JPH06238008A - Patch test instrument - Google Patents

Abstract

PURPOSE:To provide a patch test instrument which does not cause leakage of a liquid material, has no reactivity with Algene and does not give an incentive to the tested skin by forming a disc-like chamber for applying Algene, which is installed in such a manner not to lose permeability of the peripheral part of a permeable support, by a material which has no reactivity with Algene. CONSTITUTION:A support 1 is formed by applying a pressure sensitive adhesive 2 harmless to the skin to one side of a permeable fibrous sheet cut in such a size as to be easily stuck to the skin surface at the time of a test in such a manner not to lose permeability of the fibrous sheet, and disc-like chambers 3 to which Algene is applied are placed at fixed intervals on the pressure sensitive adhesive applied surface of a support 1, with their bases adhering thereto. The sheet-like support to which the bases of the disc-like chambers 3 adhere is taken as one unit and covered with a separating sheet 4 from above the disc-like chambers 3. The chambers 3 are formed by a material having no reactivity with Algene, and ethylene fluoride is used as the material for forming the chambers 3.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch test device containing a reagent agent for detecting skin contact allergy of a drug in the dermatological field.

[0002]

2. Description of the Related Art In a patch test, a substance to be tested is applied to the chamber of a patch test tool, which is applied to the skin of humans and animals to cause a sensitizing substance (allergen).
Is to be screened.

Conventionally, in this patch test, an adhesive layer such as a bandage is provided on a support of a vinyl chloride film, and a lint cloth punched out in a circle is arranged on the adhesive layer to form an allergen application part. Has been used. This device itself has the feature of being simple, but the support is not breathable, and the skin irritation of the adhesive bandage is strong, and when a liquid allergen is used, it leaks out and the irritation is strong, and it does not affect the skin surface. However, there is a drawback in that the accuracy of determination decreases due to the reaction.

As an improvement of this defect, there is a structure in which a breathable non-woven fabric is used as a support, an adhesive layer is provided thereon, and a dish-shaped chamber made of aluminum is attached. This patch test tool has the advantage that the irritation caused by the bandage is low and the allergen is completely sealed while the chamber is in close contact with the skin, so that the reaction is highly reliable.

However, the aluminum chamber has been reported by Kubo et al. (Skin 33 , special issue No. 10, 4).
2, 1991), hydrochloric acid and sulfuric acid are produced by a reaction with chlorides such as mercuric chloride and zinc chloride, and a sulfuric acid compound, and the stimulation thereof produces an erroneous determination result such as a false positive. Further, in the case of aluminum, irritation may occur due to metal allergy from the dish itself.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a patch test tool as an allergen application part, which does not leak liquid matter, does not react with allergens, and does not irritate test skin. is there.

[0007]

DISCLOSURE OF THE INVENTION The present invention provides a breathable support coated with an adhesive, and an allergen mounted on the support so as not to lose the breathability of at least the peripheral portion of the dish-shaped chamber. A patch test tool comprising a dish-shaped chamber to be coated and a release paper covering the support coated with the adhesive including the dish-shaped chamber, wherein the chamber is made of a material that is not reactive with an allergen. It is a test tool.

Materials that are not reactive with allergens include ceramics such as alumina and zirconia, or plastics that are thermoplastic, among which ethylene fluoride (tetrafluoroethylene and tetrafluoroethylene) that is particularly chemically stable and can be molded. A copolymer of ethylene) can be preferably used.

In particular, in the case of fluoroethylene plastics, it is possible to add titanium oxide as a filler to the fluoroethylene resin that constitutes the chamber so as to have a light blocking property, and a reliable judgment result can be obtained. To be

[0010]

[Function] As a chamber forming material, it is chemically stable,
In addition, by using a material that is hermetically sealed and has low skin irritation per se, reliable test results can be obtained without deterioration due to reaction with various compounds that are allergens.

In particular, the molding of the dish-shaped chamber becomes easy when thermoplastic plastics are used.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The attached drawings show embodiments of the present invention.

FIG. 1 is a view of the patch test tool of the present invention viewed from the side of a support coated with an adhesive, and FIG.
FIG. 3 is a cross-sectional view as seen from the line A, FIG. 3 is an external view of the chamber, and FIG. 4 is a view of the patch test tool after peeling off the release paper as seen from the chamber mounting surface.

In FIGS. 1 and 2, reference numeral 1 denotes a breathable fibrous sheet cut into a size that is easily attached to the skin surface during the test, for example, a length of 120 mm and a width of 30 mm. On the other hand, a support obtained by partially applying a harmless pressure-sensitive adhesive 2, for example, an acrylic pressure-sensitive adhesive, so as not to lose the air permeability of this nonwoven fabric is shown.
The bottom surface of the dish-shaped chamber 3 for applying the allergen is adhered to the pressure-sensitive adhesive application surface of the support 1 at regular intervals, and five pieces are arranged. Then, the sheet-shaped support having the bottom surface of the dish-shaped chamber 3 bonded thereto is used as one unit, and the dish-shaped chamber 3 is covered with a release paper 4 from the top to complete the sheet-shaped support.

As shown in FIG. 3, the dish-shaped chamber 3 has a volume of 0.
A disk-shaped dish having a diameter of about 10 mm and having a rim 32 forming a bottom surface 31 having a depth of about 5 mm was hot-molded with ethylene fluoride (trade name NEOFLON).

In use, as shown in FIG. 4, the release paper 4 was peeled off, and the bottom of the dish-shaped chambers 3 arranged on the support 1 was coated with a white petrolatum-based allergen for testing. I served.

To check the chemical resistance of the chamber. Each chamber was dipped in 7 kinds of acid, alkali and representative patch test test liquids shown in the table below and left standing at 40 ° C for 7 days, together with the results of chemical resistance comparison test of conventional aluminum chambers. Shown in 1.

The ethylene fluoride chamber of the present invention did not change in weight for all test agents. The appearance was only colored with iodine solution, and no change was observed with other test drugs. Good chemical resistance.

On the other hand, in the aluminum chamber, the weight was reduced by reacting with acid and alkali to generate gas and dissolve.
Further, the surface was corroded by reacting with a mercuric chloride solution, a potassium dichromate solution and an iodine solution. The appearance and weight of l-menthol and turpentine oil did not change.

[0020]

[Table 1] In conclusion, it can be said that the aluminum chamber has poor chemical resistance in the case of an aqueous solution, while the ethylene fluoride chamber has no problem at all.

Next, the stimulant properties of the champer were alternately arranged in the chambers made of ethylene fluoride and the chambers made of aluminum, and the chambers were adhered to the human back for 48 hours. The determined results are shown in Table 2.

[0022]

[Table 2] Immediately after the specimen was removed, the mold remained concentrically on the skin in both the ethylene fluoride chamber and the aluminum chamber, but the shape of the aluminum chamber was wider and deeper. Two
The cases of + at 4 hours and 48 hours are judged to be due to irritation of aluminum itself.

[0023]

The patch test tool of the present invention has the following effects.

(1) Particularly in recent years, it is most suitable for use in testing metal ions, which are a large amount of allergen substances, and samples as liquids, and accurate and highly accurate test results can be obtained.

(2) There is no metal allergy and it is safe for the subject.

[Brief description of drawings]

FIG. 1 is a plan view of an embodiment of the present invention.

FIG. 2 is a sectional view taken along line AA of FIG.

FIG. 3 shows the appearance of a coating chamber.

FIG. 4 shows a state for a test.

[Explanation of symbols]

 1 Support 2 Adhesive 3 Dish Chamber 4 Release Paper 31 Bottom of Dish Chamber 32 Rim of Dish Chamber

Claims (2)

[Claims] 1. A breathable support coated with an adhesive, a dish-shaped chamber mounted on the support for coating an allergen, and a peeling covering the substrate coated with the adhesive including the dish-shaped chamber. A patch test tool made of paper, wherein the chamber is formed of a material that is not reactive with an allergen. 2. The patch test device according to claim 1, wherein the material forming the chamber is ethylene fluoride.