JPH0633049U - Shaking reactor - Google Patents

Abstract

(57) [Summary] [Purpose] A single compact device that has both shaking and heating functions, does not use water (hot water), and therefore does not have water-related troubles and is safe to shake. A reactor is provided. [Structure] In a main body case 21, a heat block 22 for heating a test tube 21 and means for shaking and driving the agglutination reaction stage 2 (hidden in the figure) are provided. Since the reaction stage 2 is elastically supported via a rubber plate, the reaction stage 2 and the main body case 21 are
There is no danger of being injured when your fingertip is caught between.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention is a shaking reaction in which an agglutination reaction product such as blood mixed with antiserum is automatically shaken in order to promote an agglutination reaction such as a blood agglutination reaction or a latex agglutination reaction, which is applied in a clinical laboratory. It relates to the device.

[0002]

[Prior art]

 A typical example of the agglutination reaction applied in the clinical laboratory is a blood agglutination reaction. This blood type determination is generally performed using a blood test card. FIG. 3 is a process diagram schematically illustrating the operation of the blood agglutination reaction. The test sample is stored in a test tube 23, placed in a water bath 7 as indicated by arrow A and heated, and then transferred to a centrifuge 28 (arrow B). Drop onto the mold card a (arrow D), add the reagent, hold by hand (arrow E) and rock and shake. A shaker 29 for automatically performing this shaking operation has also been developed, and a blood-liquid type card a to which a reagent has been added is also placed on the reaction stage 2 of the shaker 29 as shown by an arrow F and shaken.

[0003]

[Problems to be solved by the device]

 In the prior art shown in FIG. 3, a. The water bath, the centrifuge, and the shaker are independent devices, require a large installation area, and are complicated to operate. B. In particular, the water bath is not easy to handle, it takes a long time to prepare before starting work, and there is a risk that water will be spilled on the workbench, and it takes time to wipe off water droplets from a wet test tube, causing water to evaporate. If you lose weight then you have to replenish. There is an inconvenience.

Although it is possible to combine two of the above-mentioned three devices, for example, the water bath 7 and the shaker 29 into one device, the reaction stage 2 of the shaker is driven and rocks. Therefore, if the shaker and other equipment are combined, the number of machines that come into contact with the vicinity of the reaction stage 2 increases and the risk of the fingertip being caught in the reaction stage 2 increases.

The present invention has been made in view of the above circumstances, and it takes a short time to prepare for work, does not need to replenish a consumable material (for example, water), and has no fear of running out of water. An object of the present invention is to provide a shaking reaction device capable of heating and shaking a sample with a single compact device that is not likely to be scratched by the fingertip being caught.

[0006]

[Means for Solving the Problems]

 The basic principle of the device of the present invention created to achieve the above object will be briefly described as follows: a. A metal heat block provided with a temperature control means is provided in place of the water bath so that it is not necessary to zero the water or supplement the evaporated water. b. The reaction stage is elastically supported so that there is no risk of the fingertip being caught in the vibrating reaction stage. As a concrete configuration based on the above principle, the shaking device with a sample heating function according to the present invention comprises a driving mechanism for supporting the agglutination reaction stage in a single case and swinging the test, and a test mechanism. The driving mechanism is configured to house a heating mechanism for heating the pipe, and the drive mechanism includes a member rotating in a horizontal plane, a plurality of through holes provided in the member, and one of the plurality of through holes. The support rod inserted into the support rod, the agglutination reaction stage fixed to the upper end of the support rod, the rubber plate fixed at a right angle to the support rod, and the rubber plate fixedly supporting the periphery. The heating mechanism has a metal heat block having a plurality of holes into which test tubes can be inserted, an electric heater for heating the heat block, and a plurality of preset temperatures. Temperature control means, means for displaying the set temperature, Characterized in that it comprises.

[0007]

[Advantages] According to the above configuration, the shaking mechanism portion and the heating mechanism portion are integrated as one compact device, which is convenient, and there is a risk that the swinging stage may be injured by the fingertip being caught. There is no.

[0008]

【Example】

 FIG. 1 is a partially cutaway perspective view showing an embodiment of the present invention. A drive mechanism and a heat block 22, which will be described later with reference to FIG. 2, are provided in the main body case 21. The drive means is hidden in the main body case 21 in FIG. 1, and is projected onto the main body case 21 to support the agglutination reaction stage 2. The agglutination reaction stage 2 is shaken by shaking the reaction product 17 with the blood type card a placed thereon. The heat block 22 is made of aluminum and has a hole 22a which fits the test tube 23. Although not shown, the heat block 22 is equipped with an electric heater and a thermostat, and is switched and controlled by the temperature control changeover switch 22b in two stages of 56 ° C and 85 ° C. The changeover state is the temperature control indicator lamp 22c. Is displayed by. A shaking switch 24 opens and closes an electric circuit of a drive mechanism that supports and swings the agglutination reaction stage 2. Reference numeral 25 is a main switch of this shaking reactor, 26 is a fuse, and 27 is a cord.

FIG. 2 is a perspective view of a drive mechanism that supports and swings the reaction stage 2. The horizontal bracket plate 1c and the upper arm 1d are fixed to the main body case 21. Reference numeral 2 denotes a plate-shaped stage, which is fixed to the upper end of the support rod 3 at a right angle. As shown in the figure, a card (or slide) on which the reaction product 17 such as the blood type card a is dropped is placed on the reaction stage 2. A rubber plate 4 is fixed to the support rod 3 in a flange shape. That is, the support bar 3 is fixed by penetrating the rubber plate 4 at a right angle. Reference numeral 5 denotes a rotary plate, which has a structure which is supported by a rotary plate shaft 6 with respect to the horizontal bracket plate 1c which is the stationary member and which can freely rotate in a horizontal plane. The rotary plate 5 is provided with a plurality of through holes 5a to 5f, and the distances from the rotary plate shaft 6 are different from each other. The lower end of the support rod 3 is inserted by selecting any one of the plurality of through holes.

A motor is installed in the main body case 21, and drives the worm receiving gear 9 via the worm original gear 8. A pulley shaft 11 supported by a pulley bearing 10 is fixed to the worm receiving gear 9 to rotate a drive pulley 12.

The drive pulley 12 rotatably drives the rotary plate 5 via a belt 13. When the motor is rotated, the drive pulley 12 is rotated via the worm original gear 8 and the worm receiving gear 9, and the rotary plate 5 is rotated via the belt 13. As the rotary plate 5 rotates, the through holes 5a to 5f revolve around the rotary plate shaft 6. Since the support rod 3 of this example is inserted through the through hole 5f, it is guided by the through hole 5f to perform a rasping motion. That is, the swinging motion is performed so that the center point of the rubber plate 4 is the apex and the locus circle of the through hole 5f is the bottom surface of the conical slope. In the reaction stage 2 in the state of FIG. 2, the reaction product (liquid) 17 on the reaction stage 2 is shaken and shaken by the rubbing movement of the support rod 3, and the aggregation reaction is automatically promoted. Since the agglomeration reaction apparatus of this embodiment is supported by the rubber plate 4, there is no friction surface between the pivot supporting portions of the same metal, no lubricant is required, and washing with water is possible and maintenance is easy. Further, the swing angle can be adjusted by appropriately selecting the through hole through which the support rod 3 is inserted. That is, when the support rod 3 is inserted into a through hole that is relatively close to the center like the through hole 5a, the swinging angle becomes small and a weak shaking operation is performed. Further, the swinging angle for inserting the support rod 3 into the through hole relatively far from the center such as the through hole 5d becomes large, so that a strong shaking operation is performed. As can be easily understood from the above structure and function, the rotary plate 5 does not necessarily have to be a belt driven by a belt, and is fixed to the rotary plate shaft 6 to rotate in a horizontal plane. Even if the member is an arm-shaped member having a plurality of through holes and is rotationally driven by the motor through the reduction gear train, the same operation and effect as in the previous example can be obtained. (See FIG. 1) According to the apparatus of the present embodiment, the test tube 23 can be put into the hole 22a of the heat block 22 and heated, and the temperature control changeover switch 22b is operated according to the type of the sample, and the heating temperature is changed. Can be adjusted. The temperature control state is displayed by the temperature control indicator lamp 22c. Since this heating means does not use water (hot water), there is no fear of spilling the water, and there is no need to replenish the evaporated water. In addition, the preparation time for heating the water bath prior to use is reduced. And both heating and shaking functions are performed by a single compact instrument. Therefore, the space required for installation is small and maintenance is easy. When inserting / removing the test tube 23 into / from the hole 22a provided in the heat block 22, even if a fingertip is accidentally inserted between the main body case 21 and the agglutination reaction stage 2, the reaction stage 2 will be explained with reference to FIG. Since it is supported by the rubber plate 4 as described above, there is no risk of being injured when the fingertip is pinched strongly.

[0012]

[Effect of device]

 The shaking reaction device according to the present invention is a compact single device that has both a sample heating function and a shaking function. It is safe because there is no need to replenish, and there is no risk of being injured when your fingertips are caught.

[Brief description of drawings]

FIG. 1 shows an embodiment of a shaking reaction device according to the present invention,
It is a perspective view which fractured and drawn some.

FIG. 2 is a schematic cross-sectional view of a reaction stage and its drive mechanism in the embodiment shown in FIG.

FIG. 3 is a schematic process explanatory view showing an example of a blood group reaction operation in a conventional technique.

[Explanation of symbols]

1c ... Horizontal bracket plate, 1d ... Upper arm, 2 ... Reaction stage, 3 ... Support rod, 4 ... Rubber plate, 5 ... Rotating plate, 5
a, 5f ... Through hole, 6 ... Rotating plate shaft, 7 ... Water bath,
8 ... Worm original gear, 9 ... Worm receiving gear, 10 ... Pulley bearing, 11 ... Pulley shaft, 12 ... Driving pulley, 13 ... Belt, 17 ... Reactant, 21 ... Main body case, 22 ... Heat block, 22a ... Hole, 22b ... Temperature control changeover switch, 22c ... Temperature control indicator lamp, 23 ... Test tube, 24
... shake switch, 25 ... main switch, 26 ... fuse, 27 ... cord, 28 ... centrifuge, 29 ... shaker,
a ... blood type card.

Claims (1)

[Scope of utility model registration request] 1. A single case is provided with a drive mechanism for supporting the agglutination reaction stage to drive the test tube and a heating mechanism for heating the test tube, and the drive mechanism rotates in a horizontal plane. A member, a plurality of through holes provided in the member, a support rod inserted through any one of the plurality of through holes, and an agglutination reaction stage fixed to the upper end of the support rod. A rubber plate fixed at a right angle to the support rod, and means for fixedly supporting the periphery of the rubber plate, wherein the heating mechanism has a plurality of holes into which test tubes can be inserted. A shaking characterized by comprising a metal heat block having: an electric heater for heating the heat block; a temperature control means having a plurality of set temperatures; and a means for displaying the set temperatures. Reactor.