JPH06271417A - Scrubbing granules for skin external drugs and skin external drug containing the same - Google Patents

Abstract

PURPOSE:To provide scrub granules which can be admixed to any skin treatment agents for external use to give a proper touch and develop excellent massage and cleaning effect with high safety and reduced irritation and a skin treatment agent for external use. CONSTITUTION:Water-insoluble inorganic powder and/or water-insoluble organic high-polymer powder are mixed with at least one of hardened oil powder melting over 50 deg.C, and the mixture is granulated using a water-soluble binder, dried, heat-treated so that the hardened oil in the granules is molten, then cooled down to give the objective scrub granules as an additive for skin treatment agents for external use. Further, the scrub granules are admixed in an amount ranging from 0.05 to 5.0% to give the objective skin treatment agent for external use.

Description

Detailed Description of the Invention

[0001]

The object of the present invention is to granulate a mixture of water-insoluble inorganic substance powder and / or water-insoluble organic polymer substance powder and hardened oil of the powder after granulating with a water-soluble binder. , The scrub granules for blending the external preparation for the skin obtained by melting and blending the hardened oil powder contained by heat-treating it once, and the massage effect and the cleaning effect in which the scrub granules are blended are excellent in the touch. It relates to a skin external preparation.

[0002]

2. Description of the Related Art Examination of scrub granules contained in conventionally known skin external preparations containing scrub granules seems to be classified into several types according to their materials and characteristics. That is, (1) For example, one obtained by crushing plant seed shells or one made of a material such as a hydrocarbon-based polymer such as polyethylene or polystyrene and having a particle size of about 50 μm to 1 mm. However, it is a type that the size does not change over time when used. (2) A water-soluble binder or oil or fat is used as a binder, and a powder of several μm to 20 μm is made into granules of about 200 μm to 2 mm, which gradually becomes smaller during use and disappears at the end. Type of thing. (3) Those that are in an intermediate position between the above two types, for example, those obtained by granulating powder using only wax, or those using a water-insoluble binder, etc. A type that is gradually reduced during use, as represented by. It can be classified as follows.

However, each of them has the following inconveniences and drawbacks in its manufacture or in use. That is, the type of material such as (1) has a feeling of contact of particles with the skin, and has a high massage effect and dirt removal effect (cleaning effect), but both tend to be too strong. Moreover, these effects are sustained as there is no decay or loss of particles,
Therefore, it is of course unsuitable for a person with weak skin or a person with sensitive skin, and even for a person who does not have the skin, there is a concern that the skin may be damaged due to excessive irritation during its use. In addition, since this type of scrub granule remains on the skin after use, it needs to be washed off, and therefore its use is restricted to, for example, a preparation intended for skin cleansing such as a face wash. It has drawbacks such as.

On the other hand, the granules of the type (2) are characterized in that the particles are gradually attenuated and finally disappeared due to friction or dissolution of the binder due to water and oils and fats in the formulation. In this respect, it is less irritating to the skin as compared with the type (1) described above, and therefore can be used with confidence. In addition, this type also has the advantage that it can enjoy color change and can be incorporated into external skin preparations as a whole. However, in exchange for that, the function as a scrubbing agent such as a massage effect and a cleaning effect can hardly be expected.

Further, the type (3) has an appropriate feeling of contact of the particles with the skin, and also has a massage effect and a cleaning effect. In addition, since the particles become smaller during use, the irritation is less than that of the type (1). However, such scrub granules can have various disadvantages during manufacture. First, it is difficult to adjust the hardness. For example, when the powder is granulated using only wax, the wax generally does not dissolve in water, alcohol, etc., and therefore a considerable amount must be heated and melted before use. As a result, the resulting granules tend to be too hard, and it is difficult to obtain the intended granules of appropriate hardness. Further, even when using a water-insoluble binder, a certain amount is required to granulate the powder, and at the same time, the amount of the binder determines the hardness of the particles. It is necessary to adjust the added amount in consideration of hardness and granulate, which is technically very difficult. The second point is workability and equipment in manufacturing. When using only the wax as described above, a corresponding heating facility is required, and when using the water-insoluble binder, a large amount of organic solvent must be used. In particular, if an organic solvent is used, explosion-proof equipment and ventilation equipment are required, and workability is significantly poorer than other cases. Further, in the case of granulation using a water-insoluble binder, if the formulation contains an organic solvent such as alcohol, the effect as a scrubbing agent tends to decrease as in the case of (2) above. I can't avoid becoming.

[0006]

The present inventors have conducted extensive studies for the purpose of developing a new type of scrub granule free from these various drawbacks and disadvantages. That is, the problem to be solved by the present invention is that it can be blended with any external preparation for the skin, can obtain an appropriate feel, is excellent in the massage effect and the cleaning effect, and can further reduce the irritation during use. It is an object of the present invention to provide a new type of scrub granule that has not been used so far, which is a safe scrub granule with few safe particles, and can be produced without using an organic solvent, and to provide a skin external preparation containing the scrub granule.

[0007]

The method for producing scrub granules of the present invention will be described in detail below with reference to examples. Powders, hydrogenated oils, binders and the like used in granulation, and The granulation method and the like are not limited as illustrated. In order to explain the present invention in more detail, first, the outline and characteristics of the manufacturing method will be summarized.

The scrub granules of the present invention are obtained by mixing water-insoluble powder with hardened oil powder having a melting point of 50 ° C. or higher.
And to granulate this mixed powder with water-soluble binder 1
There are two characteristics. At this time, the water-insoluble powder used is
Any material of that nature can be used. For example, inorganic minerals such as talc, titanium oxide and zinc oxide, inorganic salts such as calcium phosphate, organic synthetic polymers such as polyethylene, polystyrene, nylon powder, silicon powder, and natural polymers such as crystalline cellulose and starch. The type is typical.
In addition, the hydrogenated oil having a melting point of 50 ° C. or higher is fish oil, whale oil, or fatty oil obtained by adding hydrogen to other animal fat oil or vegetable fat oil, and examples thereof include hydrogenated rapeseed oil, hydrogenated castor oil. There are things like oil, hydrogenated sardine oil and so on. The reason for using the one having a melting point of 50 ° C. or higher is that the target scrub granules have an appropriate hardness, that the particles have a favorable particle contact feeling, massage effect, and cleaning effect, and that they are stable during storage of the compounded preparation. That is, a product having good properties is obtained. The quantitative relationship between the water-insoluble powder and the hydrogenated oil is 0.1 to 25% with respect to the total amount of the water-insoluble powder.
It is preferable to use powdered hardened oil in an amount of 2.0 to 8.0%. Although these are sufficiently kneaded and granulated with a water-soluble binder, the water-soluble binder to be used may be hydroxypropyl cellulose or polyvinylpyrrolidone. The granulation method is not particularly limited, and a general method (fluidized bed granulation method, stirring granulation method, extrusion granulation method, etc.) may be used.

The granules thus obtained are dried and then
The second feature is that heat treatment is performed. The heating condition is a temperature about 10 to 20 ° C. higher than the melting point of the used hardened oil, until the hardened oil in the granulated product melts (about 20
It is better to process for about 40 minutes. This is done to allow the hardened oil in the particles to blend in well with the water-insoluble powder.

The granules thus heat-treated are then cooled to room temperature to obtain the desired scrub granules.

[0011]

[Production Example] Nylon powder (200g), talc (200g), crystalline cellulose (100g), yellow iron oxide (5.0g), and hydrogenated rapeseed oil (20g) were mixed thoroughly, and a 5% polyvinylpyrrolidone aqueous solution was prepared. (200 g) is granulated with a stirring granulator. After drying the obtained granulated product with a drier, heat treatment is performed for 30 minutes in an incubator at 80 ° C. Then, the mixture is left standing to cool to room temperature and sieved (28 to 48 mesh) to obtain scrub granules (A).

[0012]

[Production Example] Gunjou (20 g) and hydrogenated castor oil (30 g) were added to polyethylene powder (500 g) and mixed well. This is granulated in a stirring granulator using a 7% aqueous solution of hydroxypropyl cellulose (200 g). After drying the obtained granulated product with a drier, heat treatment is performed for 30 minutes in an incubator at 80 ° C. Next, it is left to cool to room temperature and sieved (28 to 48 mesh) to obtain scrub granules (B).

[0013]

[Examples] Measurement of hardness The hardness of the scrub granules obtained by the above method was measured.
In consideration of blending with the external preparation for skin, the conditions were changed such as dry, wet with water, and wet with ethanol. The specimens, measuring instruments, test methods and results are as follows. <Sample> 1. Scrub granules (A) obtained by the production example 1. 2. Scrub granules (B) obtained in Production Example 3. Non-heat-treated product of scrub granule (B) of production example Polystyrene particles 5. Walnut seed kernels 6. Granules obtained by granulating a water-insoluble powder only with hydroxypropyl cellulose by a conventional method 7. Granules obtained by granulating a water-insoluble powder only with ethyl cellulose by a conventional method 8. Granules obtained by granulating a water-insoluble powder only with paraffin wax by a conventional method <Measuring instrument> Rheometer NRM-2002J (made by Fudo Kogyo Co., Ltd.) <Test method> 42-48 mesh by sieving the particle size of the sample And 10 tablets arbitrarily extracted were compressed in a dry state, a state moistened with water, and a state moistened with ethanol, and the crushed g number was measured using an elastic adapter. The measurement was performed 10 times for each sample, and the average value was calculated. <Results> The results are shown in the following table (Table 1).

[Table 1]

As described above, the scrub granules (samples 1 and 2) of the present invention maintain a stable hardness in any state. Also, even if you use the same material,
It can be seen that in the case of the sample that was not heat-treated (Sample 3), the hardness in the dry state was low, and it was very brittle in the presence of water or ethanol. On the other hand, conventional polystyrene grains (sample 4) and walnut seed shell grains (sample 5) were not crushed even if they were hard enough to exceed the scale of the rheometer. It is confirmed that the granules (test sample 6) granulated using only the conventional water-soluble binder are still easily affected by water and ethanol. Further, the granules granulated using only ethyl cellulose which is a non-aqueous binder (sample 7) are easily affected by alcohol, and the granules granulated using only paraffin wax (sample 8). Then, it seems to be too hard.

Next, when the scrub granules of the present invention are applied to a skin external preparation, how much should be blended in the formulation to obtain a proper feel and to exert the desired effect as a scrub agent? I examined. As the method, an emollient cream and a face-wash cream were taken as representative external skin preparations to prepare a base cream, the scrub granules of the present invention were mixed in various addition amounts, and the monitor was actually used for evaluation. .

[0016]

[Example] Production of emollient cream <Process> A. Beeswax 6.0% Cetanol 5.0% Reduced lanolin 8.0% Squalene 37.0% Fatty acid glycerin 4.0% Hydrophilic glyceryl monostearate 2.0% Polyoxyethylene sorbitan monolaurate 2.0% --- ------------------------------------- Propylene glycol 5.0% Purified water Amount based on 100 as a total amount ---------------------------. Scrub granules (A) 0.01 to 6.0% <Production Method> 75 parts of each of the oil phase part A and the water phase part B
After heating to 0 ° C. to completely dissolve it, the oil phase part A is added to the stirring water phase part B. After that, the mixture was allowed to stand with stirring, C was added when the temperature of the system reached 50 ° C., and stirring was continued and cooled to obtain an emollient cream.

[0017]

[Examples] Production of facial cleansing cream <Process> A. Myristic acid 25.0% Stearic acid 5.0% Beef fatty acid 5.0% Propylene glycol 8.0% -----------------------. ----- B. Potassium hydroxide 6.0% Purified water 10.0% ------------------------. Coconut oil fatty acid diethanolamide 6.0% Sterilizer / preservative Appropriate amount Purified water 33.3% −−−−−−−−−−−−−−−−−−−−−−−−−−−−−− --- D. Fragrance 0.7% ---------------------------------. Scrub granules (B) 0.01 to 6.0% <Production Method> The oil phase part of A is heated to 85 ° C. to completely dissolve it, and then the solution of B is slowly added to this while stirring to perform saponification. . Then, the mixed solution of C and D were added to this, and the mixture was allowed to stand with stirring. When the temperature of the system had cooled to 50 ° C., E was added, and the mixture was allowed to stand at room temperature to obtain a face cleansing cream.

[0018]

[Embodiment] Evaluation test <Monitor> Men and women in their twenties and thirties (5 persons each) <Evaluation criteria> At the beginning of use, the end, and the three stages as a comprehensive one, for each cream, the following items Was evaluated by points. Feeling, massage effect, cleaning effect Unfavorable 1 point Somewhat insufficient 2 points Normal 3 points Somewhat satisfied 4 points Good 5 points <Results> Table 2 shows various combinations of the scrub granules (A) obtained in the examples. It is the total value of the evaluation points for the emollient cream produced in different amounts. Also, Table 3
Is the total value of the evaluation points of the face cleansing cream prepared by changing the compounding amount of the scrub granules (B) obtained in the examples. For comparison, for each cream, 1% of the following used when measuring hardness
The blended materials were prepared and evaluated together. that time,
The panelists did not know the type and amount of scrub granules. Comparative 1 Non-heat-treated scrub granules (B) of Production Example Comparative 2 Polystyrene particles Comparative 3 Walnut seed shell particles Comparative 4 Granules obtained by granulating water-insoluble powder only with hydroxypropyl cellulose Comparative 5 Water-insoluble powder only with ethyl cellulose Comparison 6 Granules granulated with water-insoluble powder only with paraffin wax

[Table 2]

[Table 3]

From these test results, it was confirmed that the most suitable amount is about 0.05 to 5% when the scrub granules of the present invention are blended in the external preparation for skin. It was also found that even when water or oils and fats were contained in the formulation, the stability during use was very good compared to the conventional one, and a moderate scrubbing effect was maintained.

[0020]

INDUSTRIAL APPLICABILITY The scrub granules for blending a new type of external preparation for skin according to the present invention have a very good feeling of contact with the skin and an appropriate massage effect and cleaning effect. In addition, since it gradually becomes smaller during use, it causes less irritation to the skin. The external preparation for skin in which these are blended in the range of 0.05 to 5.0% has less irritation to the skin and has the above-mentioned effects. Therefore, a high degree of satisfaction can be obtained both immediately after the start of use and after use.

Claims (2)

[Claims] 1. A water-insoluble inorganic substance powder and / or a water-insoluble organic polymer substance powder, and one or more powders of hardened oil having a melting point of 50 ° C. or higher are mixed, and the mixture is mixed with a water-soluble bond. After granulating with an agent, it is dried, and then the dried particles are subjected to heat treatment so that the hardened oil powder contained in the particles melts, and then cooled. Scrub granules 2. A water-insoluble inorganic substance powder and / or a water-insoluble organic polymer substance powder, and one or a mixture of two or more powders of hardened oil having a melting point of 50 ° C. or more are used with a water-soluble binder. The granulated scrub granules according to claim 1 obtained by heat-treating the dried particles are blended in a range of 0.05 to 5.0%. External preparation for skin