JPH0643295B2 - Tablet manufacturing method - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to a method for producing a tablet, and more specifically, when tableting a compounded dough containing a dextrin and an oily component, the tableting property is enhanced to improve productivity. The present invention relates to a manufacturing method for improving the temperature.

[Problems to be Solved by Prior Art and Invention]

Conventionally, various oily ingredients have been used in bath agents for the purpose of protecting the skin and improving the feel of the skin after bathing,
Fragrances are used for the purpose of enhancing the bathing effect. There are various types of bath agents such as liquids, powders, granules, and tablets. At present, tablet bath agents are often used because of their easy handling.

Generally, when tablets are produced, the above-mentioned oily ingredients and the like are powdered using dextrin to prepare a compounding dough for tableting.

However, when tableting a powder containing a large amount of an oily component, the binding force of the powder itself becomes weak, and thus the obtained tablet is apt to be capped or chipped, which causes difficulty in molding. Therefore, in order to prevent this, the tableting speed has to be set low, and as a result, there has been a big problem that productivity is lowered.

Therefore, conventionally, for the purpose of improving the tableting property of tablets, a large amount of a binder was blended for tableting, but if a large amount of the binder is used, the molded product becomes large or Since the blending amount of other components such as the active ingredient of is reduced, it is necessary to increase the usage amount of the obtained tablet per one time, and it is not preferable because it gives the user a feeling of strangeness.
Further, there is a drawback that the manufacturing cost becomes high.

Furthermore, until now, various studies have been conducted on binders that can be highly effective even with a small amount of addition and manufacturing methods for increasing the mechanical strength of tablets, but satisfactory binders and manufacturing methods have not yet been obtained. Has not been done.

Therefore, it has been desired to develop a tablet manufacturing method having excellent tableting properties and productivity.

[Means for Solving the Problems]

In such an actual situation, as a result of intensive studies conducted by the present inventors, in the production of tablets containing dextrin and an oily component, dextrin and an oily component were crushed and mixed, or powder containing dextrin and an oily component was mixed. The present invention has been completed by finding that the above problems can be solved by crushing and mixing a body.

That is, the present invention, in a method for producing a tablet from a compounding dough for tableting containing dextrin and an oily component, while mixing the dextrin and the oily component while crushing, or a powder containing a dextrin and an oily component. The apparent specific gravity of the compounding dough for tableting obtained by mixing while pulverizing and then optionally mixing other components is 1.1 to the apparent specific gravity of the compounding dough for tableting when the above components are simply mixed. The present invention provides a method for producing a tablet, which is characterized in that the amount is 2.0 times.

As the dextrin used in the present invention, the volume value (specific volume) when 20 g of dextrin is gently dropped into a 300 m graduated cylinder is 5 m / g or more, particularly 7 m / g or more in view of its excellent oil absorption ability. Porous dextrin is preferred. Further, such dextrin may be commercially available one or may be one synthesized according to a conventional method.

The oily component used in the present invention is preferably one that is insoluble or sparingly soluble in water and is liquid or solid at room temperature, such as the following.

(1) Oils and fats Natural oils and fats such as soybean oil, bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef tallow, lard, etc.
Hardened oil obtained by hydrogenating these natural fats and oils, myristic acid glyceride, synthetic triglyceride such as 2-ethylhexanoic acid glyceride, diglyceride and the like.

(2) Waxes Carnauba wax, whale wax, beeswax, lanolin, etc.

(3) Hydrocarbons Liquid paraffin, petrolatum, paraffin, microcrystalline wax, ceresin, squalane, pristane, etc.

(4) Higher fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid, etc.

(5) Higher alcohols, lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, 2-
Hexyldecanol etc.

(6) Esters Cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate and the like.

(7) Essential oils (fragrances) peppermint oil, jasmine oil, sho brain oil, cypress oil, spruce oil, ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, shovel oil, pine oil, lavender oil,
Bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, rose oil, sage oil, menthol, cineole, eugenol, citral, citronellal, borneol, linalool, gerolar, camphor, thymol , Spilanthol, pinene, limonene, terpene compounds, etc.

(8) Silicone oils Dimethylpolysiloxane, methylphenylpolysiloxane, dimethyltrimethylsiloxane, amino-modified silicone, polyether-modified silicone, etc.

The above oily components can be used alone or in combination of two or more kinds. When the tablet obtained according to the present invention is used as a bath agent composition, the concentration of the oily component in the bath water is preferably 2 to 500 pp.
m of the tablet, particularly preferably 10 to 100 ppm
It is preferable to determine the compounding amount in relation to the amount of repeated use (input amount). Usually, the compounding amount is 0.5 to 50 parts by weight, particularly 1 to 30 parts by weight, per 100 parts by weight of the tablet.

In the production method of the present invention, when making a compounding dough for tableting, firstly, by mixing the dextrin and the oily component, or by pulverizing and mixing the powder containing the dextrin and the oily component, finally obtained. The apparent specific gravity of the obtained compounding material for tableting is 1.1 to 2.0 times, preferably, the apparent specific gravity of the compounding material for tableting when these components are simply mixed.
It is necessary to be 1.2 to 1.8 times. When the increase in the apparent specific gravity of the compounding material for tableting is less than 1.1 times, the improvement in the tableting property of the compounding material is not observed, and when the increase in the apparent specific gravity of the compounding material for tableting exceeds 2.0 times. In the compounding dough for tableting, exudation of the oily component is likely to occur during tableting, and the tableting property of the compounding dough becomes poor, and the appearance of the tablet obtained by exuding the oily component becomes poor. , Causes a big problem in quality.

The crushing / mixing method in the present invention is not particularly limited, and examples thereof include a crushing / mixing method using a mixing granulator such as a Henschel mixer or a high speed mixer.

When pulverizing and mixing, the dextrin and the oil component may be separately put in the mixing granulator, or both may be mixed in advance and the mixture may be put in the mixing granulator. When the dextrin and the oily component are separately charged, it does not matter which of them is charged first.

It should be noted that in the crushing / mixing step, other tablet components other than the dextrin and the oil component may coexist.

Tablets can be obtained by blending the powder containing the pulverized and mixed dextrin and the oily component thus obtained with other components, if necessary, and tableting by a conventional method.

When a tablet obtained by the production method of the present invention is used as a bath agent composition, a water-soluble polymer, a dispersant or an emulsifier for an oily component such as a surfactant are further added to the above components, if necessary, and the bath tablet is used. It is also possible to prevent the oily component from floating on the water surface when dissolved in a bath water.

As the water-soluble polymer, sodium alginate, propylene glycol alginate, gum arabic, xanthan gum, pectin, tragacanth, sodium carboxymethyl cellulose, methyl cellulose, carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soy protein, Examples thereof include gelatin, egg protein, sodium caseinate, whey protein and the like, and gum agents such as gum arabic and xanthan gum and water-soluble proteins such as sodium caseinate and whey protein are preferred.

As the above-mentioned surfactant, any of anionic / cationic / nonionic, natural / synthetic surfactants can be used.

As the nonionic surfactant, for example, glycerin fatty acid ester, propylene glycol fatty acid ester,
Sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, tetraoleic acid polyoxyethylene sorbit, polyoxyethylene alkyl ether, polytoxyethylene polyoxypropylene glycol, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene Castor oil, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester and the like,
These nonionic surfactants act as emulsifiers for the oily ingredients.

These oily component dispersants or emulsifiers are used alone or in combination of two or more, and the blending amount thereof is preferably 5 to 100 parts by weight, particularly preferably 18 to 100 parts by weight of the oily component. It is 60 parts by weight.

Further, when the tablet obtained by the production method of the present invention is a bath tablet, the following known bath agent raw materials that are commonly used in bath agents can be further blended. It is not limited to those exemplified below.

(A) Inorganic salts Sodium chloride, sodium hydrogen carbonate, sodium carbonate, borax, sodium sulfate, sodium sulfide, sodium sesquicarbonate, sodium nitrate, sodium thiosulfate, sodium polyphosphate, sodium phosphate, calcium oxide, magnesium oxide, carbonic acid Calcium, magnesium carbonate, potassium chloride, potassium sulfide, aluminum sulfate, alum, etc.

(A) Inorganic acids Boric acid, metasilicic acid, silicic acid anhydride, etc.

(C) Organic acids Succinic acid, fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid and the like.

(D) Herbal medicines fennel, oyster, chamomile, cinnamon, safflower peony, ginger, iris, ginkgo, stalks, chimpi, sojutsu, valerian, juniper, spruce, lightly-loaded, carrot, etc.

(E) Dyes Tar dyes such as Yellow No. 4, Blue No. 1, Yellow No. 202 (1), etc. specified by the Ordinance of the Ministry of Health and Welfare, food additives such as chlorophyll, riboflavin, crocin, safflower, anthraquinone, etc. Natural pigments that are recognized as products.

(F) Vitamin vitamin A, vitamin C, vitamin D, vitamin E, etc.

(G) Fine powder, which is generally called cosmetic powder, is made of acrylic resin,
Polymers such as styrene resin, epoxy resin, nylon, polyethylene, polypropylene, polyvinyl chloride, polyethylene terephthalate resin, polytetrafluoroethane, copolymers of these polymers, silicic acid, calcium silicate, natural aluminum silicate, synthetic silica Aluminum oxide, zeolite, titanium oxide, talc, kaolin, mica, bentonite, etc.

(H) Others Sulfur, Yunohana, Mineral sand, Mica powder, Neutral clay, sucrose, bactericide, preservative, and other necessary ingredients for formulation.

〔The invention's effect〕

By using the production method of the present invention, the tableting properties and productivity of tablets can be remarkably enhanced, and the compounding ability of the tableting compounding dough can be improved by increasing the specific gravity.

〔Example〕

Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.

In this example, the loose apparent specific gravity was measured and the tableting dest was performed according to the following methods.

Loose apparent specific gravity measurement Fit the attached funnel on the vibrating table of the powder tester body, and install the table with the apparent specific gravity measuring cup (100cc) under the funnel (Fig. 1). Using the attached scoop, gently insert the compounding material for tableting, which is the subject, from the top of the funnel and fill it in a heap. Then, the surface of the compounding material for tableting was ground with an attached blade and weighed with a precision balance, and the loose apparent specific gravity was calculated from the following formula.

Powder weight (g) / 100 = loose apparent specific gravity (g / cc) Tableting test Continuous tableting was performed by changing the tableting speed, and the limiting tableting speed at which capping did not occur was determined.

Example 1 and Comparative Example 1 A compounding dough for tableting having a compounding formulation shown in Table 1 was produced according to the compounding flow in Table 2 (Example 1). That is, first Henschel mixer (Mitsui Miike Kakoki Co., Ltd., 20)
Mix while adding the oily component to the dextrin.
Grinding (800 rpm, 10 minutes), then mixing the powder thus obtained, sodium hydrogencarbonate, sodium carbonate and succinic acid with a Nauta mixer (manufactured by Hosokawa Micron Co., Ltd.) (14 minutes) to give a mixture of 7 kg. After obtaining the powder, coarse particles were removed by an 8-mesh sieve to prepare a compounding dough for tableting. The loose apparent specific gravity of the compounded dough for tableting was measured. The results are shown in Table 2.

Next, hydraulic tablet press (Madeina Co., UDEF-20.100)
Tableting test of the obtained compounded dough for tableting (50 g)
/ Tablet). The results are shown in Table 2. As a comparative example, the compounding dough for tableting having the compounding recipe shown in Table 1
According to the compounding flow in the table (Comparative Example 1), it was produced by mixing (14 minutes) only with a Nauter mixer (manufactured by Hosokawa Micron Co., Ltd.), and the loose apparent specific gravity was measured and a tableting test (50 g / tablet) was performed. It was The results are shown in Table 2.

From the above results, by using the production method of the present invention, the tableting speed can be increased to about 1.4 times that of the comparative example, and the superiority of the present invention has been clarified.

Example 2, Comparative Example 2 A compounding dough for tableting having a compounding formulation shown in Table 3 was produced according to the compounding flow in Table 4 (Example 2). That is, first, sodium hydrogen carbonate, sodium carbonate, succinic acid, fumaric acid, dextrin, an oil component, polyethylene glycol and titanium oxide were mixed (14 minutes) with a Nauta mixer (manufactured by Hosokawa Micron Co., Ltd.) to prepare 7 kg of compounded powder. Got the body Next, after mixing and crushing this powder with a Henschel mixer (75, manufactured by Mitsui Miike Kakoki Co., Ltd.) (800 rpm, 10 minutes), coarse particles are removed by an 8 mesh sieve to prepare a compounding dough for tableting. did. The loose apparent specific gravity of the compounded dough for tableting was measured. The results are shown in Table 4.

Next, a tableting test (30 g / tablet) was performed on the obtained compounded tableting dough with an eccentric tableting machine (Masina DC-BOW, manufactured by Machinena Co., Ltd.). The results are shown in Table 4.

In addition, as a comparative example, the compounding dough for tableting having the compounding formulation shown in Table 3 was mixed only with a Nauter mixer (manufactured by Hosokawa Micron Co., Ltd.) according to the compounding flow shown in Table 4 (Comparative Example 2).
Then, the loose apparent specific gravity was measured and a tableting test (30 g / tablet) was performed. The results are shown in Table 4.

Using the production method of the present invention, one tablet of 30 g has 16 shots.
It was possible to tablet at a speed of / min, but in the method of the comparative example it was 23
Only g tablets could be compressed at a rate of 5 shots / minute. From the above results, the superiority of the present invention became clear.

[Brief description of drawings]

FIG. 1 is a drawing showing a schematic view of an apparatus used for measuring loose apparent specific gravity in Examples.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Yuji Ichii 2-3-30 Higashiimaizumi, Utsunomiya City, Tochigi Prefecture 2-3-30 Green Heights 2-501 (72) Inventor Hidenori Man, 423-4 Hiramatsumotocho, Utsunomiya City, Tochigi Prefecture

Claims (2)

[Claims] 1. A method for producing a tablet from a compounding dough for tableting containing dextrin and an oily component, which is obtained by mixing dextrin and an oily component while crushing, and then optionally mixing other components. A method for producing a tablet, wherein the apparent specific gravity of the compounding material for tableting is set to be 1.1 to 2.0 times the apparent specific gravity of the compounding material for tableting when the above components are simply mixed. 2. A method for producing a tablet from a compounding dough for tableting containing dextrin and an oily component, wherein powder containing dextrin and an oily component is ground and mixed,
Then, if necessary, the apparent specific gravity of the compounding material for tableting obtained by mixing other components is 1.1 to 2.0 times the apparent specific gravity of the compounding material for tableting when the above components are simply mixed. A method for producing a tablet, comprising: