JPH06293656A - Cancer preventing and treating agent derived from rice - Google Patents
Cancer preventing and treating agent derived from riceInfo
- Publication number
- JPH06293656A JPH06293656A JP5103774A JP10377493A JPH06293656A JP H06293656 A JPH06293656 A JP H06293656A JP 5103774 A JP5103774 A JP 5103774A JP 10377493 A JP10377493 A JP 10377493A JP H06293656 A JPH06293656 A JP H06293656A
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- Prior art keywords
- rice
- present
- product
- extraction
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、白米または発芽させた
米を原料として得られる、医薬、食品等の分野で使用可
能な癌予防・治療剤に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a preventive / therapeutic agent for cancer, which is obtained from polished rice or sprouted rice as a raw material and can be used in the fields of medicine, food and the like.
【０００２】[0002]
【従来の技術】現在、日本人の死亡原因として一番多い
のが癌である。この癌を予防・治療するために、様々な
薬剤が開発されている。2. Description of the Related Art Currently, cancer is the most common cause of death in Japanese. Various drugs have been developed to prevent and treat this cancer.
【０００３】しかし、これらの薬剤には、投与による副
作用や、使用量、使用期間に制限の問題がある。また、
これらは単一化された物質の混合によるものがほとんど
であるため、単一物質の副作用、さらには長期に亘る服
用により起こる安全性の面からも問題になっている。す
なわち、癌予防・治療に対して有効で、しかも、副作用
がなく、安全な癌の予防・治療剤は、未だ開発されてい
ないのが現状である。However, these drugs have problems of side effects due to administration and restrictions on the amount and period of use. Also,
Since most of these are due to the mixing of singulated substances, they pose a problem from the side effect of a single substance and also from the aspect of safety caused by long-term administration. In other words, the present situation is that a preventive / therapeutic agent for cancer that is effective for preventing / treating cancer, has no side effects, and is safe has not yet been developed.
【０００４】一方、米は主食以外に、清酒、焼酎、みり
ん、酢、麹などとして用途開発され、古くから生活に欠
かせないものとなっている。このほかには、美容的用途
として糠袋が知られている。これらは米を単なる主食で
あると見るか、またはせいぜい澱粉源としてしか見てい
なかったということによるものであると思われる。ま
た、糠袋にしても、皮膚によいとされ、慣例的にそのま
ま使用されてきたのみであり、有効成分という概念もな
ければ、その有効成分を利用するという考え方も全くな
かったのである。On the other hand, rice has been developed as a staple food, as well as sake, shochu, mirin, vinegar, koji, etc., and has been indispensable for life since ancient times. In addition to this, bran bags are known for cosmetic purposes. It is believed that these were due to the fact that rice was viewed as merely a staple food, or at best as a source of starch. Also, even if the bran bag is said to be good for the skin, it has been customarily used as it is, and there was no concept of an active ingredient, nor was there any idea of utilizing that active ingredient.
【０００５】[0005]
【発明が解決しようとする課題】現在、薬剤の人体に対
する副作用が問題となっており、全く副作用がなく、し
かも、予防・治療剤として常用しても十分に安全な癌予
防・治療剤が要求されている。At present, there is a problem of side effects of drugs on the human body, and there is a demand for a cancer preventive / therapeutic agent which has no side effect and is sufficiently safe even if it is regularly used as a preventive / therapeutic agent. Has been done.
【０００６】本発明は、安全で安価であり、常用しても
全く安全な米からの癌予防・治療剤を提供することを目
的とするものである。It is an object of the present invention to provide a preventive / therapeutic agent for cancer from rice, which is safe and inexpensive and is completely safe even when used regularly.
【０００７】[0007]
【課題を解決するための手段】本発明者らは、動植物合
和すの観点から、主食である米を中心に種々の植物成分
の研究を進めてきた。その過程で、米には今まで予測で
きなかった数多くの可能性および効果があることが判明
してきた。そこで、主食として用いられ、安全性が最も
高いことが実証されている米をテーマとして取り上げ、
米の総合利用研究を行ってきた。そのうちの一つのテー
マとして、米からの癌予防・治療剤について鋭意研究を
重ねてきたのであるが、その過程で、白米および発芽さ
せた米には、抗癌作用を有する成分が含有されているこ
とを見出し、本発明を完成するに至った。[Means for Solving the Problems] From the viewpoint of animal and plant harmony, the present inventors have conducted research on various plant components centering on rice, which is a staple food. In the process, it has become clear that rice has a number of potential and benefits that were previously unpredictable. Therefore, we picked up rice, which is used as a staple food and proved to have the highest safety, as the theme,
I have conducted comprehensive utilization research on rice. As one of the themes, we have conducted intensive research on cancer preventive and therapeutic agents from rice, and in the process, white rice and germinated rice contain ingredients with anti-cancer action. This has led to the completion of the present invention.
【０００８】本発明において、白米および発芽させた米
に含有されている抗癌作用を有する成分は、未だ解明す
るに至っていないが、白米および発芽させた米を、下記
のように処理したものは、経口投与したところ、抗癌作
用を示すことが判明した。 白米および発芽させた米の粉砕物をそのまま、ある
いはこれを含有してなるもの。 白米および発芽させた米の加水物に澱粉分解酵素ま
たは麹を作用させたものをそのまま、あるいはこれを含
有してなるもの。 白米または発芽させた米を水抽出あるいは有機溶媒
抽出したものをそのまま、あるいはこれを含有してなる
もの。 白米または発芽させた米を水抽出または有機溶媒抽
出するに当たり、その抽出前、抽出と同時または抽出後
に澱粉分解酵素または麹を作用させたものをそのまま、
あるいはこれを含有してなるもの。In the present invention, the components having anti-cancer action contained in the polished rice and the germinated rice have not yet been elucidated, but those obtained by treating the polished rice and the germinated rice as described below are , Oral administration revealed that it showed anti-cancer effect. Grinded product of white rice and germinated rice as it is or containing it. A product obtained by reacting starch hydrolyzing enzyme or koji with the hydrolyzed product of white rice and germinated rice as it is or containing it. White rice or germinated rice extracted with water or organic solvent as it is, or containing it. When water-extracted or organic solvent-extracted white rice or sprouted rice, the one left to act on starch degrading enzyme or koji before extraction, at the same time as extraction or after extraction,
Or containing this.
【０００９】本発明において使用される米は、うるち米
およびもち米の白米等、米であればなんでもよく、ま
た、発芽させた米が使用され、白米よりも効果的であ
る。The rice used in the present invention may be any rice such as non-glutinous rice and glutinous rice such as white rice, and germinated rice is used and is more effective than white rice.
【００１０】白米および発芽させた米は、そのまま用い
ても有効であるが、実用上の面から、粉砕して用いるの
が好ましい。白米および発芽させた米を粉砕して粉体化
するには、粉砕機または精米機を用い、一般的な方法を
用いて行う。この際、精米時に出てくる９２％以下の糠
を使用してもよく、安価で経済的である。[0010] White rice and sprouted rice are effective as they are, but are preferably crushed for practical use. To grind the ground rice and the sprouted rice into powder, a general method is used using a grinder or a rice mill. At this time, bran of 92% or less that appears during rice polishing may be used, which is inexpensive and economical.
【００１１】米を発芽させる場合は、胚芽のついた米を
水に浸漬して発芽させる。発芽させる水の温度は、１５
〜４０℃が好ましいが、発芽さえすれば何度でもよい。
ただし、水が腐敗する危険性があるので、腐敗しないよ
うに水を取り替えるか、また、なんらかの防腐を行うの
が好ましい。ここで、発芽とは、発芽系が動きだした時
点から発芽したものまでのものを言う。また、発芽初期
ほど優れた効果があった。この発芽した米をよく洗浄
し、乾燥して用いる。When germinating rice, germinated rice is immersed in water to germinate. The temperature of the germinated water is 15
It is preferably -40 ° C, but may be repeated as long as it germinates.
However, since there is a risk of water spoiling, it is preferable to replace the water so that it will not spoil or to carry out some kind of preservative. Here, germination refers to germination from the time when the germination system starts to move. Moreover, the effect was more excellent as early as germination. The sprouted rice is thoroughly washed, dried and used.
【００１２】白米および発芽させた米に澱粉分解酵素ま
たは麹を作用させる場合、原料の米を粉砕して顆粒ある
いは粉体化すると、表面積が大きくなるため効率が良く
なる。粉砕しなくてもよいが、この場合には、澱粉分解
反応による米組織の分解および糖化に長時間を要する。
この原料の米に加水して糖化を行う。この際、加水量は
米に対して１〜５倍量が効果的であるが、収率、作業
性、最終使用目的等により適宜選定する。When the starch degrading enzyme or koji is allowed to act on white rice and germinated rice, if the raw material rice is pulverized into granules or powder, the surface area becomes large and the efficiency is improved. It is not necessary to grind, but in this case, it takes a long time to decompose and saccharify the rice tissue by the starch decomposition reaction.
This raw material rice is saccharified by adding water. At this time, the amount of water added is effectively 1 to 5 times that of rice, but it is appropriately selected depending on the yield, workability, purpose of final use and the like.
【００１３】この白米または発芽させた米の加水物に、
澱粉分解酵素または麹を添加して澱粉分解反応を行う。
この際、蛋白分解酵素、脂肪分解酵素等の酵素を併せて
作用させてもよい。[0013] To this white rice or germinated rice water,
A starch degrading enzyme or koji is added to perform a starch degrading reaction.
At this time, enzymes such as proteolytic enzyme and lipolytic enzyme may be allowed to act together.
【００１４】澱粉分解反応は使用酵素の適温で１〜２４
時間行い、効果さえ出てくれば、反応時間は短くても長
くてもよく、また、反応温度は高くても低くてもよい。
澱粉分解反応を終了した後、加温してゆき沸騰状態にな
った時点で抽出を完了する。抽出を完了した後、そのま
まか、あるいは圧搾、濾過を行えば、清澄なエキスが得
られる。The starch decomposition reaction is 1 to 24 at a suitable temperature of the enzyme used.
The reaction time may be short or long, and the reaction temperature may be high or low, as long as the reaction is carried out for a long time and the effect is obtained.
After completion of the starch decomposition reaction, the extraction is completed when the mixture is heated to a boiling state. After completion of the extraction, a clear extract can be obtained as it is, or by pressing and filtering.
【００１５】白米または発芽させた米に含有されている
癌予防・治療剤としての有効成分が熱に安定であること
は確認できたので、水抽出の際の抽出温度は、高温が効
率的である。低温でも長時間置けば、充分に抽出を行う
ことができる。ただし、４０℃以下の低温の場合は、ｐ
Ｈを酸性あるいはアルカリ性にするか、防腐剤を加え
て、米が腐敗しないように処理することが必要である。
抽出時間は、沸騰抽出の場合には数分でよいが、それ以
下の中温の場合には、数時間から一昼夜が必要である。
低温の場合は、米の粉砕状態にもよるが、数日〜１ケ月
必要である。ただし、この場合にも、なるべく最後には
加熱するのがより効果的である。また、抽出は常圧で行
っても、減圧で行ってもよい。Since it has been confirmed that the active ingredient contained in white rice or germinated rice as a preventive / therapeutic agent for cancer is heat-stable, the extraction temperature for water extraction is high at high temperature. is there. If it is left at a low temperature for a long time, it can be sufficiently extracted. However, if the temperature is lower than 40 ° C, p
It is necessary to make H acidic or alkaline, or add a preservative to treat the rice so that it does not spoil.
The extraction time may be several minutes in the case of boiling extraction, but in the case of medium temperature below that, several hours to one day is required.
When the temperature is low, it takes several days to one month depending on the crushed state of rice. However, even in this case, it is more effective to heat at the end as much as possible. Further, the extraction may be carried out under normal pressure or under reduced pressure.
【００１６】水抽出の場合、最も問題になるのは糊化現
象である。糊状になれば、抽出効率が悪くなるばかりで
なく、実作業においては困難を極める。これを防ぐため
には、麹あるいはアミラーゼを加えて反応させるか、塩
酸などで酸性にして澱粉を切ってやればよく、この方法
を用いることにより、充分に解決でき、実用上も全く問
題はない。In the case of water extraction, the gelatinization phenomenon is the most problematic. If it becomes pasty, not only the extraction efficiency will deteriorate, but it will be extremely difficult in actual work. In order to prevent this, koji or amylase may be added and reacted, or the starch may be cut off by acidifying it with hydrochloric acid or the like. By using this method, it can be sufficiently solved and there is no problem in practice.
【００１７】抽出物中の有効成分は、酸、アルカリに安
定であるためか、酸抽出あるいはアルカリ抽出を行うの
も有効である。また、水抽出の場合、酸、アルカリで前
処理するか、米の組織に働く酵素（例えば、アミラーゼ
等）を作用させて前処理を行い、抽出する方法がはるか
に効果的である。これは、前処理により、有効成分がよ
り抽出されやすくなるためであると思われる。Since the active ingredient in the extract is stable to acid and alkali, it is also effective to perform acid extraction or alkali extraction. Further, in the case of water extraction, the method of pre-treating with acid or alkali, or pre-treating by allowing an enzyme (for example, amylase etc.) acting on the tissue of rice to act and then extracting is much more effective. This is probably because the pretreatment makes it easier for the active ingredient to be extracted.
【００１８】有機溶媒で抽出する場合も、米はなるべく
微粉砕または粉体化して抽出することが望ましい。有機
溶媒はアルコール、アセトン等の一般的な有機溶媒でよ
いが、人体に対して有害なものは抽出後、溶媒を完全に
除去する必要があるので、安全なものがよい。Also in the case of extraction with an organic solvent, it is desirable to pulverize or pulverize rice as much as possible before extraction. The organic solvent may be a general organic solvent such as alcohol and acetone, but those that are harmful to the human body need to be completely removed after extraction, so safe ones are preferable.
【００１９】上記の抽出を行うに当たり、抽出の前、抽
出と同時または抽出の後に、前記の澱粉分解反応を行っ
ても、効果は認められた。In carrying out the above-mentioned extraction, the effect was recognized even if the above-mentioned starch decomposition reaction was carried out before the extraction, at the same time as the extraction or after the extraction.
【００２０】上記のように水抽出あるいは有機溶媒抽出
したもの、また、澱粉分解反応を施したものを、さらに
アルコール発酵、乳酸発酵等の有機酸発酵を行ってもよ
く、また、適宜に除糖を行ってもよい。除糖の方法は、
微生物による処理（通気培養、アルコール発酵等）ある
いはアルコールによる凝集沈澱が用いられる。The water-extracted or organic-solvent-extracted product as described above, or the starch-decomposed product may be further subjected to organic acid fermentation such as alcohol fermentation or lactic acid fermentation, and appropriately desugarized. You may go. The method of sugar removal is
Treatment with microorganisms (aeration culture, alcoholic fermentation, etc.) or coagulation precipitation with alcohol is used.
【００２１】本発明品の抗癌作用について、以下に記載
する。The anticancer activity of the product of the present invention is described below.
【００２２】実験方法は、１群５頭で、Ｆ３４４ ８週
齢雄ラット（平均体重１８０ｇ）を個別ゲージに入れて
朝から絶食させた後、夕方に、コントロールに水を、試
験には本発明品を胃チューブで１ｍｌ投与した。３０分
後、二次投与としてコントロールに水、ポジティブコン
トロールおよび試験群に２．３Ｍ食塩水を投与した。餌
はＰｅｌｌｅｔ ｄｉｅｔ １ケを投与した。１７時間
後、胃粘膜（幽門線粘膜）を取り出して、器官培養して
複合ＤＮＡ合成を測定した。測定は培養液中に〔3 Ｈ〕
ｔｈｙｍｉｄｉｎｅを添加し、２時間培養後、組織から
ＤＮＡ合成を抽出して、液体シンチレーションカウンタ
ーで、ＤＮＡに取り込まれた〔3 Ｈ〕ｔｈｙｍｉｄｉｎ
ｅを定量した。結果を表１に示した。The test method was as follows: F344 8-week-old male rats (average weight: 180 g) were put into individual gauges and fasted from the morning in a group of 5 animals. The product was administered by gastric tube in an amount of 1 ml. Thirty minutes later, as a secondary administration, water was administered as a control, and 2.3 M saline was administered to the positive control and test groups. As the food, 1 Pellet diet was administered. After 17 hours, the gastric mucosa (pyloric mucosa) was taken out and cultured in an organ to measure complex DNA synthesis. The measurement is performed in the culture medium [ 3 H]
Thymidine was added, and after culturing for 2 hours, DNA synthesis was extracted from the tissue, and [ 3 H] thymidin incorporated into DNA was analyzed by a liquid scintillation counter.
e was quantified. The results are shown in Table 1.
【００２３】[0023]
【表１】 （注）実施例１で得られた本発明品は、固形状にして投
与した。米糠エキスとは、精米時に得られる９０〜１０
０％の糠を用いて得られたもの。[Table 1] (Note) The product of the present invention obtained in Example 1 was administered in solid form. Rice bran extract is 90 to 10 obtained when rice is polished.
Obtained using 0% bran.
【００２４】表１から分かるように、コントロールで
は、４０１±１５７〔3 Ｈ〕ｔｈｙｍｉｄｉｎｅ／μｇ
ＤＮＡの複製ＤＮＡの合成であるのに対し、ポジティブ
コントロールでは、３８８９±１５５７〔3 Ｈ〕ｔｈｙ
ｍｉｄｉｎｅ／μｇＤＮＡと約１０倍の複合ＤＮＡの合
成を示した。As can be seen from Table 1, in the control, 401 ± 157 [ 3 H] thymidine / μg
In the case of the positive control, 3889 ± 1557 [ 3 H] thy, whereas the replication of DNA is the synthesis of DNA.
It showed about 10 times more complex DNA synthesis with midine / μg DNA.
【００２５】本発明品を投与した群では、複合ＤＮＡの
合成が全ての本発明品において抑制された。実施例１お
よび３で得られた本発明品においては、効果的には弱い
が、そのまま、あるいは糖化という簡単な操作で得ら
れ、既存の設備を使い誰にでもできるものであり、非常
に経済的かつ有効的な手段である。また、抽出あるいは
抽出と糖化を組合わせることにより、その効果は、さら
に優れたものになることが判明した。In the group administered with the products of the present invention, the synthesis of complex DNA was suppressed in all the products of the present invention. The products of the present invention obtained in Examples 1 and 3 are weak in effectiveness, but can be obtained as they are or by a simple operation of saccharification, and can be used by anyone using existing equipment, which is very economical. And effective means. It was also found that the effect is further enhanced by the extraction or the combination of the extraction and the saccharification.
【００２６】さらに、実施例１１のように白米を用いた
ものは、玄米を用いたものより少量で強い効果を示すこ
とが分かった。そこで、米糠を用いて実験を行ったとこ
ろ、効果はほとんど見られなかった。すなわち、玄米が
白米に比較して効果が低いのは、玄米に糠が含まれてい
るからで、糠には阻害物質が含まれていると考えられ
る。また、実施例１２のように、米を発芽させることに
より、白米と比較して少量でもさらに強い効果が得られ
た。これは、発芽することにより糠の阻害物質を消化し
ているだけでなく、何らかの有効成分が生成されている
と考えられる。Further, it was found that the one using white rice as in Example 11 exhibited a strong effect with a smaller amount than the one using brown rice. Therefore, when an experiment was conducted using rice bran, almost no effect was seen. That is, the reason why brown rice is less effective than white rice is because brown rice contains bran, and it is considered that the bran contains an inhibitor. Further, as in Example 12, germination of rice resulted in a stronger effect even in a small amount as compared with white rice. It is considered that this is because not only the inhibitor of bran is digested by germination but also some active ingredient is produced.
【００２７】食塩は胃発癌のプロモーターと考えられて
おり、本発明品は、その作用を明らかに抑制している。
これは、明らかに抗癌剤として有効であることを示すも
のである。Salt is considered to be a promoter of gastric carcinogenesis, and the product of the present invention obviously suppresses its action.
This clearly shows that it is effective as an anticancer agent.
【００２８】さらに、実験を繰り返すことにより、癌に
なったもの事態も抑えることが判明した。Furthermore, by repeating the experiment, it was found that the situation in which cancer was caused can be suppressed.
【００２９】[0029]
【実施例】本発明の実施例について、以下に説明する。 （実施例１）白米５００ｇを粉砕機に掛け、粉体化し、
本発明品４９０ｇを得た。 （実施例２）胚芽のついたままの米１ｋｇを２５℃の水
につけ、３日間浸漬させ、米を発芽させた。この発芽米
をよく洗浄した後、５０℃で２４時間乾燥し、その後細
かく微粉砕し、本発明品９９０ｇを得た。 （実施例３）実施例１で得られた本発明品５００ｇに、
水１５００ｍｌと麹３００ｇを加え、５５℃で２０時間
放置した。その後、絞り機で絞り、本発明品１１５０ｍ
ｌと残渣１０５０ｇを得た。 （実施例４）実施例２により得られた本発明品５００ｇ
を用いて、実施例３と同様の操作を行い、別の本発明品
１２００ｍｌを得た。 （実施例５）実施例１で得られた本発明品５００ｇに、
液化酵素１０ｇと水１５０ｍｌを添加した。その後、徐
々に温度を上げてゆき、５分間煮沸抽出した後、冷却し
た。その後、絞り機で絞り、本発明品１１５０ｇと残渣
８００ｇを得た。 （実施例６）実施例２により得られた本発明品５００ｇ
を用いて、実施例５と同様の操作を行い、別の本発明品
１１７０ｇを得た。 （実施例７）実施例１で得られた本発明品５００ｇに、
４０％エタノール１０００ｍｌを添加して５日間放置し
た。その後、絞り機で絞り、本発明品７８０ｇと残渣６
８０ｇを得た。 （実施例８）実施例２により得られた本発明品５００ｇ
を用いて、実施例７と同様の操作を行い、別の本発明品
８００ｇを得た。 （実施例９）実施例１で得られた本発明品５００ｇに、
０．１Ｎ−塩酸１０００ｍｌを添加して５日間放置し
た。その後、絞り機で絞り、清澄液８００ｇと残渣６５
０ｇを得た。この清澄液を１Ｎ−ＮａＯＨで中和し、本
発明品８８０ｇを得た。 （実施例１０）実施例２により得られた本発明品５００
ｇを用いて、実施例９と同様の操作を行い、別の本発明
品８９０ｇを得た。 （実施例１１）実施例３と同様にして、白米の糖化物２
０００ｇを得た。その後、徐々に温度を上げてゆき、５
分間煮沸抽出した後、冷却した。その後、絞り機で絞
り、本発明品１２００ｍｌと残渣７５０ｇを得た。 （実施例１２）実施例２により得られた本発明品５００
ｇを用いて、実施例１１と同様の操作を行い、別の本発
明品１１５０ｍｌを得た。 （実施例１３）実施例１で得られた本発明品５００ｇ
に、４０％エタノール１０００ｍｌと麹２００ｇを添加
して、５５℃で４８時間放置した。その後、冷却し、絞
り機で絞り、本発明品１２３０ｍｌと残渣９１０ｇを得
た。 （実施例１４）実施例２により得られた本発明品５００
ｇを用いて、実施例１３と同様の操作を行い、別の本発
明品１２２０ｍｌを得た。 （実施例１５）実施例５と同様にして、玄米の抽出物２
０００ｇを得た。この抽出物に澱粉分解酵素１０ｇを添
加し、５５℃で２４時間放置した。その後、絞り機で絞
り、本発明品１２４０ｍｌと残渣７００ｇを得た。 （実施例１６）実施例２により得られた本発明品５００
ｇを用いて、実施例１５と同様の操作を行い、別の本発
明品１２３０ｍｌを得た。 （実施例１７）実施例１１で得られた本発明品１０００
ｍｌに、乾燥酵母２ｇを添加して、２０℃で７日間アル
コール発酵した後濾過して、別の本発明品９９０ｇを得
た。 （実施例１８）実施例１１で得られた本発明品１０００
ｍｌに、乾燥酵母２ｇを添加して、空気を送り込みなが
ら、３０℃で１８時間酵母の通気発酵を行った。その
後、濾過して別の本発明品８９０ｍｌを得た。 （実施例１９）実施例１１で得られた本発明品５００ｍ
ｌに、９５％エタノール１４００ｍｌを添加した後、濾
過をした。この濾液をエバポレーターで濃縮して、別の
本発明品４００ｍｌを得た。EXAMPLES Examples of the present invention will be described below. (Example 1) 500 g of white rice was pulverized by a crusher,
490 g of the product of the present invention was obtained. (Example 2) 1 kg of rice with an embryo attached was immersed in water at 25 ° C and immersed for 3 days to germinate rice. After thoroughly washing the germinated rice, it was dried at 50 ° C. for 24 hours and then finely pulverized to obtain 990 g of the product of the present invention. (Example 3) In 500 g of the product of the present invention obtained in Example 1,
1500 ml of water and 300 g of koji were added, and the mixture was left at 55 ° C. for 20 hours. After that, squeezing with a wringer, the product of the invention 1150 m
1 and 1050 g of residue were obtained. (Example 4) 500 g of the product of the present invention obtained in Example 2
Using the above, the same operation as in Example 3 was performed to obtain another 1200 ml of the present invention product. (Example 5) In 500 g of the product of the present invention obtained in Example 1,
Liquefaction enzyme 10g and water 150ml were added. Then, the temperature was gradually raised, and the mixture was boiled and extracted for 5 minutes and then cooled. Then, the product was squeezed with a squeezing machine to obtain 1150 g of the product of the present invention and 800 g of the residue. (Example 6) 500 g of the product of the present invention obtained in Example 2
Was carried out in the same manner as in Example 5 to obtain 1170 g of another product of the present invention. (Example 7) In 500 g of the product of the present invention obtained in Example 1,
1000 ml of 40% ethanol was added and left for 5 days. Then, squeezing with a squeezing machine, 780 g of the present invention product and 6
80 g was obtained. (Example 8) 500 g of the product of the present invention obtained in Example 2
Was carried out in the same manner as in Example 7 to obtain another 800 g of the present invention. (Example 9) In 500 g of the product of the present invention obtained in Example 1,
1000 ml of 0.1N hydrochloric acid was added and the mixture was left for 5 days. Then, squeeze with a squeezing machine, 800 g of the clear liquid and 65
0 g was obtained. The clear solution was neutralized with 1N-NaOH to obtain 880 g of the product of the present invention. (Example 10) The product 500 of the present invention obtained in Example 2
Using g, the same operation as in Example 9 was carried out to obtain 890 g of another product of the present invention. (Example 11) In the same manner as in Example 3, saccharified product 2 of white rice
000 g was obtained. After that, gradually raise the temperature, 5
After boiling extraction for 1 minute, it was cooled. Then, the product was squeezed with a squeezing machine to obtain 1200 ml of the product of the present invention and 750 g of a residue. (Example 12) The present invention product 500 obtained in Example 2
Using g, the same operation as in Example 11 was carried out to obtain another 1150 ml of the product of the present invention. (Example 13) 500 g of the product of the present invention obtained in Example 1
To this, 1000 ml of 40% ethanol and 200 g of koji were added and left at 55 ° C. for 48 hours. Then, it was cooled and squeezed with a squeezing machine to obtain 1230 ml of the product of the present invention and 910 g of a residue. (Example 14) The present invention product 500 obtained in Example 2
The same operation as in Example 13 was performed using g to obtain another 1220 ml of the present product. (Example 15) In the same manner as in Example 5, brown rice extract 2
000 g was obtained. 10 g of starch degrading enzyme was added to this extract, and the mixture was allowed to stand at 55 ° C. for 24 hours. Then, it was squeezed with a squeezing machine to obtain 1240 ml of the product of the present invention and 700 g of a residue. (Example 16) The present invention product 500 obtained in Example 2
The same operation as in Example 15 was carried out using g to obtain another 1230 ml of the product of the present invention. (Example 17) The present invention product 1000 obtained in Example 11
2 g of dry yeast was added to ml, and the mixture was subjected to alcohol fermentation at 20 ° C. for 7 days and then filtered to obtain 990 g of another product of the present invention. (Example 18) The product 1000 of the present invention obtained in Example 11
2 g of dry yeast was added to ml, and aeration fermentation of yeast was performed at 30 ° C. for 18 hours while blowing air. Then, it was filtered to obtain another 890 ml of the product of the present invention. (Example 19) 500 m of the product of the present invention obtained in Example 11
1400 ml of 95% ethanol was added to 1 and filtered. The filtrate was concentrated by an evaporator to obtain another 400 ml of the product of the present invention.
【００３０】[0030]
【発明の効果】本発明によれば、継続的飲食することに
より、簡単に、全く安全で、しかも、ガン予防、治療効
果を持つ優れた癌予防・治療剤が得られる。INDUSTRIAL APPLICABILITY According to the present invention, by continuously eating and drinking, an excellent cancer prophylactic / therapeutic agent which is simple, completely safe, and has a cancer prevention / treatment effect can be obtained.
【００３１】米は今まで主食であったため、食以外の新
規な分野での製法、利用用途はほとんど開発されていな
かった。さらに、米は今まで主食とされてきたものであ
り、安全性も十分に実証されているものである。すなわ
ち、本発明は、非常に優れた癌予防・治療剤を見出した
ばかりでなく、米の過剰生産といわれる現在、新たな利
用用途を見出したこと、および米のイメージアップによ
る消費拡大を図り得ることは、極めて有意義なことであ
る。Since rice has been the staple food until now, almost no development has been made on its production method or use in a new field other than food. Furthermore, rice has been the staple food until now, and its safety has been well demonstrated. That is, the present invention has not only found a very excellent cancer preventive / therapeutic agent, but has also found a new application for use, which is said to be overproduction of rice, and that it is possible to increase consumption by improving the image of rice. Is extremely meaningful.
Claims (4)
まま、あるいはこれを含有してなる癌予防・治療剤。1. A preventive / therapeutic agent for cancer, which is a ground rice or a crushed product of germinated rice as it is, or containing the same.
粉分解酵素または麹を作用させたものをそのまま、ある
いはこれを含有してなる癌予防・治療剤。2. A preventive / therapeutic agent for cancer, which comprises hydrolyzed white rice or germinated rice with a starch-degrading enzyme or koji as it is, or containing it.
は有機溶媒抽出したものをそのまま、あるいはこれを含
有してなる癌予防・治療剤。3. A preventive / therapeutic agent for cancer, which is obtained by extracting white rice or sprouted rice with water or organic solvent, as it is, or containing it.
たり、その抽出前、抽出と同時または抽出後に澱粉分解
酵素または麹を作用させたものをそのまま、あるいはこ
れを含有してなる癌予防・治療剤。4. A method for preventing / treating cancer, which comprises, before or after extraction of white rice or sprouted rice, a starch-degrading enzyme or koji, which is used as it is, or containing the same. Agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5103774A JPH06293656A (en) | 1993-04-07 | 1993-04-07 | Cancer preventing and treating agent derived from rice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5103774A JPH06293656A (en) | 1993-04-07 | 1993-04-07 | Cancer preventing and treating agent derived from rice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06293656A true JPH06293656A (en) | 1994-10-21 |
Family
ID=14362798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5103774A Pending JPH06293656A (en) | 1993-04-07 | 1993-04-07 | Cancer preventing and treating agent derived from rice |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06293656A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997037674A1 (en) * | 1996-04-05 | 1997-10-16 | Kirin Beer Kabushiki Kaisha | Substance originating in germinating seeds of gramineous plant and containing proteins and insoluble dietary fibers and use thereof |
| EP0858743A2 (en) * | 1997-02-14 | 1998-08-19 | Nisshin Flour Milling Co., Ltd. | Processes for extracting zinc rich mineral components from cereal germs |
| JP2006117575A (en) * | 2004-10-20 | 2006-05-11 | Soken Kk | Agent for resting cancer cell |
-
1993
- 1993-04-07 JP JP5103774A patent/JPH06293656A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997037674A1 (en) * | 1996-04-05 | 1997-10-16 | Kirin Beer Kabushiki Kaisha | Substance originating in germinating seeds of gramineous plant and containing proteins and insoluble dietary fibers and use thereof |
| AU722942B2 (en) * | 1996-04-05 | 2000-08-17 | Kirin Beer Kabushiki Kaisha | The substance containing proteins and insoluble dietary fibers derived from the germinated seed of a grass family plant and uses thereof |
| US6284290B1 (en) | 1996-04-05 | 2001-09-04 | Kirin Beer Kabushiki Kaisha | Substance containing proteins and insoluble dietary fibers derived from the germinated seed of a grass family plant and uses thereof |
| US6348221B1 (en) | 1996-04-05 | 2002-02-19 | Kirin Beer Kabushiki Kaisha | Substance originating in germinating seeds of gramineous plant and containing proteins and insoluble dietary fibers and use thereof |
| US6475533B2 (en) | 1996-04-05 | 2002-11-05 | Kirin Beer Kabushiki Kaisha | Substance containing proteins and insoluble dietary fibers derived from the germinated seed of a grass family plant and uses thereof |
| EP0858743A2 (en) * | 1997-02-14 | 1998-08-19 | Nisshin Flour Milling Co., Ltd. | Processes for extracting zinc rich mineral components from cereal germs |
| EP0858743A3 (en) * | 1997-02-14 | 1999-09-29 | Nisshin Flour Milling Co., Ltd. | Processes for extracting zinc rich mineral components from cereal germs |
| JP2006117575A (en) * | 2004-10-20 | 2006-05-11 | Soken Kk | Agent for resting cancer cell |
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