JPH06321722A - Antimicrobial sheet and calendar using the same sheet - Google Patents

Abstract

PURPOSE:To obtain an antimicrobial sheet, constructed by adsorbing a substance prepared by mixing propolis with an adsorbent on air-permeable paper and useful for suppressing the proliferation or sterilizing methicillin-resistant Staphylococcus aureus and a calendar using the sheet. CONSTITUTION:This antimicrobial sheet is obtained by applying layers 3, 13 and 23 composed of a substance prepared by mixing propolis with an adsorbent to sheets 2, 12, 14 and 22 made of paper. When methicillin-resistant Staphylococcus aureus (MRSA) sticks to the antimicrobial sheet, the proliferation is suppressed by the antimicrobial action of the propolis to sterilize the MRSA. Malodor from patients is removed by the deodorizing action of the propolis. Furthermore, since a comfortable fragrance is volatilized to the surroundings by the aromatic action of the propolis, the interior of a hospital is comfortable. The MRSA can effectively be prevented from proliferating even if the MRSA sticks to the side without the propolis layer of the paper sheet by especially using air-permeable sheets as the paper sheets 2, 12, 14 and 22. Since this sheet is a paper product, the production cost is low and disposal is readily carried out.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antibacterial sheet for inhibiting the growth or sterilizing methicillin-resistant Staphylococcus aureus (MRSA) and a calendar for medical institutions using the antibacterial sheet.

[0002]

2. Description of the Related Art Conventionally, nosocomial infection of methicillin-resistant Staphylococcus aureus (MRSA), which has strong resistance to most antibiotics such as methicillin, has been a serious problem in medical institutions such as hospitals and nursing homes. Has become. In other words, MRSA has almost no effect on antibiotics,
Infection of people with weakened immunity such as post-operative patients and elderly people causes deep infection such as peritonitis, resulting in high mortality. Therefore, currently, from domestic textile companies,
As measures against such MRSA infection, white coats for doctors and nurses, sheets, bedspreads, curtains, etc. have been proposed which use a fabric made of fibers having a growth-suppressing or bactericidal effect on MRSA.

[0003]

However, in actual facilities such as medical institutions and nursing homes, the above-mentioned M
The RSA breeds not only on the doctor / nurse lab coat, sheets, bedspreads, curtains, etc., but also on various items such as rooms and corridors. Therefore, if the doctor's / nurse's lab coat, sheets, bedspreads, curtains, etc. using the above-mentioned MRSA growth-suppressing fabric are used,
It is extremely insufficient as a countermeasure for RSA infection. The present invention has been made by paying attention to such problems of the conventional techniques, and expands the targets capable of suppressing the reproduction of MRSA from the above-mentioned textile products to wider articles, and
It is an object of the present invention to provide an antibacterial sheet and a calendar using the antibacterial sheet, which can effectively prevent nosocomial infection of SA.

[0004]

The antibacterial sheet of the present invention for attaining the above object is constituted by adhering a substance obtained by mixing propolis and an adsorbent to breathable paper. Further, in the present invention, the antibacterial sheet may be formed by interposing a substance obtained by mixing propolis and an adsorbent between two sheets of paper, at least one of which is breathable. Further, the calendar according to the present invention is configured by displaying the date and day of each month on the antibacterial sheet formed in a predetermined shape.

[0005]

As described above, in the antibacterial sheet according to the present invention,
A mixture of propolis and adsorbent is attached to the paper. Therefore, MR attached on this antibacterial sheet
SA is sterilized by the antibacterial action of propolis. At the same time, the bad smell from the sick person is removed by the deodorizing action of propolis. In addition, a pleasant odor due to the aroma of propolis is emitted to the surroundings, which makes the hospital comfortable. In particular, in the present invention, by using a breathable paper as this paper, even when MRSA is attached to the side of the paper on which the propolis is not attached, the MRSA is effectively used.
Will be able to prevent the breeding of. Further, in the antibacterial sheet according to the present invention, a substance in which propolis and an adsorbent are mixed may be interposed between two sheets of paper at least one of which has air permeability. According to this antibacterial sheet, MRSA attached on the air-permeable paper is sterilized by the antibacterial action of propolis. At the same time, the bad smell from the sick person is removed by the deodorizing action of propolis through the breathable paper. In addition, the pleasant odor of the aroma of propolis passes from this breathable paper and is dissipated to the surroundings, making the hospital comfortable. In particular, in the present invention, by using an air-permeable material for both of these two sheets of paper, it becomes possible to effectively prevent the propagation of MRSA even when MRSA adheres to either of the two sheets of paper. Furthermore, since the calendar according to the present invention displays the date and day of each month on the antibacterial sheet formed in a predetermined shape, it can be used by hanging it on a hospital or a nursing home. MRS on the calendar by
It becomes possible to prevent A from attaching and propagating and infecting.

[0006]

The present invention will be described below based on its embodiments. First, a natural material called propolis will be explained.
Propolis is known as a secondary product of beekeeping. Propolis is used by bees to fill gaps in their nests and to solidify areas of rattling. Bees solidify the inside of the nest, especially at the entrance, with propolis to control the temperature inside and prevent enemy attacks from the outside. However, since the inner wall of the nest is also filled with propolis, it is said to be a troublesome substance for beekeepers. Such collection of propolis is performed by excising from the inner wall of the honeycomb when exchanging the nest material or moving the nest. Although the amount collected depends on conditions such as the type of bee and the place where the hive is placed, it is said that 100 to 300 g of propolis is collected from one hive on average (JPI Corporation ( "Propolis", pages 1 and 2 issued on October 1, 1986 by Nishi-Yokohama Sanyo Building No. 303, 5-1 Hamamatsucho, Nishi-ku, Yokohama-shi, Kanagawa).

Next, the chemical components of propolis will be described. Recent studies have greatly advanced the knowledge about the components of propolis. To date, 18 kinds of components have been analyzed, and the contents of 11 kinds of substances have been clarified. Those components that have already been elucidated are the analyzes with propolis dissolved in 1/3 equivalent alcohol. According to the elucidation so far, the main component of propolis is flavonoid (flavonoide) compound, flavonas (1-4), flavonoles (5-10), flavononas (11
-13) types are available. Similarly, for propolis, terpene (t
erpena) compound has also been discovered, α-acetoxi-betuleno
l (15), aldehido aromatico, and isovanilina (16).
For flavonas (1-4), use the chemical formula 1
For noles (5-10), the chemical formula 2 is used, flavononas (11
-13), the chemical formula 3 is α-acetoxi-betulenol
For (15), the chemical formula 4 is changed to aldehido aromatico, i
See chemical formula 5 for sovanilina (16).

[Chemical 1]

[Chemical 2]

[Chemical 3]

[Chemical 4]

[Chemical 5]

[0008] Next, the conventional research results on the characteristics of propolis and its use / application will be described. First, it has been experimentally proved that propolis has a bactericidal effect and an antibacterial effect (ibid., "Propolis", p. 12). For this reason,
Application to the field of medicine, for example, as a therapeutic agent for chronic oral stomatitis (ibid., "Propolis", pages 104 to 108), and as a therapeutic agent for chronic colitis (ibid., "Propolis", Nos. 115-115). 116) and its use as a therapeutic drug for skin diseases (ibid., "Propolis", pp. 126-129), have been studied and announced. Further, it has been experimentally proved that propolis has a deodorizing power for eliminating a bad odor, and it has been pointed out that it has a potential as a deodorant. The deodorizing power of such propolis is considered to be due to the antibacterial and aromatic properties of propolis itself (ibid., “Propolis” No. 103).
page).

Further, the antibacterial action of propolis, especially MR
Experiments on the antibacterial action against bacteria to which antibiotics such as SA are hardly effective have been introduced more than ever before. It has also been pointed out that propolis has an aromatic character. That is, it has been proved that a propolis alcohol oil having a brown color and aromaticity can be produced by preparing a 30 to 40% propolis alcohol liquid, dissolving it in olive oil or corn oil at a ratio of 1: 4, and mixing well. P. 100).

In addition, the above-mentioned JPI Corporation (Nishiyokohama Sanyo Building 303, 5-1 Hamamatsucho, Nishi-ku, Yokohama-shi, Kanagawa Prefecture)
Issue) issued on October 1, 1986, in "Propolis""newdeodorant" (written by VNPRISICH), the antibacterial action of propolis, especially the antibacterial action against bacteria such as MRSA and other antibiotics are hardly effective. About the following. That is, conventionally, in folk remedies, propolis is also used to treat cancers such as eyes, octopus, and skin cancer. Propolis dissolved in alcohol is used to treat 38 post-operative patients, and propolis is affected. It has been discovered to have the property of removing an unpleasant odor. In order to check the deodorizing effect of propolis, various experiments and studies were conducted with propolis. That is, 40
Make a 20% solution of propolis in alcohol,
The experiment was conducted with a malodorous liquid taken from the patient's ear. For comparison, the same experiment was performed with pure alcohol without mixing propolis. The materials thus prepared were soaked in a tampon, the numbers were written, and five people smelled for the experiment. The olfaction of the 5 persons was tested by the VOJACHK method before the experiment. It was an olfactory test with 0.5 mg of rotten meat. As a result of this experiment, it was proved that propolis has a deodorizing effect. Alcohol had a similar odor-eliminating effect, but was less effective than the mixture with propolis. The deodorizing power of propolis is considered to be due to the antibacterial and aromatic properties of propolis itself (from "new deodorant" in "propolis").

Also, the above-mentioned JPI Corporation (Nishi Yokohama Sanyo Building 303, 5-1 Hamamatsucho, Nishi-ku, Yokohama-shi, Kanagawa Prefecture)
Issue) "Propolis" published on October 1, 1986, "Chemical composition and biological properties of propolis"
(SEPALMBAJA, SAPOPRAVKO) describes the antibacterial action of propolis as follows. That is,
The ingredients of propolis collected from various parts of Soviet Union are mainly as follows. α-acetoxi-betulenol, 5-hldroxi-4´, 7-dimetoxifla
bona, 3,5-dihidroxi-4´, 7-dimetoxiflavona, 5,7-di
hidroxi-3, 4'-dimetoxiflabona, 5-hidroxi-4 ', 7-d
imet-oxiflavona, 5,7-dihidroxi-4´-metoxiflavona,
3,5,4'-trhidroxi-7-metoxiflavona, 4 ', 3,5,7-tetra
hidroxi-3-metoxiflavona, 3,5,7-trihidroxi-4´-meto
xiflavona. Based on this scientific composition, the Soviet-produced (poplar-type) propolis of the research sample was classified as a birch tree-type propolis. An alcoholic solution of this propolis was subjected to color plate analysis with grade silicates, and was analyzed with a system of petroleum benzene ether and benzene acetone for 20
It was classified into a fraction. The 20 kinds of samples were individually tested for activity of antibacterial effect against the following cultures. Staphylococcus aureus Staphylococcus aureus Sarcina lutea Streptococcus faecalis Streptococcus faecalis Streptococcus faecalis Candida albicans is Candida albicans Saccharomyces cereus Bacillus mycoides Mycoid Bacillus subtilis Bacillus mycobacterium Alcohol or non-methyl formaldehyde was used. In particular, sample 7.8.9
The antibacterial activity was high. Specifically, the activity value against Staphylococcus aureus was 60-70 mg / m 2. Chemical analysis of 7.8.9 showed that the main components were as follows. 5-hidroxi-4´, 7-dimetoxiflavona, 3,5-dihidroxi-4
´, 7-dimetoxiflavona, 5,7-dihidroxi-2, 4-dimetoxif
lavona (from "Chemical composition and biological properties of propolis" of the same "propolis").

Furthermore, the above-mentioned JPI Corporation (30, Nishi-Yokohama Sanyo Building, 5-1 Hamamatsucho, Nishi-ku, Yokohama-shi, Kanagawa)
No. 3) "Propolis" issued on October 1, 1986
"Propolis antibacterial properties" (ISALEK
SANDROW, LNDANILOV) described the antibacterial action of propolis as follows. That is, the antibacterial property of propolis was tested against each type of bacteria. In 20 patients with skin diseases (nebu, lymphadenitis, and ulcer), the above bacteria were found in most of the patients. In conclusion, as shown in the following Table 1, it was found that propolis has an antibacterial effect, and in some cases, it has an effect more than antibiotics. None of the four bacteria tested were resistant to propolis. In addition, propolis also has the effect of increasing the resistance of the body (from the "propolis antibacterial properties" in the same "propolis").

[Table 1]

Furthermore, the above-mentioned JPI Corporation (30, Nishi-Yokohama Sanyo Building, 5-1 Hamamatsucho, Nishi-ku, Yokohama-shi, Kanagawa)
No. 3) "Propolis" issued on October 1, 1986
"Effect of propolis on various microorganisms and molds"
(L.VECHET), on the antibacterial action of propolis,
It states as follows. That is, according to LINDENFELSER, the microbial growth inhibitory effect and the bactericidal effect of propolis were proved especially in Gram-positive strains. Propolis had no effect on yeast. From various experiments, it was found that propolis showed antibacterial properties mostly in Gram-positive cocci, Micrococcus lysodelct.
Bacillus subtypes of Gram-negative bacilli such as icus, Sarcina lutea, Staphylococcus aureus (Staphylococcus aureus)
tills, a Gram-positive bacterium Corynebacterium oqu
i, mold Aspergi-llus ochraceus, some yeast Sa
It was against ccharomyces cerevisiee (from "Effect of propolis on various microorganisms and mold" in the same "propolis").

The present inventor pays attention to the bactericidal property, deodorant property, and aromatic property of propolis as described above, and by using this propolis, MRSA of medical institutions, nursing homes, etc. We have realized an antibacterial sheet that is effective in preventing hospital infections. Examples of this antibacterial sheet will be described below. FIG. 1A is a plan view showing an antibacterial sheet according to a first embodiment of the present invention, and FIG. 1B is a sectional view taken along line BB of the antibacterial sheet. In FIG. 1, reference numeral 1 indicates an antibacterial sheet, and reference numeral 2 indicates a breathable paper sheet. A propolis layer 3 made of a mixed substance (solid) obtained by mixing the above-mentioned propolis and an adsorbent is fixed to one surface of the paper sheet 2. To form the propolis layer 3, for example, a propolis solution (alcohol solution of propolis) is mixed with a well-known adsorptive substance (adsorbent) such as activated carbon, wax, beeswax, paraffin, or starch. First, an adsorbent powder containing propolis is formed. Then, the powder containing the propolis is sprayed in layers on the paper sheet 2. Thereby, the propolis layer 3 can be formed. In the first embodiment, the paper sheet 2 is a sheet having air permeability, but the present invention is not limited to this, and paper having no air permeability may be used.

Next, FIG. 2 is a partial sectional view showing a second embodiment of the antibacterial sheet according to the present invention. The antibacterial sheet 11 according to the second embodiment is configured by interposing a propolis layer 13 between two air-permeable paper sheets 12 and 14. The propolis layer 13 is made by mixing a propolis solution with an adsorbent to obtain a powder, which is made into a paper sheet 11
It is formed by spraying and fixing it in layers.
Then, the other antibacterial sheet 11 of this embodiment is formed by further adhering another paper sheet 14 on the propolis layer 13. In the second embodiment, the air-permeable paper is used for both of the two paper sheets 12 and 14, but the present invention is not limited to this, and the paper sheet 12, Non-breathable paper may be used for either one of the fourteen.

The antibacterial sheets 1 and 11 shown in FIG. 1 or FIG. 2 have antibacterial / bactericidal, deodorant and aromatic effects against MRSA due to the propolis layers 3 and 13. That is, the bacteria such as MRSA attached on the antibacterial sheets 1 and 11 (on the propolis layer 3 or on the paper sheets 2, 12 and 14) are protected from the propolis layer 3 and
The antibacterial action of the propolis in 13 suppresses the growth and sterilizes it. Further, the offensive odor and the bad odor from a sick person or the like are removed by the deodorizing action of the propolis in the propolis layer 13 being exerted directly or through the breathable paper sheets 2, 12 and 14. Further, the propolis in the propolis layer 13 produces a pleasant odor due to its aroma action, either directly or with breathable paper sheets 2, 12 ,.
As it is radiated to the surroundings through 14, the comfort of the surroundings is improved.

The antibacterial sheets 1 and 11 as shown in FIG. 1 or 2 can be used in various places and cases. For example,
By using it as a disposable paper sheet for hospitals, a disposable garbage bag made of paper, a material for disposable diapers made of paper, etc., it becomes possible to obtain anti-proliferation, sterilization, deodorant and aroma effects of MRSA. Further, in a facility such as a hospital or a nursing home, by laying the antibacterial sheets 1 and 11 under a mat or laying the antibacterial sheets 1 and 11 on the lower surface of a closet, a place where the above-mentioned bacteria easily propagate. It is possible to produce effects such as sterilization, deodorization and aroma in. The antibacterial sheet 1 of the first and second embodiments described above
In No. 11, both are configured by fixing a mixture of a propolis and an adsorbent on a paper sheet in a layered manner by spraying or the like, but the present invention is not limited to this, and, for example, propolis An antibacterial sheet containing propolis may be produced by immersing a paper sheet in a propolis solution dissolved in alcohol and then freeze-drying the sheet.

Next, FIG. 3 is a perspective view showing an embodiment of a calendar using the antibacterial sheet according to the present invention. That is, the antibacterial sheet as shown in FIG. 1 or FIG. 2 is cut into 12 pieces in a predetermined size, and the date of each month, the day of the week, and the like are displayed on the sheet, whereby the calendar of this example is manufactured. It By hanging the thus-produced calendar in a facility of a hospital or a nursing home, it is possible to prevent the MRSA attached to the calendar from being propagated and sterilized, and effectively prevent MRSA from being infected through the calendar. be able to. In addition, the comfort in the facility is improved by the action of deodorizing the bad odor and the offensive odor of the propolis contained in the calendar and the aroma action of releasing a comfortable odor.

Further, FIG. 4 is a sectional view showing a mattress using the antibacterial sheet according to the present invention. This mattress has
An antibacterial sheet 21 having a propolis layer 23 fixed on a paper sheet 22 is used, which is similar to that shown in FIG.
That is, the antibacterial sheet 21 is placed on the thick cotton 24, and the cloth cover 25 is formed around the antibacterial sheet 21 to form the mattress. As a result, the bacteria such as MRSA adhering to the mattress are suppressed in growth due to the bactericidal action of propolis and sterilized. Further, the offensive odor emitted by the sick person is removed by the deodorizing action of propolis, and at the same time, a pleasant odor is emitted from the propolis. Although an example in which the antibacterial sheet is used for the mattress is shown here, the present invention is not limited to this, and the antibacterial sheet can also be used for the mattress or bed cover. Although a duvet cover made of a fabric having an MRSA growth-suppressing action has already been provided, the paper sheet is used in this embodiment as compared with these cloth products, so that the manufacturing cost is reduced. There are merits that it is small and disposal is easy.

[0020]

As described above, in the antibacterial sheet according to the present invention, the substance obtained by mixing the propolis and the adsorbent is attached to the paper. Therefore, the MRSA attached on this antibacterial sheet is sterilized by the antibacterial action of propolis, which suppresses its reproduction. At the same time, the bad smell from the sick person is removed by the deodorizing action of propolis. In addition, a pleasant odor due to the aroma of propolis is emitted to the surroundings, which makes the hospital comfortable. Particularly in the present invention,
By using a breathable paper sheet, it is possible to effectively prevent MRSA from growing even when MRSA is attached to the side of the paper sheet where the propolis layer is absent. Further, in the present invention, the antibacterial sheet may have a substance in which propolis and an adsorbent are mixed between two sheets of paper, at least one of which is breathable. Therefore, when this antibacterial sheet is used, MRSA attached to the air-permeable paper is sterilized by the antibacterial action of propolis to suppress the reproduction. At the same time, the bad smell from the sick person is removed by the deodorizing action of propolis through the breathable paper. In addition, the pleasant odor of the aroma of propolis passes from this breathable paper and is dissipated to the surroundings, making the hospital comfortable. Particularly, in the present invention, by using an air-permeable material for both of these two sheets of paper, it is possible to use MR on any of the two sheets of paper.
Even when SA adheres, MRSA can be effectively prevented from breeding. Furthermore, the calendar according to the present invention has the antibacterial sheet formed in a predetermined shape, and displays the date and day of each month, so by using this in a hospital or nursing home, MRSA is prevented from propagating on the calendar and MRSA is prevented from being infected via the calendar. Further, in the present invention, since the paper sheet is used, there is an advantage that the manufacturing cost can be reduced as compared with the conventional cloth-made product having the MRSA reproduction suppressing effect. Further, since the paper sheet is used, the disposal process such as incineration is extremely easy as compared with the cloth product.

[Brief description of drawings]

1A is a plan view showing an antibacterial sheet according to a first embodiment of the present invention, and FIG. 1B is a sectional view taken along line BB thereof.

FIG. 2 is a partial cross-sectional view showing an antibacterial sheet according to a second embodiment of the present invention.

FIG. 3 is a perspective view showing a calendar according to an embodiment of the present invention.

FIG. 4 is a cross-sectional view showing a mattress using the antibacterial sheet according to the present invention.

[Explanation of symbols]

 1,11 Antibacterial sheet 2,12,14,22 Paper sheet 3,13,23 Propolis layer

[Procedure amendment]

[Submission date] October 15, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be amended] Title of invention

[Correction method] Change

[Correction content]

Title of the invention Antibacterial sheet and calendar using this sheet

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location D21H 19/10 21/36

Claims (3)

[Claims] 1. An antibacterial sheet for inhibiting the growth of methicillin-resistant Staphylococcus aureus (MRSA), characterized in that a substance obtained by mixing propolis and an adsorbent is attached to paper. 2. A methicillin-resistant Staphylococcus aureus (MR) characterized in that a substance obtained by mixing a propolis and an adsorbent is interposed between two sheets of paper at least one of which is breathable.
SA) antibacterial sheet for suppressing proliferation. 3. A calendar using an antibacterial sheet, comprising the antibacterial sheet of claim 1 or 2 formed in a predetermined shape, and the date of each month and the day of the week displayed on it.