JPH06199696A - Carcinostatic anticancer agent - Google Patents

Abstract

PURPOSE:To provide a carcinostatic anticancer agent effective for quickly ameliorating and treating malignant tumor of mammals including human without causing side effect by daily oral administration. CONSTITUTION:The objective carcinostatic anticancer agent contains a substance having superoxide dismutase(SOD)-like activity and/or antioxidation activity (including scavenger function), a phenolic compound and a sugar compound such as glycoprotein and saccharified flavonoid.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an anticancer agent / anticancer agent.

[0002]

2. Description of the Related Art Conventionally, many therapeutic agents for destroying cancer cells and immunosuppressive agents such as steroids have been known for malignant tumors such as carcinoma and sarcoma.

[0003]

However, these therapeutic agents have strong side effects because they not only kill cancer cells but also act on normal cells.

Immunosuppressive agents such as steroids also have strong side effects, making it difficult to obtain sufficient effects.
These drugs were difficult to use orally, and were ingested mainly by drip or intravenous injection, which placed a heavy burden on patients.

An object of the present invention is to solve the above-mentioned problems and to provide an effective anti-cancer / anti-cancer agent which can orally take a malignant tumor daily and has no side effect.

Therefore, as a result of intensive studies to solve the above-mentioned object, the present inventors have found that superoxide dismutase (SOD) -like activity for removing active oxygen in the body and / or antioxidant ability (superoxide radical). (Including a scavenger function of capturing active oxygen) such as, and a phenol compound and glycoprotein,
The present invention has been completed based on the finding that a composition containing a sugar compound such as a glycated flavonoid has an excellent effect on a malignant tumor and has a safe anticancer / anticancer function without side effects.

[0007] SOD-like activity refers to a substance having an activity (physiological function) similar to the SOD activity for converting superoxide radicals into hydrogen peroxide, and as a substance having SOD-like activity, amino acids and peptides such as copper (II) are used. ) Complex,
Low molecular weight compounds such as manganese complex, fat-soluble ascorbic acid, porphyrin metal complex, polyamine metal complex, etc. are mentioned, and those having antioxidant ability are vitamin C, vitamin E, uric acid, glutathione, β-carotene, calatase, glutathione peroxin. Examples include dase.

Examples of the phenol compound include one selected from the group of guaiacol, phenol, eugenol, phenylethanol and the like, or a mixture thereof.

Examples of sugar compounds such as glycoproteins and glycated flavonoids include one selected from the group consisting of aspalathin, orientin (lutexin), cis-orientin (lutonaretin), isoquercitin, rutin or a mixture thereof.

The present invention also provides phosphorus, iron, calcium,
The effect is more excellent if one or more kinds of minerals such as sodium, potassium, magnesium, copper, zinc, manganese, quercetin, selenium, etc. or a mixture thereof is mixed.

All of the constituents of the present invention are non-toxic and meet the pharmacological criteria. There are no deaths in the acute toxicity test for rats, and no biochemical blood test or histopathological test is performed. No abnormality was found.

The present invention exhibits an excellent effect for the first time by containing a substance having SOD-like activity and / or antioxidant ability, a glycated flavonoid and a phenol compound, and a mineral added as necessary. The composition has a titer of SOD-like activity and / or antioxidant ability of 10,000 to 100,000 units / g, sugar compound 2 to
20 mg / g, 1 to 30 mg / g of a proteinaceous substance, 1 to 20% of a phenol compound, and when adding minerals, it is necessary to contain 10 to 500 mg / g.

The substance having an SOD-like activity and / or antioxidant ability, the sugar component and the phenol compound used in the present invention are mixed alone and directly administered in any form such as solution, powder granules, tablets, emulsions and jellies. Alternatively, it can be mixed with other foods and drinks.

Although the dose varies depending on the kind and degree of the target disease, it is preferably used within the range of 2 to 40 mg / kg / day, and when used as a beverage, 0.1 to
It is preferable to eat and drink the 3.0% solution at 100 ml to 500 ml / day.

[0015]

[Function] Although the factors that cause cancer are complex and unclear, there are possibilities that active oxygen in the body is deeply involved. In the present invention, it is considered that a substance having a superoxide dismutase (SOD) -like activity having an action of removing active oxygen such as a superoxide radical and a substance having an antioxidant action such as a sugar compound act in combination. .

[0016]

[Effects] The present invention allows daily orally ingestion of malignant tumors of mammals including humans, has no side effects, and can be rapidly treated for improvement.

[0017]

【Example】

Production Example Glycated flavonoids 1 to 50 mg / g, protein 2 to 20%, and phenol 3 to 15% as a sugar compound are mixed in a solution state, and a titer of 20,000 units / g as SOD-like activity and / or antioxidant ability is mixed. It was prepared as described above. Distilled water was added to the obtained composition to obtain a solution containing 0.25% of the composition.

[Animal] In the experiment, F344 strain (Charles River) and Wistar strain rat (SRL) were used. All animals have free access to food (Oriental yeast, solid feed) in a breeding room with a room temperature of 24 ± 1 ° C and a relative humidity of 55 ± 5% under a 12-hour light-dark cycle (light period from 7 am to 7 pm) after acquisition. Raised below.

Example 1 Pancreas of a solution-administered group in which the composition obtained by drinking the solution obtained in the Production Example in place of water for daily intake to rats and a rat (control group) in which normal water was ingested To investigate changes in cancer,
The results are shown in Table 1. As a result, the incidence of pancreatic cancer was low and the degree of malignant tumor was low in the administration group.

[Table 1]

Example 2 The solution obtained in Production Example was mixed with C3HIOT / 2 cells to examine the carcinogenic inhibitory effect (AB). Furthermore, irradiation was conducted to induce carcinogenesis, and the carcinogenic inhibitory effect of the present invention was investigated (CD
E). The result is shown in FIG.

Example 3 Using the solution obtained in the production example, the active oxygen removing / eliminating action depending on the addition amount of the solution in a test tube was examined. The result is shown in FIG. According to FIG. 2, ESR in the test tube
A large signal (waveform) indicates the presence of active oxygen, and it can be seen that the amount of active oxygen decreases as the amount of solution added increases.

Then, the solution obtained in the production example was fed to rats instead of water for 8 weeks to examine the amount of active oxygen in adipose tissue. The result is shown in FIG.

[Brief description of drawings]

FIG. 1 is a diagram showing a carcinogenesis suppressing effect.

FIG. 2 is a diagram showing changes in active oxygen according to the amount of solution added in a test tube.

FIG. 3 shows changes in ESR signal in abdominal adipose tissue.

[Explanation of symbols]

 A: Normal product B: 10% solution added C: Normal product irradiated with radiation D: 2% solution added with irradiation E: 10% solution added with irradiation

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Internal reference number FI Technical indication location A61K 31/375 7431-4C 31/70 8314-4C (72) Inventor Masatoshi Nakano New Chiryu City, Aichi Prefecture 36-16 Chano, Hayashi-cho (72) Inventor Hiroshi Okumura 2-13 Shiraiwa-cho, Isahaya-shi, Nagasaki Nishi-isahaya Heights D-301 (72) Inventor Kenji Komatsu 561-20 Hamada-go, Togitsu-cho, Nishisonogi-gun, Nagasaki Prefecture

Claims (3)

[Claims] 1. Superoxide dismutase (SO
D) An anti-cancer / anti-cancer agent containing a substance having a similar activity and / or an antioxidant ability (including a scavenger function), a phenol compound, and a glyco compound such as a glycoprotein and a glycated flavonoid. 2. The antitumor / anticancer agent according to claim 1, wherein the phenol compound is one selected from the group consisting of guaiacol, phenol, eugenol, phenylethanol and the like, or a mixture thereof. 3. The glyco compound such as glycoprotein and glycated flavonoid is one or a mixture thereof selected from the group consisting of aspalathin, orientin (lutexin), cis-orientin (lutonaretin), isoquercitin, rutin and the like. The anticancer / anticancer agent according to claim 1.