JPH06225921A - Bag and tube for medical treatment - Google Patents

Abstract

PURPOSE:To prevent a component which gives bad influence to a living body from eluting into blood, to improve blood compatibility and to reduce damage given to thrombocyte by constituting a bag and a tube for medical treatment of a mixture of an aliph. polyester expressed by a specified repeating unit or at least one of the aliph. polyester and another polymer. CONSTITUTION:An aliph. polyester of a formula (where x is an integer of at least 0 and y and z are each an integer of at least 1 and R is a hydrogen atom, an unsatd. or satd. aliph. hydrocarbon group, or a satd. aliph. hydrocarbon group having a halogen atom or a functional group of hydroxyl, carboxyl, suifo or amino group) is synthesized by a microorganism or a chem. synthesis method. The aliph. polyester like this alone or a mixt. of at least one of the aliph. polyester and another polymer is made into a bag or a tube for medical treatment.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical bag and tube, the purpose of which is to be used as a blood transfusion set, an infusion set, a blood circuit, etc. The present invention is to provide a medical bag and a tube which have a small degree of damage to blood platelets and have extremely high safety even when blood is circulated and stored for a long time.

[0002]

2. Description of the Related Art Blood transfusion is an important treatment for massive blood loss that often occurs during a major accident or a major surgery that requires a long time. Generally, in the case of a large amount of blood loss exceeding several 100 ml, whole blood transfusion in which whole blood is injected into a patient's vein is required, but in other cases, a method of component transfusion in which only blood components necessary for the patient are transfused. Is adopted. Further, if a small amount of blood is lost, blood transfusion is not required, and a method of administering only an infusion solution such as electrolytes, nutrients and plasma substitutes intravascularly, subcutaneously or intraperitoneally is also adopted. When administering such an infusion solution or transfusing blood, an infusion solution such as a tube or a bag (syringe), a transfusion set, a blood circuit or the like is usually used. Most of the bags and tubes for blood transfusion and infusion use soft polyvinyl chloride from the viewpoints of moldability, flexibility, good mechanical strength, low cost, etc. Di-2-ethylhexyl phthalate (DEHP) was included. In addition, in such a bag or tube, in order to prevent aggregation and adhesion of blood filled inside and to improve antithrombotic properties against blood, an anticoagulant such as heparin is added to the polymer, Alternatively, it was chemically bonded to the surface. In particular, platelets, which play an important role in hemostasis, are easily destroyed during blood transfusion, and easily adhere to the inner wall surface of blood collection devices and blood transfusion sets, making it difficult to send them to the blood of recipients. It had been.

[0003]

However, an infusion set, a blood transfusion set or a blood circuit such as a tube or a bag usually has a long contact time with the blood because the blood is circulated or stored for a long time, and the soft poly- In a vinyl chloride blood transfusion set, there was a problem that the contained plasticizer (di-2-ethylhexyl phthalate (DEHP)) was dissolved in blood or infusion during use, which adversely affects the living body. That is, di-2-ethylhexyl phthalate (DE contained in a blood transfusion set as a plasticizer)
Regarding HP), there are many reports on toxicity, di-2-ethylhexyl phthalate (DEHP) that inhibits cell proliferation and elutes against stored platelets reduces the hypotonic shock recovery rate of platelets. Things were known. On the other hand, when heparin, which is an anticoagulant, is added to the polymer of the transfusion set, it is difficult to control the release rate, and when it is chemically bonded to the polymer surface, the antithrombotic effect of heparin is present. There were problems such as being deactivated. Therefore, in the industry, even if blood is circulated or stored for a long period of time, components that adversely affect the living body are not eluted in the blood, and anti-thrombogenicity, anti-hemolytic property, etc. Of medical bags and tubes that can be used as a set for blood transfusion and infusion that can send blood into recipient's blood without destroying platelets that have an important blood compatibility in blood components as much as possible. Creation was desired.

[0004]

According to the present invention, there is provided a medical bag and tube, or an aliphatic polyester, characterized by comprising an aliphatic polyester represented by a repeating unit represented by the following formula 4 (Chemical formula 4). By providing a medical bag and a tube made of a mixture of at least one kind and another polymer, the above conventional problems are alleviated.

[Chemical 4] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)

[0005]

The aliphatic polyester represented by the repeating unit represented by the following formula 5 (Chemical formula 5) and a mixture of the aliphatic polyester and another polymer, or a laminate thereof, has anti-hemolytic property and anti-hemolytic property. It is extremely excellent in blood compatibility such as thrombus formation, and has little damage to platelets. It does not require the plasticizer or anticoagulant mentioned above and is safe even if it is kept in contact with blood for a long time. It suitably acts as a material for medical bags and tubes used in the administration of.

[Chemical 5] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)

[0006]

The structure of the medical bag and tube according to the present invention will be described in detail below. The aliphatic polyester represented by the repeating unit represented by the following formula 6 (formula 6) used in the present invention is synthesized by a microorganism or by a chemical synthesis method.

[Chemical 6] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)

As a method for synthesizing by a microorganism, for example, a microorganism having a polyester synthesizing ability is first subjected to a pre-culture in which the microorganism is grown in a nutrient-rich medium and an essential component for the growth of the microorganism such as nitrogen, phosphorus or various inorganic nutrients. There is a method of culturing in two stages, that is, the latter stage of culturing in which the polyester is produced and accumulated in the microbial cells by limiting any one of them. In this way, by not containing any one of the growth essential components such as nitrogen in the culture in the latter stage or by depleting the growth essential component in the culture, the growth of the bacterial cells is restricted, and the polyester synthesis becomes efficient. You can do it well. Examples of microorganisms capable of synthesizing polyester include Alcaligenes eutrophus H 16 and Alcaligenes faecalis.
, Alcaligenes latus, etc., Pseud
omonas acidovorans , Pseudomonas oleovorans and other Pseudomonas species, Paracoccus denitrificans , Rhodos
Although pirillum rubrum and the like are preferably exemplified, the invention is not particularly limited, and a specific kind selected from microorganisms having a polyester synthesizing ability is appropriately and suitably used. Further, as this culturing method, either a batch method or a continuous culturing may be used and is not particularly limited. The cells grown by the first-stage culture are separated from the culture solution by filtration or centrifugation, and transferred to the second-stage culture, or they grow in the medium during the process of growing the cells in the first-stage culture. After consuming at least one of the essential components, the culture is transferred to the latter stage. The culturing conditions are that the temperature is 20
The culture is carried out aerobically in the range of about -40 ° C and pH of about 6-10.

At this time, it is more preferable for the production and accumulation of polyester to limit nitrogen or phosphorus as an essential component for growth than inorganic nutrients such as potassium and magnesium, but it is not particularly limited. Examples of suitable medium components include carbon sources such as glucose, fructose, saccharides such as mannose, synthetic carbon sources such as methanol, ethanol, acetic acid, butyric acid, yeast extract, peptone, and natural products such as meat extract. However, it is not particularly limited. Suitable examples of the nitrogen source include inorganic nitrogen compounds such as ammonia, ammonium salts and nitrates, organic nitrogen compounds such as peptone, yeast extract and meat extract. Phosphates are preferably provided as the phosphorus source, and cations of inorganic salts such as potassium, magnesium, calcium, iron, manganese, cobalt, zinc and copper are preferably provided as the inorganic nutrients.

As described above, in the synthetic method using a microorganism, any carbon source selected depending on the structure of the aliphatic polyester to be obtained is used alone or in the subsequent culture in which polyester is produced and accumulated in the cells. Used in mixing. This substrate is preferably used continuously during the subsequent culture, but it may be used even partially, or may be given in several divided doses. After completion of the culture, the bacterial cells are separated from the culture solution by filtration or centrifugation, and the polyester accumulated in the bacterial cells is extracted. The extraction method is not particularly limited, but it can be easily obtained by extracting with a solvent such as chloroform and precipitating the extract with a poor solvent such as hexane.

In the microbial synthesis method as described above, the microorganism used and the carbon source used in the latter culture are:
Various selections can be made depending on the structure of the aliphatic polyester to be obtained. That is, a 3-hydroxybutyrate unit represented by the following formula (7) (hereinafter referred to as 3HB)
In the case of synthesizing a homopolymer consisting of, one of the above-mentioned microorganisms having polyester-producing ability is used, and this microorganism is cultivated by the above-mentioned two-stage culturing method of the former stage and the latter stage,
In particular, glucose, fructose, acetic acid, butyric acid, methanol or the like may be used as a carbon source in the latter stage of culturing.

[Chemical 7] (However, n represents an integer of 1 or more.)

Further, 3HB represented by the following equation 8 (Formula 8)
And 3-hydroxyvalerate unit (hereinafter referred to as 3HV)
Copolymer with (P (3HB-co-3HV)) (hereinafter, P
Is a polymer), Alcaligenes eutrophus may be used as the microorganism, and propionic acid, valeric acid, pentanol, etc. may be used as the carbon source particularly in the latter-stage culture.

[Chemical 8] (However, in the formula, x and y represent an integer of 1 or more.)

Further, 3HB represented by the following equation 9 (Formula 9)
And 4-hydroxybutyrate unit (hereinafter referred to as 4HB)
When synthesizing a copolymer with (P (3HB-co-4HB)), Pseudomonas acidovorans is used as a microorganism, and 4-hydroxybutyric acid, 1,4-butanediol, etc., as a carbon source particularly in the latter stage of culture. Can be used.

[Chemical 9] (However, in the formula, x and y represent an integer of 1 or more.)

Among the microorganisms, Pseudomonas o
Using leovorans , octanoic acid,
When nonanoic acid or the like is used, a polyhydroxyalkanoate (hereinafter referred to as P
(Denoted as HA) can be synthesized.

[Chemical 10] (However, in the formula, m represents an integer of 2 to 8, and n represents an integer of 1 or more.)

On the other hand, in the chemical synthesis method, for example, triethyl aluminum (AlEt ₃ ) or diethyl zinc (ZnEt) is used.
₂ ) is reacted with water or alcohol to synthesize an initiator or methylaluminoxane to perform ring-opening polymerization of a lactone to obtain 3HB from β-butyrolactone.
Polycaprolactone (hereinafter referred to as PCL) can be synthesized from ε-caprolactone as a homopolymer.

The above 3HB homopolymer and P (3
Aliphatic polyesters such as HB-co-3HV), P (3HB-co-4HB), and polycaprolactone are biodegradable polyesters that are decomposed by the action of microorganisms. In the present invention, such an aliphatic polyester is used alone or a mixture of at least one kind of the aliphatic polyester and another polymer is used as a medical bag and a tube. In the present invention, the medical bag and the tube, from the above materials, to prepare a film or non-woven fabric, molded into a bag or tube,
A set used for a blood transfusion set, an infusion set, a blood circuit, and the like. Further, in the present invention, in particular, the above-mentioned aliphatic polyester may be used alone or a mixture of the aliphatic polyester and another polymer may be provided at a contact portion with blood or an infusion to form a medical bag and a tube.
In this case, the above-mentioned material is used for the inner surface portion which is the contact portion with blood or infusion solution, and other material is used for the other portion, that is, the outer peripheral portion of the aliphatic polyester or the mixture of the aliphatic polyester and the other polymer. A structure for coating may be adopted, and any structure may be adopted without limitation according to the purpose.

The other polymer mixed with the aliphatic polyester is not particularly limited, but since the polyester is a thermoplastic resin, a thermoplastic polymer is preferable for molding. Specifically, for example, polyethylene,
Polypropylene, polyvinyl chloride, polyvinylidene chloride, polyvinyl acetate, polystyrene, polyvinyl alcohol, ethylene / vinyl alcohol copolymer, acrylic polymers such as polymethylmethacrylate, aromatic polyesters such as polyethylene terephthalate and polybutylene terephthalate, nylon Polyamides such as 6 and nylon 66, polyurethanes such as 2,6-polyurethane, thermoplastic elastomers such as styrene elastomers such as block copolymers of butadiene and styrene, block copolymers of polybutylene terephthalate and polytetramethylene oxide glycol. Suitable examples include polyester elastomers such as polymers, olefin elastomers, urethane elastomers, amide elastomers, etc. Can, it is possible to use these polymers in admixture alone or two or more.

According to the present invention, the following equation 11 (Formula 11)
Two or more kinds of the aliphatic polyesters represented by the repeating unit shown by may be mixed and used, and any one may be mixed in any ratio depending on the intended site and the degree of the wound.

[Chemical 11] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)

Further, when the aliphatic polyester is mixed with other polymers, any combination may be appropriately used depending on the intended use. The aliphatic polyester is 5 to 95% by weight, and the other polymer is used. May be arbitrarily mixed within the range of 95 to 5% by weight, and is not particularly limited. Further, in addition to the above, the medical bag and tube according to the present invention may be appropriately added with any additive such as a filler and an antioxidant as necessary within a range not impairing the effects of the present invention. Good.

[0019]

The effects of the medical bag and tube according to the present invention will be further clarified below with reference to Examples and Comparative Examples. However, the present invention is not limited to the following examples.

Example 1 Poly-3-hydroxybutyrate (hereinafter referred to as P3HB) (manufactured by Aldrich) was molded by a uniaxial extruder with a T-die (T-die temperature 210 ° C.), thickness 500 μm, width 60 cm. And the film. Extruder with die for tube manufacturing (die temperature 2
Molded using 10 ℃, inner diameter 12mm, thickness 1m
m tube was made. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

Example 2 Copolymer of 3-hydroxybutyrate and 3-hydroxyvalerate (P (76% 3H
B-co-24% 3HV)) is molded by a uniaxial extruder with a T-die (T-die temperature 190 ° C), and the thickness is 500μ.
The film was m and had a width of 60 cm. In addition, molding was performed using an extruder with a tube manufacturing die (die temperature 190 ° C.) to produce a tube having an inner diameter of 12 mm and a thickness of 1 mm. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

Example 3 A polyester was prepared using Pseudomonas acidovorans IFO-13582. First, in 1 liter of distilled water, 10 g of polypeptone, 10 g of yeast extract, (NH ₄ ) ₂ SO ₄
A culture solution was prepared by mixing 5 g of meat extract and 5 g of meat extract, and the cells were cultured in this culture solution at 26 ° C. for 48 hours to grow the cells.
Pre-stage culture was performed. After the completion of the first-stage culture, the cells were separated by centrifugation. A culture solution was prepared according to the following formulation using inorganic nutrients such as phosphorus, magnesium and trace elements, and 1,4-butanediol as a carbon source. After adjusting this culture solution to pH 7.0, the separated bacterial cells were transferred to this culture solution. Subsequent culture was carried out at 26 ° C. for 98 hours in this culture medium to produce and accumulate the polyester copolymer in the cells. (In 1 liter of distilled water) K ₂ HPO ₄ 5.8g MgSO ₄ 0.12g KH ₂ PO ₄ 3.7g 1,4-butanediol 1.0g * Trace element 1ml * Trace element solution is the following inorganic nutrient in 1N hydrochloric acid Is included. FeSO ₄・ 7H ₂ O 2.78g CaCl ₂・ 2H ₂ O 1.67g MnCl ₂・ 4H ₂ O 1.98g CuCl ₂・ 2H ₂ O 0.17g CoSO ₄・ 7H ₂ O 2.81g ZnSO ₄・ 7H ₂ O 0.29g End of culture After that, the cells are separated from the culture solution by centrifugation,
After washing with water, it was extracted with chloroform. The extract was once concentrated, and hexane was added to this concentrate to precipitate the obtained polyester. The precipitate was collected and dried to obtain a microorganism-derived polyester. The composition of the obtained polyester was 3H from the result of the integral value of 100MHz ¹ H-NMR.
It was found that B was 10% and 4HB was 90%. This polyester (P (10% 3HB-co-90% 4H
B)) is a single-screw extruder with T-die (T-die temperature 100
(° C.) to form a film having a thickness of 500 μm and a width of 60 cm. In addition, molding was performed using an extruder with a die for tube production (die temperature 100 ° C), and an inner diameter of 12
A tube having a thickness of 1 mm and a thickness of 1 mm was prepared. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

Example 4 Poly-3 used in Example 1
-Hydroxybutyrate and commercially available polypropylene (trade name: UBE Polypro J109GB, Ube Industries, Ltd.)
And) were melt-mixed at a ratio of 5: 5 by weight (temperature: 200 ° C.) and molded by a uniaxial extruder with a T-die (T-die temperature: 200 ° C.), thickness: 500 μm, width: 60
cm film. In addition, an extruder with a die for tube production (molding using a die temperature of 200 ° C,
A tube having an inner diameter of 12 mm and a thickness of 1 mm was produced. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

(Example 5) P (76) used in Example 2
% 3HB-co-24% 3HV) copolymer and commercially available polyethylene (trade name; Mirason 50, Mitsui Petrochemical Co., Ltd.)
Made by a uniaxial extruder with a T-die (T-die temperature 200 ° C), and a weight ratio of 7: 3, and a thickness of 500 μm, width 60 cm.
And the film. In addition, molding is performed using an extruder with a die for tube production (die temperature 200 ° C),
A tube having an inner diameter of 12 mm and a thickness of 1 mm was produced. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

Example 6 P (10) used in Example 3
% 3HB-co-90% 4HB) copolymer and a commercially available polyamide elastomer (trade name: Bepax 5562MN01,
Toray Co., Ltd.) was melt-mixed in a weight ratio of 3: 7 (temperature 150 ° C.) and molded by a uniaxial extruder with T-die (T-die temperature 150 ° C.), thickness 500 μm, width 60 cm. And the film. In addition, molding was performed using an extruder with a tube manufacturing die (die temperature 150 ° C.) to produce a tube having an inner diameter of 12 mm and a thickness of 1 mm. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

Comparative Example 1 100 parts by weight of polyvinyl chloride (average degree of polymerization = 1300), 60 parts by weight of di-2-ethylhexyl phthalate, 10 parts by weight of epoxidized soybean oil, and 3 parts by weight of metal soap. Were mixed and melt-mixed by a roll at 170 ° C. After that, it is molded by a uniaxial extruder with a T-die (T-die temperature 80 ° C) to a thickness of 500.
The film has a thickness of 60 μm and a width of 60 cm. Further, molding was performed using an extruder with a die for producing a tube (die temperature: 180 ° C.) to produce a tube having an inner diameter of 12 mm and a thickness of 1 mm. This tube was cut at 15 cm, and one end was closed by heat sealing to give a test tube.

(Comparative Example 2) A commercially available liquid silicone rubber (trade name; SE6705, manufactured by Toray Dow Corning Silicone Co., Ltd.) was cast on a glass plate, and the temperature was 1 ° C at 100 ° C.
By heating for 0 minutes, a film having a thickness of 850 μm and a width of 60 cm was produced. Further, a glass test tube having a diameter of 13 mm was dipped in this solution, then heated and removed from the glass test tube to prepare a silicon rubber tube having an inner diameter of 12 mm and a thickness of 1 mm.

COMPARATIVE EXAMPLE 3 A commercially available aromatic ether polyurethane (trade name; Peretane 2363 (80AE), Dow Chemical Co., Ltd.) was added to tetrahydrofuran in an amount of 12% by weight.
It was dissolved at a concentration of. This solution was cast on glass and then dried to obtain a film having a thickness of 100 μm. Also, a glass test tube with a diameter of 13 mm was dipped in this solution, dried, and then removed from the glass test tube.
A polyurethane tube having a thickness of m and a thickness of 1 mm was prepared.

[0029]

[Test Example] Using the films and tubes prepared in Examples 1 to 6 and Comparative Examples 1 to 3, the following tests for blood compatibility were conducted.

(Influence on Platelets) Regarding the behavior of adhesion to the platelet material, the number of adhered platelets and the degree of deformation were observed. The films obtained in Examples 1 to 6 and Comparative Examples 1 to 3 were washed with alcohol and dried. The blood obtained from the limb vein of an adult dog was centrifuged at 80 G for 6 minutes, and the obtained platelet-rich plasma (upper fraction containing platelets) was obtained in Examples 1 to 6 and Comparative Examples 1 to 3 above. A few drops were gently dropped on each of the obtained films and left at room temperature for 30 minutes. Then, in order to remove non-adherent platelets, each film was moved up and down a few times in physiological saline, and then a 1% glutaraldehyde solution (0.1M phosphate buffer (pH
It was immersed in 7.4) and fixed at 2 ° C. for 2 hours. Then, each film was dehydrated and dried with alcohol, and the surface condition was observed with a scanning electron microscope. The number of adhered platelets per 0.025 mm ^{2 of} each film was counted, and the degree of deformation of platelets was evaluated at each stage. The results are shown in Table 1.

[Table 1]

(Antihemolytic Test) 1.0 ml of blood obtained from a rabbit vein was added to the tubes obtained in Examples 1 to 6 and Comparative Examples 1 to 3, and the mixture was added at 37 ° C. and 50 rpm. It was shaken for 6 hours. Then, the blood cells were separated and removed by centrifugation at 2000 G for 10 minutes at room temperature. The amount of hemoglobin released into plasma due to the destruction of red blood cells in the supernatant was measured by the following procedure, and the degree of hemolysis was determined. To 300 μl of supernatant plasma obtained by centrifugation, 3.0 ml of a color reagent for hemoglobin measurement (manufactured by Wako Pure Chemical Industries, Ltd.) was added,
After leaving at room temperature for 10 minutes, the absorbance at 541 nm was measured to calculate the amount of free hemoglobin. The results are shown in Table 2.

[Table 2]

(Antithrombogenicity Test) 1.0 ml of blood obtained from a rabbit vein was added to the tubes obtained in Examples 1 to 6 and Comparative Examples 1 to 3, and the mixture was added at 37 ° C. and 50 rpm. Shaken at. Predetermined time (60 seconds, 300 seconds, 600 seconds, 1800
100 μl every 2 seconds) and physiological saline containing phospholipids (0.1% by weight) and 25 mM calcium ion 2
Added in 00 μl. The time from the time of addition to the occurrence of blood coagulation was measured and defined as the coagulation time. The results are shown in Table 2.

[Table 2]

As is clear from the results shown in Table 1, in the films of Examples, the adhesion number of platelets was very small as compared with Comparative Examples, and it was found that there was almost no deformation of platelets. As is clear from the results in Table 2, the amount of hemoglobin released into plasma (mg / dl) in the tube of the example was very small compared to the comparative example, and the time until coagulation of blood occurred. I know it's long.

[0034]

As described in detail above, the present invention has the following formula 12.
A medical bag and tube comprising at least one of aliphatic polyesters represented by the repeating unit shown in Chemical formula 12 or at least one of the aliphatic polyesters.
Since it is a medical bag and tube consisting of a mixture of seeds and other polymers, as is clear from the results of the above-mentioned Examples and Test Examples, the damage to the platelets to be contacted is small, and the adhesion of the platelets is slight, Moreover, the release of hemoglobin is small, and the coagulation time is long.
It has excellent blood compatibility such as antithrombotic and anticoagulant properties, and it does not require plasticizers or anticoagulants and is safe even if it is kept in contact with blood for a long time. As a blood transfusion set, infusion set, blood circuit It has the effect of being an excellent medical bag and tube that can be used.

[Chemical 12] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)

Claims (5)

[Claims] 1. A medical bag and tube comprising an aliphatic polyester represented by a repeating unit represented by the following formula 1 (Formula 1). [Chemical 1] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.) 2. The medical bag and tube according to claim 1, wherein the aliphatic polyester is synthesized by a microorganism. 3. The medical bag and tube according to claim 1, wherein the aliphatic polyester is synthesized by a chemical synthesis method. 4. A medical bag and tube comprising a mixture of at least one type of aliphatic polyester represented by the repeating unit represented by the following formula 2 (Formula 2) and another polymer. [Chemical 2] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.) 5. A contact portion of an aliphatic polyester represented by a repeating unit represented by the following formula 3 (Chemical Formula 3) or a mixture of at least one kind of the aliphatic polyester and another polymer with a blood or an infusion solution. And a medical bag and tube. [Chemical 3] (However, in the formula, x is an integer of 0 or more, y and z are integers of 1 or more, R is a hydrogen atom, a saturated aliphatic hydrocarbon group, an unsaturated aliphatic hydrocarbon group, a halogen atom or a hydroxyl group at the terminal, a carboxyl group. Represents a saturated aliphatic hydrocarbon group having a functional group of any one of a group, a sulfonic acid group, and an amino group.)