, and the tackiness is reduced.

[Means for solving problems]

In such an actual situation, the present inventor has conducted diligent research to overcome the above-mentioned drawbacks, and as a result, specific water-soluble polymer substances, primary alcohol monoesters of methoxyethylene / maleic anhydride copolymers and polyvalent metals have been obtained. The present invention has been completed based on the finding that a patch containing a salt and a patch containing polybutene are excellent in shape retention and tackiness, do not cause sagging, and do not exude an oil component.

That is, the present invention relates to 1 to 30% by weight of a water-soluble polymer substance that crosslinks by reacting with a polyvalent metal ion, 2 to 10% by weight of a primary alcohol monoester of a methoxyethylene / maleic anhydride copolymer, and a polyvalent It is intended to provide a patch composition containing a metal salt. Further, the present invention further provides a patch composition containing polybutene therein.

Examples of the water-soluble polymer substance that is crosslinked by reacting with the polyvalent metal ion used in the present invention include gelatin, polyacrylic acid, sodium polyacrylate, polyvinyl carboxy copolymer, polyvinyl alcohol, vinyl acetate copolymer. , Carboxymethyl cellulose, sodium alginate, methoxyethylene / maleic anhydride copolymer, and the like. The amount of the water-soluble polymer substance used is 1 to 30% by weight of the entire patch composition (hereinafter, simply indicated as%).
Is preferred.

The methoxyethylene / maleic anhydride copolymer is preferably a copolymer of methoxyethylene and maleic anhydride in a ratio of 1: 1 (mol) and having a molecular weight of 10,000 to 80,000. The primary alcohol monoester thereof has 1 carbon atoms. Monoesters of primary alcohols of -7 are preferred. The amount used is appropriately in the range of 2 to 10% of the whole patch composition.

The polybutene preferably has a degree of polymerization of 5 to 70, more preferably 8 to 40. The usage is
Although not particularly limited, a range of 0.1 to 20%, particularly 0.5 to 10% of the whole patch composition is usually suitable. Furthermore, in the composition of the present invention, methoxyethylene
When the mixing ratio of the primary alcohol monoester of the maleic anhydride copolymer and the polybutene is 20: 1 to 1:10, the tackiness is strong, and the range of 5: 1 to 1: 5 gives the best results.

The polyvalent metal salt in the case of crosslinking the above water-soluble polymer compound is not particularly limited, but usually calcium chloride, magnesium chloride, aluminum chloride, potassium carbonate, ammonium carbonate, iron carbonate, aluminum sulfate, sulfate sulfate. Two
Water-soluble salts such as iron and magnesium sulfate are preferably used. In addition, calcium hydroxide, ferric hydroxide, aluminum hydroxide, calcium carbonate, magnesium carbonate, calcium phosphate, magnesium stearate, aluminum stearate, calcium citrate, barium sulfate,
A sparingly water-soluble or slightly water-soluble salt such as barium hydroxide, aluminum allantoinate, aluminum acetate, bismuth subnitrate, and bismuth subgallate can also be used. Although the amount of the polyvalent metal salt used is not particularly limited, it is usually the crosslinkable site 1 of the water-soluble polymer substance.
The amount is preferably 0.01 to 5 equivalents, and particularly preferably 0.1 to 2 equivalents. If the polyvalent metal salt is less than 0.05 equivalent, ion sequestration may occur and gelation may not occur.
If the amount is more than 5 equivalents, the degree of cross-linking may be too high and the water separation phenomenon may occur.

The patch composition of the present invention may contain, in addition to the above-mentioned components, optional components usually used in patches. For example, one or more moisturizers such as propylene glycol, glycerin, sorbitol, polyethylene glycol, sodium lactate (the content is usually 0 to 30% of the total composition); kaolin, talc, bentonite,
1 of inorganic powder such as titanium dioxide, zinc oxide, silicic acid anhydride
Or two or more (the content is usually 0 to 30%); methyl salicylate, glycol salicylate, -menthol, deer oil, eucalyptus oil, d-camphor, capsicum extract, nonyl acid vanillylamide, tocopherol acetate, diphenhydramine, Chlorpheniramine maleate, thymol, indomethacin, ketoprofen, ibuprofen, flurbiprofen, mefenamic acid, etc. 1 or 2 or more types (composition amount is usually 0 to 20%); Properties, adhesiveness, shape retention, etc.), latex such as acrylic resin emulsion, vinyl acetate emulsion, fluid paraffin, vegetable oil, lard,
Beef tallow and the like can be appropriately mixed as needed.

The patch composition thus obtained is composed of paper, woven fabric, non-woven fabric,
It can be used by applying it to a support (backing) such as a plastic film and, if necessary, applying a facing such as a polyethylene film.

[Action]

The patch composition of the present invention comprises 1 to 30% by weight of a water-soluble polymer substance that crosslinks by reacting with a polyvalent metal ion, 2 to 10% of a primary alcohol monoester of a methoxyethylene / maleic anhydride copolymer, and By containing a polyvalent metal salt and polybutene, it has excellent shape retention and tackiness.

〔The invention's effect〕

The patch of the present invention has excellent shape retention and adhesiveness,
When the shape-retaining property is increased, the tackiness is lowered, and when the tackiness is enhanced, the problem of the conventional patch, which is easily sagging, is remarkably improved, and there is no sagging due to heat or sweat, and good adhesiveness is exhibited. An excellent usability can be obtained.

〔Example〕

 Next, the present invention will be described in more detail with reference to examples.

Example 1 A patch composition having the following formulation was prepared and applied as a poultice plaster onto a non-woven fabric or a lint cloth, and then a polyethylene film was applied thereon to give a poultice preparation. This product had good adhesiveness and did not sag due to moisture such as sweat or body temperature.

Prescription: Sodium polyacrylate 5.0 (%) (Aronbis S, Nippon Pure Chemical Industries, Ltd.) Carboxymethyl cellulose 2.0 (Daicel CMC1260, Daicel Chemical Industries, Ltd.) Polyacrylic acid 3.0 (Dyulimer AC-10H, Nippon Pure Chemical Industries, Ltd.) Co., Ltd. Methoxyethylene / maleic anhydride copolymer 5.0 (molar ratio 1: 1) butanol monoester (molecular weight: about 50,000) ethanol 5.0 glycerin 20.0 Medicinal component methyl salicylate 2.0-menthol 1.0 d-camphor 1.0 polysorbate 80 2.0 sulfuric acid Aluminum 0.5 water residue Examples 2 to 5 A patch composition having the formulation shown in Table 1 was prepared and applied as a poultice plaster onto a non-woven fabric or a lint cloth, and then a polyethylene film was applied to the poultice composition. And The shape retention and tackiness of this poultice and the poultice obtained in Example 1 were examined. The results are shown in Table 2. As a comparison,
The formulation of Example 1 with the butanol monoester of the methoxyethylene / maleic anhydride copolymer removed (Comparative Example 1), and the formulation of Example 2 with the butanol monoester of the methoxyethylene / maleic anhydride copolymer and polybutene. Was used (Comparative Example 2), and the formulation of Example 2 from which the butanol monoester of the methoxyethylene / maleic anhydride copolymer, polybutene, and potassium cariban were removed (Comparative Example 3) was used.

Claims (2)

[Claims] 1. A primary alcohol monoester 2-1 of a methoxyethylene / maleic anhydride copolymer of 1 to 30% by weight of a water-soluble polymer substance which is crosslinked by reacting with a polyvalent metal ion.
A patch composition containing 0% by weight and a polyvalent metal salt. 2. The patch composition according to claim 1, which further contains polybutene.