JPH06285161A - Hollow fiber cleaning method - Google Patents

Abstract

PURPOSE:To prevent removal of hole diameter holding agent from a hollow fiber membrane wall by cleaning in manufacturing a dialyzer, and prevent deterioration of water permeability by supplying an aliphatic hydrocarbon having specified values of an ozone breaking coefficient and a boiling point to the inner part of hollow fiber for selectively cleaning and eliminating oily material inside the hollow fiber while leaving the hole diameter holding agent in the hollow fiber. CONSTITUTION:Hollow fibers are bundled to be installed in a case of plastic such as polystyrene resin, acrylic resin, and polycarbonate resin, both ends of the hollow fiber bundle are fixed with binding agent of polyurethane or the like, and bound parts are cut to open the end parts of the hollow fiber for manufacturing the blood dialyzer. Aliphatic hydrocarbon is then supplied into the inner part of the hollow fiber for selectively cleaning and eliminating oily material such as liquid paraffin, etc., attached to the inner part of the hollow fiber, while leaving glycerine as hole diameter holding agent inside the hollow fiber without being dissolved. For the aliphatic hydrocarbon, that having a boiling point of 130 deg.C or less, and an ozone breaking coefficient of zero is used.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for cleaning hollow fibers used in hemodialyzers.

[0002]

2. Description of the Related Art Conventionally, cellulose, cellulose acetate,
When a solution or melt of cellulose triacetate, polyacrylonitrile, polymethylmethacrylate, etc. is extruded from an orifice, oily substances such as liquid paraffin and isopropyl myristate are simultaneously exhaled inside the hollow fiber, and the state is filled with the oily substance. The hollow fiber of is spun. The hollow fiber fibers spun in this manner are bundled and loaded into the case of a hemodialyzer made of plastic such as polystyrene resin, acrylic resin, and polycarbonate resin,
After fixing both ends of the hollow fiber bundle with an adhesive, the adhesive is cut to open the ends of the hollow fibers to manufacture a hemodialyzer.
Then, the oily substance adhering to the inside of the hollow fiber is treated with ethyl alcohol or fluorochlorohydrocarbon to wash and remove the oily substance. However, when treated with ethyl alcohol, glycerin, which is a pore size holding material present inside the hollow fibers, is also washed and removed, and the water permeability of the hollow fiber bundle after washing is significantly reduced. Even if the hollow fiber in such a state is treated with glycerin again, it does not return to the original state.
Also, when treating with ethyl alcohol. There is also a method of preliminarily adding several% of glycerin to ethyl alcohol for washing, but this method complicates the step of vapor-depositing ethyl alcohol after washing, and the efficiency of the hemodialyzer manufactured is also lowered. In addition, when treated with fluorohydrocarbons, the substance destroys the ozone layer and deteriorates the global environment. Depending on the type of fluorohydrocarbon chloride, hemodialysis consisting of plastics such as polystyrene resin, acrylic resin, polycarbonate resin, etc. The case of the vessel may be destroyed.

[0003]

DISCLOSURE OF THE INVENTION The present invention has the above-mentioned problem of the prior art, namely, it prevents glycerol, which is a pore size-retaining agent, from being removed from the hollow fiber membrane wall during the manufacture of a hemodialyzer using a hollow fiber, and cleans it. This is to prevent a decrease in water permeability due to.

[0004]

The present invention relates to a liquid paraffin containing an aliphatic hydrocarbon having an ozone depletion coefficient of zero and a boiling point of 130 ° C. or less in the production of a hemodialyzer using a hollow fiber, The present invention relates to a method for cleaning a hollow fiber, which comprises selectively removing an oily substance such as isopropyl myristate by washing and leaving glycerol, which is a pore size retaining agent, in the hollow fiber.

That is, according to the present invention, the hollow fiber fibers are bundled and loaded into a case made of plastic such as polystyrene resin, acrylic resin or polycarbonate resin, and the both ends of the hollow fiber fiber bundle are fixed with an adhesive such as polyurethane and then bonded. The part is cut and the end of the hollow fiber is opened to manufacture a hemodialyzer. Then, an aliphatic hydrocarbon is poured into the hollow fiber to selectively wash and remove oily substances such as liquid paraffin and isopropyl myristate adhering to the inside of the hollow fiber,
Glycerin, which is a pore size retaining agent, is left inside the hollow fiber without being dissolved in the detergent.

The aliphatic hydrocarbons having a boiling point of 130 ° C. or less as used in the present invention are pentane, hexane and octane and have an ozone depletion potential of zero. Therefore, it does not damage the global environment and does not damage the plastic case such as polystyrene resin, acrylic resin, or polycarbonate resin that is loaded with the hollow fiber bundle. Further, the surface tension is very low, and the fine particles of the hollow fiber can easily and evenly enter, so that only the oily substance can be efficiently washed and removed, and the drying can be performed relatively easily.

The present invention will be specifically described below with reference to examples.

EXAMPLE When a solution of cellulose acetate was extruded through an orifice,
At the same time, an oily substance such as liquid paraffin was discharged into the inside of the hollow fiber to spin the hollow fiber filled with the oily substance. The hollow fiber fibers spun in this manner are bundled and loaded into the cases of hemodialyzers made of three types of plastics, polystyrene resin, acrylic resin, and polycarbonate resin, and both ends of the hollow fibers are bonded with urethane adhesive. After fixed, it was cut and the end of the hollow fiber was opened to manufacture a hemodialyzer. Then, n-hexane having a boiling point of 69 ° C. was flown inside the hollow fiber. Then, the liquid paraffin existing inside the hollow fiber was selectively removed, but the glycerin contained inside the hollow fiber remained without being dissolved. Then, when air at 60 ° C. was supplied for 5 minutes, the amount of remaining n-hexane was 1
It was below mg / m ² , and the efficiency of the manufactured hemodialyzer was high.

Comparative Example 1 In the same washing method as in Example 1 above, ethyl alcohol was used for washing instead of using the aliphatic hydrocarbon having a boiling point of 130 ° C. or less. The dialysis efficiency was significantly reduced.

Comparative Example 2 When 1,1-dichloro-1-fluoroethane was used for cleaning by the same cleaning method as in the above Example, a case of a hemodialyzer made of polystyrene resin, acrylic resin, polycarbonate resin plastic was found. It became cloudy and finally cracked and could not be washed.

COMPARATIVE EXAMPLE 3 The same cleaning method as in the above-mentioned example was used for cleaning with a boiling point of 174 ° C.
-When decane was used, air at 60 ° C was supplied for 5 minutes after washing, but the amount of residual n-decane was 2000 mg / m 2.
² and not removed.

[0012]

EFFECTS OF THE INVENTION According to the present invention, there is no problem of environmental pollution and damage to the module, and it is possible to prevent deterioration of water permeability of the hollow fiber due to washing during the dialyzer manufacturing process. Provide the thread.

Claims (1)

[Claims] 1. In the production of a hemodialyzer using a hollow fiber, liquid paraffin and isopropyl milliliter which are present in the hollow fiber by flowing an aliphatic hydrocarbon having an ozone depletion potential of zero and a boiling point of 130 ° C. or less into the hollow fiber. A method for cleaning a hollow fiber, which comprises selectively removing an oily substance such as a state by washing and leaving the pore diameter retaining agent in the hollow fiber.